MAEHAMA Tomohiko

J-GLOBAL         Last updated: Jul 4, 2017 at 02:55
MAEHAMA Tomohiko
Kobe University
Graduate School of Medicine Faculty of Medical Sciences
Job title
Associate Professor

Research Areas


Academic & Professional Experience

Kobe University Graduate School of Medicine

Published Papers

Nishio M, Maehama T, Goto H, Nakatani K, Kato W, Omori H, Miyachi Y, Togashi H, Shimono Y, Suzuki A
Genes to cells : devoted to molecular & cellular mechanisms   22(1) 6-31   Jan 2017   [Refereed]
Nakatani K, Maehama T, Nishio M, Goto H, Kato W, Omori H, Miyachi Y, Togashi H, Shimono Y, Suzuki A
Journal of biochemistry      Dec 2016   [Refereed]
Maehama T, Kawahara K, Nishio M, Suzuki A, Hanada K
The Journal of biological chemistry   289(30) 20802-20812   Jul 2014   [Refereed]
Maehama T, Fukasawa M, Date T, Wakita T, Hanada K
Biochemical and biophysical research communications   440(1) 150-156   Oct 2013   [Refereed]
Nishio M, Otsubo K, Maehama T, Mimori K, Suzuki A
Cancer science   104(10) 1271-1277   Jul 2013   [Refereed]
Kukimoto I, Maehama T, Sekizuka T, Ogasawara Y, Kondo K, Kusumoto-Matsuo R, Mori S, Ishii Y, Takeuchi T, Yamaji T, Takeuchi F, Hanada K, Kuroda M
PloS one   8(11) e80583   2013   [Refereed]
Suzuki A, Kogo R, Kawahara K, Sasaki M, Nishio M, Maehama T, Sasaki T, Mimori K, Mori M
Cancer science   103(4) 632-637   Apr 2012   [Refereed]
Sasaki M, Kawahara K, Nishio M, Mimori K, Kogo R, Hamada K, Itoh B, Wang J, Komatsu Y, Yang YR, Hikasa H, Horie Y, Yamashita T, Kamijo T, Zhang Y, Zhu Y, Prives C, Nakano T, Mak TW, Sasaki T, Maehama T, Mori M, Suzuki A
Nature medicine   17(8) 944-951   Jul 2011   [Refereed]
Tanaka M, Hara H, Nishina H, Hanada K, Hagiwara K, Maehama T
Biochemical and biophysical research communications   397(3) 505-508   Jul 2010   [Refereed]
Malchinkhuu E, Sato K, Maehama T, Ishiuchi S, Yoshimoto Y, Mogi C, Kimura T, Kurose H, Tomura H, Okajima F
Molecular biology of the cell   20 5156-5165   Dec 2009   [Refereed]
Maehama T, Tanaka M, Nishina H, Murakami M, Kanaho Y, Hanada K
The Journal of biological chemistry   283(50) 35053-35059   Dec 2008   [Refereed]
Malchinkhuu E, Sato K, Maehama T, Mogi C, Tomura H, Ishiuchi S, Yoshimoto Y, Kurose H, Okajima F
Biochemical and biophysical research communications   366(4) 963-968   Feb 2008   [Refereed]
Maehama T
Biological & pharmaceutical bulletin   30(9) 1624-1627   Sep 2007   [Refereed]
Okahara F, Itoh K, Nakagawara A, Murakami M, Kanaho Y, Maehama T
Molecular biology of the cell   17(11) 4888-4895   Nov 2006   [Refereed]
Nigorikawa K, Yoshikawa K, Sasaki T, Iida E, Tsukamoto M, Murakami H, Maehama T, Hazeki K, Hazeki O
Molecular pharmacology   70 1143-1149   Sep 2006   [Refereed]
Suzuki T, Kanai Y, Hara T, Sasaki J, Sasaki T, Kohara M, Maehama T, Taya C, Shitara H, Yonekawa H, Frohman MA, Yokozeki T, Kanaho Y
Molecular and cellular biology   26(16) 6149-6156   Aug 2006   [Refereed]
[Regulation of the lipid phosphatase PTEN].
Maehama T
Seikagaku. The Journal of Japanese Biochemical Society   78 133-137   Feb 2006   [Refereed]
Miyazaki H, Yamazaki M, Watanabe H, Maehama T, Yokozeki T, Kanaho Y
FEBS letters   579(30) 6834-6838   Dec 2005   [Refereed]
Sasaki J, Sasaki T, Yamazaki M, Matsuoka K, Taya C, Shitara H, Takasuga S, Nishio M, Mizuno K, Wada T, Miyazaki H, Watanabe H, Iizuka R, Kubo S, Murata S, Chiba T, Maehama T, Hamada K, Kishimoto H, Frohman MA, Tanaka K, Penninger JM, Yonekawa H, Suzuki A, Kanaho Y
The Journal of experimental medicine   201 859-870   Mar 2005   [Refereed]
Okahara F, Itoh K, Ebihara M, Kobayashi M, Maruyama H, Kanaho Y, Maehama T
Analytical biochemistry   336(1) 138-140   Jan 2005   [Refereed]


PTEN and mytotubularin: novel phosphoinositide phosphatases
Annu. Rev. Biochem.   70, 247-279    2001
Crystal structure of the PTEN tumor suppressor: implications for its phosphoinositide phosphatase activity and membrane binding
Cell   99, 323-334    1999
The tumor suppressor, PTEN/MMAC1, dephosphorylates the lipid second messenger, phosphatidylinositol 3,4,5-trisphosphate
J. Biol. Chem.   273 (22), 13375-13378    1998

Association Memberships


Research Grants & Projects

Ministry of Education, Culture, Sports, Science and Technology: Grants-in-Aid for Scientific Research(挑戦的萌芽研究)
Project Year: 2011 - 2012    Investigator(s): Tomohiko MAEHAMA
Small GTPases play pivotal roles in diverse intracellular signal transduction pathways. In this study, we applied RIRAG method to several small GTPases and found novel signaling pathway that ERK activation was induced by CDC42. The RIRAG method, i...
Ministry of Education, Culture, Sports, Science and Technology: Grants-in-Aid for Scientific Research(基盤研究(B))
Project Year: 2007 - 2009    Investigator(s): Tomohiko MAEHAMA
Cellular lipids function as building blocks of biomembranes and signaling molecules thereby being fundamental components for all cells. In this study, we analyzed the function of cellular lipids for infection cycle of hepatitis C virus and infecti...
Ministry of Education, Culture, Sports, Science and Technology: Grants-in-Aid for Scientific Research(基盤研究(B))
Project Year: 2004 - 2005    Investigator(s): Yasunori KANAHO
We have investigated activation mechanisms and physiological functions of phosphatidylinositol 4-phosphate 5-kinase (PIP5K) which produces the pleiotropic phospholipid, phosphatidylinositol 4,5-bisphosphate, in neuronal cells. So far, we have obta...
Ministry of Education, Culture, Sports, Science and Technology: Grants-in-Aid for Scientific Research(基盤研究(B))
Project Year: 2002 - 2003    Investigator(s): Yasunori KANAHO
Mammalian phospholipase D (PLD) is a novel signal transducing enzyme, which is believed to play roles in a wide variety of cell functions. Two mammalian PLD isozymes, PLD1 and PLD2,have been identified. Although activation mechanisms and physiolog...
Study of Lipid Second Messengers