KITABAYASHI Issay

J-GLOBAL         Last updated: Oct 10, 2018 at 18:37
 
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Name
KITABAYASHI Issay
Affiliation
National Cancer Center, Research Institute
Section
Division of Hematological Malignancy
Job title
Deputy Director/Chief
Degree
Ph.D.(The University of Tokyo)

Research Areas

 
 

Academic & Professional Experience

 
Apr 2010
 - 
Today
Vice Director/Chief, Division of Hematological Malignancy, National Cancer Center Research Institute
 
Oct 2002
 - 
Mar 2010
Chief, Molecular Oncology Division, National Cancer Center Research Institute
 

Awards & Honors

 
 
Molecular study of acute myeloid leukemia and its application for therapy, JCA-Mauvernay Award, Japanese Cancer Association
 

Published Papers

 
Asano Y, Kawase T, Okabe A, Tsutsumi S, Ichikawa H, Tatebe S, Kitabayashi I, Tashiro F, Namiki H, Kondo T, Semba K, Aburatani H, Taya Y, Nakagama H, Ohki R
Scientific reports   6 19174   Jan 2016   [Refereed]
Nakagawa M, Kitabayashi I
Cancer science   109(8) 2342-2348   Aug 2018   [Refereed]
Tabu K, Muramatsu N, Mangani C, Wu M, Zhang R, Kimura T, Terashima K, Bizen N, Kimura R, Wang W, Murota Y, Kokubu Y, Nobuhisa I, Kagawa T, Kitabayashi I, Bradley M, Taga T
Stem cells (Dayton, Ohio)   34(5) 1151-1162   Jan 2016   [Refereed]
Shima H, Takamatsu-Ichihara E, Shino M, Yamagata K, Katsumoto T, Aikawa Y, Fujita S, Koseki H, Kitabayashi I
Blood   131(16) 1833-1845   Apr 2018   [Refereed]
Ikawa Y, Nishimura R, Maeba H, Fujiki T, Kuroda R, Noguchi K, Fukuda M, Mase S, Araki R, Mitani Y, Sato T, Terui K, Ito E, Kitabayashi I, Yachie A
Leukemia & lymphoma   1-3   Feb 2018   [Refereed]
Dong Y, Isono KI, Ohbo K, Endo TA, Ohara O, Maekawa M, Toyama Y, Ito C, Toshimori K, Helin K, Ogonuki N, Inoue K, Ogura A, Yamagata K, Kitabayashi I, Koseki H
Molecular and cellular biology   37(19)    Oct 2017   [Refereed]
Ogoh H, Yamagata K, Nakao T, Sandell LL, Yamamoto A, Yamashita A, Tanga N, Suzuki M, Abe T, Kitabayashi I, Watanabe T, Sakai D
Scientific reports   7(1) 11922   Sep 2017   [Refereed]
[I. Identification of a Possible Therapeutic Target for Chondrosarcoma with IDH Mutant Inhibitors].
Nakagawa M, Nakatani F, Kitabayashi I
Gan to kagaku ryoho. Cancer & chemotherapy   44(3) 212-216   Mar 2017   [Refereed]
Takamatsu-Ichihara E, Kitabayashi I
International journal of hematology   103(6) 634-642   Jun 2016   [Refereed]
Ogawara Y, Kitabayashi I
[Rinsho ketsueki] The Japanese journal of clinical hematology   56(8) 1045-1052   Aug 2015   [Refereed]
Ogawara Y, Katsumoto T, Aikawa Y, Shima Y, Kagiyama Y, Soga T, Matsunaga H, Seki T, Araki K, Kitabayashi I
Cancer research   75(10) 2005-2016   May 2015   [Refereed]
Aikawa Y, Yamagata K, Katsumoto T, Shima Y, Shino M, Stanley ER, Cleary ML, Akashi K, Tenen DG, Kitabayashi I
Cancer science   106(3) 227-236   Mar 2015   [Refereed]
Okuda H, Kawaguchi M, Kanai A, Matsui H, Kawamura T, Inaba T, Kitabayashi I, Yokoyama A
Nucleic acids research   42(7) 4241-4256   Apr 2014   [Refereed]
Iwamoto C, Takenaka K, Urata S, Yamauchi T, Shima T, Kuriyama T, Daitoku S, Saito Y, Miyamoto T, Iwasaki H, Kitabayashi I, Itoh K, Kishimoto J, Kohda D, Matozaki T, Akashi K
Experimental hematology   42(3) 163-171.e1   Mar 2014   [Refereed]
Suzuki M, Yamagata K, Shino M, Aikawa Y, Akashi K, Watanabe T, Kitabayashi I
Cancer science   105(3) 315-323   Mar 2014   [Refereed]
Miyagi S, Koide S, Saraya A, Wendt GR, Oshima M, Konuma T, Yamazaki S, Mochizuki-Kashio M, Nakajima-Takagi Y, Wang C, Chiba T, Kitabayashi I, Nakauchi H, Iwama A
Stem cell reports   2(2) 145-152   Feb 2014   [Refereed]
Nakahata S, Ichikawa T, Maneesaay P, Saito Y, Nagai K, Tamura T, Manachai N, Yamakawa N, Hamasaki M, Kitabayashi I, Arai Y, Kanai Y, Taki T, Abe T, Kiyonari H, Shimoda K, Ohshima K, Horii A, Shima H, Taniwaki M, Yamaguchi R, Morishita K
Nature communications   5 3393   Feb 2014   [Refereed]
Shima H, Yamagata K, Aikawa Y, Shino M, Koseki H, Shimada H, Kitabayashi I
International journal of hematology   99(1) 21-31   Jan 2014   [Refereed]
Nakamoto-Matsubara R, Sakata-Yanagimoto M, Enami T, Yoshida K, Yanagimoto S, Shiozawa Y, Nanmoku T, Satomi K, Muto H, Obara N, Kato T, Kurita N, Yokoyama Y, Izutsu K, Ota Y, Sanada M, Shimizu S, Komeno T, Sato Y, Ito T, Kitabayashi I, Takeuchi K, Nakamura N, Ogawa S, Chiba S
PloS one   9(10) e109714   2014   [Refereed]
Shimizu K, Yamagata K, Kurokawa M, Mizutani S, Tsunematsu Y, Kitabayashi I
Cancer science   104(8) 1033-1038   Aug 2013   [Refereed]
Shima Y, Honma Y, Kitabayashi I
Cancer research   73(14) 4278-4288   Jul 2013   [Refereed]
Haga A, Ogawara Y, Kubota D, Kitabayashi I, Murakami Y, Kondo T
Electrophoresis   34(11) 1670-1678   Jun 2013   [Refereed]
Rokudai S, Laptenko O, Arnal SM, Taya Y, Kitabayashi I, Prives C
Proceedings of the National Academy of Sciences of the United States of America   110(10) 3895-3900   Mar 2013   [Refereed]
Iwanami A, Gini B, Zanca C, Matsutani T, Assuncao A, Nael A, Dang J, Yang H, Zhu S, Kohyama J, Kitabayashi I, Cavenee WK, Cloughesy TF, Furnari FB, Nakamura M, Toyama Y, Okano H, Mischel PS
Proceedings of the National Academy of Sciences of the United States of America   110(11) 4339-4344   Mar 2013   [Refereed]
Yokoyama A, Ficara F, Murphy MJ, Meisel C, Hatanaka C, Kitabayashi I, Cleary ML
PloS one   8(9) e73649   2013   [Refereed]
[Transcriptional regulation].
Katsumoto T, Kitabayashi I
Nihon rinsho. Japanese journal of clinical medicine   70 Suppl 2 75-78   Apr 2012   [Refereed]
Satow R, Shitashige M, Jigami T, Fukami K, Honda K, Kitabayashi I, Yamada T
Gastroenterology   142(3) 572-581   Mar 2012   [Refereed]
Mishima Y, Miyagi S, Saraya A, Negishi M, Endoh M, Endo TA, Toyoda T, Shinga J, Katsumoto T, Chiba T, Yamaguchi N, Kitabayashi I, Koseki H, Iwama A
Blood   118(9) 2443-2453   Sep 2011   [Refereed]
Shima Y, Kitabayashi I
International journal of hematology   94(2) 134-141   Aug 2011   [Refereed]
Yokoyama A, Ficara F, Murphy MJ, Meisel C, Naresh A, Kitabayashi I, Cleary ML
Journal of cell science   124(Pt 13) 2208-2219   Jul 2011   [Refereed]
Ozeki C, Sawai Y, Shibata T, Kohno T, Okamoto K, Yokota J, Tashiro F, Tanuma S, Sakai R, Kawase T, Kitabayashi I, Taya Y, Ohki R
The Journal of biological chemistry   286(20) 18251-18260   May 2011   [Refereed]
Aikawa Y, Katsumoto T, Zhang P, Shima H, Shino M, Terui K, Ito E, Ohno H, Stanley ER, Singh H, Tenen DG, Kitabayashi I
Nature medicine   16(5) 580-5, 1p following 585   May 2010   [Refereed]
Yokoyama A, Lin M, Naresh A, Kitabayashi I, Cleary ML
Cancer cell   17(2) 198-212   Feb 2010   [Refereed]
Yamagata K, Kitabayashi I
Biochemical and biophysical research communications   390(4) 1355-1360   Dec 2009   [Refereed]
Kitoh A, Ono M, Naoe Y, Ohkura N, Yamaguchi T, Yaguchi H, Kitabayashi I, Tsukada T, Nomura T, Miyachi Y, Taniuchi I, Sakaguchi S
Immunity   31(4) 609-620   Oct 2009   [Refereed]
Hibiya K, Katsumoto T, Kondo T, Kitabayashi I, Kudo A
Developmental biology   329(2) 176-190   May 2009   [Refereed]
Katsumoto T, Yoshida N, Kitabayashi I
Cancer science   99(8) 1523-1527   Aug 2008   [Refereed]
[Transcription regulation and leukemia].
Kitabayashi I
Nihon rinsho. Japanese journal of clinical medicine   65 Suppl 1 41-45   Jan 2007   [Refereed]
Enari M, Ohmori K, Kitabayashi I, Taya Y
Genes & development   20(9) 1087-1099   May 2006   [Refereed]
Yokoyama A, Kitabayashi I, Ayton PM, Cleary ML, Ohki M
Blood   100(10) 3710-3718   Nov 2002   [Refereed]
Suhara W, Yoneyama M, Kitabayashi I, Fujita T
The Journal of biological chemistry   277(25) 22304-22313   Jun 2002   [Refereed]

Misc

 
Kitabayashi,I.,Saka,F.,Gachelin,G.and Yokoyama,K.: Nucleotide sequence of rat c-jun protooncogene.
Nucleic Acids Res.18,3400(1990).   
Ozawa,K.,Saka,F.,Kitabayashi,I.,Imai,T.,Soeda,E.,Israel,A., Gachelin,G.and Yokoyama,K.:Comparison of the promoter regions of H-2Kb and H2Kbml class I MHC genes.
Nucleic Acids Res.18,4185-4190(1990).   
Kai,T.,Song,J.,Tashiro,H.,Saka,F.,Ozawa,K.,Kitabayashi,I., Miwa,T.,Soeda,E.and Yokoyama,K.:Rapid method for construction of yeast artificial chromosome human DNA libraries involving the trapping of cells in agarose films.
FEBS Letters 275,77-85(1990).   
Kitabayashi,I.,Chiu,R.,Gachelin,G.and Yokoyama,K.:E1A-dependent up-regulation of c-jun/AP-1 activity.
Nucleic Acids Res.19,649-655(1991).   
Kobayashi,H.,Kitabayashi,I.,Matsumoto,K.and Hirokawa,H.: Primer protein of bacteriophage M2 exposes the RGD receptor site upon linking the first deoxynucleotide.
Mol.Gen.Genet.226,65-69(1991).   

Research Grants & Projects

 
Ministry of Education, Culture, Sports, Science and Technology: Grants-in-Aid for Scientific Research(基盤研究(B))
Project Year: 2007 - 2009    Investigator(s): Issay KITABAYASHI
MOZ (MOnocytic leukemia Zinc finger protein) and MORF (MOz Related Factor), Myst-type histone acetyltransferases, are involved in chromosome translocations associated with FAB-M4/5 subtypes of acute myeloid leukemia. We have reported that MOZ is e...
Ministry of Education, Culture, Sports, Science and Technology: Grants-in-Aid for Scientific Research(特定領域研究)
Project Year: 2005 - 2009    Investigator(s): Issay KITABAYASHI
The AML1 gene is the most frequent target of chromosome translocations and other mutations in acute myeloid leukemia. We purified AML1 complex and found that the complex contained p300/CBP, MOZ, PML, and HIPK2 as well as CBFb. PML is a nuclear pro...
Ministry of Education, Culture, Sports, Science and Technology: Grants-in-Aid for Scientific Research(基盤研究(B))
Project Year: 2003 - 2005    Investigator(s): Issay KITABAYASHI
The genes encoding the AML1/CBFβ transcription factor complex are the most frequent targets of chromosome translocations found in human leukemia. We previously purified AML1 complexes, and found that the complex contains histone acetyltransferases...
Ministry of Education, Culture, Sports, Science and Technology: Grants-in-Aid for Scientific Research(基盤研究(B))
Project Year: 2000 - 2002    Investigator(s): Issay KITABAASHI
Chromosome translocations are frequently found in human leukemia and resultant fusion proteins and/or disregulation of specific gene expressions are involved in leukemogenesis. We found that the p300 and MOZ genes, which enocode histone acetyltran...
Ministry of Education, Culture, Sports, Science and Technology: Grants-in-Aid for Scientific Research(特定領域研究(A))
Project Year: 1999 - 2000    Investigator(s): Kazuo KITABAYASHI
The AML1-CBFβ transcription factor complex is the most frequent target of chromosomal rearrangements in human leukemia. In the t (8 ; 21) translocation associated with acute myeloid leukemia, the AML1 gene is juxtaposed to the MTG8 gene. We show t...
Mechanism of Leukemogenesis
Differentiation of Hematopoietic cells
Chromatin Function in transcriptional regulation