論文

査読有り
2017年10月

EPC1/TIP60-Mediated Histone Acetylation Facilitates Spermiogenesis in Mice

MOLECULAR AND CELLULAR BIOLOGY
  • Yixin Dong
  • ,
  • Kyo-ichi Isono
  • ,
  • Kazuyuki Ohbo
  • ,
  • Takaho A. Endo
  • ,
  • Osamu Ohara
  • ,
  • Mamiko Maekawa
  • ,
  • Yoshiro Toyama
  • ,
  • Chizuru Ito
  • ,
  • Kiyotaka Toshimori
  • ,
  • Kristian Helin
  • ,
  • Narumi Ogonuki
  • ,
  • Kimiko Inoue
  • ,
  • Atsuo Ogura
  • ,
  • Kazutsune Yamagata
  • ,
  • Issay Kitabayashi
  • ,
  • Haruhiko Koseki

37
19
記述言語
英語
掲載種別
研究論文(学術雑誌)
DOI
10.1128/MCB.00082-17
出版者・発行元
AMER SOC MICROBIOLOGY

Global histone hyperacetylation is suggested to play a critical role for replacement of histones by transition proteins and protamines to compact the genome during spermiogenesis. However, the underlying mechanisms for hyperacetylation-mediated histone replacement remains poorly understood. Here, we report that EPC1 and TIP60, two critical components of the mammalian nucleosome acetyltransferase of H4 (NuA4) complexes, are coexpressed in male germ cells. Strikingly, genetic ablation of either Epc1 or Tip60 disrupts hyperacetylation and impairs histone replacement, in turn causing aberrant spermatid development. Taking these observations together, we reveal an essential role of the NuA4 complexes for histone hyperacetylation and subsequent compaction of the spermatid genome.

Web of Science ® 被引用回数 : 7

リンク情報
DOI
https://doi.org/10.1128/MCB.00082-17
PubMed
https://www.ncbi.nlm.nih.gov/pubmed/28694333
Web of Science
https://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcAuth=JSTA_CEL&SrcApp=J_Gate_JST&DestLinkType=FullRecord&KeyUT=WOS:000410277100002&DestApp=WOS_CPL