Molecular pathological approach ti epigenome mechanisms of multistage human carcinogenesis, JCA Women Scientists Award, Japanese Cancer Association
Winner: Yae Kanai
Feb 2006
Cancer development, invasion and metastasis: Epigenetic research based on histopathological approach, Tamiya Prize, Foundation for Promotion of Cancer Research
Sep 2003
DNA methylation abnormalities participating in multistage human carcinogenesis, Incitement Award of the Japanese Cancer Association, Japanese Cancer Association
Mar 2002
DNA methylation alterations during multistage human carcinogenesis, Incitement Award of the Japanese Society of Pathology, Japanese Society of Pathology
Winner: Yae Kanai
Nov 2000
Inactivation of E-cadherin cell adhesion system in human cancer invasion and metastasis, Baelz Prize, ベルツ財団
Tsumura K, Arai E, Tian Y, Shibuya A, Nishihara H, Yotani T, Yamada Y, Takahashi Y, Maeshima AM, Fujimoto H, Nakagawa T, Kume H, Homma Y, Yoshida T, Kanai Y.
Carcinogenesis 40(11) 1308-1319 Jun 2019 [Refereed]
DNA methylation alterations in human cancers. In: Epigenetics in Human Disease. ed. Tollefsbol T.
Kanai Y, Arai E.
Elsevier, Amsterdam 2012
DNA methylation status in chronic liver disease and hepatocellular carcinoma. In: Molecular Genetics of Liver Neoplasia. ed. Wang XW, Grisham JW, Thorgeirsson S
Kanai Y, Arai E.
Springer, New York 2010
Role of immunohistochemical expression of DNA methyltransferase 1 protein in gastric carcinoma. In: Handbook of Immunohistochemistry and in situ Hybridization of Human Carcinomas. Vol.4: Molecular Genetics, Gastrointestinal Carcinoma, and Ovarian Carcinom
Kanai Y, Arai E, Etoh T.
Elsevier, CA 2006
Multiple mechanisms for inactivation of E-cadherin cell adhesion system in cancer. In: Epithelial Morphogenesis in Development and Disease, eds. Birchmeier, W., Birchmeier, C.
Intratumor DNA methylation heterogeneity reflects differentiation plasticity and malignant progression of human glioblastoma: a methylome analysis using microdissected specimens.
Genome-wide DNA methylation analysis during non-alcoholic steatohepatitis-related multistage hepatocarcinogenesis: Comparison with hepatitis virus-related carcinogenesis.
Risk estimation of pancreatic adenocarcinomas based on epigenome-wide association study
MEXT,JSPS: Grant-in-Aid for Scientific Research
Project Year: Apr 2016 - Mar 2019 Investigator(s): 金井 弥栄
本研究は、エピゲノムワイド関連解析 (epigenome-wide association study [EWAS])を基盤とし、検診等の血液検査で難治がんである膵がん発症の高危険群を捕捉するためのリスク診断法を開発することを目的とする。質の高い問診情報・診療情報等の付随した充分数の末梢血検体におけるゲノム網羅的DNAメチル化解析結果を基に、質の高い臨床病理情報の付随した前がん段階にある組織検体におけるエピゲノム解析結果を参照し、血液細胞組成の影響を排除し、DNAメチル化率の精密定量結果に...
