The increasing interest in cross-laminated timber (CLT) construction has resulted in multiple international research projects and publications covering the manufacturing and performance of CLT. Multiple regions and countries have adopted provisions for CLT into their engineering design standards and building regulations. Designing and building CLT structures, also in earthquake-prone regions is no longer a domain for early adopters, but is becoming a part of regular timber engineering practice. The increasing interest in CLT construction has resulted in multiple regions and countries adopting provisions for CLT into their engineering design standards. However, given the economic and legal differences between each region, some fundamental issues are treated differently, particularly with respect to seismic design. This article reflects the state-of-the-art on seismic design of CLT buildings including both, the global perspective and regional differences comparing the seismic design practice in Europe, Canada, the United States, New Zealand, Japan, China, and Chile.