KASAHARA Masanori

J-GLOBAL         Last updated: Apr 24, 2019 at 14:13
 
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Name
KASAHARA Masanori
Affiliation
Hokkaido University
Job title
Executive Vice President and Professor
Degree
M.D., Ph.D.(Hokkaido University)

Profile

Prof. Kasahara received his M.D. and Ph.D. from Hokkaido University, Japan, where he is currently Executive Vice President. He was a postdoctoral fellow with Prof. Jan Klein at the Max Planck Institute for Biology, Germany, where he studied genetics of the MHC. His research interests include the role of the MHC in health and disease, as well as the genetics and evolution of the immune system. Prof. Kasahara served as dean of the School of Medicine from 2013 to 2017.

Research Areas

 
 

Academic & Professional Experience

 
2017
 - 
Today
Executive Vice President, Hokkaido University
 
2017
 - 
Today
Professor, Department of Pathology, Hokkaido University Faculty of Medicine
 
2013
 - 
2017
Dean, Hokkaido University Graduate School of Medicine
 
2004
 - 
2017
Professor, Department of Pathology, Hokkaido University Graduate School of Medicine
 
2011
 - 
2013
Vice Dean, Hokkaido University Graduate School of Medicine
 
2005
 - 
2007
Director, Department of Surgical Pathology, Hokkaido University Hospital
 
1998
 - 
2004
Professor, The Graduate University for Advanced Studies
 
1992
 - 
1998
Associate Professor, Hokkaido University School of Medicine
 

Education

 
1980
 - 
1984
Pathology (PhD), Graduate School, Division of Medicine, Hokkaido University
 
1974
 - 
1980
Medicine (MD), School of Medicine, Hokkaido University
 

Awards & Honors

 
2014
Japan Pathology Award, Japanese Society of Pathology
 
2007
Furuta Award, Japanese Society for Developmental and Comparative Immunology
 

Published Papers

 
Kasahara M, Flajnik MF, Takahama Y
Immunogenetics   71(3) 137-139   Jan 2019   [Refereed]
Kasahara M, Flajnik MF
Immunogenetics   71(3) 251-261   Jan 2019   [Refereed]
Tomaru U, Konno S, Miyajima S, Kimoto R, Onodera M, Kiuchi S, Murata S, Ishizu A, Kasahara M
Cell reports   26(3) 639-651.e2   Jan 2019   [Refereed]
Kajikawa M, Ose T, Fukunaga Y, Okabe Y, Matsumoto N, Yonezawa K, Shimizu N, Kollnberger S, Kasahara M, Maenaka K
Nature communications   9(1) 4330   Oct 2018   [Refereed]
Miyatake Y, Kuribayashi-Shigetomi K, Ohta Y, Ikeshita S, Subagyo A, Sueoka K, Kakugo A, Amano M, Takahashi T, Okajima T, Kasahara M
Scientific reports   8(1) 14054   Sep 2018   [Refereed]
Murata S, Takahama Y, Kasahara M, Tanaka K
Nature immunology   19(9) 923-931   Aug 2018   [Refereed]
Miyatake Y, Ohta Y, Ikeshita S, Kasahara M
Oncotarget   9(52) 29845-29856   Jul 2018   [Refereed]
Park JK, Otsuka N, Tomaru U, Suzuki H, Azuma M, Okamoto K, Yamashiro K, Kasahara M
Human pathology   80 104-112   Jun 2018   [Refereed]
Yoshida S, Shime H, Takeda Y, Nam JM, Takashima K, Matsumoto M, Shirato H, Kasahara M, Seya T
Cancer science   109(4) 956-965   Apr 2018   [Refereed]
Sutoh Y, Mohamed RH, Kasahara M
Frontiers in immunology   9 1059   2018   [Refereed]
Ono J, Shime H, Takaki H, Takashima K, Funami K, Yoshida S, Takeda Y, Matsumoto M, Kasahara M, Seya T
Journal of biomedical science   24(1) 79   Oct 2017   [Refereed]
Ohigashi I, Ohte Y, Setoh K, Nakase H, Maekawa A, Kiyonari H, Hamazaki Y, Sekai M, Sudo T, Tabara Y, Sawai H, Omae Y, Yuliwulandari R, Tanaka Y, Mizokami M, Inoue H, Kasahara M, Minato N, Tokunaga K, Tanaka K, Matsuda F, Murata S, Takahama Y
JCI insight   2(10)    May 2017   [Refereed]
Kiuchi S, Tomaru U, Ishizu A, Imagawa M, Kiuchi T, Iwasaki S, Suzuki A, Otsuka N, Deguchi T, Shimizu T, Marukawa K, Matsuno Y, Kasahara M
Human pathology   60 66-74   Feb 2017   [Refereed]
Yoshida S, Shime H, Funami K, Takaki H, Matsumoto M, Kasahara M, Seya T
PloS one   12(1) e0169360   2017   [Refereed]
Kasamatsu J, Deng M, Azuma M, Funami K, Shime H, Oshiumi H, Matsumoto M, Kasahara M, Seya T
BMC immunology   17(1) 9   May 2016   [Refereed]
The next top models. Ancient immunity
KASAHARA Masanori
Cell   163(1) 19-19   Sep 2015   [Refereed][Invited]
Kasahara M, Sutoh Y
Immunological reviews   267(1) 72-87   Sep 2015   [Refereed]
Yamada Y, Tomaru U, Ishizu A, Ito T, Kiuchi T, Ono A, Miyajima S, Nagai K, Higashi T, Matsuno Y, Dosaka-Akita H, Nishimura M, Miwa S, Kasahara M
Laboratory investigation; a journal of technical methods and pathology      Apr 2015   [Refereed]
Fujita H, Hatanaka Y, Sutoh Y, Suzuki Y, Oba K, Hatanaka KC, Mitsuhashi T, Otsuka N, Fugo K, Kasahara M, Matsuno Y
The journal of histochemistry and cytochemistry : official journal of the Histochemistry Society   63(3) 217-227   Mar 2015   [Refereed]
Iinuma C, Waki M, Kawakami A, Yamaguchi M, Tomaru U, Sasaki N, Masuda S, Matsui Y, Iwasaki S, Baba T, Kasahara M, Yoshiki T, Paletta D, Herrmann T, Ishizu A
International immunology   27(2) 105-114   Feb 2015   [Refereed]
Miyatake Y, Sheehy N, Ikeshita S, Hall WW, Kasahara M
Cancer letters   357(1) 355-363   Feb 2015   [Refereed]
Kiuchi S, Ikeshita S, Miyatake Y, Kasahara M
Experimental and molecular pathology   98(1) 41-46   Feb 2015   [Refereed]
Tomaru U, Tsuji T, Kiuchi S, Ishizu A, Suzuki A, Otsuka N, Ito T, Ikeda H, Fukasawa Y, Kasahara M
Histopathology      Jan 2015   [Refereed]
Kasahara M
Results and problems in cell differentiation   57 175-192   2015   [Refereed]
Mohamed RH, Sutoh Y, Itoh Y, Otsuka N, Miyatake Y, Ogasawara K, Kasahara M
PloS one   10(4) e0123258   2015   [Refereed]
Ando R, Noda K, Tomaru U, Kamoshita M, Ozawa Y, Notomi S, Hisatomi T, Noda M, Kanda A, Ishibashi T, Kasahara M, Ishida S
Investigative ophthalmology & visual science      Jul 2014   [Refereed]
Ikeshita S, Miyatake Y, Otsuka N, Kasahara M
Experimental and molecular pathology   97 171-175   Jul 2014   [Refereed]
Venkatesh B, Lee AP, Swann JB, Ohta Y, Flajnik MF, Kasahara M, Boehm T, Warren WC
Nature   511 E9-10   Jul 2014   [Refereed]
Ströbel P, Hartmann E, Rosenwald A, Kalla J, Ott G, Friedel G, Schalke B, Kasahara M, Tomaru U, Marx A
Histopathology   64 557-566   Mar 2014   [Refereed]
Yamada Y, Tomaru U, Ishizu A, Kiuchi T, Kasahara M, Matsuno Y
Journal of clinical pathology   67 276-278   Mar 2014   [Refereed]
Venkatesh B, Lee AP, Ravi V, Maurya AK, Lian MM, Swann JB, Ohta Y, Flajnik MF, Sutoh Y, Kasahara M, Hoon S, Gangu V, Roy SW, Irimia M, Korzh V, Kondrychyn I, Lim ZW, Tay BH, Tohari S, Kong KW, Ho S, Lorente-Galdos B, Quilez J, Marques-Bonet T, Raney BJ, Ingham PW, Tay A, Hillier LW, Minx P, Boehm T, Wilson RK, Brenner S, Warren WC
Nature   505 174-179   Jan 2014   [Refereed]
Kanda R, Sutoh Y, Kasamatsu J, Maenaka K, Kasahara M, Ose T
PloS one   9 e85875   Jan 2014   [Refereed]
Kasahara M, Sutoh Y
Advances in immunology   122 59-90   2014   [Refereed]
Tomaru U, Kasahara M
Archivum immunologiae et therapiae experimentalis   61 357-365   Oct 2013   [Refereed]
Kasahara M
Immunology and cell biology      Oct 2013   [Refereed]
Ibusuki A, Kawai K, Yoshida S, Uchida Y, Nitahara-Takeuchi A, Kuroki K, Kajikawa M, Ose T, Maenaka K, Kasahara M, Kanekura T
The Journal of investigative dermatology      Aug 2013   [Refereed]
Miyatake Y, Oliveira AL, Jarboui MA, Ota S, Tomaru U, Teshima T, Hall WW, Kasahara M
The American journal of pathology   182 1832-1842   May 2013   [Refereed]
Kasahara M
Seminars in cell & developmental biology   24 81-82   Feb 2013   [Refereed]
Fukaya S, Matsui Y, Tomaru U, Kawakami A, Sogo S, Bohgaki T, Atsumi T, Koike T, Kasahara M, Ishizu A
Laboratory investigation; a journal of technical methods and pathology   93 72-80   Jan 2013   [Refereed]
Kasahara M, Yoshida S
Immunogenetics   64 855-867   Dec 2012   [Refereed]
Nakazawa D, Tomaru U, Suzuki A, Masuda S, Hasegawa R, Kobayashi T, Nishio S, Kasahara M, Ishizu A
Arthritis and rheumatism   64 3779-3787   Nov 2012   [Refereed]
Tomaru U, Yamada Y, Ishizu A, Kuroda T, Matsuno Y, Kasahara M
Journal of clinical pathology   65 858-859   Sep 2012   [Refereed]
Yoshida S, Mohamed RH, Kajikawa M, Koizumi J, Tanaka M, Fugo K, Otsuka N, Maenaka K, Yagita H, Chiba H, Kasahara M
Journal of immunology (Baltimore, Md. : 1950)   188 3972-3979   Apr 2012   [Refereed]
Tomaru U, Takahashi S, Ishizu A, Miyatake Y, Gohda A, Suzuki S, Ono A, Ohara J, Baba T, Murata S, Tanaka K, Kasahara M
The American journal of pathology   180 963-972   Mar 2012   [Refereed]
Sutoh Y, Kondo M, Ohta Y, Ota T, Tomaru U, Flajnik MF, Kasahara M
Immunogenetics   64 49-58   Jan 2012   [Refereed]
Boehm T, McCurley N, Sutoh Y, Schorpp M, Kasahara M, Cooper MD
Annual review of immunology   30 203-220   2012   [Refereed]
Ng SY, Chow BK, Kasamatsu J, Kasahara M, Lee LT
PloS one   7 e44691   2012   [Refereed]
Katsurada T, Kobayashi W, Tomaru U, Baba T, Furukawa S, Ishizu A, Takeda K, Sakamoto N, Asaka M, Takeda H, Kasahara M
PloS one   7 e44113   2012   [Refereed]
Masuda S, Iwasaki S, Tomaru U, Sato J, Kawakami A, Ichijo K, Sogo S, Baba T, Katsumata K, Kasahara M, Ishizu A
PloS one   7 e52918   2012   [Refereed]
Yamada Y, Tomaru U, Ishizu A, Kiuchi T, Marukawa K, Matsuno Y, Kasahara M
The American journal of surgical pathology   35 1296-1304   Sep 2011   [Refereed]
Nakano F, Yabe I, Tsuji-Akimoto S, Ishizu A, Tanaka S, Kasahara M, Sasaki H
Rinsho shinkeigaku = Clinical neurology   51 197-202   Mar 2011   [Refereed]
Iwasaki S, Masuda S, Baba T, Tomaru U, Katsumata K, Kasahara M, Ishizu A
Cytometry. Part A : the journal of the International Society for Analytical Cytology   79 46-56   Jan 2011   [Refereed]
Kasamatsu J, Sutoh Y, Fugo K, Otsuka N, Iwabuchi K, Kasahara M
Proceedings of the National Academy of Sciences of the United States of America   107 14304-14308   Aug 2010   [Refereed]
Kasamatsu J, Oshiumi H, Matsumoto M, Kasahara M, Seya T
Developmental and comparative immunology   34 855-865   Aug 2010   [Refereed]
Kondo M, Maruoka T, Otsuka N, Kasamatsu J, Fugo K, Hanzawa N, Kasahara M
Immunogenetics   62 441-450   Jul 2010   [Refereed]
Tatsumi K, Sou YS, Tada N, Nakamura E, Iemura S, Natsume T, Kang SH, Chung CH, Kasahara M, Kominami E, Yamamoto M, Tanaka K, Komatsu M
The Journal of biological chemistry   285 5417-5427   Feb 2010   [Refereed]
Flajnik MF, Kasahara M
Nature reviews. Genetics   11 47-59   Jan 2010   [Refereed]
Kasahara M
Progress in molecular biology and translational science   92 7-36   2010   [Refereed]
Kasahara M
Progress in molecular biology and translational science   92 61; discussion 62-4   2010   [Refereed]
Tomaru U, Ishizu A, Murata S, Miyatake Y, Suzuki S, Takahashi S, Kazamaki T, Ohara J, Baba T, Iwasaki S, Fugo K, Otsuka N, Tanaka K, Kasahara M
Blood   113 5186-5191   May 2009   [Refereed]
[Structure and function of non-classical MHC class I molecules].
Kajikawa M, Kasahara M
Seikagaku. The Journal of Japanese Biochemical Society   81 189-199   Mar 2009   [Refereed]
Kasahara M, Kasamatsu J, Sutoh Y
Zoological science   25 969-975   Oct 2008   [Refereed]
Holland LZ, Albalat R, Azumi K, Benito-Gutiérrez E, Blow MJ, Bronner-Fraser M, Brunet F, Butts T, Candiani S, Dishaw LJ, Ferrier DE, Garcia-Fernàndez J, Gibson-Brown JJ, Gissi C, Godzik A, Hallböök F, Hirose D, Hosomichi K, Ikuta T, Inoko H, Kasahara M, Kasamatsu J, Kawashima T, Kimura A, Kobayashi M, Kozmik Z, Kubokawa K, Laudet V, Litman GW, McHardy AC, Meulemans D, Nonaka M, Olinski RP, Pancer Z, Pennacchio LA, Pestarino M, Rast JP, Rigoutsos I, Robinson-Rechavi M, Roch G, Saiga H, Sasakura Y, Satake M, Satou Y, Schubert M, Sherwood N, Shiina T, Takatori N, Tello J, Vopalensky P, Wada S, Xu A, Ye Y, Yoshida K, Yoshizaki F, Yu JK, Zhang Q, Zmasek CM, de Jong PJ, Osoegawa K, Putnam NH, Rokhsar DS, Satoh N, Holland PW
Genome research   18 1100-1111   Jul 2008   [Refereed]
Rat CD4+CD8+ macrophages kill tumor cells through an NKG2D- and granzyme/perforin-dependent mechanism.
Baba T, Iwasaki S, Maruoka T, Suzuki A, Tomaru U, Ikeda H, Yoshiki T, Kasahara M, Ishizu A
Journal of immunology (Baltimore, Md. : 1950)   180 2999-3006   Mar 2008   [Refereed]
Yashiroda H, Mizushima T, Okamoto K, Kameyama T, Hayashi H, Kishimoto T, Niwa S, Kasahara M, Kurimoto E, Sakata E, Takagi K, Suzuki A, Hirano Y, Murata S, Kato K, Yamane T, Tanaka K
Nature structural & molecular biology   15 228-236   Mar 2008   [Refereed]
Two novel NKG2D ligands of the mouse H60 family with differential expression patterns and binding affinities to NKG2D.
Takada A, Yoshida S, Kajikawa M, Miyatake Y, Tomaru U, Sakai M, Chiba H, Maenaka K, Kohda D, Fugo K, Kasahara M
Journal of immunology (Baltimore, Md. : 1950)   180 1678-1685   Feb 2008   [Refereed]
Furlong RF, Younger R, Kasahara M, Reinhardt R, Thorndyke M, Holland PW
Molecular biology and evolution   24 2681-2686   Dec 2007   [Refereed]
Kasahara M
Current opinion in immunology   19 547-552   Oct 2007   [Refereed]
Chen J, Zhao X, Lai Y, Suzuki A, Tomaru U, Ishizu A, Takada A, Ikeda H, Kasahara M, Yoshiki T
Experimental and molecular pathology   83 125-130   Aug 2007   [Refereed]
Kasamatsu J, Suzuki T, Ishijima J, Matsuda Y, Kasahara M
Immunogenetics   59 329-331   Apr 2007   [Refereed]
Busso D, Goldweic NM, Hayashi M, Kasahara M, Cuasnicú PS
Biology of reproduction   76 701-708   Apr 2007   [Refereed]
Kim HM, Oh SC, Lim KJ, Kasamatsu J, Heo JY, Park BS, Lee H, Yoo OJ, Kasahara M, Lee JO
The Journal of biological chemistry   282 6726-6732   Mar 2007   [Refereed]
Hirano Y, Hayashi H, Iemura S, Hendil KB, Niwa S, Kishimoto T, Kasahara M, Natsume T, Tanaka K, Murata S
Molecular cell   24 977-984   Dec 2006   [Refereed]
MHC class I-like MILL molecules are beta2-microglobulin-associated, GPI-anchored glycoproteins that do not require TAP for cell surface expression.
Kajikawa M, Baba T, Tomaru U, Watanabe Y, Koganei S, Tsuji-Kawahara S, Matsumoto N, Yamamoto K, Miyazawa M, Maenaka K, Ishizu A, Kasahara M
Journal of immunology (Baltimore, Md. : 1950)   177 3108-3115   Sep 2006   [Refereed]
Miyatake Y, Ikeda H, Ishizu A, Baba T, Ichihashi T, Suzuki A, Tomaru U, Kasahara M, Yoshiki T
The American journal of pathology   169 189-199   Jul 2006   [Refereed]
Baba T, Ishizu A, Iwasaki S, Suzuki A, Tomaru U, Ikeda H, Yoshiki T, Kasahara M
Blood   107 2004-2012   Mar 2006   [Refereed]
Pancer Z, Saha NR, Kasamatsu J, Suzuki T, Amemiya CT, Kasahara M, Cooper MD
Proceedings of the National Academy of Sciences of the United States of America   102 9224-9229   Jun 2005   [Refereed]
Hagfish leukocytes express a paired receptor family with a variable domain resembling those of antigen receptors.
Suzuki T, Shin-I T, Fujiyama A, Kohara Y, Kasahara M
Journal of immunology (Baltimore, Md. : 1950)   174 2885-2891   Mar 2005   [Refereed]
Watanabe Y, Maruoka T, Walter L, Kasahara M
European journal of immunology   34 1597-1607   Jun 2004   [Refereed]
Kasahara M, Suzuki T, Pasquier LD
Trends in immunology   25 105-111   Feb 2004   [Refereed]
Kasahara M, Watanabe Y, Sumasu M, Nagata T
Proceedings of the National Academy of Sciences of the United States of America   99(21) 13687-13692   Oct 2002   [Refereed]
Murata S, Udono H, Tanahashi N, Hamada N, Watanabe K, Adachi K, Yamano T, Yui K, Kobayashi N, Kasahara M, Tanaka K, Chiba T
The EMBO journal   20 5898-5907   Nov 2001   [Refereed]
Evidence that human epididymal protein ARP plays a role in gamete fusion through complementary sites on the surface of the human egg.
Cohen DJ, Ellerman DA, Busso D, Morgenfeld MM, Piazza AD, Hayashi M, Young ET, Kasahara M, Cuasnicu PS
Biology of reproduction   65(4) 1000-1005   Oct 2001   [Refereed]
Flajnik MF, Kasahara M
Immunity   15(3) 351-362   Sep 2001   [Refereed]
Yawata M, Murata S, Tanaka K, Ishigatsubo Y, Kasahara M
Immunogenetics   53(2) 119-129   Mar 2001   [Refereed]
A half-type ABC transporter TAPL is highly conserved between rodent and man, and the human gene is not responsive to interferon-gamma in contrast to TAP1 and TAP2.
Kobayashi A, Kasano M, Maeda T, Hori S, Motojima K, Suzuki M, Fujiwara T, Takahashi E, Yabe T, Tanaka K, Kasahara M, Yamaguchi Y, Maeda M
Journal of biochemistry   128(4) 711-718   Oct 2000   [Refereed]
Genome paralogy: a new perspective on the organization and origin of the major histocompatibility complex.
Kasahara M
Current topics in microbiology and immunology   248 53-66   2000   [Refereed]
A new perspective on the organization and origin of the major histocompatibility complex
Curr. Top. Microbiol. Immunol.   248 53-66   2000
Growth retardation in mice lacking the proteasome activator PA28gamma.
Murata S, Kawahara H, Tohma S, Yamamoto K, Kasahara M, Nabeshima Y, Tanaka K, Chiba T
The Journal of biological chemistry   274(53) 38211-38215   Dec 1999   [Refereed]
The chromosomal duplication model of the major histocompatibility complex
Immunol. Rev.   167 17-32   1999
The MHC class I ligand-generating system: roles of immunoproteasomes and the interferon-gamma-inducible proteasome activator PA28.
Tanaka K, Kasahara M
Immunological reviews   163 161-176   Jun 1998   [Refereed]

Misc

 
Evolution of the class II major histocompatibility complex alleles in higher primates.
Immunol. Rev.   113    1990
The role of tumor derived cytokines on the immune system of mice bearing a mammary adenocarcinoma.
J. Immunol.   146    1991
The mouse male germ cell-specific gene Tpx-1 : Molecular structure, mode of expression in spermatogenesis, and dsequence similarity to two non-mammalian genes.
Mammalian Genome   3    1992

Works

 
MHC-peptide interaction
1996 - 2001

Research Grants & Projects

 
Ministry of Education, Culture, Sports, Science and Technology: Grants-in-Aid for Scientific Research(基盤研究(C))
Project Year: 2007 - 2008    Investigator(s): Nobuhisa ISHIGURO
Ministry of Education, Culture, Sports, Science and Technology: Grants-in-Aid for Scientific Research(基盤研究(B))
Project Year: 2007 - 2008    Investigator(s): Masanori KASAHARA
Ministry of Education, Culture, Sports, Science and Technology: Grants-in-Aid for Scientific Research(基盤研究(B))
Project Year: 2002 - 2004    Investigator(s): Masanori KASAHARA
The aims of this project were to study the structure, function and evolution of natural killer (NK) receptors and their ligands using multidisciplinary approaches such as immunogenetics, comparative genomics and immunobiology. Major research accom...
Ministry of Education, Culture, Sports, Science and Technology: Grants-in-Aid for Scientific Research(基盤研究(B))
Project Year: 1999 - 2001    Investigator(s): Masanori KASAHARA
The proteasome is the multi-subunit protease responsible for the production of peptides bound by MHC class I molecules. In this study, we attempted to gain insights into the structure, function, and origin of IFN-γ regulated proteasome subunits. T...
Ministry of Education, Culture, Sports, Science and Technology: Grants-in-Aid for Scientific Research(国際学術研究, 基盤研究(B))
Project Year: 1998 - 2001    Investigator(s): Masanori KASAHARA
The self-nonself discrimination system of vertebrates was built over evolutionary time. Therefore, to understand the biological significance of the system, it is insufficient to study only humans and mice. The aim of this project was, therefore, t...