AKITA Hirotoshi

J-GLOBAL         Last updated: Apr 10, 2019 at 12:26
 
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Name
AKITA Hirotoshi
Affiliation
Hokkaido University
Section
Graduate School of Medicine, Department of Medical Oncology
Job title
Professor
Degree
(BLANK)(Hokkaido University)

Research Interests

 
 

Research Areas

 
 

Education

 
 
 - 
1987
Graduate School, Division of Medicine, Hokkaido University
 
 
 - 
1981
Faculty of Medicine, Hokkaido University
 

Awards & Honors

 
1995
Shinoi-Kawai Award of Japan Lung cancer Society
 

Published Papers

 
Early prediction of lenvatinib treatment efficacy by using 18F-FDG PET/CT in patients with unresectable or advanced thyroid carcinoma that is refractory to radioiodine treatment: a protocol for a non-randomized single-arm multicenter observational study.
Takeuchi S, Shiga T, Hirata K, Taguchi J, Magota K, Ariga S, Gouda T, Ohhara Y, Homma R, Shimizu Y, Kinoshita I, Tsuji Y, Homma A, Iijima H, Tamaki N, Dosaka-Akita H.
BMJ Open.   30 e021001   Aug 2018   [Refereed]
Clinicopathologic Features and Immune Microenvironment of Non-Small-cell Lung Cancer With Primary Resistance to Epidermal Growth Factor Receptor Tyrosine Kinase Inhibitors.
Takashima Y, Sakakibara-Konishi J, Hatanaka Y, Hatanaka KC, Ohhara Y, Oizumi S, Hida Y, Kaga K, Kinoshita I, Dosaka-Akita H, Matsuno Y, Nishimura M.
Clin Lung Cancer.   19 352-359   2018   [Refereed]
Genomic testing for pancreatic cancer in clinical practice as real-world evidence.
Hayashi H, Tanishima S, Fujii K, Mori R, Okamura Y, Yanagita E, Matsuoka R, Amano T, Kinoshita I, Komatsu Y, Dosaka-Akita H, Nishihara H.
Pancreatology   18 647-654   2018   [Refereed]
A phase II study of carboplatin, pemetrexed, and bevacizumab followed by erlotinib and bevacizumab maintenance for nonsquamous non-small cell lung cancer with wild-type EGFR (HOT1101)
Taichi Takashina, Hajime Asahina, Satoshi Oizumi1, Noriyuki Yamada, Masao Harada, Kei Takamura, Hiroshi Yokouchi, Toshiyuki Harada, Osamu Honjo, Takahiro Ogi, Naoto Morikawa, Ichiro Kinoshita, Ryoichi Honda, Kosuke Nakano, Kenya Kanazawa, Toraji Amano, Hirotoshi Dosaka‑Akita, Hiroshi Isobe, Masaharu Nishimura on behalf of Hokkaido Lung Cancer Clinical Study Group.
Int J Clin Oncol.      2018   [Refereed]
Numb has distinct function in lung adenocarcinoma and squamous cell carcinoma.
Kikuchi H, Sakakibara-Konishi J, Furuta M, Kikuchi E, Kikuchi J, Oizumi S, Hida Y, Kaga K, Kinoshita I, Dosaka-Akita H, Nishimura M.
Oncotarget.   9 29379-29391   2018   [Refereed]
Harada T, Amano T, Ikari T, Takamura K, Ogi T, Fujikane T, Fujita Y, Taima K, Tanaka H, Sasaki T, Okumura S, Sugawara S, Yokouchi H, Yamada N, Morikawa N, Dosaka-Akita H, Isobe H, Nishimura M.
Front Pharmacol.   16 972-972   2018   [Refereed]
A randomized phaseII trial of erlotinib versus S-1 as a third- or fourth-linetherapy for patients with wild-type EGFR non-small cell lung cancer (HOT1002).
Ikezawa Y, Asahina H, Oizumi S, Watanabe M, Takamura K, Kawai Y, Yamada N, Harada T, Kinoshita I, Fujita Y, Miyauchi E, Ogi T, Amano T, Furuta M, Sakakibara-Konishi J, Nishihara H, Dosaka-Akita H, Isobe H, Nishimura M; Hokkaido Lung Cancer Clinical Study Group.
Cancer Chemother Pharmacol.   80 955-963   2017   [Refereed]
Identification of novel serum autoantibodies against EID3 in non-functional pancreatic neuroendocrine tumors.
Hontani K, Tsuchikawa T, Hiwasa T, Nakamura T, Ueno T, Kushibiki T, Takahashi M, Inoko K, Takano H, Takeuchi S, Dosaka-Akita H, Kuwatani M, Sakamoto N, Hatanaka Y, Mitsuhashi T, Shimada H, Shichinohe T, Hirano S.
Oncotarget.   31 106206-106221   2017   [Refereed]
Autophagy-dependent regulation of tumor metastasis by myeloid cells.
Jinushi M, Morita T, Xu Z, Kinoshita I, Dosaka-Akita H, Yagita H, Kawakami Y.
PLoS One.   7 e0179357.-e0179357.   2017   [Refereed]
Immunohistochemical profiling of receptor tyrosine kinases, MED12, and TGF-βRII of surgically resected small cell lung cancer, and the potential of c-kit as a prognostic marker.
Yokouchi H, Nishihara H, Harada T, Ishida T, Yamazaki S, Kikuchi H, Oizumi S, Uramoto H, Tanaka F, Harada M, Akie K, Sugaya F, Fujita Y, Takamura K, Kojima T, Higuchi M, Honjo O, Minami Y, Watanabe N, Goto A, Suzuki H, Dosaka-Akita H, Isobe H, Nishimura M, Munakata M.
Oncotarget.   13 39711-39726   2017   [Refereed]
Sakakibara-Konishi J, Ikezawa Y, Oizumi S, Kikuchi J, Kikuchi E, Mizugaki H, Kinoshita I, Dosaka-Akita H, Nishimura M.
Int J Clin Oncol.   22 257-268   2017   [Refereed]
Expression of Notch1 and Numb in small cell lung cancer.
Kikuchi H, Sakakibara-Konishi J, Furuta M, Yokouchi H, Nishihara H, Yamazaki S, Uramoto H, Tanaka F, Harada M, Akie K, Sugaya F, Fujita Y, Takamura K, Kojima T, Harada T, Higuchi M, Honjo O, Minami Y, Watanabe N, Oizumi S, Suzuki H, Ishida T, Dosaka-Akita H, Isobe H, Munakata M, Nishimura M.
Oncotarget.   7 10348-10358   2017   [Refereed]
Intravenous magnesium premedication has prophylactic efficacy against cisplatin-induced nephrotoxicity without an influence on serum magnesium level.
Saito Y, Kobayashi M, Yamada T, Kasashi K, Honma R, Takeuchi S, Shimizu Y, Kinoshita I, Dosaka-Akita H, Iseki K.
Support Care Cancer.   25 481-487   2017   [Refereed]
Role of targeted therapy in metastatic colorectal cancer.
Ohhara Y, Fukuda N, Takeuchi S, Honma R, Shimizu Y, Kinoshita K, Dosaka-Akita H.
World J Gastrointest Oncol   8 642-655   2016   [Refereed]
Hishida T, Miyaoka E, Yokoi K, Tsuboi M, Asamura H, Kiura K, Takahashi K, Dosaka-Akita H, Kobayashi H, Date H, Tada H, Okumura M, Yoshino I; Japanese Joint Committee of Lung Cancer Registry.
J Thorac Oncol,   11 1529-1537   2016   [Refereed]
Takashina T, Kinoshita I, Kikuchi J, Shimizu Y, Sakakibara-Konishi J, Oizumi, S, Nishimura M, Dosaka-Akita H.
Cancer Sci,   107 955-962   2016   [Refereed]
Survey of the management of chemotherapy-induced peripheral neuropathy in Japan: Japanese Society of Medical Oncology.
Hirayama Y, Sasaki J, Dosaka-Akita H, , Ishitani K.
ESMO Open   1 e000053-e000053   2016   [Refereed]
Elmansuri AZ, Tanino MA, Mahabir R, Wang L, Kimura T, Nishihara H, Kinoshita I, Dosaka-Akita H, Tsuda M, Tanaka S.
Oncotarget.   10 27094-27107   2016   [Refereed]
Yokouchi H, Ishida T, Yamazaki S, Kikuchi H, Oizumi S, Uramoto H, Tanaka F, Harada M, Akie K, Sugaya F, Fujita Y, Fukuhara T, Takamura K, Kojima T, Harada T, Higuchi M, Matsuura Y, Honjo O, Minami Y, Watanabe N, Nishihara H, Suzuki H, Dosaka-Akita H, Isobe H, Nishimura M, Munakata M
Lung Cancer.   90 548-553   2015   [Refereed]
Sugawara S, Oizumi S, Minato K, Harada T, Inoue A, Fujita Y, Maemondo M, Yoshizawa H, Ito K, Gemma A, Nishitsuji M, Harada M, Isobe H, Kinoshita I, Morita S, Kobayashi K, Hagiwara K, Kurihara M, Nukiwa T; North East Japan Study Group and Tokyo Cooperative Oncology Group.
Ann Oncol.   26 888-894   2015   [Refereed]
Fukuhara T, Maemondo M, Inoue A, Kobayashi K, Sugawara S, Oizumi S, Isobe H, Gemma A, Harada M, Yoshizawa H, Kinoshita I, Fujita Y, Saijo Y, Hagiwara K, Morita S, Nukiwa T.
Lung Cancer.   88 181-186   2015   [Refereed]
Komohara Y, Morita T, Annan DA, Horlad H, Ohnishi K, Yamada S, Nakayama T, Kitada S, Suzu S, Kinoshita I, Dosaka-Akita H, Akashi K, Takeya M, Jinushi M.
Cancer Immunol Res.   3 999-1007   2015   [Refereed]
Iida T, Shiba M, Yoshino I, Miyaoka E, Asamura H, Date H, Okumura M, Tada H, Nakanishi Y, Dosaka-Akita H, Kobayashi H, Takahashi K, Inoue M, Yokoi K; Japanese Joint Committee of Lung Cancer Registry.
J Thorac Oncol.   10 1076-1082   2015   [Refereed]
130. Yamada Y, Tomaru U, Ishizu A, Ito T, Kiuchi T, Ono A, Miyajima S, Nagai K, Higashi T, Matsuno Y, Dosaka-Akita H, Nishimura M, Miwa S, Kasahara M
Lab Invest   95 625-634   2015   [Refereed]
Mizumachi T, Homma A, Kakizaki T, Sakashita T, Kano S, Hatakeyama H, Tsuchiya K, Yasuda K, Onimaru R, Shirato H, Taguchi J, Shimizu Y, Kinoshita I, Akita H, Fukuda S
Int J Clin Oncol   20 431-437   2015   [Refereed]
130. Honma R, Kinoshita I, Miyoshi E, Tomaru U, Matsuno Y, Shimizu Y, Takeuchi S, Kobayashi Y, Kaga K, Taniguchi N, and Dosaka-Akita H
Oncology   88 298-308   2015   [Refereed]
122. Ragin C, Obikoya-Malomo M, Kim S, Chen Z, Flores-Obando R, Gibbs D, Koriyama C, Aguayo F, Koshiol J, Caporaso NE, Carpagnano GE, Ciotti M, Dosaka-Akita H, Fukayama M, Goto A, Spandidos DA, Gorgoulis V, Heideman DAM, van Boerdonk RAA, Hiroshima K, Iwakawa R, Kastrinakis NG, Kinoshita I, Akiba S, Landi MT, H. Liu E, Wang JL, Mehra R, Khuri FR, Lim WT, Owonikoko TK, Ramalingam S, Sarchianaki E, Syrjanen K, Tsao MS, Sykes J, Hee SW, Yokota J, Zaravinos A, Taioli E
Carcinogenesis   35 1267-1275   2013   [Refereed]
121. Baghdadi M, Yoneda A, Yamashina T, Nagao H, Komohara Y, Nagai S, Akiba H, Foretz M, Yoshiyama H, Kinoshita I, Dosaka-Akita H, Takeya M, Viollet B, Yagita H, Jinushi M
Immunity   39 1070-1081   2013   [Refereed]
120. Zhao S, Kuge Y, Zhao Y, Takeuchi S, Hirata K, Takei T, Shiga T, Dosaka-Akita H and Tamaki N
BMC Cancer   13 525-525   2013   [Refereed]
119. Harada T, Oizumi S, Ito K, Takamura K, Kikuchi E, Kuda T, Sugawara S, Suzuki A, Maemondo M, Fujita Y, Kinoshita I, Inoue A, Hommura F, Katsuura Y, Dosaka-Akita H, Isobe H, Nishimura M
Oncologist   18 439-445   2013   [Refereed]
118. Ishikawa K, Miyamoto M, Yoshioka T, Kadoya M, Li L, Mishra R, Ichinokawa K, Shoji Y, Matsumura Y, Hida Y, Kaga K, Kato T, Kaji M, Ohbuchi T, Itoh T, Dosaka-Akita H, Matsui Y, Hirano S
Oncol Rep.   29 1315-1321   2013   [Refereed]
116. Baghdadi M, Nagao H, Yoshiyama H, Akiba H, Yagita H, Dosaka-Akita H, Jinushi M.
Cancer Immunol Immunother.   62 629-637   2013   [Refereed]
Kikuchi J, Takashina T, Kinoshita I, Kikuchi E, Shimizu Y, Sakakibara-Konishi J, Oizumi S, Marquez VE, Nishimura M, Dosaka-Akita H
Lung cancer (Amsterdam, Netherlands)   78 138-143   Nov 2012   [Refereed]
Baghdadi M, Nagao H, Yoshiyama H, Akiba H, Yagita H, Dosaka-Akita H, Jinushi M
Cancer immunology, immunotherapy : CII      Nov 2012   [Refereed]
Chiba S, Baghdadi M, Akiba H, Yoshiyama H, Kinoshita I, Dosaka-Akita H, Fujioka Y, Ohba Y, Gorman JV, Colgan JD, Hirashima M, Uede T, Takaoka A, Yagita H, Jinushi M
Nature immunology   13(9) 832-842   Sep 2012   [Refereed]
Sakakibara-Konishi J, Oizumi S, Kikuchi J, Kikuchi E, Mizugaki H, Kinoshita I, Dosaka-Akita H, Nishimura M
BMC cancer   12 286   Jul 2012   [Refereed]
Tanaka K, Tsuchikawa T, Miyamoto M, Maki T, Ichinokawa M, Kubota KC, Shichinohe T, Hirano S, Ferrone S, Dosaka-Akita H, Matsuno Y, Kondo S
International journal of oncology   40 965-974   Apr 2012   [Refereed]
Jinushi M, Chiba S, Baghdadi M, Kinoshita I, Dosaka-Akita H, Ito K, Yoshiyama H, Yagita H, Uede T, Takaoka A
Cancer research   72(1) 56-65   Jan 2012   [Refereed]
Sakakibara-Konishi J, Oizumi S, Kinoshita I, Shinagawa N, Kikuchi J, Kato M, Inoue T, Katoh N, Onimaru R, Shirato H, Dosaka-Akita H, Nishimura M
Lung cancer (Amsterdam, Netherlands)   74 248-252   Nov 2011   [Refereed]
Takeuchi S, Zhao S, Kuge Y, Zhao Y, Nishijima K, Hatano T, Shimizu Y, Kinoshita I, Tamaki N, Dosaka-Akita H
Oncology reports   26 725-730   Sep 2011   [Refereed]
Jinushi M, Chiba S, Yoshiyama H, Masutomi K, Kinoshita I, Dosaka-Akita H, Yagita H, Takaoka A, Tahara H
Proceedings of the National Academy of Sciences of the United States of America   108(30) 12425-12430   Jul 2011   [Refereed]
Kikuchi J, Kinoshita I, Shimizu Y, Kikuchi E, Takeda K, Aburatani H, Oizumi S, Konishi J, Kaga K, Matsuno Y, Birrer MJ, Nishimura M, Dosaka-Akita H
Lung cancer (Amsterdam, Netherlands)   72 229-237   May 2011   [Refereed]
Takeuchi S, Honma R, Taguchi J, Amano T, Shimizu Y, Kinoshita I, Kubota K, Matsuno Y, Dosaka-Akita H
Case reports in oncology   4 260-266   May 2011   [Refereed]
[Superior vena cava syndrome].
Taguchi J, Kinoshita I, Akita H
Gan to kagaku ryoho. Cancer & chemotherapy   38 518-523   Apr 2011   [Refereed]
Expression of LGR5, an intestinal stem cell marker, during each stage of colorectal tumorigenesis.
Takeda K, Kinoshita I, Shimizu Y, Matsuno Y, Shichinohe T, Dosaka-Akita H
Anticancer research   31 263-270   Jan 2011   [Refereed]
Hiroshima K, Dosaka-Akita H, Usuda K, Ogura S, Kusunoki Y, Kodama T, Saito Y, Sato M, Tagawa Y, Baba M, Hirano T, Horai T, Matsuno Y
Acta cytologica   55(2) 173-179   2011   [Refereed]
Akie K, Oizumi S, Ogura S, Shinagawa N, Kikuchi E, Fukumoto S, Harada M, Kinoshita I, Kojima T, Harada T, Fujita Y, Ohsaki Y, Dosaka-Akita H, Isobe H, Nishimura M, Hokkaido Lung Cancer Clinical Study Group
Oncology   81(2) 84-90   2011   [Refereed]
Kikuchi J, Kinoshita I, Shimizu Y, Kikuchi E, Konishi J, Oizumi S, Kaga K, Matsuno Y, Nishimura M, Dosaka-Akita H
Cancer   116(12) 3015-3024   Jun 2010   [Refereed]
Asahina H, Oizumi S, Inoue A, Kinoshita I, Ishida T, Fujita Y, Sukoh N, Harada M, Maemondo M, Saijo Y, Dosaka-Akita H, Isobe H, Nukiwa T, Nishimura M, Hokkaido Lung Cancer Clinical Study Group
Oncology   79 423-429   2010   [Refereed]
[Molecular targeted drugs in the developmental stage: 2) Various molecular targets and therapeutic agents under investigation].
Akita H
Nihon Naika Gakkai zasshi. The Journal of the Japanese Society of Internal Medicine   98 1894-1900   Aug 2009   [Refereed]

Misc

 
A complex pattern of translational initiation and phosphorylation in L-myc proteins
Oncogene   6(2)    1991
The transactiration domain of the c-jun proto-oncoprotein is required for cotransformation of rat embryo cells
Molecular and Cellular Biology   11(11)    1991
Prognostic value of nuclew DNA content and expression of ras oncogene product in lung cancer
Cancer Research   51(12)    1991
Prognostic Signiticance of the expression of ras oncogene produet in non-small cell lung cancer
Cancer   69(1)    1992
A transtected L-myc gene can substitute for c-myc in blocking murine erythroleukomia differentiation
Molecular and Cellular Biology   9(6)    1989

Books etc

 
Prognostic Factors of Lung Cancer
1995   
Current Review Today's Cancer Chemotherapy
1996   

Conference Activities & Talks

 
Genomic Medicine for Precision Oncology in Japan [Invited]
AKITA Hirotoshi
10 Nov 2018   
Molecular Target Therapy in the Era of Precision Medicine. [Invited]
AKITA Hirotoshi
28 Sep 2018   
Clinical Implementation of a Comprehensive Targeted Amplicon Sequencing System for the Patients with Gastrointestinal Cancer as a Real World Evidence in Japan.
Hideyuki Hayashi, Shigeki Tanishima, Ryo Mori, Yasunobu Okamura, Emmy Yanagita, Ryosuke Matsuoka, Toraji Amano, Ichiro Kinoshita, Yoshito Komatsu, Hirotoshi Akita, Hiroshi Nishihara.
2018 Gastrointestinal Cancers Symposium   19 Jan 2018   

Association Memberships

 
 

Research Grants & Projects

 
Study on the genetic abnormality in Lung Cancer
Study on the antisense therapy in cancer
Altered Expression of RB and p16INK4 in lung cancer
biological and clinical significance of altered expression of GnT-V and GalNAc-T3 in human cancers
Project Year: 2000