藤田正一 (Shoichi Fujita) - マイポータル - researchmap

基本情報

所属: 旧所属北海道大学大学院獣医学研究科教授,副学長

学位: 医学博士(Ph.D.)
理学修士(M.A.)

J-GLOBAL ID: 200901054039950066
researchmap会員ID: 1000000993

外部リンク: http://www.hokudai.ac.jp/veteri/

研究キーワード

4

研究分野

1

ライフサイエンス / 獣医学 /

学歴

4

- 1979年

アルバート・アインスタイン医科大学大学院, 分子薬理学, 薬理学
- 1979年

ALBERT EINSTEIN COLLEGE OF MEDECINE, MOLECULAR PHARMACOLOGY, PHARMACOLOGY
- 1968年

北海道大学, 獣医学部, 獣医
- 1968年

北海道大学

委員歴

2

1992年

獣医学会, 編集委員
1992年

毒科学会, 評議員,編集委員,集会委員,理事

MISC

329

Inhibitory effects of endogenous dopaminergic neurotoxin, norsalsolinol on dopamine secretion in PC12 rat pheochromocytoma cells

Y Maruyama, H Teraoka, H Iwata, A Kazusaka, S Fujita

NEUROCHEMISTRY INTERNATIONAL 38(7) 567-572 2001年6月
In vivo evidence for accelerated generation of hydroxyl radicals in liver of Long-Evans Cinnamon (LEC) rats with acute hepatitis.

Free Radic Biol Med. 30(5) 547-54 2001年
The antioxidant effect of DL-alpha-lipoic acid on copper-induced acute hepatitis in Long-Evans Cinnamon (LEC) rats

H Yamamoto, T Watanabe, H Mizuno, K Endo, J Fukushige, T Hosokawa, A Kazusaka, S Fujita

FREE RADICAL RESEARCH 34(1) 69-80 2001年
P450 in wild animals as biomarker of environmental impact.

Biomarkers 6(1) 13-25 2001年
Negative correlation between plasma thyroid hormone levels and chlorinated hydrocarbon levels accumulated in seal from the coast of Hokkaido, Japan.

Environ Toxicol Chem 20(5) 1092-1097 2001年
Norsalsolinol uptake into secretory vesicles via vesicular monoamine transporter and its secretion by membrane depolarization or purinoceptor stimulation in PC12 cells.

Yutaka MARUYAMA, Yuko SUZUKI, Akio KAZUSAKA, Shoichi FUJITA

J Vet Med Sci 63(5) 493-497 2001年
Uptake of the dopaminergic neurotoxin, norsalsolinol, into PC12 cells via dopamine transporter

Y. Maruyama, Y. Suzuki, A. Kazusaka, S. Fujita

Archives of Toxicology 75(4) 209-213 2001年
Accumulation of diacylglycerol induced by CCl4-derived radicals in rat liver membrane and its inhibition with radical trapping reagent--FT-IR spectroscopic and HPLC chromatographic observations.

Jpn J Vet Res. 47(3-4) 135-44 2000年
Application of FT-IR and ESR spectroscopic techniques to the study of CCl4-induced peroxidation in rat liver microsomes.

Jpn J Vet Res. 47(3-4) 151-4 2000年
FTIR spectroscopic and HPLC chromatographic studies of carbon tetrachloride induced acute hepatitis in rats: Damage in liver phospholipid membrane

S Yoon, A Kazusaka, S Fujita

BIOPOLYMERS 57(5) 267-271 2000年
Identification of novel cytochrome P450 1A genes from five marine mammal species.

Aquat Toxicol. 51(2) 145-153 2000年
Preventive properties of birch sap against oxidative stress in rats.

Proceedings of the 2 nd International Symposium on Sap Utilization in Bifuka'2000 149-1153 2000年
Decrease in hepatic CYP2C11 mRNA and increase in heme oxygenase activey after intracerebroebroventricular injection of bacterial endotoxin

J. Vet. Med. Sci. 61(609-613) 1999年
Mechanism of decrease in levels of hepatic P450 isoxymes induced by intracerebral endotoxin : independence from sympathetic nervous and adrenocoroical systems

Arch. Toxicl. 73(41-49) 1999年
Cytochrome P450 isoformes responsible for the N-deethyation and cyclohexane-hydration of NS-21

Xenobiotica 29(243-252) 1999年
Preliminary survey of lead poeisoning of Steller's Sea Eagle(Haliaeetus Albicilla)in Hokkaido, Japan.

Environ. Toxicol. 18(448-451) 1999年
Differential alterations en levels of hepatic microsomal cytochrome P450 isozymes following intracerebroventricular injectial lipopolysaccharide in rats.

Arch. Toxicol. 72(492-498) 1999年
Organochlorine pesticides and polychlorinated biphenyl congeners in wild terrestrial mammals and birds from Chubu region, Japan: Interspecies comparison of the residue levels and compositions

H Hoshi, N Minamoto, H Iwata, K Shiraki, R Tatsukawa, S Tanabe, S Fujita, K Hirai, T Kinjo

CHEMOSPHERE 36(15) 3211-3221 1998年6月
Molecular basis of the Dark Agouti rat drug oxidation polymorphism: Importance of CYP2D1 and CYP2D2

Y Yamamoto, T Tasaki, A Nakamura, H Iwata, A Kazusaka, FJ Gonzalez, S Fujita

PHARMACOGENETICS 8(1) 73-82 1998年2月
環境汚染物質暴露に対する生物指標としての肝シトクロムP450の有用性-北海道沿岸に棲息アザラシを用いた検討-

第126回日本獣医学会 1998年

もっとみる

書籍等出版物

5

Possible mechanism for aging-associated feminization of drug metabolizing ability of male and female rat liver. in "Liver and Aging-1990"

Elsevier Science Publishers B. V. 1991年
Effect of senescence on the hepatic metabolism of drugs affecting the central nervous system in rats and mice. in "Liver and Aging-1986"

Elsevier Science, Amsterdam 1986年
Modulation of metabolic activation of benzo(a)pyrene by azo dyes.

The 5th International Conference on cytochrome P-450 1985年
The mechanism of the senescence-associated loss of sex difference in drug metabolizing enzyme activities. in "Cytochrome P-450 Biochemistry, Biophysics and Induction"

Elsevier Sciences 1985年
Hepatic microsomal monooxygenase and azoreductase activities in aging Fishcer-344 rats : Importance of sex associated differences in aging study. in "Liver and Aging-1982"

Elsevier Press 1982年

所属学協会

6

共同研究・競争的資金等の研究課題

6