HARA Hiroshi

J-GLOBAL         Last updated: Apr 13, 2019 at 10:20
 
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Name
HARA Hiroshi
Affiliation
Fuji Women's University
Section
Faculty of Human Life Sciences Department of Food Science and Human Nutrition
Job title
Professor
Degree
PhD(Hokkaido University)

Research Areas

 
 

Committee Memberships

 
2010
   
 
Japanese Society of Nutrition and Food Science  Editor
 

Awards & Honors

 
2004
"Ingestion of water-soluble soybean fiber improves gastrectomy-induced calcium malabsorption and osteopenia in rats.", 9th John M. Kinney International Award for general Nutrition
 
2002
Award of Japanese Society of Digestion and Absorption, October 26, 2002
 

Published Papers

 
Tanaka S, Trakooncharoenvit A, Nishikawa M, Ikushiro S, Hara H
Journal of agricultural and food chemistry      Mar 2019   [Refereed]
Komatsu Y, Wada Y, Izumi H, Shimizu T, Takeda Y, Hira T, Hara H
Food chemistry   277 423-431   Mar 2019   [Refereed]
Ikuta A, Sakurai T, Nishimukai M, Takahashi Y, Nagasaka A, Hui SP, Hara H, Chiba H
Clinica chimica acta; international journal of clinical chemistry   493 1-7   Feb 2019   [Refereed]
Chen W, Hira T, Nakajima S, Hara H
Bioscience, biotechnology, and biochemistry   82(11) 1992-1999   Nov 2018   [Refereed]
Hira T, Ogasawara S, Yahagi A, Kamachi M, Li J, Nishimura S, Sakaino M, Yamashita T, Kishino S, Ogawa J, Hara H
Molecular nutrition & food research   62(19) e1800146   Oct 2018   [Refereed]
Hori S, Hara H, Ishizuka S
Bioscience, biotechnology, and biochemistry   82(12) 1-9   Sep 2018   [Refereed]
Tanaka S, Oyama M, Nishikawa M, Ikushiro S, Hara H
Bioscience, biotechnology, and biochemistry   82(12) 1-12   Sep 2018   [Refereed]
Hayakawa M, Hira T, Nakamura M, Iida T, Kishimoto Y, Hara H
Biochemical and biophysical research communications      Feb 2018   [Refereed]
Iwasaki Y, Sendo M, Dezaki K, Hira T, Sato T, Nakata M, Goswami C, Aoki R, Arai T, Kumari P, Hayakawa M, Masuda C, Okada T, Hara H, Drucker DJ, Yamada Y, Tokuda M, Yada T
Nature communications   9(1) 113   Jan 2018   [Refereed]
Hara H, Kume S, Iizuka T, Fujimoto Y, Kimura A
Bioscience, biotechnology, and biochemistry   82(4) 1-7   Nov 2017   [Refereed]
Hira T, Yanagihara K, Koga T, Takahashi K, Nagura T, Uchino H, Hara H
Bioscience, biotechnology, and biochemistry   81(11) 2186-2194   Nov 2017   [Refereed]
Hira T, Koga T, Sasaki K, Hara H
Biochemical and biophysical research communications   492(2) 161-165   Oct 2017   [Refereed]
Hira T, Suto R, Kishimoto Y, Kanahori S, Hara H
European journal of nutrition   57(3) 965-979   Feb 2017   [Refereed]
Tanaka S, Shinoki A, Hara H
Journal of agricultural and food chemistry   64(49) 9335-9341   Oct 2016   [Refereed]
Lee Y, Yoshitsugu R, Kikuchi K, Joe GH, Tsuji M, Nose T, Shimizu H, Hara H, Minamida K, Miwa K, Ishizuka S
The British journal of nutrition   116(4) 603-610   Aug 2016   [Refereed]
Nakajima S, Hira T, Iwaya H, Hara H
Molecular and cellular endocrinology   430 108-114   Jul 2016   [Refereed]
Maeba R, Araki A, Ishii K, Ogawa K, Tamura Y, Yasunaga M, Minami U, Komori A, Okazaki T, Nishimukai M, Hara H, Fujiwara Y
Clinica chimica acta; international journal of clinical chemistry   453 134-140   Jan 2016   [Refereed]
Joe GH, Andoh M, Shinoki A, Lang W, Kumagai Y, Sadahiro J, Okuyama M, Kimura A, Shimizu H, Hara H, Ishizuka S
Biomedical research (Tokyo, Japan)   37(3) 179-186   2016   [Refereed]
Hira T, Yahagi A, Nishimura S, Sakaino M, Yamashita T, Hara H
Journal of agricultural and food chemistry   63(37) 8177-8181   Sep 2015   [Refereed]
Ishikawa Y, Hira T, Inoue D, Harada Y, Hashimoto H, Fujii M, Kadowaki M, Hara H
Food & function   6(8) 2525-2534   Aug 2015   [Refereed]
Hira T, Ikee A, Kishimoto Y, Kanahori S, Hara H
The British journal of nutrition   114(1) 34-42   Jul 2015   [Refereed]
Ishikawa Y, Hira T, Inoue D, Harada Y, Hashimoto H, Fujii M, Kadowaki M, Hara H
Food & function   6(8) 2525-2534   Aug 2015   [Refereed]
Nakajima S, Hira T, Hara H
The British journal of nutrition   113(9) 1477-1488   May 2015   [Refereed]
Hagio M, Shimizu H, Joe GH, Takatsuki M, Shiwaku M, Xu H, Lee JY, Fujii N, Fukiya S, Hara H, Yokota A, Ishizuka S
Toxicology letters   232(1) 246-252   Jan 2015   [Refereed]
Maeba R, Nishimukai M, Sakasegawa S, Sugimori D, Hara H
Advances in clinical chemistry   70 31-94   2015   [Refereed]
Muramatsu M, Hira T, Mitsunaga A, Sato E, Nakajima S, Kitahara Y, Eto Y, Hara H
American journal of physiology. Gastrointestinal and liver physiology   306(12) G1099-107   Jun 2014   [Refereed]
Nishimukai M, Maeba R, Ikuta A, Asakawa N, Kamiya K, Yamada S, Yokota T, Sakakibara M, Tsutsui H, Sakurai T, Takahashi Y, Hui SP, Chiba H, Okazaki T, Hara H
Clinica chimica acta; international journal of clinical chemistry   437 147-154   Nov 2014   [Refereed]
Nakajima S, Hira T, Yahagi A, Nishiyama C, Yamashita T, Imagi J, Hara H
Molecular nutrition & food research   58(5) 1042-1051   May 2014   [Refereed]
Nagamine R, Ueno S, Tsubata M, Yamaguchi K, Takagaki K, Hira T, Hara H, Tsuda T
Food & function   5(9) 2309-2316   Sep 2014   [Refereed]
Nishimukai M, Maeba R, Yamazaki Y, Nezu T, Sakurai T, Takahashi Y, Hui SP, Chiba H, Okazaki T, Hara H
Journal of lipid research   55(5) 956-965   May 2014   [Refereed]
Nagamine R, Ueno S, Tsubata M, Yamaguchi K, Takagaki K, Hira T, Hara H, Tsuda T
Food & function   5(9) 2309-2316   Sep 2014   [Refereed]
Phuwamongkolwiwat P, Suzuki T, Hira T, Hara H
European journal of nutrition   53(2) 457-468   Mar 2014   [Refereed]
Shimizu H, Hagio M, Iwaya H, Tsuneki I, Lee JY, Fukiya S, Yokota A, Miyazaki H, Hara H, Ishizuka S
Journal of nutritional science and vitaminology   60(6) 450-454   2014   [Refereed]
Joe GH, Andoh M, Nomura M, Iwaya H, Lee JS, Shimizu H, Tsuji Y, Maseda H, Miyazaki H, Hara H, Ishizuka S
Bioscience, biotechnology, and biochemistry   78(3) 462-465   2014   [Refereed]
Yamazaki Y, Kondo K, Maeba R, Nishimukai M, Nezu T, Hara H
Journal of oleo science   63(5) 527-537   2014   [Refereed]
Matsumoto M, Hagio M, Inoue R, Mitani T, Yajima M, Hara H, Yajima T
PloS one   9(4) e93529   2014   [Refereed]
Mizuno Y, Ninomiya Y, Nakachi Y, Iseki M, Iwasa H, Akita M, Tsukui T, Shimozawa N, Ito C, Toshimori K, Nishimukai M, Hara H, Maeba R, Okazaki T, Alodaib AN, Amoudi MA, Jacob M, Alkuraya FS, Horai Y, Watanabe M, Motegi H, Wakana S, Noda T, Kurochkin IV, Mizuno Y, Schönbach C, Okazaki Y
PLoS genetics   9(2) e1003286   Feb 2013   [Refereed]
Shinoki A, Lang W, Thawornkuno C, Kang HK, Kumagai Y, Okuyama M, Mori H, Kimura A, Ishizuka S, Hara H
Food chemistry   136(2) 293-296   Jan 2013   [Refereed]
Iwaya H, Fujii N, Hagio M, Hara H, Ishizuka S
Bioscience, biotechnology, and biochemistry   77(7) 1461-1466   2013   [Refereed]
Suwendi E, Iwaya H, Lee JS, Hara H, Ishizuka S
Biomedical research (Tokyo, Japan)   33(6) 329-336   Dec 2012   [Refereed]
原  博
GI Res   21(1) 3-11   Feb 2013   [Invited]
Tsuruta T, Inoue R, Tsukahara T, Nakamoto M, Hara H, Ushida K, Yajima T
Animal science journal = Nihon chikusan Gakkaiho   83(12) 799-804   Dec 2012   [Refereed]
Ishizuka S, Shiwaku M, Hagio M, Suzuki T, Hira T, Hara H
Biomedical research (Tokyo, Japan)   33(3) 159-165   Jun 2012   [Refereed]
Nakajima S, Hira T, Hara H
Molecular nutrition & food research   56(5) 753-760   May 2012   [Refereed]
Iwaya H, Maeta K, Hara H, Ishizuka S
Experimental biology and medicine (Maywood, N.J.)   237(4) 451-460   Apr 2012   [Refereed]
Iwaya H, Lee JS, Yamagishi S, Shinoki A, Lang W, Thawornkuno C, Kang HK, Kumagai Y, Suzuki S, Kitamura S, Hara H, Okuyama M, Mori H, Kimura A, Ishizuka S
PloS one   7(11) e50658   2012   [Refereed]
Chen W, Hira T, Nakajima S, Tomozawa H, Tsubata M, Yamaguchi K, Hara H
Bioscience, biotechnology, and biochemistry   76(6) 1104-1109   2012   [Refereed]

Misc

 
Feedings of nondigestible saccharides promote bioavailability of quercetin glucosides with suppression of degrading luminal quercetin aglycone in rats
13(2) 97-106   2009

Books etc

 
Plasma/Serum Plasmalogens: Methods of Analysis and Clinical Significance. Ed. by GREGORY S. MAKOWSKI “ADVANCES IN CLINICAL CHEMISTRY Vol. 70”
HARA Hiroshi (Part:Joint Work)
Academic Press (ELSEVIER)   2015   
Functional Food Peptides for Appetite Control. Study on Developing Appetite-suppressive and CCK-releasing Food Peptides Derived from Dietary Proteins.
Md. Kaosar Niaz Bin Sufian, Hiroshi Hara, Tohru Hira (Part:Joint Work)
LAP LAMBERT Academic Publising   2012   
Serum choline plasmalogen is a reliable biomarker for atherogenic status. “Coronary Artery Disease - New Insights and Novel Approaches"
Ryouta MAEBA, Hiroshi HARA (Part:Joint Work)
In Tech - Open Access Publisher   2012   
A nondigestible saccharide enhances transcellular transport of myricetin glycosides in rat small intestine. - A newly defined mechanism of flavonoid absorption. ed: Nelson Cho and Susan Almeida “Dietary Fiber and Health”
Noriko Matsukawa , Megumi Matsumoto, Hiroshi Hara (Part:Joint Work)
2012   
Plasma/Serum Plasmalogens: Methods of Analysis and Clinical Significance.
HARA Hiroshi (Part:Joint Work)

Conference Activities & Talks

 
Role of the Digestive Tracts in Nutritional Effects of Foods [Invited]
HARA Hiroshi
21 May 2017   
Soybean derived bioactive peptides stimulating gut hormone secretion. [Invited]
HARA Hiroshi
ISNFF Conference and Exhibition, Bioactive Proteins and Peptides in Health and Disease, Orlando, FL, US   8 Oct 2016   
Peptides derived from rice proteins stimulate GLP-1 secretion and suppress blood glucose. [Invited]
Hiroshi Hara, Yuki Ishikawa, Motoni Kadowaki, Tohru Hira
107th American Oil Chemist’s Society (AOCS) Annual Meeting. Protein and Co-Product Division, Salt Lake City, Utah, US   1 May 2016   
Appetite suppressive peptides derived from soybean -Involvement of enteroendocrine system. [Invited]
Hiroshi Hara, Shingo Nakajima, Tohru Hira
106th American Oil Chemist’s Society (AOCS) Annual Meeting. Protein and Co-Product Division, Orlando, FL, US   3 May 2015   
Effects of resistant maltodextrin and fructooligosaccharides on fasting GLP-1 levels and glucose tolerance in rats. [Invited]
Tohru Hira, Asuka Ikee, Yuka Kishimoto, Sumiko Kanahori, Hiroshi Hara
10th Vahouny Fiber Symposium. Bethesda MD, US   26 May 2014   
PHYSIOLOGICAL FUNCTION OF SOYBEAN PEPTIDES [Invited]
HARA Hiroshi
PS1-6 Diversity of physiological functions of amino acids and peptides. International Congress of Nutrition (ICN2013, IUNS), Granada, Spain   16 Sep 2013   
PHYSIOLOGICAL FUNCTION OF SOYBEAN PEPTIDES in PS1-6 Diversity of physiological functions of amino acids and peptides. [Invited]
Hiroshi Hara, Shingo Nakajima, Tohru Hira
International Congress of Nutrition (ICN2013, IUNS), Granada, Spain   15 Sep 2013   
Clinical implications of blood plasmalogens as a biomarker of atherosclerosis. [Invited]
Hiroshi Hara, Megumi Nishimukai, Yuya Yamazaki, Tohru Nezu, Seiji Koike, Shu-Ping Hui, Hitoshi Chiba, Ryota Maeba
The 2011 Annual Conference of International Society for Nutraceuticals and Functional Foods (ISNFF)   17 Nov 2011   ISNFF
A newly defined promotion mechanism of flavonoid glycoside absorption by a nondigestible saccharide in the rat small intestine. [Invited]
Noriko Matsukawa, Megumi Matsumoto, Hiroshi Hara
The 9th Vahouny Fiber Symposium   11 Jun 2010   Vahouny Fiber Symposium
Fructooligosaccharides improved insulin sensitivity associated with suppression of adipocytokine releases from the mesenteric fat cells in rats. [Invited]
Aki Shinoki, H. Hara
The 9th Vahouny Fiber Symposium   9 Jun 2010   Vahouny Fiber Symposium
Myo-inositol treatment increases serum plasmalogens and decreases small dense LDL in hyperlipidemic subjects. [Invited]
Ryota Maeba, Hiroshi Hara
2nd International symposium on “Rice and Disease Prevention”   26 Oct 2008   International symposium on “Rice and Disease Prevention”
Enhancements of flavonoid absorption by a nondigestible fructose disaccharide through dual mechanisms in the rat small and large intestine. [Invited]
Hiroshi Hara, Noriko Matsukawa Akiko Tamura and Megumi Matsumoto
The Sixth International Fructan Symposium- Fructan 2008   30 Jul 2008   The Sixth International Fructan Symposium
Physiological effects of short-chain fatty acids produced from prebiotics in the colon. [Invited]
Hiroshi Hara
JICA seminar Bioindustry II   21 Jun 2005   JICA
Stimulatory effects of difructose anhydrides on mineral absorption. [Invited]
Hiroshi Hara
The Fifth International Fructan Symposium- Fructan 2004   6 Dec 2004   The Fifth International Fructan Symposium
Oligosaccharides, a functional food to promote calcium absorption and prevent osteoporosis. [Invited]
Hiroshi Hara
JICA seminar Bioindustry II   22 Jun 2004   JICA
Oligosaccharides function to promote calcium absorption and prevent osteoporosis. [Invited]
Hiroshi Hara
Korea Food and Nutrition Foundation symposium, Oligosaccharide and its health function.   7 Nov 2003   Korea Food and Nutrition Foundation
Low concentrations of quercetin in diet inhibit crypt cell mitosis throughout the alimentary tract, and suppress aberrant crypt foci in the colon. [Invited]
Jennifer M. Gee, Hiroshi Hara, Ian T. Johnson
101st Annual Meeting of the American Gastroenterological Association   2000   the American Gastroenterological Association
Antiproliferative effects of quercetin in the rat gastrointestinal tract [Invited]
Hiroshi Hara, Jenifer M. Gee, Ian T. Johnson
COST98 Workshop, Effects of antinutrients on the nutritional value of legume diets   21 Jun 1998   Eeropian Union
Evaluation of Short-chain fatty acid Production in the Cecum of Fiber Fed Rats. [Invited]
Hara H., Saito Y., Idei A., Kiriyama S
International Conference and Industrial Exhibition on Food hydrocolloids, Food Hydrocolloid: structures, properties, and functions   1992   Food Hydrocolloid

Works

 
Physiological effects of short-chain fatty acids produced from prebiotics in the colon.
2006
Oligosaccharides, a functional food to promote calcium absorption and prevent osteoporosis.
2004

Research Grants & Projects

 
食後の消化管ホルモン分泌応答や栄養吸収の時空間的解析とその栄養学的意義
Ministry of Education, Culture, Sports, Science and Technology: 科学研究費補助金(挑戦的研究(萌芽)
Project Year: Apr 2018 - Mar 2019    Investigator(s): Hiroshi HARA
Study on physiological effects of isomalto-megalo-saccharides
Ministry of Education, Culture, Sports, Science and Technology: 科学研究費補助金(基盤研究(A)
Project Year: Apr 2017 - Mar 2019    Investigator(s): Hiroshi HARA
Study on sensing mechanism of low-digestible saccharides in nutrient-sensing enteroendocrine cells
Ministry of Education, Culture, Sports, Science and Technology: 科学研究費補助金(挑戦的萌芽研究
Project Year: Apr 2016 - Mar 2017    Investigator(s): Hiroshi HARA
Ministry of Education, Culture, Sports, Science and Technology: Grants-in-Aid for Scientific Research(基盤研究(B))
Project Year: Apr 2007 - Mar 2010    Investigator(s): Hiroshi HARA
From various dietary peptides, we found that country bean peptide and beer yeast peptide have potent activity to stimulate a satiating gut hormone CCK in enteroeondcrine cell line. Oral preload of beer yeast peptide reduced following food consumpt...
Promotive effects of oligosaccharides on flavonoid absorption
Project Year: 2002   
Ministry of Education, Culture, Sports, Science and Technology: Grants-in-Aid for Scientific Research(基盤研究(B))
Project Year: 1998 - 2000    Investigator(s): Hiroshi HARA
The aims of this study were to establish a model of colon cancer by ionizing radiation in rats and to compare the effects of dietary fiber feeding on cancer development with those in a chemically-induced colon cancer model. We first succeed to dev...
Ministry of Education, Culture, Sports, Science and Technology: Grants-in-Aid for Scientific Research(試験研究(B), 基盤研究(A))
Project Year: 1995 - 1997    Investigator(s): Fusao TOMITA
1.Preparation of Raw Material for Oligosaccharides Production : Extraction and purification of inulin from chicory was attempted according to the method of sugar purification from beet, and was successfully achieved. Preparation of levan was also ...
Physiological properties of plasmalogen, antioxidative phopholipid.
Improvement of Technical Infrastructure SCF Promotion System for Intellectual Infrastructure of Research and Development
Project Year: 1996   
Ministry of Education, Culture, Sports, Science and Technology: Grants-in-Aid for Scientific Research(一般研究(C))
Project Year: 1994 - 1995    Investigator(s): Hiroshi HARA
1) Intensity of cecal calcium absorption was increased after feeding of eater-soluble and high fermentable dietary fiber, which was evaluated by arterio-cecal venous difference in calcium concentration.2) We estimate capacity of calcium absorption...
Intestinal sensory mechanism of food peptides for stimulation of gut hormones.
Project Year: 1990   
Physiological effects of nondigestible saccharides (Dietary fibers and oligosacchrides).
Project Year: 1986   

Patents

 
351495
3425664
2000-204042
3997114
2006-022003
2006-056837
2006-143623
2006-193459
2006-232725
2006-241057
2007-43940
2007-230978
2007-51132
2007-191462
2008-231057