2017年
Astilbe thunbergii reduces postprandial hyperglycemia in a type 2 diabetes rat model via pancreatic alpha-amylase inhibition by highly condensed procyanidins
BIOSCIENCE BIOTECHNOLOGY AND BIOCHEMISTRY
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- 巻
- 81
- 号
- 9
- 開始ページ
- 1699
- 終了ページ
- 1705
- 記述言語
- 英語
- 掲載種別
- 研究論文(学術雑誌)
- DOI
- 10.1080/09168451.2017.1353403
- 出版者・発行元
- TAYLOR & FRANCIS LTD
Type 2 diabetes mellitus (T2DM) is a common global health problem. Prevention of this disease is an important task, and functional food supplements are considered an effective method. We found potent pancreatic -amylase inhibition in Astilbe thunbergii root extract (AT) and confirmed that AT treatment in a T2DM rat model reduces post-starch administration blood glucose levels. Activity-guided isolation revealed procyanidin (AT-P) as the -amylase inhibitory component with IC50=1.7g/mL against porcine pancreatic -amylase. Structure analysis of AT-P revealed it is a B-type procyanidin comprised of four types of flavan-3-ols, some with a galloyl group, and catechin attached as the terminal unit. The abundant AT-P content and its comparable -amylase inhibition to acarbose, the anti-diabetic medicine, suggest that AT is a promising food supplement for diabetes prevention.
- リンク情報
- ID情報
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- DOI : 10.1080/09168451.2017.1353403
- ISSN : 0916-8451
- eISSN : 1347-6947
- Web of Science ID : WOS:000407488800006