論文

査読有り 責任著者
2015年3月

Intestinal epithelial cells promote secretion of leptin and adiponectin in adipocytes

BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
  • Rino Ishihara
  • ,
  • Yuki Mizuno
  • ,
  • Akiho Miwa
  • ,
  • Akihiro Hamada
  • ,
  • Takeshi Tsuruta
  • ,
  • Martin Wabitsch
  • ,
  • Kei Sonoyama

458
2
開始ページ
362
終了ページ
368
記述言語
英語
掲載種別
研究論文(学術雑誌)
DOI
10.1016/j.bbrc.2015.01.118
出版者・発行元
ACADEMIC PRESS INC ELSEVIER SCIENCE

Although leptin and adiponectin are the predominant adipokines, how their circulating levels are regulated is incompletely understood. The present study tested whether intestinal epithelial cells influence the expression and secretion of these adipokines by adipocytes. Leptin gene expression and secretion by cultured human primary adipocytes and Simpson-Golabi-Behmel Syndrome adipocytes increased upon coculture with human enterocytic Caco-2 cells or incubation in conditioned medium of Caco-2 cells. Although adiponectin secretion increased, its mRNA levels decreased. Tissue homogenate of the ileum (but not the jejunum, colon, or liver) of nonobese C57BL/6J mice also stimulated leptin and adiponectin secretion by cultured murine 3T3-L1 adipocytes. However, ileal homogenate of obese KK-Ay mice had no effect on leptin and adiponectin secretion. We propose that as yet unidentified humoral factors released from intestinal epithelial cells are involved in regulating circulating leptin and adiponectin levels. Decreased production of such factors may contribute to hyperphagia in KK-Ay mice. (C) 2015 Elsevier Inc. All rights reserved.

リンク情報
DOI
https://doi.org/10.1016/j.bbrc.2015.01.118
PubMed
https://www.ncbi.nlm.nih.gov/pubmed/25656573
Web of Science
https://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcAuth=JSTA_CEL&SrcApp=J_Gate_JST&DestLinkType=FullRecord&KeyUT=WOS:000351482200024&DestApp=WOS_CPL
ID情報
  • DOI : 10.1016/j.bbrc.2015.01.118
  • ISSN : 0006-291X
  • eISSN : 1090-2104
  • PubMed ID : 25656573
  • Web of Science ID : WOS:000351482200024

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