OGASAWARA Kazumasa

J-GLOBAL         Last updated: Mar 2, 2019 at 13:22
 
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Name
OGASAWARA Kazumasa
URL
http://www.shiga-med.ac.jp/~hpatho2/
Affiliation
Shiga University of Medical Science
Section
Undergraduate School of Medicine, Faculty of Medicine, Shiga University of Medical Science Undergraduate School of Medicine Faculty of Medicine
Job title
Professor

Research Areas

 
 

Academic & Professional Experience

 
1984
 - 
1985
Institute of Immunological Science, Hokkaido University, Research Assistant
 
1985
 - 
1987
NIH, NIAID, visiting fellow
 
1987
 - 
1999
Institute of Immunological Science, Hokkaido University, Associate Prof.
 

Education

 
 
 - 
1980
Faculty of Medicine, Hokkaido University
 
 
 - 
1984
Graduate School, Division of Medicine, Hokkaido University
 

Published Papers

 
Ryosuke Murai, Ryosuke Murai, Yasushi Itoh, Susumu Kageyama, Misako Nakayama, Hirohito Ishigaki, Kazuo Teramoto, Mitsuhiro Narita, Tetsuya Yoshida, Keiji Tomita, Ken Ichi Kobayashi, Akinori Wada, Masayuki Nagasawa, Shigehisa Kubota, Kazumasa Ogasawara, Akihiro Kawauchi
PLoS ONE   13(9) e0204745   Sep 2018   [Refereed]
© 2018 Murai et al. This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are c...
Tetsuro Hanada, Shunichiro Tsuji, Misako Nakayama, Shiro Wakinoue, Kyoko Kasahara, Fuminori Kimura, Takahide Mori, Kazumasa Ogasawara, Takashi Murakami
Reproductive Biology and Endocrinology   16(1) 9   Feb 2018   [Refereed]
© 2018 The Author(s). Background: Endometriosis is a known cause of infertility. Differences in immune tolerance caused by regulatory T cells (Tregs) and transforming growth factor-β (TGF-β) are thought to be involved in the pathology of endometri...
Asuka Morizane, Tetsuhiro Kikuchi, Takuya Hayashi, Hiroshi Mizuma, Sayuki Takara, Hisashi Doi, Aya Mawatari, Matthew F. Glasser, Takashi Shiina, Hirohito Ishigaki, Yasushi Itoh, Keisuke Okita, Emi Yamasaki, Daisuke Doi, Hirotaka Onoe, Hirotaka Onoe, Kazumasa Ogasawara, Shinya Yamanaka, Shinya Yamanaka, Jun Takahashi, Jun Takahashi
Nature Communications   8(1) 385   Dec 2017   [Refereed]
© 2017 The Author(s). The banking of human leukocyte antigen (HLA)-homozygous-induced pluripotent stem cells (iPSCs) is considered a future clinical strategy for HLA-matched cell transplantation to reduce immunological graft rejection. Here we sho...
Ishigaki H, Shiina T, Ogasawara K
Inflammation and regeneration   38 30   2018   [Refereed]
Kisu I, Umene K, Adachi M, Emoto K, Nogami Y, Banno K, Itagaki I, Kawamoto I, Nakagawa T, Narita H, Yoshida A, Tsuchiya H, Ogasawara K, Aoki D
Human reproduction (Oxford, England)   32(12) 2581   Dec 2017   [Refereed]
Kisu Iori, Umeneo Kiyoko, Adachi Masataka, Emoto Katsura, Nogami Yuya, Banno Kouji, Itagaki Iori, Kawamoto Ikuo, Nakagawa Takahiro, Narita Hayato, Yoshida Atsushi, Tsuchiya Hideaki, Ogasawara Kazumasa, Aoki Daisuke
HUMAN REPRODUCTION   32(10) 2026-2035   Oct 2017   [Refereed]
Sugita Sunao, Makabe Kenichi, Fujii Shota, Iwasaki Yuko, Kamao Hiroyuki, Shiina Takashi, Ogasawara Kazumasa, Takahashi Masayo
STEM CELL REPORTS   9(5) 1501-1515   Nov 2017   [Refereed]
Maki Kiso, Kiyoko Iwatsuki-Horimoto, Seiya Yamayoshi, Ryuta Uraki, Mutsumi Ito, Noriko Nakajima, Shinya Yamada, Masaki Imai, Eiryo Kawakami, Yuriko Tomita, Satoshi Fukuyama, Satoshi Fukuyama, Yasushi Itoh, Kazumasa Ogasawara, Tiago J.S. Lopes, Tiago J.S. Lopes, Tokiko Watanabe, Tokiko Watanabe, Louise H. Moncla, Louise H. Moncla, Hideki Hasegawa, Thomas C. Friedrich, Thomas C. Friedrich, Gabriele Neumann, Yoshihiro Kawaoka, Yoshihiro Kawaoka, Yoshihiro Kawaoka
Journal of Infectious Diseases   216(5) 582-593   Sep 2017   [Refereed]
© The Author 2017. Published by Oxford University Press for the Infectious Diseases Society of America. All rights reserved. Antiviral compounds (eg, the neuraminidase inhibitor oseltamivir) are invaluable for the treatment of individuals infected...
Ishigaki H, Maeda T, Inoue H, Akagi T, Sasamura T, Ishida H, Inubushi T, Okahara J, Shiina T, Nakayama M, Itoh Y, Ogasawara K
Cancer research   77(21) 6001-6010   Sep 2017   [Refereed]
Yang M, Yang H, Guan H, Kato T, Mukaisho K, Sugihara H, Ogasawara K, Terada T, Tooyama I
Acta histochemica et cytochemica   50(1) 49-55   Feb 2017   [Refereed]
Misako Nakayama, Yasushi Itoh, Shintaro Shichinohe, Rumi Nakabayashi, Hirohito Ishigaki, Yoshihiro Sakoda, Yoshihiro Sakoda, Quynh Mai Le, Yoshihiro Kawaoka, Yoshihiro Kawaoka, Hiroshi Kida, Hiroshi Kida, Hiroshi Kida, Kazumasa Ogasawara, Kazumasa Ogasawara
Vaccine   35(7) 1008-1017   Feb 2017   [Refereed]
© 2017 Elsevier LtdThe efficacy and detrimental effect of mucosal vaccination with an inactivated influenza vaccine were examined in a macaque model by intranasal administration with small amounts of inactivated whole virus particles and challenge...
Fumihiko Yasui, Yasushi Itoh, Ai Ikejiri, Masahiro Kitabatake, Nobuo Sakaguchi, Nobuo Sakaguchi, Keisuke Munekata, Shintaro Shichinohe, Yukiko Hayashi, Hirohito Ishigaki, Misako Nakayama, Yoshihiro Sakoda, Hiroshi Kida, Kazumasa Ogasawara, Michinori Kohara
Scientific Reports   6    Nov 2016   [Refereed]
© The Author(s) 2016.H5N1 highly pathogenic avian influenza (H5N1 HPAI) virus causes elevated mortality compared with seasonal influenza viruses like H1N1 pandemic influenza (H1N1 pdm) virus. We identified a mechanism associated with the severe sy...
Obara H, Kisu I, Kato Y, Yamada Y, Matsubara K, Emoto K, Adachi M, Matoba Y, Umene K, Nogami Y, Banno K, Tsuchiya H, Itagaki I, Kawamoto I, Nakagawa T, Ishigaki H, Itoh Y, Ogasawara K, Saiki Y, Sato SI, Nakagawa K, Shiina T, Aoki D, Kitagawa Y
Scientific reports   6    Oct 2016   [Refereed]
Sugita S, Iwasaki Y, Makabe K, Kamao H, Mandai M, Shiina T, Ogasawara K, Hirami Y, Kurimoto Y, Takahashi M
Stem cell reports   7(4) 635-648   Oct 2016   [Refereed]
Adachi M, Kisu I, Nagai T, Emoto K, Banno K, Umene K, Nogami Y, Tsuchiya H, Itagaki I, Kawamoto I, Nakagawa T, Ogasawara K, Aoki D
Acta obstetricia et gynecologica Scandinavica   95(9) 991-998   Sep 2016   [Refereed]
Maeda K, Kawai H, Sanada M, Terashima T, Ogawa N, Idehara R, Makiishi T, Yasuda H, Sato S, Hoshi K, Yahikozawa H, Nishi K, Itoh Y, Ogasawara K, Tomita K, Indo HP, Majima HJ
JAMA neurology   73(8) 990-993   Aug 2016   [Refereed]
Shichinohe S, Itoh Y, Nakayama M, Ozaki H, Soda K, Ishigaki H, Okamatsu M, Sakoda Y, Kida H, Ogasawara K
Virology   493 38-38   Jun 2016   [Refereed]
Seita Y, Tsukiyama T, Iwatani C, Tsuchiya H, Matsushita J, Azami T, Okahara J, Nakamura S, Hayashi Y, Hitoshi S, Itoh Y, Imamura T, Nishimura M, Tooyama I, Miyoshi H, Saitou M, Ogasawara K, Sasaki E, Ema M.
Scientific reports   6 24868   Apr 2016   [Refereed]
Kawamura T, Miyagawa S, Fukushima S, Maeda A, Kashiyama N, Kawamura A, Miki K, Okita K, Yoshida Y, Shiina T, Ogasawara K, Miyagawa S, Toda K, Okuyama H, Sawa Y
Stem cell reports   6(3) 312-320   Mar 2016   [Refereed]
Misako Nakayama, Hiroichi Ozaki, Yasushi Itoh, Kosuke Soda, Hirohito Ishigaki, Masatoshi Okamatsu, Yoshihiro Sakoda, Yoshihiro Sakoda, Chun Ho Park, Hideaki Tsuchiya, Hiroshi Kida, Hiroshi Kida, Hiroshi Kida, Kazumasa Ogasawara, Kazumasa Ogasawara
Pathology International   66(12) 686-686   Jan 2016   [Refereed]
© 2016 Japanese Society of Pathology and John Wiley & Sons Australia, Ltd.H9N2 avian influenza virus causes sporadic human infection. Since humans do not possess acquired immunity specific to this virus, we examined the pathogenicity of an H9N2 vi...
Shiina T, Yamada Y, Aarnink A, Suzuki S, Masuya A, Ito S, Ido D, Yamanaka H, Iwatani C, Tsuchiya H, Ishigaki H, Itoh Y, Ogasawara K, Kulski JK, Blancher A
Immunogenetics   67(10) 563-578   Oct 2015   [Refereed]
Itoh Y, Shichinohe S, Nakayama M, Igarashi M, Ishii A, Ishigaki H, Ishida H, Kitagawa N, Sasamura T, Shiohara M, Doi M, Tsuchiya H, Nakamura S, Okamatsu M, Sakoda Y, Kida H, Ogasawara K
Antimicrobial agents and chemotherapy   59(8) 4962-4973   Aug 2015   [Refereed]
Mohamed RH, Sutoh Y, Itoh Y, Otsuka N, Miyatake Y, Ogasawara K, Kasahara M
PloS one   10(4) e0123258   Apr 2015   [Refereed]
Araki S, Imai S, Ishigaki H, Mimura T, Nishizawa K, Ueba H, Kumagai K, Kubo M, Mori K, Ogasawara K, Matsusue Y
Acta orthopaedica   86(1) 119-126   Feb 2015   [Refereed]
Ohshio Y, Teramoto K, Hanaoka J, Tezuka N, Itoh Y, Asai T, Daigo Y, Ogasawara K
Cancer science   106(2) 134-142   Feb 2015   [Refereed]
Ishigaki H, Nakae A, Nakai M, Ogasawara K
Internal medicine (Tokyo, Japan)   54(4) 437-438   2015   [Refereed]
Itoh Y, Yoshida R, Shichinohe S, Higuchi M, Ishigaki H, Nakayama M, Pham VL, Ishida H, Kitano M, Arikata M, Kitagawa N, Mitsuishi Y, Ogasawara K, Tsuchiya H, Hiono T, Okamatsu M, Sakoda Y, Kida H, Ito M, Quynh Mai L, Kawaoka Y, Miyamoto H, Ishijima M, Igarashi M, Suzuki Y, Takada A
PLoS pathogens   10(6) e1004192   Jun 2014   [Refereed]
Iori Kisu, Yojiro Kato, Hideaki Tsuchiya, Lkuo Kawamoto, Takahiro Nakagawa, Kazumasa Ogasawara, Kazumasa Ogasawara, Tomohisa Hayakawa, Yasuko Yamayoshi, OSamu Iketani, Makoto Mihara, Kouji Banno, Shin Ichi Sato, Takashi Shiina, Daisuke Aoki
International Journal of Pharmacology   10 487-493   Jan 2014
© 2014 Asian Network for Scientific InformationIntramuscular or intravenous injection of Cyclosporine A (CyA) has been performed in some transplantation animal studies, including non-hwnan primates. However, the pharmacokinetics after subcutaneous...
Kitano M, Itoh Y, Ishigaki H, Nakayama M, Ishida H, Pham VL, Arikata M, Shichinohe S, Tsuchiya H, Kitagawa N, Kobayashi M, Yoshida R, Sato A, Le QM, Kawaoka Y, Ogasawara K
Antimicrobial Agents and Chemotherapy   58(8) 4795-4803   2014
Muramoto Y, Shoemaker J, Le M, Itoh Y, Tamura D, Sakai-Tagawa Y, Imai H, Uraki R, Takano R, Kawakami E, Ito M, Okamoto K, Ishigaki H, Mimuro H, Sasakawa C, Matsuoka Y, Noda T, Fukuyama S, Ogasawara K, Kitano H, Kawaoka Y
J Virol   88 8981-8997   2014
Nakayama M, Shichinohe S, Itoh Y, Ishigaki H, Kitano M, Arikata M, Pham VL, Ishida H, Kitagawa N, Okamatsu M, Sakoda Y, Ichikawa T, Tsuchiya H, Nakamura S, Le QM, Ito M, Kawaoka Y, Kida H, Ogasawara K
PLoS ONE   8(12) e82740   2013
Pham VL, Nakayama M, Itoh Y, Ishigaki H, Kitano M, Arikata M, Ishida H, Kitagawa N, Shichinohe S, Okamatsu M, Sakoda Y, Tsuchiya H, Nakamura S, Kida H, Ogasawara K
PLoS ONE   8(9) e75910   2013
Masahiko Arikata, Masahiko Arikata, Yasushi Itoh, Masatoshi Okamatsu, Toshinaga Maeda, Takashi Shiina, Keiko Tanaka, Shingo Suzuki, Misako Nakayama, Yoshihiro Sakoda, Hirohito Ishigaki, Ayato Takada, Hideaki Ishida, Kosuke Soda, Loi van Pham, Hideaki Tsuchiya, Shinichiro Nakamura, Ryuzo Torii, Takeshi Shimizu, Hidetoshi Inoko, Iwao Ohkubo, Hiroshi Kida, Hiroshi Kida, Kazumasa Ogasawara
PLoS ONE   7    May 2012
We made an H1N1 vaccine candidate from a virus library consisting of 144 (= 16 HA×9 NA) non-pathogenic influenza A viruses and examined its protective effects against a pandemic (2009) H1N1 strain using immunologically naïve cynomolgus macaques to...
Nakamura S, Tsuchiya H, Okahara N, Nakagawa T, Ohara N, Yamamoto H, Li T, Takeda N, Ogasawara K, Torii R.
J Vet Med Sci.   74 279-283   2012
Arikata M, Itoh Y, Okamatsu M, Maeda T, Shiina T, Tanaka K, Suzuki S, Nakayama M, Sakoda Y, Ishigaki H, Takada A, Ishida H, Soda K, Pham VL, Tsuchiya H, Nakamura S, Torii R, Shimizu T, Inoko H, Ohkubo I, Kida H, Ogasawara K
PLos ONE      2012
Hidefumi Ito, Masataka Nakamura, Osamu Komure, Takashi Ayaki, Reika Wate, Hirofumi Maruyama, Yoshimi Nakamura, Kengo Fujita, Satoshi Kaneko, Yoko Okamoto, Masafumi Ihara, Tetsuro Konishi, Kazumasa Ogasawara, Asao Hirano, Hirofumi Kusaka, Ryuji Kaji, Ryosuke Takahashi, Hideshi Kawakami
Acta Neuropathologica   122 223-229   Aug 2011
We investigated a family manifesting amyotrophic lateral sclerosis (ALS) with a heterozygous E478G mutation in the optineurin (OPTN) gene. Clinically, slow deterioration of motor function, mood and personality changes, temporal lobe atrophy on neu...
Ishigaki H, Miyauchi J, Yokoe A, Nakayama M, Yanagi T, Taga T, Ohta S, Itoh Y, Ogasawara K
Hum Pathol   42 141-145   2011
Kitano M, Itoh Y, Kodama M, Ishigaki H, Nakayama M, Ishida H, Baba K, Noda T, Sato K, Nihashi Y, Kanazu T, Yoshida R, Torii R, Sato A, Ogasawara K
Antimicrobial Agents and Chemotherapry   55 4961-4970   2011
Kengo Maeda, Yuri Katayama, Toshiro Sugimoto, Mariko Somura, Yuri Kajino, Kazumasa Ogasawara, Hitoshi Yasuda
Journal of Neurology, Neurosurgery and Psychiatry   81 1175-1177   Oct 2010
Hirofumi Maruyama, Hiroyuki Morino, Hidefumi Ito, Hidefumi Ito, Yuishin Izumi, Hidemasa Kato, Yasuhito Watanabe, Yoshimi Kinoshita, Masaki Kamada, Masaki Kamada, Hiroyuki Nodera, Hidenori Suzuki, Osamu Komure, Shinya Matsuura, Keitaro Kobatake, Nobutoshi Morimoto, Koji Abe, Naoki Suzuki, Masashi Aoki, Akihiro Kawata, Takeshi Hirai, Takeo Kato, Kazumasa Ogasawara, Asao Hirano, Toru Takumi, Hirofumi Kusaka, Koichi Hagiwara, Ryuji Kaji, Hideshi Kawakami
Nature   465 223-226   May 2010
Amyotrophic lateral sclerosis (ALS) has its onset in middle age and is a progressive disorder characterized by degeneration of motor neurons of the primary motor cortex, brainstem and spinal cord1. Most cases of ALS are sporadic, but about 10% are...
Taichiro Miyake, Taichiro Miyake, Osamu Sawada, Masashi Kakinoki, Tomoko Sawada, Hajime Kawamura, Kazumasa Ogasawara, Masahito Ohji
Investigative Ophthalmology and Visual Science   51 1606-1608   Mar 2010
Purpose. To evaluate the pharmacokinetics of intravitreally injected bevacizumab in the systemic circulation and the aqueous humor and its effect on vascular endothelial growth factor (VEGF) in the aqueous humor. Methods. Bevacizumab (1.25 mg/50 μ...
Yasushi Itoh, Hiroichi Ozaki, Hirohito Ishigaki, Yoshihiro Sakoda, Tomoya Nagata, Tomoya Nagata, Kosuke Soda, Norikazu Isoda, Taichiro Miyake, Taichiro Miyake, Hideaki Ishida, Kiyoko Okamoto, Misako Nakayama, Hideaki Tsuchiya, Ryuzo Torii, Hiroshi Kida, Hiroshi Kida, Kazumasa Ogasawara, Kazumasa Ogasawara
Vaccine   28 780-789   Jan 2010
Development of H7N7 highly pathogenic avian influenza virus (HPAIV) vaccines is an urgent issue since human cases of infection with this subtype virus have been reported and most humans have no immunity against H7N7 viruses. We made an H7N7 vaccin...
Kitano M, Itoh Y, Kodama M, Ishigaki H, Nakayama M, Nagata T, Ishida H, Tsuchiya H, Torii R, Baba K, Yoshida R, Sato A, Ogasawara K
Virology   407 178-184   2010
Miyake T, Soda K, Itoh Y, Sakoda Y, Ishigaki H, Nagata T, Ishida H, Nakayama M, Ozaki H, Tsuchiya H, Torii R, Kida H, Ogasawara K
J Med Primatol.   39 58-70   2010
Yoshitaka Kashima, Yoshitaka Kashima, Mizuho Ikeda, Yasushi Itoh, Yoshihiro Sakoda, Tomoya Nagata, Tomoya Nagata, Taichiro Miyake, Taichiro Miyake, Kosuke Soda, Hiroichi Ozaki, Misako Nakayama, Hitomi Shibuya, Masatoshi Okamatsu, Hirohito Ishigaki, Hideaki Ishida, Toshihiro Sawai, Toshihiro Sawai, Yoshihiro Kawaoka, Yoshihiro Kawaoka, Hiroshi Kida, Hiroshi Kida, Kazumasa Ogasawara
Vaccine   27 7402-7408   Dec 2009
Outbreaks of highly pathogenic avian influenza viruses (HPAIVs) would cause disasters worldwide. Various strategies against HPAIVs are required to control damage. It is thought that the use of non-pathogenic avian influenza viruses as live vaccine...
Arata Takeuchi, Yasushi Itoh, Akiko Takumi, Chitose Ishihara, Noriko Arase, Noriko Arase, Tadashi Yokosuka, Haruhiko Koseki, Sho Yamasaki, Sho Yamasaki, Yoshimi Takai, Jun Miyoshi, Kazumasa Ogasawara, Takashi Saito, Takashi Saito
Journal of Immunology   183 4220-4228   Oct 2009
In vivo immune response is triggered in the lymph node, where lymphocytes for entry into, retention at, and migration to effector sites are dynamically regulated. The molecular mechanism underlying retention regulation is the key to elucidating in...
Takuya Fujita, Koji Teramoto, Yoshitomo Ozaki, Jun Hanaoka, Noriaki Tezuka, Yasushi Itoh, Tohru Asai, Shozo Fujino, Keiichi Kontani, Kazumasa Ogasawara
Cancer Research   69 5142-5150   Jun 2009
Tumor-draining lymph nodes (DLN) are the most important priming sites for generation of antitumor immune responses. They are also the location where an immunosuppressive cytokine, transforming growth factor-β (TGF-β), plays a critical role in supp...
Takeuchi A, Itoh Y, Takumi A, Ishihara C, Arase N, Yokosuka T, Koseki H, Yamasaki S, Takai Y, Miyoshi J, Ogasawara K, Saito T
J Immunol   183 4220-4228   2009
Kita YF, Hosomichi K, Kohara S, Itoh Y, Ogasawara K, Tsuchiya H, Torii R, Inoko H, Blancher A, Kulski1 JK, Shiina T
Immunogenetics   61 635-648   2009
Itoh Y, Segawa H, Kito K, Hodohara K, Ishigaki H, Sugihara H, Fujiyama Y, Ogasawara K.
Pathol Res Pract.   205 143-147   2009
Miyake T, Sawada O, Kakinoki M, Sawada T, Kawamura H, Ogasawara K, Ohji M
Invest Ophth Vis Sci.      2009
Takeuchi A, Itoh Y, Takumi A, Ishihara C, Arase N, Yokosuka T, Koseki H, Yamasaki S, Takai Y, Miyoshi J, Ogasawara K, Saito T
J Immunol.      2009
Kashima Y, Ikeda M, Itoh Y, Sakoda Y, Nagata T, Miyake T, Soda K, Ozaki H, Nakayama M, Shibuya H, Okamatsu M, Ishigaki H, Ishida H, Sawai T, Kawaoka Y, Kida H, Ogasawara K
Vaccine   27 7402-7408   2009
Intranasal administration of a live non-pathogenic avian H5N1 influenza virus from a virus library confers protective immunity against H5N1 highly pathogenic avian influenza virus infection in mice: Comparison of formulations and administration ro...
Kita YF, Hosomichi K, Kohara S, Itoh Y, Ogasawara K, Tsuchiya H, Torii R, Inoko H, Blancher A, Kulski JK, Shiina T
Immunogenetics   61 635-648   2009
Fujita T, Teramoto K, Ozaki Y, Hanaoka J, Tezuka N, Itoh Y, Asai T, Fujino S, Kontani K, Ogasawara K
Cancer Res.   69 5142-5150   2009
Itoh Y, Shinya K, Kiso M, Watanabe T, Sakoda Y, Hatta M, Muramoto Y, Tamura D, Sakai-Tagawa Y, Noda T, Sakabe S, Imai M, Hatta Y, Watanabe S, Li C, Yamada S, Fujii K, Murakami S, Imai H, Kakugawa S, Ito M, Takano R, Iwatsuki-Horimoto K, Shimojima M, Horimoto T, Goto H, Takahashi K, Makino A, Ishigaki H, Nakayama M, Okamatsu M, Takahashi K, Warshauer D, Shult PA, Saito R, Suzuki H, Furuta Y, Yamashita M, Mitamura K, Nakano K, Nakamura M, Brockman-Schneider R, Mitamura H, Yamazaki M, Sugaya N, Suresh M, Ozawa
Nature   460 1021-1025   2009
Yoshiko Yamamoto, Yoshiko Yamamoto, Hirohito Ishigaki, Hideaki Ishida, Yasushi Itoh, Yoichi Noda, Kazumasa Ogasawara
Microbiology and Immunology   52(1) 47-53   Jan 2008
It is known that the number of ImC, expressing myeloid markers, CD11 band Gr-1, increase with tumor growth and ImC play a role in the escape of tumor cells from immunosurveillance in tumor-bearing mice and cancer patients. However, the mechanisms ...
Itoh Y, Ozaki H, Tsuchiya H, Okamoto K, Torii R, Sakoda Y, Kawaoka Y, Ogasawara K, Kida H
Vaccine   26 562-572   2008
Keiichi Kontani, Koji Teramoto, Yoshitomo Ozaki, Satoru Sawai, Noriaki Tezuka, Hideaki Ishida, Kiichi Kajino, Shozo Fujino, Akira Yamauchi, Osamu Taguchi, Reiji Kannagi, Hiroyasu Yokomise, Kazumasa Ogasawara
Oncology Reports   17 895-902   Apr 2007
In order to achieve sufficient therapeutic potency, it has been proposed that vaccine therapy with dendritic cells needs to be combined with manipulation of immunological checkpoints, such as inhibition of regulatory T cells and blockade of negati...
Cytotoxic T Lymphocytes in Patients with Metastatic Cancer Using Penicillin-killed Streptococcus Pyogenes (OK432) and Anti-CD40 Antibody.
Kontani K, Teramoto K, Ozaki Y, Sawai S, Tezuka N, Ishida H, Kajino K, Fujino S, Yamauchi A, Taguchi O, Kannagi R, Yokomise H, Ogasawara K
Oncol Rep   17 895-902   2007
Teramoto K, Kontani K, Fujita T, Ozaki Y, Sawai S, Tezuka N, Fujino S, Itoh Y, Taguchi O, Kannagi R, Ogasawara K
Cancer Immunol Immunother   56 331-342   2007
Nagata T, Toyota T, Ishigaki H, Ichihashi T, Kajino K, Kashima Y, Itoh Y, Mori M, Nishida M, Yamamura H, Taneichi M, Uchida T, Ogasawara K
Vaccine   25 4914-4921   2007
Watanabe A, Shiina T, Shimizu S, Hosomichi K, Yanagiya K, Kita YF, Kimura T, Soeda E, Torii R, Ogasawara K, Kulski JK, Inoko H
Genomics   89 402-412   2007
Kajino K, Nakamura I, Bamba H, Sawai T, Ogasawara K
Immunology   120(1) 28-37   2007
Makino S, Kaji R, Ando S, Tomizawa M, Yasuno K, Goto S, Matsumoto S, Tabuena MD, Maranon E, Dantes M, Lee LV, Ogasawara K, Tooyama I, Akatsu H, Nishimura M, Tamiya G
Am J Hum Genet   80(3) 393-406   2007
Kiichi Kajino, Ichiro Nakamura, Ichiro Nakamura, Hiromichi Bamba, Hiromichi Bamba, Toshihiro Sawai, Toshihiro Sawai, Kazumasa Ogasawara, Kazumasa Ogasawara
Immunology   120 28-37   Dec 2006
It has recently been shown that immature dendritic cells (DCs) stimulated by a danger signal undergo transient maturation followed by exhaustion. However, the exact mechanism for this has not been elucidated. In this study, we show that interleuki...
Hirohito Ishigaki, Hirohito Ishigaki, Yoshiko Yamamoto, Yoshiko Yamamoto, Hideaki Ishida, Kiichi Kajino, Yasushi Itoh, Yoshihide Fujiyama, Kazumasa Ogasawara, Kazumasa Ogasawara
Microbiology and Immunology   50 655-662   Aug 2006
Tumor-infiltrating stroma cells (TISC) as well as tumors themselves are thought to be involved in tumor-related immunosuppression, which is one of the critical mechanisms of tumor escape from immune surveillance. However, preparation of TISC is di...
Maiko Taneichi, Hideaki Ishida, Kiichi Kajino, Kazumasa Ogasawara, Yuriko Tanaka, Michiyuki Kasai, Masahito Mori, Mitsuhiro Nishida, Hiroyuki Yamamura, Junichiro Mizuguchi, Tetsuya Uchida, Tetsuya Uchida
Journal of Immunology   177 2324-2330   Aug 2006
We have previously demonstrated that liposomes with differential lipid components display differential adjuvant effects when Ags are chemically coupled to their surfaces. In the present study, Ag presentation of liposome-coupled OVA was investigat...
Keiichi Kontani, Kiichi Kajino, Cheng Long Huangi, Shozo Fujino, Osamu Taguchi, Akira Yamauchi, Hiroyasu Yokomise, Kazumasa Ogasawara
Cancer immunology, immunotherapy : CII   55 579-587   May 2006
Since immunity is generally suppressed by immunoregulatory factors, such as transforming growth factor-beta (TGF-beta), interleukin (IL)-10, and vascular endothelial growth factor (VEGF), produced by tumor cells or stromal cells surrounding tumor ...
K. Sano, T. Shiina, S. Kohara, K. Yanagiya, K. Hosomichi, S. Shimizu, T. Anzai, A. Watanabe, K. Ogasawara, R. Torii, J. K. Kulski, J. K. Kulski, H. Inoko
Tissue Antigens   67 297-306   Apr 2006
Cynomolgus macaques (Macaca fascicularis, Mafa), alias the crab-eating monkeys or long-tailed macaques, live across a vast range of South-East Asia. These non-human primates have emerged as important animal models in infectious and chronic disease...
Preparation and Functional Analysis of Tumor-Infiltrating Stoma Cells Using Bone Marrow Chimera Mice.
Ishigaki H, Yamamoto Y, Ishida H, Kajino K, Itoh Y, Fujiyama Y, Ogasawara K
Microbiol Immunol   50 655-662   2006
Taneichi M, Ishida H, Kajino K, Ogasawara K, Tanaka Y, Kasai M, Mori M, Nishida M, Yamamura H, Mizuguchi J, Uchida T
J Immunol   177 2324-2330   2006
Sano K, Shiina T, Kohara S, Yanagiya K, Hosomichi K, Shimizu S, Watanabe A, Ogasawara K, Torii R, Inoko H
Tissue Antigen      2006
Takikita-Suzuki M, Takeuchi E, Nakashima Y, Yamamoto T, Mukai K, Ogasawara K
Human Pathol      2006
Yasushi Itoh, Yasushi Itoh, Ze Wang, Hideaki Ishida, Katrin Eichelberg, Noriki Fujimoto, Noriki Fujimoto, Jin Makino, Jin Makino, Kazumasa Ogasawara, Ronald N. Germain
European Journal of Immunology   35 3187-3195   Nov 2005
Polarized Th1 and Th2 cells expressing the same TCR produce distinct biochemical responses to ligand engagement. Compared to Th1 cells, Th2 cells show altered substrate tyrosine phosphorylation and a diminished or transient Ca2+ response. Here we ...
Keiichi Kontani, Keiichi Kontani, Kazumasa Ogasawara
Biotherapy   19 339-346   Jul 2005
Impairment in maturation processes of dendritic cells (DCs) is one of the critical escape mechanisms of cancer cells from attack by the host immune system in cancer patients. To restore the unresponsiveness of anti-tumor immunity, use of sufficien...
Hiromichi Bamba, Hiromichi Bamba, Hirohito Ishigaki, Hideaki Ishida, Kiichi Kajino, Kiichi Kajino, Yoshihide Fujiyama, Kazumasa Ogasawara
Microbiology and Immunology   49 89-95   Mar 2005
Peritoneal exudate cells (PEC) have long been used as antigen presenting cells (APC), because they have been considered to contain mainly macrophages. However, it is still unclear specifically which cells of the peritoneal exudate function as APC....
Itoh Y., Wang Z., Ishida H., Eichelberg K., Fujimoto N., Makino J., Ogasawara K., Germain RN.
European Journal of Immunology   35 3187-3195   2005
B1-B cells are the main antigen presenting cells in CpG-ODN-stimulated peritoneal exudates cells.
Bamba H, Ishigaki H, Ishida H, Kajino K, Fujiyama Y, Ogasawara K
Microbiol Immunol   49 89-95   2005
Phenotypic stability of mature dendritic cells tuned by TLR or CD40 to control the efficiency of cytotoxic T cell priming.
Nakamura I, Kajino K, Bamba H, Itoh H, Takikita M, Ogasawara K
Microbiol Immunol   48 211-219   2004
Noriki Fujimoto, Noriki Fujimoto, Hideaki Ishida, Ichiro Nakamura, Ichiro Nakamura, Kazumasa Ogasawara, Kazumasa Ogasawara, Yasushi Itoh
Microbiology and Immunology   47 1017-1024   Dec 2003
Strength of T cell antigen receptor (TCR) signaling drives the development of Th1 and Th2 subsets from naive T helper precursors. The quantity of interleukin-12 (IL-12) from antigen presenting cells (APC) is also profoundly involved in Th developm...
Koji Teramoto, Keiichi Kontani, Keiichi Kontani, Yoshitomo Ozaki, Satoru Sawai, Noriaki Tezuka, Toshi Nagata, Shozo Fujino, Yasushi Itoh, Osamu Taguchi, Yukio Koide, Tohru Asai, Iwao Ohkubo, Kazumasa Ogasawara
Cancer Research   63 7920-7925   Nov 2003
Vaccine immunotherapy must induce helper and cytotoxic cell-mediated immunity to generate the powerful antitumor immune responses needed to suppress cancer progression. We reported previously that a 16-amino acid peptide analogue derived from pige...
Kazunori Onoè, Toshihiko Gotohda, Hiroki Nishihori, Toshimasa Aranami, Chikako Iwabuchi, Cristina Iclozan, Taiki Morohashi, Kazumasa Ogasawara, Robert A. Good, Kazuya Iwabuchi
Transplant Immunology   12 79-88   Oct 2003
T cells acquire immune functions during expansion and differentiation in the thymus. Mature T cells respond to peptide antigens (Ag) derived from foreign proteins when these peptide Ag are presented on the self major histocompatibility complex (MH...
Mikiko Takikita-Suzuki, Mikiko Takikita-Suzuki, Mikiko Takikita-Suzuki, Masakazu Haneda, Masakiyo Sasahara, M. Koji Owada, Takahiko Nakagawa, Motohide Isono, Shoichi Takikita, Daisuke Koya, Kazumasa Ogasawara, Ryuichi Kikkawa
American Journal of Pathology   163 277-286   Jul 2003
We previously reported that the platelet-derived growth factor B-chain (PDGF-B)/PDGF receptor (PDGFR) axis is involved in tubular regeneration after ischemia/reperfusion injury of the kidney. In the present study, we examined the activation of Src...
DNA encoding a pan-MHC class II peptide analogue augmented antigen-specific cellular immunity and suppressive effects on tumor growth elicited by DNA vaccine immunology.
Teramoto K, Kontani K, Okazaki Y, Sawai S, Tezuka M, Nagata T, Koide Y, Fujino S, Itoh Y, Ogasawara K
Cancer Res   63 7920-7925   2003
Quantities of interleukin-12p40 in mature CD8a negative dendritic cells correlate with strength of TCR signal and determine Th cell development.
Fujimoto N, Ishida H, Nakamura I, Ogasawara K, Itoh Y
Microbiol Immunol   47 1017-1024   2003
Activation of Src kinase in PDGF-B-dependent tubular regeneration after acute ischemic renal injury.
Takikita-Suzuki M, Haneda M, Sasahara M, Owada MM, Nakagawa T, Isono M, Takikita S, Koya D, Ogasawara K, Kikkawa R
American Journal of Pathology   163 277-286   2003
Ai Ninomiya, Kazumasa Ogasawara, Kiichi Kajino, Ayato Takada, Hiroshi Kida
Vaccine   20 3123-3129   Aug 2002
Mucosal immunity is critical for protection from viral infections. We attempted to activate mucosal cytotoxic T lymphocytes (CTLs) specific for influenza A virus nucleoprotein (NP) which play an important role in protective immunity. It has been s...
Kontani K, Taguchi O, Ozaki Y, Hanaoka J, Tezuka N, Sawai S, Inoue S, Fujino S, Maeda T, Itoh Y, Ogasawara K, Sato H, Ohkubo I, Kudo T
Cancer Gene Therapy   9 330-337   2002
Ninomiya A, Ogasawara K, Kajino K, Takada A, Kida H
Vaccine   20 3123-3129   2002
The role of antigen presenting cells and partial agonists in Th1 and Th2 differentiation
Itoh Y, Fujimoto N, Ishida H, Ogasawara K
Kyoto T Cell Conference The 3rd International Workshop      2002
Kazuya Iwabuchi, Chikako Iwabuchi, Saori Tone, Daisuke Itoh, Noriko Tosa, Izumi Negishi, Kazumasa Ogasawara, Toshimitsu Uede, Kazunori Onoé, Kazunori Onoé
Blood   97 1765-1775   Mar 2001
Development of natural killer 1.1+ (NK1.1+) CD3+ (NK1.1+ T) cells was analyzed in zeta-associated protein 70 (ZAP-70) null (-/-) mice. Both NK1.1+ TCRαβ+ and NK1.1+ TCRγδ+ cell populations were absent in the thymus and spleen. By contrast, the num...
Defective development of NK1.1 + T cell antigen receptor (TCR) ab+ cells in zeta-associated protein (ZAP) null mice with an accu
Iwabuchi K, Iwabuchi C, Tone S, Itoh D, Tosa N, Negishi I, Ogasawara K, Uede T, Onoe K
Blood   97 1765-1775   2001
T. Morohashi, K. Ogasawara, N. Kitaichi, K. Iwabuchi, K. Onoe
Bone Marrow Transplantation   26 1069-1076   Dec 2000
Lethally irradiated AKR mice received BMT from H-2D and minor lymphocyte stimulatory (Mls)-1 disparate B10.A mice. No GVHD signs were detected in AKR recipients of T cell-depleted BM cells (1 x 107) alone ([B10.A → AKR] T-). When B10.A splenic T c...
K. Namba, K. Ogasawara, N. Kitaichi, T. Morohashi, Y. Sasamoto, S. Kotake, H. Matsuda, K. Iwabuchi, C. Iwabuchi, S. Ohno, K. Onoe
Journal of Immunology   165 2962-2969   Sep 2000
We have defined a peptide K2 (ADKDVVVLTSSRTGGV) that corresponds to residues 201-216 of bovine interphotoreceptor retinoid-binding protein and induces experimental autoimmune uveoretinitis (EAU)4 in H-2A(k)-carrying mice (H-2A(k) mice). In this st...
Daisuke Ito, Daisuke Ito, Kazumasa Ogasawara, Kazuhiro Matsushita, Taiki Morohashi, Kenichi Namba, Naoto Matsuki, Nobuyoshi Kitaichi, Yukio Inuyama, Masuo Hosokawa, Eiichi Nakayama, Kazuya Iwabuchi, Kazunori Onoé, Kazunori Onoé
Immunobiology   201 527-540   Jan 2000
Recently it has been shown that modulation of CD40 molecules on antigen (Ag) carrying dendritic cells (DC) can bypass T cell help, resulting in priming cytotoxic T lymphocytes (CTL) specific for the Ag. In the present study we attempted to prime p...
Significant MLR but not CTL responses against recipient antigens generated in T cells from bone marrow chimeras recovered from GVHD.
Morohashi T, Ogasawara K, Kitaichi N, Iwabuchi K, Ono? K
Bone Marrow Transplant   26 1069-1076   2000
Delayed clearance of zymosan-induced granuloma and depressed phagocytosis of macrophages with concomitant up-regulated kinase activities of src-family in a human monocyte chemoattractant protein-1 transgenic mouse.
Ato M, Iwabuchi K, Matsuki N, Mukaida N, Iwabuchi C, Takahashi A, Takayanagi T, Dondog E, Hatakeyama S, Ishikura H, Kato M, Negishi I, Nishihori H, Ogasawara K, Matsushima K, Onoe K
Immunobiol   201 432-449   2000

Misc

 
MORIZANE ASUKA, DOI DAISUKE, KIKUCHI TETSUHIRO, OKITA KEISUKE, TAKARA SAYUKI, MIZUMA HIROSHI, ONOE HIROTAKA, HAYASHI TAKUYA, SHIINA TAKASHI, ISHIGAKI KOJI, OGASAWARA KAZUMASA, YAMANAKA SHIN'YA, TAKAHASHI JUN
再生医療   14 196   Feb 2015
NAKAYAMA MISAKO, OYANAGI HIROKI, TAKEMURA SHIZUKI, UMANO SHINJI, HAYASHI YUJI, YOSHIDA AKIKO, ISHIGAKI HIROHITO, ITO YASUSHI, OGASAWARA KAZUMASA, SUGIHARA HIROYUKI
診断病理   31(2) 152-159   Apr 2014
MORIZANE ASUKA, DOI DAISUKE, KIKUCHI TETSUHIRO, OKITA KEISUKE, MIZUMA HIROSHI, ONOE HIROTAKA, HAYASHI TAKUYA, SHIINA TAKASHI, OGASAWARA KAZUMASA, YAMANAKA SHIN'YA, TAKAHASHI JUN
MHC (Web)   21(1) 75 (WEB ONLY)   Apr 2014
MORIZANE ASUKA, DOI DAISUKE, KIKUCHI TETSUHIRO, OKITA KEISUKE, MIZUMA HIROSHI, ONOE HIROTAKA, HAYASHI TAKUYA, SHIINA TAKASHI, OGASAWARA KAZUMASA, YAMANAKA SHIN'YA, TAKAHASHI JUN
再生医療   13 312   Jan 2014
SHIINA TAKASHI, YAMADA SACHIHO, TANAKA KEIKO, KAMETANI YOSHIE, IWATANI CHIZURU, TSUCHIYA HIDEAKI, ITO YASUSHI, YAMANAKA HISASHI, NAKAGAWA HIROSHI, OTA MASAHO, INOKO HIDETOSHI, OGASAWARA KAZUMASA
再生医療   12 280   Feb 2013
SHIINA TAKASHI, KITA YUKI, TANAKA KEIKO, KONO AZUMI, SUZUKI SHINGO, HOSOMICHI KAZUYOSHI, KATSUYAMA YOSHIHIKO, TSUCHIYA HIDEAKI, OTABE KOJI, SAKAMOTO KENGO, KURATA MASAAKI, NOMURA MINORU, YAMANAKA HISASHI, NAKAGAWA HIROSHI, ITO YASUSHI, OTA MASAHO, INOKO HIDETOSHI, TORII RYUZO, OGASAWARA KAZUMASA
MHC   17(2) 156   Aug 2010
KITA YUKI, TANAKA KEIKO, HOSOMICHI ISSEI, OGASAWARA KAZUSEI, TORII RYUZO, INOKO HIDETOSHI, SHIINA TAKASHI
MHC   16(2) 161   Aug 2009
KITA YUKI, SHIINA TAKASHI, KOHARA SAKAE, OGASAWARA KAZUMASA, TORII RYUZO, ANTOINE BLANCHER, INOKO HIDETOSHI
生化学   1P-0715   2008
ISHIGAKI HIROHITO, ITO YASUSHI, OGASAWARA KAZUMASA, OKABE HIDETOSHI, NAKASU SATOSHI, YAMAMOTO MAYUMI, TAGA TAKASHI, OTA SHIGERU
Neuro-Oncologyの進歩   16(1) 71-72   Jun 2007
KURATA RIHO, SHIINA TAKASHI, HOSOMICHI KAZUYOSHI, KINTO SATOMI, TORII RYUZO, OGASAWARA KAZUMASA, INOKO HIDETOSHI
生化学   1P-0598   2007
KONTANI KEIICHI, TERAMOTO KOJI, OZAKI YOSHITOMO, TEZUKA NORIAKI, SAWAI SATOSHI, KAJINO KIICHI, TARUMI SHINTARO, YAMAMOTO YASUMICHI, FUJINO SHOZO, YAMAUCHI KIYOAKI, YOKOMISE HIROYASU, OGASAWARA KAZUMASA
Biotherapy (Tokyo)   19(Supplement 1) 70   Oct 2005
KONTANI KEIICHI, OGASAWARA KAZUMASA
Biotherapy (Tokyo)   19(4) 339-346   Jul 2005
URABE HIROSHI, KAWAI HIROMICHI, OI JIRO, MAEDA KENGO, YASUDA SAI, TAKIKITA MIKIKO, OGASAWARA KAZUNARI
臨床神経学   45(2) 189   Feb 2005
OGASAWARA KAZUMASA
化学療法の領域   20(11) 1689-1694   Nov 2004
TAKIKITA MIKIKO, TAKEUCHI EIJI, KUNISHIMA FUMIHITO, MUKAI KOICHI, OGASAWARA KAZUMASA
診断病理   21(1) 66-68   Jan 2004
UCHIDA TETSUYA, MORI MASATO, OKUMA KUNIO, KIBA MAMORU, OGASAWARA ISSEI, ISHIKAWA AKIRA, AKATSUKA TOSHITAKA
創薬等ヒューマンサイエンス研究重点研究報告書 平成15年度 第5分野 健康寿命延伸・予防診断・治療法の開発に関する研究   55-60   2004
UCHIDA TETSUYA, MORI MASATO, OKUMA KUNIO, KIBA MAMORU, OGASAWARA KAZUMASA, ISHIKAWA AKIRA, AKATSUKA TOSHITAKA, TSUNEUCHI SHIDO
創薬等ヒューマンサイエンス研究総合研究報告書 平成13-15年度 第5分野 健康寿命延伸・予防診断・治療法の開発に関する研究   66-70   2004
BABA HIROMICHI, KAJINO KIICHI, NAKAMURA ICHIRO, OGASAWARA KAZUMASA
日本免疫学会総会・学術集会記録   33 135   Nov 2003
UCHIDA TETSUYA, MORI MASATO, OKUMA KUNIO, KOBA MAMORU, OGASAWARA KAZUSEI, KAKIUCHI SHIDO
創薬等ヒューマンサイエンス研究重点研究報告書 平成14年度 第5分野 健康寿命延伸・予防診断・治療法の開発に関する研究   67-73   2003
OGASAWARA ISSEI, ITO YASUSHI, KAJINO KIICHI
成人病と生活習慣病   32(10) 1375-1376   Oct 2002
HOSOYA YASUHISA, TOKUBAYASHI MASAKI, SHIO SHIGEO, KAWASAKI CHIHIRO, WAKAGI SHIGETARO, YASUDA KAZUHIRO, TAKAMORI YASUE, TAKIKITA MIKIKO, OGASAWARA KAZUMASA
Gastroenterol Endosc   44(Supplement 1) 562   Mar 2002
OGASAWARA KAZUMASA
臨床病理   49(12) 1225-1232   Dec 2001
K. Ogasawara
Rinsho byori. The Japanese journal of clinical pathology   49 1225-1232   Jan 2001
Two signals are required for activation of T lymphocytes. Formation of tri-molecular complex among T cell antigen receptor(TCR), major histocompatibility complex(MHC) molecule, and antigen peptide produces signal 1 via TCR. Thus, signal 1 is antig...
OGASAWARA KAZUMASA
臨床免疫   36(4) 650-656   Oct 2001
TSUJI ATSUSHI, AMANO SHIGERU, HAYASE YONEKO, FUKUOKA JUN'YA, IHARA NOBUO, TORII RYUZO, MATSUDA MASAYUKI, OGASAWARA KAZUMASA
てんかん研究   19(1) 54   Feb 2001
FUKUOKA JUN'YA, KOJIMA CHIKAKO, TAKIKITA MIKIKO, KAJINO KIICHI, ITO YASUSHI, OGASAWARA KAZUMASA
リンパ学   23(2) 109   Nov 2000

Conference Activities & Talks

 
TERAMOTO KAZUO, ENDO YOSHIHIRO, UEDA YUJI, OGASAWARA KAZUMASA
日本透析医学会雑誌   28 May 2015   
ITO YASUSHI, SHICHINOHE SHINTARO, NAKAYAMA MISAKO, ISHIGAKI HIROHITO, OGASAWARA KAZUMASA
日本病理学会会誌   23 Mar 2015   
NAKABAYASHI RUMI, NAKAYAMA MISAKO, ITO YASUSHI, ISHIGAKI HIROHITO, OGASAWARA KAZUMASA
日本病理学会会誌   23 Mar 2015   
NAKAYAMA MISAKO, ITO YASUSHI, ISHIGAKI HIROHITO, OGASAWARA KAZUMASA
日本病理学会会誌   23 Mar 2015   
ISHIGAKI HIROHITO, NAKAYAMA MISAKO, ITO YASUSHI, OGASAWARA KAZUMASA
日本病理学会会誌   23 Mar 2015   

Research Grants & Projects

 
Immunoman, pulation
Production of peptide vaccines
Analysis of antigen recognition mechanism by T cells