ARIKAWA Jiro

J-GLOBAL         Last updated: Nov 7, 2017 at 11:27
 
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Name
ARIKAWA Jiro
Affiliation
Hokkaido University
Section
Graduate School of Medicine, Division of Medicine
Job title
Professor

Research Interests

 
 

Research Areas

 
 

Academic & Professional Experience

 
2008
   
 
- Professor,Department of Microbiology,Graduate school of medicine
 

Awards & Honors

 
2010
Joel Dalrymple Award
 

Published Papers

 
Nishio S, Tsuda Y, Ito R, Shimizu K, Yoshimatsu K, Arikawa J
Japanese journal of infectious diseases   70(4) 388-393   Jul 2017   [Refereed]
Shimizu K, Isozumi R, Takami K, Kimata I, Shiokawa K, Yoshimatsu K, Tsuda Y, Nishio S, Arikawa J
The Journal of veterinary medical science   79(7) 1261-1263   Jul 2017   [Refereed]
Gamage CD, Yoshimatsu K, Sarathkumara YD, Kulendiran T, Nanayakkara N, Arikawa J
International journal of infectious diseases : IJID : official publication of the International Society for Infectious Diseases   57 77-78   Apr 2017   [Refereed]
Antibody detection from Middendorf's vole (Microtus middendorffii) against Tula virus captured in Mongolia
Yoshimatsu K, Arai S, Shimizu K, Tsuda Y, Boldgiv B, Boldbaatar B, Sergelen E, Ariunzaya D, Enkhmandal O, Tuvshintugs S, Morikawa S, Arikawa J
Japanese Journal of Veterinary Research   65(1) 39-44   Feb 2017   [Refereed]
Obana S, Shimizu K, Yoshimatsu K, Hasebe F, Hotta K, Isozumi R, Nguyen HT, LE MQ, Yamashiro T, Tsuda Y, Arikawa J
The Journal of veterinary medical science   79(1) 76-81   Jan 2017   [Refereed]
Shimizu K, Koma T, Yoshimatsu K, Tsuda Y, Isegawa Y, Arikawa J
Virology journal   14(1) 13   Jan 2017   [Refereed]
Tsuda Y, Igarashi M, Ito R, Nishio S, Shimizu K, Yoshimatsu K, Arikawa J
Biomedical research (Tokyo, Japan)   38(2) 89-97   2017   [Refereed]
Shimizu K, Hamaguchi S, Ngo CC, Li TC, Ando S, Yoshimatsu K, Yasuda SP, Koma T, Isozumi R, Tsuda Y, Fujita H, Pham TT, LE MQ, Dang AD, Nguyen TQ, Yoshida LM, Ariyoshi K, Arikawa J
The Journal of veterinary medical science   78(11) 1677-1681   Dec 2016   [Refereed]
Koarashi Y, Cáceres AG, Saca FM, Flores EE, Trujillo AC, Alvares JL, Yoshimatsu K, Arikawa J, Katakura K, Hashiguchi Y, Kato H
Acta tropica   158 83-87   Jun 2016   [Refereed]
Shiokawa K, Gamage CD, Koizumi N, Sakoda Y, Shimizu K, Tsuda Y, Yoshimatsu K, Arikawa J
The Journal of veterinary medical science   78(2) 221-230   Feb 2016   [Refereed]
Hotta K, Pham HT, Hoang HT, Trang TC, Vu TN, Ung TT, Shimizu K, Arikawa J, Yamada A, Nguyen HT, Nguyen HL, Le MT, Hayasaka D
Vector borne and zoonotic diseases (Larchmont, N.Y.)   16(2) 96-102   Feb 2016   [Refereed]
新興・再興感染症と人獣共通感染症 -発生状況とその背景-
ARIKAWA Jiro
化学療法の領域   31(6) 1248-1253   May 2015
Hamaguchi S, Cuong NC, Tra DT, Doan YH, Shimizu K, Tuan NQ, Yoshida LM, Mai le Q, Duc-Anh D, Ando S, Arikawa J, Parry CM, Ariyoshi K, Thuy PT
The American journal of tropical medicine and hygiene   92(5) 972-978   May 2015   [Refereed]
YOSHIMATSU KUMIKO, ARIKAWA JIRO
医学のあゆみ   253(1) 63-67   Apr 2015
First evidence of Seoul hantavirus in the wild rat population in the Netherlands.
Verner-Carlsson J, Lõhmus M, Sundström K, Strand TM, Verkerk M, Reusken C, Yoshimatsu K, Arikawa J, van de Goot F, Lundkvist Å
Infection ecology & epidemiology   5 27215   Feb 2015   [Refereed]
YOSHIMURA AYA, MUSASHI MANABU, KANEKO TAKEAKI, ONISHI SHUNSUKE, ORITO CHIEKO, KAWAHARA YUKAKO, HASHINO SATOSHI, MORIMATSU MASAMI, KONNO SATOSHI, ARIKAWA JIRO, ISHII TETSUYA, SAWAMURA MASAYA, UEDA ICHIRO
アレルギー   63(8) 1132-1139   Sep 2014
Yasuda SP, Gamage CD, Koizumi N, Nishio S, Isozumi R, Shimizu K, Koma T, Amada T, Suzuki H, Yoshimatsu K, Arikawa J
Genes & genetic systems   89(2) 71-80   Sep 2014   [Refereed]
Yoshimatsu K, Arikawa J
Viruses   6 3097-3109   Aug 2014   [Refereed]
Yoshimatsu K, Arikawa J
Virus research   187 77-83   Jul 2014   [Refereed]
Koma T, Yoshimatsu K, Nagata N, Sato Y, Shimizu K, Yasuda SP, Amada T, Nishio S, Hasegawa H, Arikawa J
Journal of virology   88 7178-7188   Jul 2014   [Refereed]
Amada T, Yoshimatsu K, Koma T, Shimizu K, Gamage CD, Shiokawa K, Nishio S, Ahlm C, Arikawa J
Virology journal   11 87   May 2014   [Refereed]
Shimizu K, Yoshimatsu K, Koma T, Yasuda SP, Arikawa J
Virus research   178 349-356   Dec 2013   [Refereed]
Amada T, Yoshimatsu K, Yasuda SP, Shimizu K, Koma T, Hayashimoto N, Gamage CD, Nishio S, Takakura A, Arikawa J
Journal of virological methods   193(1) 42-49   Oct 2013   [Refereed]
Ibrahim IN, Shimizu K, Yoshimatsu K, Yunianto A, Salwati E, P Yasuda S, Koma T, Endo R, Arikawa J
The Journal of veterinary medical science / the Japanese Society of Veterinary Science   75(8) 1003-1008   Sep 2013   [Refereed]
Koma T, Yoshimatsu K, Yasuda SP, Li T, Amada T, Shimizu K, Isozumi R, Mai LT, Hoa NT, Nguyen V, Yamashiro T, Hasebe F, Arikawa J
Epidemiol Infect   141(9) 1876-1884   Sep 2013   [Refereed]
To examine the prevalence of human pathogens carried by rats in urban areas in Hanoi and Hai Phong, Vietnam, we live-trapped 100 rats in January 2011 and screened them for a panel of bacteria and viruses. Antibodies against Leptospira interrogans ...
Nakamura I, Hang'ombe BM, Sawa H, Kobayashi S, Orba Y, Ishii A, Thomas Y, Isozumi R, Yoshimatsu K, Mweene AS, Takada A, Sugimoto C, Arikawa J
The Journal of veterinary medical science / the Japanese Society of Veterinary Science   75(6) 819-825   Jul 2013   [Refereed]
苅和宏明, 尾崎由佳, 真田崇弘, 池中良徳, 石塚真由美, 坪田敏男, 好井健太朗, 吉松組子, 有川二郎, 高島郁夫
獣医畜産新報   166(4) 262-264   Apr 2013
Li TC, Yoshizaki S, Ami Y, Suzaki Y, Yasuda SP, Yoshimatsu K, Arikawa J, Takeda N, Wakita T
Veterinary microbiology   163(1-2) 54-61   Apr 2013   [Refereed]
吉村彩, 武藏学, 金子壮朗, 大西俊介, 折戸智恵子, 川原由佳子, 森松正美, 今野哲, 有川二郎
Campus Health   50(1) 316   Mar 2013
実験動物感染症の現状 - ハンタウイルス感染症.
ARIKAWA Jiro
実験動物ニュース   62(1) 13-16   Jan 2013
Li TC, Ami Y, Suzaki Y, Yasuda SP, Yoshimatsu K, Arikawa J, Takeda N, Takaji W
Emerging infectious diseases   19 115-118   Jan 2013   [Refereed]
吉松組子, 有川二郎
ウイルス   62(2) 239-250   Dec 2012
Schlegel M, Tegshduuren E, Yoshimatsu K, Petraityte R, Sasnauskas K, Hammerschmidt B, Friedrich R, Mertens M, Groschup MH, Arai S, Endo R, Shimizu K, Koma T, Yasuda S, Ishihara C, Ulrich RG, Arikawa J, Köllner B
Archives of virology   157(11) 2179-2187   Nov 2012   [Refereed]
Sanada T, Seto T, Ozaki Y, Saasa N, Yoshimatsu K, Arikawa J, Yoshii K, Kariwa H
The Journal of general virology   93(10) 2237-2246   Oct 2012   [Refereed]
Koma T, Yoshimatsu K, Taruishi M, Miyashita D, Endo R, Shimizu K, Yasuda SP, Amada T, Seto T, Murata R, Yoshida H, Kariwa H, Takashima I, Arikawa J
Journal of virological methods   185(1) 74-81   Oct 2012   [Refereed]
Saasa N, Sánchez-Hernández C, de Lourdes Romero-Almaraz M, Guerrero-Ibarra E, Almazán-Catalán A, Yoshida H, Miyashita D, Ishizuka M, Sanada T, Seto T, Yoshii K, Ramos C, Yoshimatsu K, Arikawa J, Takashima I, Kariwa H
Virus research   168(1-2) 88-96   Sep 2012   [Refereed]
Luan VD, Yoshimatsu K, Endo R, Taruishi M, Huong VT, Dat DT, Tien PC, Shimizu K, Koma T, Yasuda SP, Nhi L, Huong VT, Arikawa J
The Journal of veterinary medical science / the Japanese Society of Veterinary Science   74(9) 1155-1162   Sep 2012   [Refereed]
Sanada T, Kariwa H, Saasa N, Yoshikawa K, Seto T, Morozov VG, Tkachenko EA, Ivanov LI, Yoshimatsu K, Arikawa J, Yoshii K, Takashima I
The Journal of veterinary medical science / the Japanese Society of Veterinary Science   74(9) 1237-1242   Sep 2012   [Refereed]
Isozumi R, Yoshimatsu K, Yamashiro T, Hasebe F, Nguyen BM, Ngo TC, Yasuda SP, Koma T, Shimizu K, Arikawa J
Emerging infectious diseases   18 1383-1385   Aug 2012   [Refereed]
Saasa N, Yoshida H, Shimizu K, Sánchez-Hernández C, Romero-Almaraz Mde L, Koma T, Sanada T, Seto T, Yoshii K, Ramos C, Yoshimatsu K, Arikawa J, Takashima I, Kariwa H
Virology   428 48-57   Jun 2012   [Refereed]
土佐紀子, 吉松組子, 有川二郎
実験動物と環境   (39) 1-7   Apr 2012
有川二郎
日本臨床 別冊 新領域別症候群シリーズ   (18) 701-705   Mar 2012
Kariwa H, Yoshikawa K, Tanikawa Y, Seto T, Sanada T, Saasa N, Ivanov LI, Slonova R, Zakharycheva TA, Nakamura I, Yoshimatsu K, Arikawa J, Yoshii K, Takashima I
The American journal of tropical medicine and hygiene   86(3) 545-553   Mar 2012   [Refereed]
Kariwa H, Yoshida H, Sánchez-Hernández C, Romero-Almaraz Mde L, Almazán-Catalán JA, Ramos C, Miyashita D, Seto T, Takano A, Totani M, Murata R, Saasa N, Ishizuka M, Sanada T, Yoshii K, Yoshimatsu K, Arikawa J, Takashima I
Virus research   163 486-494   Feb 2012   [Refereed]
Yasuda SP, Yoshimatsu K, Koma T, Shimizu K, Endo R, Isozumi R, Arikawa J
The Journal of veterinary medical science / the Japanese Society of Veterinary Science   74(2) 215-219   Feb 2012   [Refereed]
有川二郎
最新医学   66(12) 2661-2667   Dec 2011
Li TC, Yoshimatsu K, Yasuda SP, Arikawa J, Koma T, Kataoka M, Ami Y, Suzaki Y, Mai le TQ, Hoa NT, Yamashiro T, Hasebe F, Takeda N, Wakita T
The Journal of general virology   92(12) 2830-2837   Dec 2011   [Refereed]
Sanada T, Kariwa H, Nagata N, Tanikawa Y, Seto T, Yoshimatsu K, Arikawa J, Yoshii K, Takashima I
Virus research   160(1-2) 108-119   Sep 2011   [Refereed]
Effect of environmental enrichment after the occurrence of wet bedding created by mice and abnormal fur in mice.
Tosa N, Yoshimatsu K, Arikawa J
J Am Assoc Lab Anim Sci   50(5) 779-780   Sep 2011   [Refereed]

Misc

 
吉松 組子, 有川 二郎
医学のあゆみ   253(1) 63-67   Apr 2015
Journal of Virology   84(1) 459-474   2010
Hemorrhagic Fever with Renal Syndrome in Vietnam: Description of Disease and Implication of Virus and Potential Rodent Hosts
in press   2009
Hiroaki KARIWA, Evgeniy A. TKACHENKO, Vyacheslav G. MOROZOV, Takahiro SETO, Yoichi TANIKAWA, Sergey I. KOLOMINOV, Sergey N. BELOV, Ichiro NAKAMURA, Nobuo HASHIMOTO, Alexander E. BALAKIEV, Tamara K. DZAGURNOVA, Nur Hardy bin Abu DAUD, Daisuke MIYASHITA, Olga A. MEDVEDKINA, Mina NAKAUCHI, Mariko ISHIZUKA, Kentaro YOSHII, Kumiko YOSHIMATSU, Jiro ARIKAWA, Ikuo TAKASHIMA
Journal of Veterinary Medical Science   71(12) 1569-1578   2009
Thua Thang TRUONG, Kumiko YOSHIMATSU, Koichi ARAKI, Byoung-Hee LEE, Ichiro NAKAMURA, Rika ENDO, Kenta SHIMIZU, Shumpei P. YASUDA, Takaaki KOMA, Midori TARUISHI, Megumi OKUMURA, Uyen Ninh TRUONG, Jiro ARIKAWA
Journal of Veterinary Medical Science   71(10) 1357-1363   2009
Acute febrile illness caused by hantavirus:serological and molecular
103 407-412   2009
Seroepidemiological study in a Puumala virus outbreak area in
198 83-91   2009
Proceedings of the National Academy of Sciences of the United States of America   105(42) 16296-16301   2008
Hiroshi YAMAMOTO, Tian-Cheng LI, Chihiro KOSHIMOTO, Kaori ITO, Masakazu KITA, Nobumoto MIYASHITA, Jiro ARIKAWA, Kenichi YAGAMI, Masahide ASANO, Hideo TEZUKA, Noboru SUZUKI, Tsutomu KUROSAWA, Toshiyuki SHIBAHARA, Masato FURUYA, Shirou MOHRI, Hiroshi SATO, Kazutaka OHSAWA, Kentaro IBUKI, Naokazu TAKEDA
Experimental Animals   57(4) 367-376   2008
Lack of vertical transmission of Hantaan virus from persistently infected dam to progeny in
1605-1609   2008

Books etc

 
感染症事典
感染症編集委員会編 (Part:Contributor, サル痘、腎症候性出血熱、ダニ媒介性脳炎、チクングニヤ熱、ハンタウイルス肺症候群)
オーム社   Jan 2012   ISBN:978-4274211355
新臨床内科学 第9版
高久史麿、尾形悦郎、黒川清、矢崎義雄 監修 (Part:Contributor, ハンタウイルス肺症候群)
医学書院   Feb 2009   ISBN:978-4260003056
バイオセーフティの事典―病原微生物とハザード対策の実際
バイオメディカルサイエンス研究会 編 (Part:Contributor, ハンタウイルス)
医学評論社   Dec 2008   ISBN:978-4872119039
獣医感染症カラーアトラス 第2版
見上彪 監修 (Part:Contributor, ハンタウイルス感染症(腎症候性出血熱とハンタウイルス肺症候群))
文永堂出版   Jun 2006   ISBN:978-4830032035
動物の感染症 第2版
小沼操・菊池直哉・杉本千尋・明石博臣・澤田拓士・宝達勉 編 (Part:Contributor, 腎症候性出血熱、兎粘液腫、兎ウイルス性出血病、アルゼンチン出血熱、ボリビア出血熱、ベネズエラ出血熱、ハンタウイルス肺症候群、ラッサ熱、マウス白血病)
May 2006   ISBN:9784874021231
からだの科学増刊 新興再興感染症:SARSの教訓
岡部 信彦 編 (Part:Contributor, 第2部 新興感染症 5.ハンタウイルス感染症(HPS、HFRS))
Apr 2004   
動物の感染症 Infectious Diseases of Animals
Mar 2002   ISBN:4-87402-074-7
実験動物感染病の対応マニュアル
前島一淑監修, 有川二郎・浦野徹・柴原壽行・高鳥浩介編 (Part:Joint Editor, 鶏痘、腎症候性出血熱、センダイウイルス感染症、唾液腺涙腺炎、伝染性喉頭気管炎、伝染性ファブリキウス嚢病、乳酸脱水素酵素ウイルス感染病、ニューカッスル病、ニワトリ伝染性気管支炎、ニワトリ脳脊髄炎、脳心筋炎ウイルス病(マウス)、ポリオーマウイルス感染病、マウスアデノウイルス感染病、マウス肝炎、マウス丘疹病、マウス胸腺ウイルス感染病、マウスKウイルス感染病、マウスサイトメガロウイルス感染病、マウス痘瘡、マウス乳ガンウイルス感染病、マウス白血病、マウス微小ウイルス感染病、マウスロタウイルス腸炎、マレック病、モルモ)
Jun 2000   ISBN:978-4900659285
獣医伝染病学
清水悠紀臣 編 (Part:Contributor, 腎症候性出血熱、アルゼンチン出血熱、ボリビア出血熱、ベネズエラ出血熱)
近代出版   Oct 1995   ISBN:978-4874024980
図解・実験動物技術集
日本実験動物技術者協会関西支部図解実験動物技術集委員会 編 (Part:Contributor, マウス観察項目の記号化と観察項目表.)
アドスリー   Jul 1992   ISBN:4-931283-01-2

Conference Activities & Talks

 
Rattus tanezumi is an important reservoir of rat hepatitis E virus.
Obana S, Shimizu K, Yoshimatsu K, Hsede F, Hotta K, Isozumi R, Nguyen Thy Hoa, Le Guynh Mai, Yamasiro T, Arikawa J
第63回日本ウイルス学会学術集会   22 Nov 2015   
重症熱性血小板減少症候群ウイルスのウイルスタンパクの細胞内局在の解析
伊東諒、津田祥美、西尾佐奈恵、清水健太、吉松組子、有川二郎
第63回日本ウイルス学会学術集会   22 Nov 2015   
An amino acid substitution in the glycoprotein of severe fever with thrombocytopenia syndrome virus enhances membrane fusion activity
Tsuda Y, Nishio S, Ito R, Yoshida R, Takada A, Arikawa J, Yoshimatsu K
第63回日本ウイルス学会学術集会   22 Nov 2015   
Establishment of substrains from strain YG1 of SFTSV with high or low pH-dependent cell – fision activity
西尾佐奈恵、津田祥美、伊東諒、清水健太、有川二郎、吉松組子
第63回日本ウイルス学会学術集会   22 Nov 2015   
Studies on hantavirus infection and leptospirosis in Sri Lanka
吉松組子、塩川愛絵、Chandika D. Gamage, 清水健太、津田祥美、有川二郎
第63回日本ウイルス学会学術集会   22 Nov 2015   
Prevalence of leptospires in peridomestic rodents and shrews in Kandy District, Sri Lanka.
Shiokawa K, Rathnayake S, Karunadasa I, Gamage T, Gamage CD, Yoshimatsu K, Arikawa J
The 9th International Leptospirosis Society Scientific Meeting (ILS 2015)   7 Oct 2015   
腎症候性出血熱マウスモデルにおける腎出血の発現にCD8陽性T細胞が関与する
清水健太、吉松組子、有川二郎
第158回日本獣医学会学術集会   7 Sep 2015   
Antigenic properties of hantavirus nucleocapsid (N) protein and its application to antigen for immunochromatographic (ICG) test.
Yoshimatsu K, Shimizu K, Tsuda Y, Arikawa J
The 16th Negative Strand Virus Meeting (NSV2015)   14 Jun 2015   
Characterization of Hokkaido virus, Genus Hantavirus and generation of the reassortant virus with Puumala virus.
Kariwa H, TSanada T, Iwasaki R, Yoshimatsu K, Arikawa J, Yoshii K, Takashima I
48th Joint Working Conference on Viral Diseases Panels, US-Japan Cooperative Medical Science Program   28 Jan 2015   
Analysis of intracellular localization of virus proteins of severe fever with thrombocytopenia syndrome virus.
Ito R, Tsuda Y, Nishio S, Shimizu K, Yoshimatsu K, Arikawa J
US-Japan Cooperative Medical Science Program, 17th International Conference on Emerging Infectious Diseases (EID) in the Pacific Rim   25 Jan 2015   

Research Grants & Projects

 
Ministry of Education, Culture, Sports, Science and Technology: Grants-in-Aid for Scientific Research(若手研究(B))
Project Year: 2011 - 2013    Investigator(s): ISOZUMI RIE
Leptospirosis is wide spread disease especially in tropical developing countries, which cause symptom in human often severe to lethal. Early diagnosis and early treatment is quite important to avoid bad outcome, but it is difficult to diagnose at ...
Ministry of Education, Culture, Sports, Science and Technology: Grants-in-Aid for Scientific Research(基盤研究(C))
Project Year: 2011 - 2013    Investigator(s): Kumiko MORIMATSU
The investigation of hantavirus-associated infectious diseases in Southeast Asia and South Asia had been conducted. Throughout the investigation, many examples of fever of unknown origin (FUO) were found from febrile diseases. In this report, it ...
Ministry of Education, Culture, Sports, Science and Technology: Grants-in-Aid for Scientific Research(基盤研究(C))
Project Year: 2010 - 2012    Investigator(s): Nobuhisa ISHIGURO
Human bocaviruses (HBoV) 1, 2, 3, and 4 (HBoV1-4) were detected in 132 (15.5%), 5 (0.6%), 3 (0.4%), and 5 (0.6%) of 850 nasopharyngeal swab samples collected from children (0 month to 7 years old) with respiratory tract infections, respectively. O...
Ministry of Education, Culture, Sports, Science and Technology: Grants-in-Aid for Scientific Research(基盤研究(A))
Project Year: 2007 - 2009    Investigator(s): Ken-ichi YAGAMI
Microsphere fluorescent immunoassay (MFI) allows simultaneous detection of antibodies to multiple rodent pathogens using a small volume of sera. In the present study, we examined the specificity and sensitivity of MFI in serologic diagnosis for in...
Ministry of Education, Culture, Sports, Science and Technology: Grants-in-Aid for Scientific Research(基盤研究(B))
Project Year: 2006 - 2008    Investigator(s): Jiro ARIKAWA
Ministry of Education, Culture, Sports, Science and Technology: Grants-in-Aid for Scientific Research(基盤研究(A))
Project Year: 2005 - 2008    Investigator(s): Ikuo TAKASHIMA
Ministry of Education, Culture, Sports, Science and Technology: Grants-in-Aid for Scientific Research(基盤研究(B))
Project Year: 2004 - 2007    Investigator(s): Hiroaki KARIWA
In this study, new diagnostic methods were developed and the epidemiological surveys were carried out on West Nile fever and hantavirus infections which are potentially introduced into Japan.1) Development of diagnostic methods for West Nile fever...
Ministry of Education, Culture, Sports, Science and Technology: Grants-in-Aid for Scientific Research(基盤研究(B))
Project Year: 2004 - 2006    Investigator(s): Masatsugu SUZUKI
1. Nine hundred and seventy six sika deer serum samples were examined. Although 25 (2.6%) of them were positive for anti-HEV IgG, the antibody, titers were very low. HEV RNA was not detected in these samples.2. In 87 wild boar, 2.6% of them were p...
Ministry of Education, Culture, Sports, Science and Technology: Grants-in-Aid for Scientific Research(基盤研究(B))
Project Year: 2003 - 2005    Investigator(s): Takashi AGUI
We selected mouse hepatitis virus, Sendai virus, Mycoplasma plumonis, and hantavirus from the aspect of the frequency and danger upon infectious accidents. We determined antigenic epitopes by incubating polyclonal anti-sera with peptide tips produ...
Ministry of Education, Culture, Sports, Science and Technology: Grants-in-Aid for Scientific Research(基盤研究(C))
Project Year: 2001 - 2003    Investigator(s): Hiroaki KARIWA
To know the epidemiology of viral zoonotic diseases such as hemorrhagic fever with renal syndrome (HFRS) and tick-borne encephalitis (TBE) in Japan, we conducted an epizootiological survey in various points of Japan. Anti-hantavirus antibodies wer...
Ministry of Education, Culture, Sports, Science and Technology: Grants-in-Aid for Scientific Research(基盤研究(B))
Project Year: 2001 - 2003    Investigator(s): Hiroaki KARIWA
To know the epidemiology of viral zoonotic diseases such as hemorrhagic fever with renal syndrome (HFRS) and tick-borne encephalitis (TBE) in Far East Russia, we Conducted an epizootiological survey in Khabarovsk. Anti-hantavirus antibodies were d...
Ministry of Education, Culture, Sports, Science and Technology: Grants-in-Aid for Scientific Research(基盤研究(B))
Project Year: 2001 - 2003
1. It was clarified that recombinant Hantavirus envelope glycoproteins G1 and G2 (GPs) had the cell-fusion activity by using CAG promotor-expression system. Fusion-responsible epitope on GPs was found to locate in the neutralization (FRNT)-relatin...
Ministry of Education, Culture, Sports, Science and Technology: Grants-in-Aid for Scientific Research(基盤研究(B))
Project Year: 1999 - 2001    Investigator(s): Jiro ARIKAWA
1. Nucleocapsid (N) proteins of Hantaan, Seoul and Dobrava viruses were expressed by E. coli and baculovirus systems. The recombinant proteins by both systems produced enough amount of recombinant proteins and retained the anti genicity similar to...
Ministry of Education, Culture, Sports, Science and Technology: Grants-in-Aid for Scientific Research(基盤研究(B))
Project Year: 1999 - 2000    Investigator(s): Jiro ARIKAWA
1. Epidemiologic conditions and status of vaccine development in China were investigated. Information regarding to nucleotide sequence of Chinese isolates and diagnostic procedures for serodiagnosis were exchanged.2. Technical information for gene...
Ministry of Education, Culture, Sports, Science and Technology: Grants-in-Aid for Scientific Research(基盤研究(A))
Project Year: 1998 - 2000    Investigator(s): Jiro ARIKAWA
1. Hantavirus infection was enhanced about 10 times by addition of lectins (DBA and SBA) which specifically bind to N-acetylgalactosamine. This enhancement was considered to caused by the cross linking between receptor to virion by the lectins.2. ...
Ministry of Education, Culture, Sports, Science and Technology: Grants-in-Aid for Scientific Research(基盤研究(C))
Project Year: 1998 - 1999    Investigator(s): Hiroaki KARIWA
Epidemiological study was conducted in Japan and Far East Russia and the followings were revealed.1. Hantavirus was identified in the urine from infected rats. Since newborn rats intranasally inoculated with the urine containing virus had the viru...
Ministry of Education, Culture, Sports, Science and Technology: Grants-in-Aid for Scientific Research(基盤研究(B))
Project Year: 1997 - 1998    Investigator(s): Mikinori KUWABARA
Using multislice MT images of thoracic and abdominal organs in laboratory small animals, three-dimensional (3-d) images were constructed by superimposing them on the computer with the volume ray tracing software. Positive contrast agent was orally...
Ministry of Education, Culture, Sports, Science and Technology: Grants-in-Aid for Scientific Research(基盤研究(B))
Project Year: 1997 - 1998    Investigator(s): Hiroshi SATO
1. A serological investigation by means of an enzyme immuno assay for herpes B virus (Cercopithecine herpesvirus 1) was performed on 962 sera of healthy nonhuman primates reared in laboratory animal facilities which belong to Japanese Association ...
Ministry of Education, Culture, Sports, Science and Technology: Grants-in-Aid for Scientific Research(基盤研究(A))
Project Year: 1996 - 1998    Investigator(s): Kazuyoshi MAEJIMA
In order to detect rapidly and control exactly the emerging / re-emerging infectious diseases in laboratory animals and persons such as animal technicians and researchers, a practical manual "Practical Manual : Diagnosis, Prevention and Control of...
Ministry of Education, Culture, Sports, Science and Technology: Grants-in-Aid for Scientific Research(基盤研究(A))
Project Year: 1996 - 1998    Investigator(s): Ikuo TAKASHIMA
1) Tick-borne encephalitis ; Endemic areas of tick-borne encephalitis were distributed in 4 districs of southern Hokkaido. Two strains of tick-borne encephalitis were isolated from 600 individuals of Ixodes ovatus ticks, giving a field infection r...
Ministry of Education, Culture, Sports, Science and Technology: Grants-in-Aid for Scientific Research(国際学術研究)
Project Year: 1996 - 1997    Investigator(s): Jiro ARIKAWA
Japanese investigator, Dr. Sugiyama carried out a epizootiologicstudy of wild rodents at Beijing and Xian city. A total of 100 rodents were captured from the two regions and were examined for their antibody and antigen distribution.Chinese investi...
Ministry of Education, Culture, Sports, Science and Technology: Grants-in-Aid for Scientific Research(一般研究(B), 基盤研究(B))
Project Year: 1994 - 1996    Investigator(s): Jiro ARIKAWA
1. Animal models for studying respiratory infection, enteric infection and systemic infections were established by using mice and Sendai virus, rotavirus and hantavirus, respectively.2. MDP-Lys (L18) was selected as a immunoadjuvant and examined i...
Ministry of Education, Culture, Sports, Science and Technology: Grants-in-Aid for Scientific Research(試験研究(B), 基盤研究(A))
Project Year: 1994 - 1996    Investigator(s): Jiro ARIKAWA
1. Recombinant baculovirus expressing hantavirus nucleocapsid protein (Bac.HTN-NP) was applied for the antigen of ELISA.Specificity of the ELISA was the same to that of the IFA which uses infected Vero E6 cells as antigen. However, the ELISA had a...
Ministry of Education, Culture, Sports, Science and Technology: Grants-in-Aid for Scientific Research(総合研究(A))
Project Year: 1993 - 1995    Investigator(s): Yoshitake NISHIMUNE
We found that nude rat was very sensitive in the hantavirus infection. In order to study the mechanism of hantavirus infection, nude rats were used as an indicator of the detection of infection.First of all, we have produced rats having different ...
Ministry of Education, Culture, Sports, Science and Technology: Grants-in-Aid for Scientific Research(国際学術研究)
Project Year: 1993 - 1995    Investigator(s): Jiro ARIKAWA
1.In 1993 and 1995, head investigator (Dr. Arikawa), and Japanese investigators (Drs. Hashimoto, Morimatsu, Kariwa) visited Swedish Institute for Infectious Disease control, and Helsinki University Institute for Virology and made information excha...
Ministry of Education, Culture, Sports, Science and Technology: Grants-in-Aid for Scientific Research(総合研究(A))
Project Year: 1992 - 1994    Investigator(s): Ichiro AZUMA
Recently, great advances have been made in the field of the developments of viral vaccines, especially recombinant proteins, synthetic peptides and purified components of viruses were developed as vaccines. These recombinant protein and synthetic ...
Ministry of Education, Culture, Sports, Science and Technology: Grants-in-Aid for Scientific Research(試験研究(B))
Project Year: 1991 - 1993    Investigator(s): Jiro ARIKAWA
1. SCID mice inoculated i.p. with Hantaan virus and Seoul virus developed systemic infection and died after 32 to 38 days post infection.2. Viral antigen was detected from various organs including kidney. Although no hemorrhagic manifestations was...
Ministry of Education, Culture, Sports, Science and Technology: Grants-in-Aid for Scientific Research(一般研究(C))
Project Year: 1990 - 1992    Investigator(s): Jiro ARIKAWA
1) All the neutralizing monoclonal antibodies to Hantaan virus envelope proteins examined so far caused antibody-dependent enhancement of infection to macrophage cell lines with subneutralizing amount of the antibodies. Thus, it seemed to be diffi...