松田彰 (Akira Matsuda) - マイポータル

基本情報

所属: 北海道大学大学院薬学研究院創薬科学研究教育センター特任教授

学位: 薬学博士(北海道大学)

J-GLOBAL ID: 200901040239555349
researchmap会員ID: 1000001629

研究キーワード

研究分野

経歴

学歴

委員歴

論文

Chemical ligation of oligonucleotides using an electrophilic phosphorothioester

Hideto Maruyama, Ryota Oikawa, Mayu Hayakawa, Shono Takamori, Yasuaki Kimura, Naoko Abe, Genichiro Tsuji, Akira Matsuda, Satoshi Shuto, Yoshihiro Ito …

NUCLEIC ACIDS RESEARCH 45(12) 7042-7048 2017年7月査読有り
Divergent synthesis of kinase inhibitor derivatives, leading to discovery of selective Gck inhibitors

Takanori Matsumaru, Makoto Inai, Kana Ishigami, Toshiki Iwamatsu, Hiroshi Maita, Satoko Otsuguro, Takao Nomura, Akira Matsuda, Satoshi Ichikawa, Masahiro Sakaitani …

BIOORGANIC & MEDICINAL CHEMISTRY LETTERS 27(10) 2144-2147 2017年5月査読有り
An oligodeoxyribonucleotide containing 5-formyl-2 '-deoxycytidine (fC) at the CpG site forms a covalent complex with DNA cytosine-5 methyltransferases (DNMTs)

Kousuke Sato, Kyoji Kawamoto, Shintaro Shimamura, Satoshi Ichikawa, Akira Matsuda

BIOORGANIC & MEDICINAL CHEMISTRY LETTERS 26(22) 5395-5398 2016年11月査読有り
Chemical Screening Identifies EUrd as a Novel Inhibitor Against Temozolomide-Resistant Glioblastoma-Initiating Cells

Yoshihiro Tsukamoto, Naoki Ohtsu, Smile Echizenya, Satoko Otsuguro, Ryosuke Ogura, Manabu Natsumeda, Mizuho Isogawa, Hiroshi Aoki, Satoshi Ichikawa, Masahiro Sakaitani …

STEM CELLS 34(8) 2016-2025 2016年8月査読有り
Design, Synthesis and Biological Evaluation of a Structurally Simplified Syringolin A Analogues

Takuya Chiba, Shun Kitahata, Akira Matsuda, Satoshi Ichikawa

CHEMICAL & PHARMACEUTICAL BULLETIN 64(7) 811-816 2016年7月査読有り
Revisited Mechanistic Implications of the Joullié-Ugi Three-Component Reaction.

Katsuyama A, Matsuda A, Ichikawa S

Organic letters 18(11) 2552-2555 2016年6月査読有り
Structural insights into inhibition of lipid I production in bacterial cell wall synthesis

Ben C. Chung, Ellene H. Mashalidis, Tetsuya Tanino, Mijung Kim, Akira Matsuda, Jiyong Hong, Satoshi Ichikawa, Seok-Yong Lee

NATURE 533(7604) 557-+ 2016年5月査読有り
Design, Synthesis, and Biological Activity of Isosyringolin A

Shun Kitahata, Takuya Chiba, Takashi Yoshida, Masaki Ri, Shinsuke Iida, Akira Matsuda, Satoshi Ichikawa

ORGANIC LETTERS 18(9) 2312-2315 2016年5月査読有り
Structure-activity relationship study of syringolin A as a potential anticancer agent

Takuya Chiba, Akira Matsuda, Satoshi Ichikawa

BIOORGANIC & MEDICINAL CHEMISTRY LETTERS 25(21) 4872-4877 2015年11月査読有り
Rolling Circle Translation of Circular RNA in Living Human Cells

Naoko Abe, Ken Matsumoto, Mizuki Nishihara, Yukiko Nakano, Aya Shibata, Hideto Maruyama, Satoshi Shuto, Akira Matsuda, Minoru Yoshida, Yoshihiro Ito …

SCIENTIFIC REPORTS 5 16435 2015年11月査読有り
Carbacaprazamycins: Chemically Stable Analogues of the Caprazamycin Nucleoside Antibiotics

Satoshi Ichikawa, Mayumi Yamaguchi, Lee Shang Hsuan, Yuta Kato, Akira Matsuda

ACS INFECTIOUS DISEASES 1(4) 151-156 2015年4月査読有り
Design, synthesis and biological evaluation of 5 '-C-piperidinyl-5 '-O-aminoribosyluridines as potential antibacterial agents

Takeshi Nakaya, Akira Matsuda, Satoshi Ichikawa

ORGANIC & BIOMOLECULAR CHEMISTRY 13(28) 7720-7735 2015年査読有り
An intracellular buildup reaction of active siRNA species from short RNA fragments

Hideto Maruyama, Yuko Nakashima, Satoshi Shuto, Akira Matsuda, Yoshihiro Ito, Hiroshi Abe

CHEMICAL COMMUNICATIONS 50(11) 1284-1287 2014年査読有り
PK-PD modeling of 1-(3-C-ethynyl-beta-D-ribo-pentofuranosyl)cytosine and the enhanced antitumor effect of its phospholipid derivatives in long-circulating liposomes

Akitsugu Takada, Hiroyuki Kamiya, Satoshi Shuto, Akira Matsuda, Hideyoshi Harashima

INTERNATIONAL JOURNAL OF PHARMACEUTICS 377(1-2) 52-59 2009年7月査読有り
Three-dimensional structure-activity relationship study of belactosin A and its stereo- and regioisomers: Development of potent proteasome inhibitors by a stereochemical diversity-oriented strategy

Keisuke Yoshida, Kazuya Yamaguchi, Akira Mizuno, Yuka Unno, Akira Asai, Takayuki Sone, Hideyoshi Yokosawa, Akira Matsuda, Mitsuhiro Arisawa, Satoshi Shuto

Organic and Biomolecular Chemistry 7(9) 1868-1877 2009年査読有り
Synthesis of 1-arylpiperazyl-2-phenylcyclopropanes designed as antidopaminergic agents: Cyclopropane-based conformationally restricted analogs of haloperidol

Kazuya Yamaguchi, Yuji Kazuta, Kazufumi Hirano, Shizuo Yamada, Akira Matsuda, Satoshi Shuto

BIOORGANIC & MEDICINAL CHEMISTRY 16(19) 8875-8881 2008年10月査読有り
Synthesis of 5″-branched derivatives of cyclic ADP-carbocyclic-ribose, a potent Ca²⁺-mobilizing agent: The first antagonists modified at the N1-ribose moiety

Natsumi Sakaguchi, Takashi Kudoh, Takayoshi Tsuzuki, Takashi Murayama, Takashi Sakurai, Akira Matsuda, Mitsuhiro Arisawa, Satoshi Shuto

Bioorganic and Medicinal Chemistry Letters 18(13) 3814-3818 2008年7月1日査読有り
Synthesis of 2,3- and 3,4-methanoamino acid equivalents with stereochemical diversity and their conversion into the tripeptide proteasome inhibitor belactosin a and its highly potent cis-cyclopropane stereoisomer

Keisuke Yoshida, Kazuya Yamaguchi, Takayuki Sone, Yuka Unno, Akira Asai, Hideyoshi Yokosawa, Akira Matsuda, Mitsuhiro Arisawa, Satoshi Shuto

Organic Letters 10(16) 3571-3574 2008年査読有り
Substitution at the 8-position of 3 ''-deoxy-cyclic ADP-carbocyclic-ribose, a highly potent Ca2+-mobilizing agent, provides partial agonists

Takashi Kudoh, Takashi Murayama, Akira Matsuda, Satoshi Shuto

BIOORGANIC & MEDICINAL CHEMISTRY 15(8) 3032-3040 2007年4月査読有り

MISC

280

ヌクレオシド系天然物の全合成を基盤とした抗薬剤耐性菌薬シーズの創製研究

市川聡, 谷野哲也, 伊井謙介, 松田彰

有機合成化学協会誌 69(9) 1020-1033 2011年9月1日
奨励賞受賞阿部洋氏の業績

松田彰

ファルマシア 46(6) 2010年6月1日
化学レビュー(第18回)創薬化学新たな切り口で結核菌と戦う!

市川聡, 松田彰

化学 65(2) 30-34 2010年2月
奨励賞受賞市川聡氏の業績

松田彰

ファルマシア 44(6) 2008年6月1日
ピラノースの配座制御に基づく立体選択的グリコシル化反応

周東智, 市川聡, 阿部洋, 松田彰

有機合成化学協会誌 : JOURNAL OF Synthetic Organic Chemistry JAPAN 66(1) 52-62 2008年1月1日
分子構造から考える薬物の作用機序(3)抗A型およびB型インフルエンザウイルス薬--ザナミビル水和物とリン酸オセルタミビル

松田彰

医薬ジャ-ナル 43(4) 5-10 2007年4月
A method for designing conformationally restricted analogues based on allylic strain: Synthesis of a novel class of noncompetitive NMDA receptor antagonists having the acrylamide structure

Y Ohmori, A Yamashita, R Tsujita, T Yamamoto, K Taniuchi, A Matsuda, S Shuto

JOURNAL OF MEDICINAL CHEMISTRY 46(25) 5326-5333 2003年12月
Construction of a cis-cyclopropane via reductive radical decarboxylation. Enantioselective synthesis of cis- and trans-1-arylpiperazyl-2-phenyleyclopropanes designed as antidopaminergic agents

K Yamaguchi, Y Kazuta, H Abe, A Matsuda, S Shuto

JOURNAL OF ORGANIC CHEMISTRY 68(24) 9255-9262 2003年11月
No enhancement of nuclear entry by direct conjugation of a nuclear localization signal peptide to linearized DNA

M Tanimoto, H Kamiya, N Minakawa, A Matsuda, H Harashima

BIOCONJUGATE CHEMISTRY 14(6) 1197-1202 2003年11月
Convergent synthesis and unexpected Ca2+-mobilizing activity of 8-substituted analogues of cyclic ADP-carbocyclic-ribose, a stable mimic of the Ca2+-mobilizing second messenger cyclic ADP-ribose

S Shuto, M Fukuoka, T Kudoh, C Garnham, A Galione, BVL Potter, A Matsuda

JOURNAL OF MEDICINAL CHEMISTRY 46(22) 4741-4749 2003年10月
ポリアミン修飾オリゴヌクレオチドの合成とアンチセンス，アンチジーン分子としての性質

上野義仁, 松田彰

有機合成化学協会誌 55,207-216(9) 890-899 2003年9月1日
A study on the conformation-anomeric effect-stereoselectivity relationship in anomeric radical reactions, using conformationally restricted glucose derivatives as substrates

H Abe, M Terauchi, A Matsuda, S Shuto

JOURNAL OF ORGANIC CHEMISTRY 68(19) 7439-7447 2003年9月
A versatile modification of on-column oligodeoxynucleotides using a copper-catalyzed oxidative acetylenic coupling reaction

N Minakawa, Y Ono, A Matsuda

JOURNAL OF THE AMERICAN CHEMICAL SOCIETY 125(38) 11545-11552 2003年9月
Crystallization and preliminary X-ray analysis of human uridine-cytidine kinase 2

NN Suzuki, K Koizumi, M Fukushima, A Matsuda, F Inagaki

ACTA CRYSTALLOGRAPHICA SECTION D-BIOLOGICAL CRYSTALLOGRAPHY 59 1477-1478 2003年8月
New base pairing motifs. The synthesis and thermal stability of oligodeoxynucleotides containing imidazopyridopyrimidine nucleosides with the ability to form four hydrogen bonds

N Minakawa, N Kojima, S Hikishima, T Sasaki, A Kiyosue, N Atsumi, Y Ueno, A Matsuda

JOURNAL OF THE AMERICAN CHEMICAL SOCIETY 125(33) 9970-9982 2003年8月
Synthesis, thermal stability and resistance to enzymatic hydrolysis of the oligonucleotides containing 5-(N-aminohexyl)carbamoyl-2 '-O-methyluridines

T Ito, Y Ueno, Y Komatsu, A Matsuda

NUCLEIC ACIDS RESEARCH 31(10) 2514-2523 2003年5月
Cyclopropane-based conformational restriction of histamine. (1S,2S)-2-(2-aminoethyl)-1-(1H-imidazol-4-yl)cyclopropane, a highly selective agonist for the histamine H-3 receptor, having a cis-cyclopropane structure

Y Kazuta, K Hirano, K Natsume, S Yamada, R Kimura, SI Matsumoto, K Furuichi, A Matsuda, S Shuto

JOURNAL OF MEDICINAL CHEMISTRY 46(10) 1980-1988 2003年5月
A systematic study of the hydride reduction of cyclopropyl ketones with structurally simplified substrates. Highly stereoselective reductions of trans-substituted cyclopropyl ketones via the bisected s-cis conformation

Y Kazuta, H Abe, T Yamamoto, A Matsuda, S Shuto

JOURNAL OF ORGANIC CHEMISTRY 68(9) 3511-3521 2003年5月
The first radical method for the introduction of an ethynyl group using a silicon tether and its application to the synthesis of 2 '-deoxy-2 '-C-ethynylnucleosides

M Sukeda, S Ichikawa, A Matsuda, S Shuto

JOURNAL OF ORGANIC CHEMISTRY 68(9) 3465-3475 2003年5月
An improved large scale synthesis of 1,4-anhydro-4-thio-D-ribitol

N Minakawa, Y Kato, K Uetake, D Kaga, A Matsuda

TETRAHEDRON 59(10) 1699-1702 2003年3月

もっとみる

書籍等出版物

アンチセンスDNAの設計と応用、田辺、脇、小島、北編集、

「マラリア学ラボマニュアル」菜根出版 2000年

松田彰

基本情報

研究キーワード

研究分野

経歴

学歴

委員歴

論文

MISC

書籍等出版物

担当経験のある科目(授業)

所属学協会

共同研究・競争的資金等の研究課題

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