早狩誠 (Makoto Hayakari) - マイポータル - researchmap

基本情報

所属: 弘前大学大学院医学研究科薬剤学講座教授

学位: 医学博士(弘前大学)
薬学修士(東北大学)

J-GLOBAL ID: 200901061491960792
researchmap会員ID: 1000002931

研究キーワード

5

研究分野

3

経歴

1

2006年8月 - 現在

弘前大学大学院医学研究科薬剤学講座, 教授・薬剤部長

受賞

1

1987年

日本薬学会東北支部奨励賞

MISC

37

Nuclear localization of STAT5A modified with O-linked N-acetylglucosamine and early involution in the mammary gland of Hirosaki hairless rat

N Nanashima, J Asano, M Hayakari, T Nakamura, H Nakano, T Yamada, T Shimizu, M Akita, Y Fan, S Tsuchida

JOURNAL OF BIOLOGICAL CHEMISTRY 280(52) 43010-43016 2005年12月
Enzymatic detection of precursor cell populations of preneoplastic foci positive for gamma-glutamyltranspeptidase in rat liver

K Satoh, G Takahashi, T Miura, M Hayakari, Hatayama, I

INTERNATIONAL JOURNAL OF CANCER 115(5) 711-716 2005年7月
Differentiation induction of human keratinocytes by phosphatidylethanolamine-binding protein

T Yamazaki, H Nakano, M Hayakari, M Tanaka, J Mayama, S Tsuchida

JOURNAL OF BIOLOGICAL CHEMISTRY 279(31) 32191-32195 2004年7月
Inhibition of 3T3-L1 adipocyte differentiation by 6-ethoxyzolamide: repressed peroxisome proliferator-activated receptor gamma mRNA and enhanced CCAAT/enhancer binding protein beta mRNA levels

T Takahata, T Kumano, K Ookawa, M Hayakari, Kakizaki, I, S Tsuchida

BIOCHEMICAL PHARMACOLOGY 67(9) 1667-1675 2004年5月
Kinetic-controlled hydrolysis of Leu-Val-Val-hemorphin-7 catalyzed by angiotensin-converting enzyme from rat brain

M Hayakari, K Satoh, H Izumi, T Kudoh, J Asano, T Yamazaki, S Tsuchida

PEPTIDES 24(7) 1075-1082 2003年7月
Characterization of cell death induced by ethacrynic acid in a human colon cancer cell line DLD-1 and suppression by N-acetyl-L-cysteine.

Cancer Sci. 94(10):886-893. 2003年
Enhanced sensitivity to cis-diamminedichloroplatinum(II) of a human carcinoma cell line with mutated p53 gene by cyclin-dependent kinase inhibitor p21(WAF1) expression.

Cancer Sci. 94(3):286-91. 2003年
Polymorphic glutathione S-transferase subunit 3 of rat liver exhibits different susceptibilities to carbon tetrachloride: differences in their interactions with heat-shock protein 90.

Biochem J. 372 (Pt 2):611-6 2003年
Nrf2 transactivator-independent GSTP1-1 expression in 'GSTP1-1 positive' single cells inducible in female mouse liver by DEN: a preneoplastic character of possible initiated cells

K Satoh, K Itoh, M Yamamoto, M Tanaka, M Hayakari, K Ookawa, T Yamazaki, T Sato, S Tsuchida, Hatayama, I

CARCINOGENESIS 23(3) 457-462 2002年3月
Lipid peroxidation end products-responded induction of a preneoplastic marker enzyme glutathione S-transferase P-form (GST-P) in rat liver on admistration via the portal vein.

Mutat Res. 483(1/2) 65-72 2001年
Polymorphism of the glutathione transferase subunit 3 in Sprague-Dawley rats involves a reactive cysteine residue

T Kumano, J Kimura, M Hayakari, T Yamazaki, D Sawamura, S Tsuchida

BIOCHEMICAL JOURNAL 350(2) 405-412 2000年9月
Induction of apoptosis and cell cycle arrest in mouse colon 26 cells by benastatin A

Ikuko Kakizaki, Keizoh Ookawa, Takashi Ishikawa, Makoto Hayakari, Takaaki Aoyagi, Shigeki Tsuchida

Japanese Journal of Cancer Research 91(11) 1161-1168 2000年
Decreased expression of the peroxisomal bifunctional enzyme and carbonyl reductase in human hepatocellular carcinomas

K Suto, H Kajihara-Kano, Y Yokoyama, M Hayakari, J Kimura, T Kumano, T Takahata, H Kudo, S Tsuchida

JOURNAL OF CANCER RESEARCH AND CLINICAL ONCOLOGY 125(2) 83-88 1999年2月
A 1-hour enzyme-linked immunosorbent assay for quantitation of acrolein- and hydroxynenenal-modified proteins by epitope-bound casein matrix method

Anal. Biochem. 270(2) 323-328 1999年
Quantitative differences in the active-site hydrophobicity of five human glutathione S-transferase isoenzymes: Water-soluble carcinogen-selective properties of the neoplastic GSTP1-1 species

K Satoh, R Sato, T Takahata, S Suzuki, M Hayakari, S Tsuchida, Hatayama, I

ARCHIVES OF BIOCHEMISTRY AND BIOPHYSICS 361(2) 271-276 1999年1月
Altered glutathione transferase levels in rat skin inflamed due to contact hypersensitivity: induction of the Alpha-class subunit 1

J Kimura, M Hayakari, T Kumano, H Nakano, K Satoh, S Tsuchida

BIOCHEMICAL JOURNAL 335 605-610 1998年11月
Identification of glutathione S-transferase p-1 as the class pi form dominantly expressed in mouse hepatic adenomas

K Ookawa, H Nakano, Kakizaki, I, Hatayama, I, H Kajihara-Kano, J Kimura, M Hayakari, T Takahata, K Satoh, S Tsuchida

JAPANESE JOURNAL OF CANCER RESEARCH 89(6) 641-648 1998年6月
Immune recognition of botulinum neurotoxin type A: Regions recognized by T cells and antibodies against the protective H-C fragment (residues 855-1296) of the toxin

M Oshima, M Hayakari, JL Middlebrook, MZ Atassi

MOLECULAR IMMUNOLOGY 34(14) 1031-1040 1997年10月
腫瘍マーカーとしてのGlutathion S-transferaseの有用性

臨床病理 45(12) 1125 1997年
Reduction of oxysterol levels up-regulates HMG-CoA reductase activity in rat liver.

Atherosclerosis 131(2) 237 1997年

もっとみる

書籍等出版物

1

Purification of angiotensin-converting enzyme from human intestine.

Kinins V, part B 1989年

所属学協会

6

共同研究・競争的資金等の研究課題

7