長内智宏 (Tomohiro Osanai) - マイポータル

基本情報

所属: 弘前大学医学部医学科助教授・准教授

学位: 医学博士

J-GLOBAL ID: 200901055797640791
researchmap会員ID: 1000003035

研究キーワード

研究分野

ライフサイエンス / 循環器内科学 /

MISC

Upregulation of soluble vascular endothelial growth factor receptor type 1 by endogenous prostacyclin inhibitor coupling factor 6 in vascular endothelial cells: a role of acidosis-induced c-Src activation

Takashi Echizen, Tomohiro Osanai, Toshihiro Ashitate, Hiroaki Yokoyama, Shuji Shibutani, Makoto Tanaka, Hirofumi Tomita, Koji Magota, Ken Okumura

HYPERTENSION RESEARCH 32(3) 182-187 2009年3月
Coupling factor 6 enhances Src-mediated responsiveness to angiotensin II in resistance arterioles and cells

Tomohiro Osanai, Hirofumi Tomita, Motoi Kushibiki, Masahiro Yamada, Makoto Tanaka, Toshihiro Ashitate, Takashi Echizen, Chisato Katoh, Koji Magota, Ken Okumura

CARDIOVASCULAR RESEARCH 81(4) 780-787 2009年3月
Coupling factor 6 downregulates platelet endothelial cell adhesion molecule-1 via c-Src activation and acts as a proatherogenic molecule

Akiko Kumagai, Tomohiro Osanai, Chisato Katoh, Makoto Tanaka, Hirofumi Tomita, Takeshi Morimoto, Reiichi Murakami, Koji Magota, Ken Okumura

ATHEROSCLEROSIS 200(1) 45-50 2008年9月
Vasoconstrictor effect of aldosterone via angiotensin II type 1 (AT(1)) receptor: possible role of AT(1) receptor dimerization

Masahiro Yamada, Motoi Kushibiki, Tomohiro Osanai, Hirofumi Tomita, Ken Okumura

CARDIOVASCULAR RESEARCH 79(1) 169-178 2008年7月
Therapeutic challenge to adiposity of the heart

Tomohiro Osanai, Ken Okumura

CIRCULATION RESEARCH 100(8) 1106-1108 2007年4月
Therapeutic challenge to adiposity of the heart.

Osanai T, Okumura K

Cir Res. 100 1106-1108 2007年
Effect of vasoconstrictor coupling factor 6 on gene expression profile in human vascular endothelial cells: enhanced release of asymmetric dimethylarginine

M Tanaka, T Osanai, R Murakami, S Sasaki, H Tomita, N Maeda, K Satoh, K Magota, K Okumura

JOURNAL OF HYPERTENSION 24(3) 489-497 2006年3月
Intracellular signaling for vasoconstrictor coupling factor 6 - Novel function of beta-subunit of ATP synthase as receptor

T Osanai, K Magota, M Tanaka, M Shimada, R Murakami, S Sasaki, H Tomita, N Maeda, K Okumura

HYPERTENSION 46(5) 1140-1146 2005年11月
Troglitazone and 15-deoxy-Delta(12,14)-prostaglandin J(2) inhibit shear-induced coupling factor 6 release in endothelial cells

H Tomita, T Osanai, T Toki, S Sasaki, N Maeda, R Murakami, K Magota, M Yasujima, K Okumura

CARDIOVASCULAR RESEARCH 67(1) 134-141 2005年7月
Tumor necrosis factor  as an endogenous stimulator for circulating coupling factor 6.

Sasaki S, Osanai T, Tomita H, Matsunaga T, Magota K, Okumura K

Cardiovasc Res 62(3) 578-586 2004年6月
Tumor necrosis factor alpha as an endogenous stimulator for circulating coupling factor 6

S Sasaki, T Osanai, H Tomita, T Matsunaga, K Magota, K Okumura

CARDIOVASCULAR RESEARCH 62(3) 578-586 2004年6月
Circulating coupling factor 6 in human hypertension: role of reactive oxygen species

T Osanai, S Sasaki, T Kamada, N Fujiwara, T Nakano, H Tomita, T Matsunaga, K Magota, K Okumura

JOURNAL OF HYPERTENSION 21(12) 2323-2328 2003年12月
Plasma concentration of coupling factor 6 and cardiovascular events in patients with end-stage renal disease

T Osanai, M Nakamura, S Sasaki, H Tomita, M Saitoh, H Osawa, H Yamabe, S Murakami, K Magota, K Okumura

KIDNEY INTERNATIONAL 64(6) 2291-2297 2003年12月
Effect of shear stress on asymmetric dimethylarginine release from vascular endothelial cells

T Osanai, M Saitoh, S Sasaki, H Tomita, T Matsunaga, K Okumura

HYPERTENSION 42(5) 985-990 2003年11月
Enhanced activity of variant phospholipase C-1 protein (R257H) detected in patients with coronary artery spasm.

Nakano T, Osanai T, Tomita H, Sekimata M, Homma Y, Okumura K

Circulation 105(17) 2024-2029 2002年4月
Mitochondrial coupling factor 6 is present on the surface of human vascular endothelial cells and is released by shear stress

T Osanai, S Okada, K Sirato, T Nakano, M Saitoh, K Magota, K Okumura

CIRCULATION 104(25) 3132-3136 2001年12月
Mitochondrial coupling factor 6 as a potent endogenous vasoconstrictor

T Osanai, M Tanaka, T Kamada, T Nakano, K Takahashi, S Okada, K Sirato, K Magota, S Kodama, K Okumura

JOURNAL OF CLINICAL INVESTIGATION 108(7) 1023-1030 2001年10月
Cross talk between prostacyclin and nitric oxide under shear in Smooth muscle cell:role in monocyte adhesion

Am J Physiol Heart Circ Physiol 281 H177-182 2001年
Enhanced phospholipase C activity in the cultured skin fibroblast obtained from patients with coronary spastic angina: Possible role for enhanced vasoconstrictor response

K Okumura, T Osanai, T Kosugi, H Hanada, H Ishizaka, T Fukushi, T Kamada, T Miura, T Hatayama, T Nakano …

JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY 36(6) 1847-1852 2000年11月
Enhanced phospholipase C activity in the cultured skin fibroblast obtained from patients with coronary spastic angina: possible role for enhanced vasoconstrictor response.

Okumura K, Osanai T, Kosugi T, Hanada H, Ishizaka H, Fukushi T, Kamada T, Miura T, Hatayama T, Nakano T …

J Am Coll Cardiol. 36 2000年

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長内智宏

基本情報

研究キーワード

研究分野

MISC

所属学協会

共同研究・競争的資金等の研究課題

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