論文

査読有り
2005年6月

IFN-gamma: A cytokine essential for rejection of CTL-resistant, virus-infected cells

JOURNAL OF INTERFERON AND CYTOKINE RESEARCH
  • S Yamaguchi
  • ,
  • J Tashiro-Yamaji
  • ,
  • K Lee
  • ,
  • T Takahashi
  • ,
  • K Sano
  • ,
  • Y Endo
  • ,
  • M Nakanishi
  • ,
  • A Eguchi
  • ,
  • M Okada
  • ,
  • H Nomi
  • ,
  • Y Yamamoto
  • ,
  • H Takenaka
  • ,
  • T Kubota
  • ,
  • R Yoshida

25
6
開始ページ
328
終了ページ
337
記述言語
英語
掲載種別
研究論文(学術雑誌)
DOI
10.1089/jir.2005.25.328
出版者・発行元
MARY ANN LIEBERT INC

We recently demonstrated differential susceptibility of cells expressing viral antigen to killing by antigen-specific cytotoxic T lymphocytes (CTLs). In addition, interferon-gamma (IFN-gamma) has been implicated in the clearance of some viruses from tissues. We explored the role of IFN-gamma in the cytotoxicity of Sendai virus-specific CTLs against virus- infected RL male 1 (T cell leukemia) or Meth A (fibrosarcoma) cells, as well as the growth of subcutaneously (s.c.) transplanted, virus-infected cells in IFN-gamma(+/+) or IFN-gamma(-/-) mice of the syngeneic strain (BALB/c). Sendai virus-specific CTLs were cytotoxic against virus- infected RL male 1 cells, and s.c. transplanted, virus-infected RL male 1 cells were acutely rejected from IFN-gamma(+/+) or IFN-gamma(-/-) mice. In contrast, the CTLs were inactive toward virus-infected Meth A cells, but s.c. transplanted, virus-infected Meth A cells were acutely rejected from IFN-gamma(+/+) but not IFN-gamma(-/-) mice. The s.c. growth of virus-infected Meth A cells in the mutant mice was markedly inhibited by s.c. injections of IFN-gamma, and the rejection from IFN-gamma(+/+) mice was delayed after specific elimination of macrophages by intravenous (i.v.) injections of dichloromethylene diphosphonate-containing liposomes. These results suggest an essential role of IFN-gamma and involvement of macrophage in the rejection of CTL-resistant, virus-infected cells.

Web of Science ® 被引用回数 : 7

リンク情報
DOI
https://doi.org/10.1089/jir.2005.25.328
Web of Science
https://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcAuth=JSTA_CEL&SrcApp=J_Gate_JST&DestLinkType=FullRecord&KeyUT=WOS:000230138500004&DestApp=WOS_CPL

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