論文

査読有り
2004年2月

Platelet responses and anaphylaxis-like shock induced in mice by intravenous injection of whole cells of oral streptococci

ORAL MICROBIOLOGY AND IMMUNOLOGY
  • M Ohba
  • ,
  • M Shibazaki
  • ,
  • T Sasano
  • ,
  • M Inoue
  • ,
  • H Takada
  • ,
  • Y Endo

19
1
開始ページ
26
終了ページ
30
記述言語
英語
掲載種別
研究論文(学術雑誌)
DOI
10.1046/j.0902-0055.2002.00107.x
出版者・発行元
WILEY-BLACKWELL

Intravenous injection of lyophilized whole cells of various oral streptococcal strains into muramyldipeptide (MDP)-primed C3H/HeN mice induces rapid anaphylactoid shock. Here we examined the mechanism underlying this shock. In non-primed mice, Streptococcus intermedius K-213K (SiK213) and Streptococcus constellatus T21 (ScT21) produced little or no sign of shock. In MDP-primed mice, SiK213 caused lethal shock, while ScT21 only had a weak effect. SiK213 induced decreases in blood platelets and 5-hydroxytryptamine (5HT) preceding the shock, while the effects of ScT21 were weak. The SiK213-induced 5HT decrease and shock were reduced by a complement-C5 inhibitor. These results suggest that (i) streptococcal bacterial cells can induce rapid platelet responses, (ii) complement-dependent degradation of platelets may be involved in streptococcus-induced shock, (iii) the streptococcus-induced platelet degradation or degranulation may occur largely in the systemic circulation, and (iv) platelets may play a role not only in infectious diseases caused by gram-negative bacteria, but also in diseases caused by gram-positive bacteria.

Web of Science ® 被引用回数 : 11

リンク情報
DOI
https://doi.org/10.1046/j.0902-0055.2002.00107.x
Web of Science
https://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcAuth=JSTA_CEL&SrcApp=J_Gate_JST&DestLinkType=FullRecord&KeyUT=WOS:000187407500004&DestApp=WOS_CPL

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