Feb, 2004
Platelet responses and anaphylaxis-like shock induced in mice by intravenous injection of whole cells of oral streptococci
ORAL MICROBIOLOGY AND IMMUNOLOGY
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- Volume
- 19
- Number
- 1
- First page
- 26
- Last page
- 30
- Language
- English
- Publishing type
- Research paper (scientific journal)
- DOI
- 10.1046/j.0902-0055.2002.00107.x
- Publisher
- WILEY-BLACKWELL
Intravenous injection of lyophilized whole cells of various oral streptococcal strains into muramyldipeptide (MDP)-primed C3H/HeN mice induces rapid anaphylactoid shock. Here we examined the mechanism underlying this shock. In non-primed mice, Streptococcus intermedius K-213K (SiK213) and Streptococcus constellatus T21 (ScT21) produced little or no sign of shock. In MDP-primed mice, SiK213 caused lethal shock, while ScT21 only had a weak effect. SiK213 induced decreases in blood platelets and 5-hydroxytryptamine (5HT) preceding the shock, while the effects of ScT21 were weak. The SiK213-induced 5HT decrease and shock were reduced by a complement-C5 inhibitor. These results suggest that (i) streptococcal bacterial cells can induce rapid platelet responses, (ii) complement-dependent degradation of platelets may be involved in streptococcus-induced shock, (iii) the streptococcus-induced platelet degradation or degranulation may occur largely in the systemic circulation, and (iv) platelets may play a role not only in infectious diseases caused by gram-negative bacteria, but also in diseases caused by gram-positive bacteria.
- Link information
- ID information
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- DOI : 10.1046/j.0902-0055.2002.00107.x
- ISSN : 0902-0055
- Web of Science ID : WOS:000187407500004