論文

査読有り
2004年1月

Effects of weekly administrations of alendronate plus clodronate on young mouse tibia: Localized action at the proximal growth plate

CALCIFIED TISSUE INTERNATIONAL
  • Y Monma
  • ,
  • H Funayama
  • ,
  • H Mayanagi
  • ,
  • Y Endo

74
1
開始ページ
115
終了ページ
121
記述言語
英語
掲載種別
研究論文(学術雑誌)
DOI
10.1007/s00223-002-2156-5
出版者・発行元
SPRINGER-VERLAG

Alendronate (A), a typical aminobisphosphonate (aminoBP), has a strong bone-resorption-inhibitory activity (BRIA). However, like other aminoBPs it has inflammatory side effects. In contrast, the BRIA of clodronate (C), a non-aminoBP, is much weaker, and in animal experiments it suppresses aminoBP-induced inflammatory reactions. In the present study, we examined the effects of weekly administrations of A (1.6 mumol/kg) + C (160 mumol/kg) on the tibias in young mice and compared them to those induced by A or C alone. Radiophotography showed that A increased bone density at a selective site in the tibia. Indeed, one week after the final injection of A (given alone), clear sclerotic lines (tentatively called BP-lines) were visible at sites corresponding to the location of the growth plate at the time of the each injection. C also produced BP-lines, although they were weaker than those produced by A. Combined administration of A and C produced similar BP-lines as seen in mice given A alone. These results together with other physicochemical effects of A on the tibia suggest that (1) each injection of A and C inhibits bone resorption selectively and transiently at the tibial growth plate in young mice, although minor effects on other sites cannot be excluded, and (2) the combination of A and C keeps still a strong BRIA. Our findings may suggest a strategy for the prevention or reduction of some inflammatory side effects of A or other aminoBPs.

Web of Science ® 被引用回数 : 18

リンク情報
DOI
https://doi.org/10.1007/s00223-002-2156-5
Web of Science
https://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcAuth=JSTA_CEL&SrcApp=J_Gate_JST&DestLinkType=FullRecord&KeyUT=WOS:000188662700016&DestApp=WOS_CPL

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