論文

査読有り
2003年10月

Do peritoneal macrophages play an essential role in the progression of acute pancreatitis in rats?

PANCREAS
  • Y Mikami
  • ,
  • K Takeda
  • ,
  • K Shibuya
  • ,
  • H Qiu-Feng
  • ,
  • H Shimamura
  • ,
  • J Yamauchi
  • ,
  • S Egawa
  • ,
  • M Sunamura
  • ,
  • H Yagi
  • ,
  • Y Endo
  • ,
  • S Matsuno

27
3
開始ページ
253
終了ページ
260
記述言語
英語
掲載種別
研究論文(学術雑誌)
DOI
10.1097/00006676-200310000-00011
出版者・発行元
LIPPINCOTT WILLIAMS & WILKINS

Introduction: Macrophages are considered to play an essential role in the events leading to systemic inflammatory response. Some are known to reside in the peritoneal cavity but there are no reports defining the participation of peritoneal macrophages (PMs) in the progression of acute pancreatitis.
Aim: To clarify the role of PMs in the progression of acute pancreatitis.
Methodology: Acute pancreatitis was induced in rats from which macrophages other than PMs were greatly depleted, and in rats greatly depleted of macrophages including PMs. Macrophages were depleted by the injection of liposome encapsulated dichloromethylene bisphosphonate. After the induction of acute pancreatitis, local pancreatic inflammation, intraperitoneal inflammation and lung injury were compared between the 2 groups.
Results: Local pancreatic inflammation did not differ between the 2 groups. However, intraperitoneal inflammation was clearly improved by the depletion of PMs. Serum cytokine level and lung injury were also improved by the depletion of PMs.
Conclusion: Peritoneal macrophages extend inflammation from the pancreas to the peritoneal cavity and subsequently induce lung injury in acute pancreatitis. Peritoneal macrophages play an essential role in the systemic inflammatory response and the progression of acute pancreatitis in the rat.

Web of Science ® 被引用回数 : 28

リンク情報
DOI
https://doi.org/10.1097/00006676-200310000-00011
Web of Science
https://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcAuth=JSTA_CEL&SrcApp=J_Gate_JST&DestLinkType=FullRecord&KeyUT=WOS:000185573400011&DestApp=WOS_CPL

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