論文

査読有り
2003年3月

Effect of nutritive and tonic crude drugs on physical fatigue-induced stress models in mice

PHARMACOLOGICAL RESEARCH
  • T Tadano
  • ,
  • O Nakagawasai
  • ,
  • F Niijima
  • ,
  • K Tan-no
  • ,
  • M Hanawa
  • ,
  • Y Sakata
  • ,
  • D Sutoo
  • ,
  • Y Nemoto
  • ,
  • Y Ida
  • ,
  • Y Endo

47
3
開始ページ
195
終了ページ
199
記述言語
英語
掲載種別
研究論文(学術雑誌)
DOI
10.1016/S1043-6618(02)00318-3
出版者・発行元
ACADEMIC PRESS LTD ELSEVIER SCIENCE LTD

The present study was undertaken to investigate the acute anti-fatigue effect of a liquid nutritive and tonic crude drugs (NTDs) on stress induced in mice. After forced walking for 3 or 6 h, the NTDs (applied orally, 10 ml/kg) significantly increased locomotor activity, while the administration of NTDs after rapid eye movement (REM) sleep deprivation stress and after immobilization stress did not show a specific effect, having a similar effect as the vehicle with added vitamins, taurine and caffeine. The administration of NTDs after freezing due to electric shock stress showed a specific effect which was not seen in other control groups, water, vehicle (ethanol) and vehicle including vitamins, taurine and caffeine and so resemble the specific effect of NTDs in the stress of forced walking. The present results indicate that the NTDs produced an anti-fatigue effect on the decreased locomotor activity after forced walking and immobility induced by electric stimulation. However, the crude drugs were not effective in improving immobility after sleep deprivation or immobilization stress. (C) 2003 Elsevier Science Ltd. All rights reserved.

Web of Science ® 被引用回数 : 11

リンク情報
DOI
https://doi.org/10.1016/S1043-6618(02)00318-3
Web of Science
https://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcAuth=JSTA_CEL&SrcApp=J_Gate_JST&DestLinkType=FullRecord&KeyUT=WOS:000181345200004&DestApp=WOS_CPL

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