論文

査読有り
2003年1月

Elevation of histidine decarboxylase activity in the stomach of mice by ulcerogenic drugs

EUROPEAN JOURNAL OF PHARMACOLOGY
  • K Ayada
  • ,
  • S Oguri
  • ,
  • K Yamaguchi
  • ,
  • K Kumagai
  • ,
  • Y Endo

460
1
開始ページ
63
終了ページ
69
記述言語
英語
掲載種別
研究論文(学術雑誌)
DOI
10.1016/S0014-2999(02)02878-9
出版者・発行元
ELSEVIER SCIENCE BV

Histamine is involved in the development of gastric lesions. To examine the contribution of the histamine-forming enzyme, histidine decarboxylase, to drug-induced gastric lesions, we compared the effects of aspirin, indomethacin and dexamethasone on histidine decarboxylase activity in mice. Administration of these drugs, orally or intraperitoneally, elevated histidine decarboxylase activity in the stomach but not in the liver, lung or spleen, dexamethasone being the most potent. In contrast, acetaminophen (a non-ulcerogenic drug) was inactive. These results and our previously reported findings (elevation of histidine decarboxylase activity by lipopolysaccharide, interleukin-1 and tumour necrosis factor, and by different types of stress) suggest that an elevation of histidine decarboxylase activity in the stomach may be a common feature of the responses to ulcerogenic stimuli. The possible participation of histidine decarboxylase in gastric lesions is discussed on the basis of the known actions of histamine, our findings and the effect of histamine H, receptor antagonists on histidine decarboxylase activity. (C) 2002 Elsevier Science B.V. All rights reserved.

Web of Science ® 被引用回数 : 8

リンク情報
DOI
https://doi.org/10.1016/S0014-2999(02)02878-9
Web of Science
https://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcAuth=JSTA_CEL&SrcApp=J_Gate_JST&DestLinkType=FullRecord&KeyUT=WOS:000180963500009&DestApp=WOS_CPL

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