Itaru Mizoguchi

Neutrophil extracellular traps inhibit osteoclastogenesis.

Kento Numazaki, Hiroyuki Tada, Takashi Nishioka, Eiji Nemoto, Kenji Matsushita, Itaru Mizoguchi, Shunji Sugawara

Biochemical and biophysical research communications, 705 149743-149743, Feb 29, 2024
The Effect of Electroless Nickel–Polytetrafluoroethylene Coating on the Frictional Properties of Orthodontic Wires

Kento Numazaki, Masatoshi Takahashi, Arata Ito, Yukyo Takada, Itaru Mizoguchi

Metals, 14(2), Feb, 2024
Distribution of alpha‐synuclein in rat salivary glands

Tomiko Nishitani, Yoshihiro Mitoh, Takehiro Yajima, Daisuke Tachiya, Tomohiro Hoshika, Tomohiro Fukunaga, Yoshihiro Nishitani, Ryusuke Yoshida, Itaru Mizoguchi, Hiroyuki Ichikawa …

The Anatomical Record, Jan 29, 2024
Generating Bone Marrow Chimeric Mouse Using GPR120 Deficient Mouse for the Study of DHA Inhibitory Effect on Osteoclast Formation and Bone Resorption.

Jinghan Ma, Hideki Kitaura, Fumitoshi Ohori, Takahiro Noguchi, Aseel Marahleh, Ria Kinjo, Kayoko Kanou, Jiayi Ren, Mariko Miura, Kohei Narita …

International journal of molecular sciences, 24(23), Nov 30, 2023
Effect of age on orthodontic tooth movement in mice

Kayoko Kanou, Hideki Kitaura, Takahiro Noguchi, Fumitoshi Ohori, Aseel Marahleh, Ria Kinjo, Jinghan Ma, Jiayi Ren, Kouetsu Ogasawara, Itaru Mizoguchi

Journal of Dental Sciences, Sep, 2023 Peer-reviewed
The role of TRPV2 as a regulator on the osteoclast differentiation during orthodontic tooth movement in rats

Shohei Shigemi, Tadasu Sato, Mayuri Sakamoto, Takehiro Yajima, Takahiro Honda, Hiroka Tsumaki, Toru Deguchi, Hiroyuki Ichikawa, Tomohiro Fukunaga, Itaru Mizoguchi

Scientific Reports, 13(1), Aug 22, 2023
Combined surgical-orthodontic and prosthetic treatment of a partially edentulous patient with skeletal Class III malocclusion

Kento Numazaki, Masahiro Seiryu, Kensuke Yamauchi, Nobuhiro Yoda, Arata Ito, Itaru Mizoguchi

Clinical and Investigative Orthodontics, Jul 19, 2023 Peer-reviewed
Three-dimensional morphologic analysis of the maxillary alveolar bone after anterior tooth retraction with temporary anchorage devices

Arata Ito, Atsushi Mayama, Toshihito Oyanagi, Hiroki Ogura, Masahiro Seiryu, Tomohiro Fukunaga, Hideki Kitaura, Itaru Mizoguchi

The Angle Orthodontist, 93(6) 667-674, Jul 17, 2023
Fermented Rice Bran Supplementation Inhibits LPS-Induced Osteoclast Formation and Bone Resorption in Mice.

Takahiro Noguchi, Hideki Kitaura, Aseel Marahleh, Afifah Zahra Agista, Yusuke Ohsaki, Hitoshi Shirakawa, Itaru Mizoguchi

Nutrients, 15(13), Jul 5, 2023
RNA-seq解析下顎頭軟骨細胞における機械的刺激とエストロゲンの関連性

土田仁, 中尾友也, 溝口到

日本顎関節学会雑誌, 35(Suppl.) 110-110, Jul, 2023
IL-33 induces histidine decarboxylase, especially in c-kit+ cells and mast cells, and roles of histamine include negative regulation of IL-33-induced eosinophilia

Kanan Bando, Yukinori Tanaka, Saka Winias, Shunji Sugawara, Itaru Mizoguchi, Yasuo Endo

Inflammation Research, Feb 1, 2023
Azilsartan inhibits inflammation-triggered bone resorption and osteoclastogenesis in vivo via suppression of TNF-α expression in macrophages.

Ziqiu Fan, Hideki Kitaura, Jiayi Ren, Fumitoshi Ohori, Takahiro Noguchi, Aseel Marahleh, Jinghan Ma, Kayoko Kanou, Mariko Miura, Kohei Narita …

Frontiers in endocrinology, 14 1207502-1207502, 2023
The osteocyte and its osteoclastogenic potential.

Aseel Marahleh, Hideki Kitaura, Fumitoshi Ohori, Takahiro Noguchi, Itaru Mizoguchi

Frontiers in endocrinology, 14 1121727-1121727, 2023
Histamine acts via H4-receptor stimulation to cause augmented inflammation when lipopolysaccharide is co-administered with a nitrogen-containing bisphosphonate.

Kanan Bando, Yukinori Tanaka, Tetsu Takahashi, Shunji Sugawara, Itaru Mizoguchi, Yasuo Endo

Inflammation research : official journal of the European Histamine Research Society ... [et al.], 71(12) 1603-1617, Dec, 2022
下顎頭軟骨細胞における機械的負荷とエストロゲンの関連性網羅的遺伝子発現解析

土田仁, 中尾友也, 佐藤宏賢, 溝口到, 飯嶋雅弘

日本矯正歯科学会大会プログラム・抄録集, 81回 201-201, Oct, 2022
Analysis of Coating Loss from Coated Stainless Steel Orthodontic Wire

Arata Ito, Hideki Kitaura, Takahiro Noguchi, Fumitoshi Ohori, Itaru Mizoguchi

APPLIED SCIENCES-BASEL, 12(19), Oct, 2022
Titanium nanotopography induces osteocyte lacunar-canalicular networks to strengthen osseointegration.

Xindie He, Masahiro Yamada, Jun Watanabe, Watcharaphol Tiskratok, Minoru Ishibashi, Hideki Kitaura, Itaru Mizoguchi, Hiroshi Egusa

Acta biomaterialia, 151 613-627, Oct 1, 2022
成長期ラット下顎頭軟骨細胞に対する荷重負荷とエストロゲンが及ぼす影響次世代シークエンスによる網羅的解析

土田仁, 中尾友也, 溝口到

日本顎関節学会雑誌, 34(Suppl.) 131-131, Jul, 2022
Immediate Tooth Autotransplantation with Root Canal Filling and Partially Demineralized Dentin/Cementum Matrix into Congenital Missing Tooth Region.

Masaru Murata, Yasuhiro Nakanishi, Kaoru Kusano, Yukito Hirose, Junichi Tazaki, Toshiyuki Akazawa, Itaru Mizoguchi

Journal of functional biomaterials, 13(2), Jun 16, 2022
Salt-Sensitive Hypertension Induces Osteoclastogenesis and Bone Resorption via Upregulation of Angiotensin II Type 1 Receptor Expression in Osteoblasts

Adya Pramusita, Hideki Kitaura, Fumitoshi Ohori, Takahiro Noguchi, Aseel Marahleh, Yasuhiko Nara, Ria Kinjo, Jinghan Ma, Kayoko Kanou, Yukinori Tanaka …

Frontiers in Cell and Developmental Biology, 10, Apr 4, 2022

Misc.

167

Loeys-Dietz症候群における口腔顎顔面領域の形態学的特徴

沼崎研人, 佐々木聡史, 溝口到

東北大学歯学雑誌, 39/40/41(2/1-2/1) 50-50, Jun, 2022
Investigation of the Effect of Anti-c-fms Antibody on Osteoclast formation in Ovariectomized Mice

Yasuhiko Nara, Hideki Kitaura, Saika Ogawa, Wei-Ren Shen, Jiawei Qi, Fumitoshi Ohori, Takahiro Noguchi, Aseel Marahleh, Adya Pramusita, Ria Kinjo …

JOURNAL OF BONE AND MINERAL RESEARCH, 37 124-124, Feb, 2022
Salt-Sensitive Hypertension Induces Systemic Bone Resorption Via Upregulation of Angiotensin II Type 1 Receptor in Osteoblast

Adya Pramusita, Hideki Kitaura, Saika Ogawa, Fumitoshi Ohori, Takahiro Noguchi, Aseel Marahleh, Yasuhiko Nara, Ria Kinjo, Itaru Mizoguchi

JOURNAL OF BONE AND MINERAL RESEARCH, 37 95-95, Feb, 2022
東北大学病院矯正歯科における先天疾患症例について

佐々木聡史, 北浦英樹, 溝口到

東北矯正歯科学会雑誌, 29(1) 61-62, Dec, 2021
上顎骨前方牽引装置を用いて骨格的改善を行った軟骨無形成症を伴う骨格性III級症例

野口隆弘, 北浦英樹, 溝口到

東北矯正歯科学会雑誌, 29(1) 78-79, Dec, 2021
Loeys-Dietz症候群における口腔顎顔面領域の形態学的特徴

沼崎研人, 佐々木聡史, 溝口到

日本矯正歯科学会大会プログラム・抄録集, 80回 221-221, Nov, 2021
歯科矯正用アンカースクリューを用いた前歯牽引に伴う歯槽骨の形態変化の解析

伊藤新, 真山敦, 大柳俊仁, 小倉裕樹, 清流正弘, 溝口到

日本矯正歯科学会大会プログラム・抄録集, 80回 183-183, Nov, 2021
矯正学的歯の移動における骨細胞のネクロプトーシスの検出

大堀文俊, 北浦英樹, 小川紗衣香, 野口隆弘, マラーレ・アジール, 奈良靖彦, アディア・プラムスィタ, 金城里阿, 加納佳与子, 溝口到

日本矯正歯科学会大会プログラム・抄録集, 80回 146-146, Nov, 2021
マイクロオステオパーフォレーションによる矯正学的歯の移動促進におけるTNF-αの役割

金城里阿, 北浦英樹, 小川紗衣香, 大堀文俊, 野口隆弘, アジール・マラーレ, 奈良靖彦, アディア・プラムスィタ, 溝口到

日本矯正歯科学会大会プログラム・抄録集, 80回 147-147, Nov, 2021
矯正学的歯の移動時に出現する骨芽細胞はGli1陽性歯根膜細胞に由来する

関有里, 建部廣明, 北浦英樹, 飯嶋雅弘, 溝口到, 細矢明宏

日本矯正歯科学会大会プログラム・抄録集, 80回 151-151, Nov, 2021
卵巣摘出マウスにおける矯正学的歯の移動と歯根吸収について

奈良靖彦, 北浦英樹, 小川紗衣香, 大堀文俊, 野口隆弘, マラーレ・アジール, アディア・プラムスィタ, 金城里阿, マー・ジンハン, 加納佳与子 …

日本矯正歯科学会大会プログラム・抄録集, 80回 152-152, Nov, 2021
Marfan症候群を有する患者に対し全身状態のモニタリングのもとで矯正歯科治療を行った一症例

佐々木聡史, 北浦英樹, 溝口到

日本矯正歯科学会大会プログラム・抄録集, 80回 223-223, Nov, 2021
開咬症例における歯科矯正用アンカースクリューを用いた矯正治療と外科的矯正治療の後戻りの比較

小倉裕樹, 北浦英樹, 大柳俊仁, 清流正弘, 真山敦, 伊藤新, 溝口到

日本矯正歯科学会大会プログラム・抄録集, 80回 185-185, Nov, 2021
Non-extraction crowding case treated with miniscrew implants (MI).

岡山三紀, 溝口到, 飯嶋雅弘

北海道医療大学歯学雑誌, 40(1), 2021
東北大学病院矯正歯科における10年間の先天性疾患症例の実態調査

佐々木聡史, 北浦英樹, 前田敏博, 小川紗衣香, 小倉裕樹, 亀田真衣, 金城里阿, 茂見翔平, 沼崎研人, 溝口到

東北矯正歯科学会雑誌, 28(1) 57-58, Dec, 2020
Investigation of the Molecular Mechanism of TNF-alpha-Induced RANK on Osteoclast Precursors in Orthodontic Tooth Movement

Takahiro Noguchi, Hideki Kitaura, Saika Ogawa, Fumitoshi Ohori, Aseel Marahleh, Yasuhiko Nara, Adya Pramusita, Ria Kinjo, Itaru Mizoguchi

JOURNAL OF BONE AND MINERAL RESEARCH, 35 93-93, Nov, 2020
Investigation of Effect of IL-33 on TNF-alpha-Induced Osteoclast Formation and Orthodontic Tooth Movement

Fumitoshi Ohori, Hideki Kitaura, Saika Ogawa, Takahiro Noguchi, Aseel Marahleh, Yasuhiko Nara, Adya Pramusita, Ria Kinjo, Itaru Mizoguchi

JOURNAL OF BONE AND MINERAL RESEARCH, 35 94-94, Nov, 2020
Treatment of Lip Protrusion and Occlusal Plane Cant using Orthodontic Anchor Screw in the Case of Skeletal Class I with Achondroplasia

木村晴地, 清流正弘, 溝口到

東北矯正歯科学会雑誌, 28(1), 2020
TNF-alpha Directly Enhances Osteocyte RANKL Expression and Promotes Osteoclast Formation

Aseel Marahleh, Hideki Kitaura, Fumitoshi Ohori, Akiko Kishikawa, Saika Ogawa, Wei-Ren Shen, Jiawei Qi, Takahiro Noguchi, Yasuhiko Nara, Itaru Mizoguchi

JOURNAL OF BONE AND MINERAL RESEARCH, 34 238-238, Dec, 2019
TNF-alpha stimulates the expression of RANK during orthodontic tooth movement

Takahiro Noguchi, Hideki Kitaura, Akiko Kishikawa, Saika Ogawa, Jiawei Qi, Wei-Ren Shen, Fumitoshi Ohori, Aseel Marahleh, Yasuhiko Nara, Itaru Mizoguchi

JOURNAL OF BONE AND MINERAL RESEARCH, 34 236-236, Dec, 2019

Books and Other Publications

Oral Histology and Embryology

MIZOGUCHI Itaru (Role: Contributor)

Feb, 2015
顎変形症の術前歯科矯正治療のすすめ方

溝口到 (Role: Contributor, 上顎臨床例ープレシジョンリンガルアーチー、トランスパラタルアーチ)

ヒョーロン・パブリッシャーズ, Jun, 2012
歯科矯正学第５版

溝口到 (Role: Contributor, 矯正力と生体反応)

医歯薬出版, Mar, 2011
最新歯科衛生士教本歯科矯正

溝口到 (Role: Contributor, 矯正歯科診断、顎変形症)

医歯薬出版, Feb, 2011
Mandibular helical axis during opening and closing movement. In silico Dentistry

MEDGIT, 2008
Three-dimensional (3-D) simulation of orthognathic surgery using a multimodal image-fusion technique. In silico Dentistry –the evolution of computational oral health science-

MEDIGIT, 2008
歯の移動の臨床バイオメカニクス

(Role: Joint editor, 臨床：歯根吸収の危険因子)

医歯薬出版, May, 2006
改訂版新しい歯科矯正学

溝口到 (Role: Contributor, 不正咬合の原因)

永末書店, 2006
イラストレイテッド・クリニカルデンティストリー第４巻小児歯科疾患・口腔病変・不正咬合

溝口到 (Role: Contributor, 不正咬合の原因、顎外固定装置)

医歯薬出版, 2002

Presentations

上顎片側遊離端欠損および下顎中間欠損を有する骨格性反対咬合患者に顎矯正手術を施行した1例

沼崎研人, 清流正弘, 山内健介, 依田信裕, 真山敦, 大柳俊仁, 小倉裕樹, 溝口到

日本顎変形症学会雑誌, May, 2022, (NPO)日本顎変形症学会
下顎関節突起切除術を併用し矯正歯科治療を行った片側性下顎関節突起過形成を伴う顔面非対称症例

岸川明子, 福永智広, 清流正弘, 茂見翔平, 溝口到

東北矯正歯科学会雑誌, Dec, 2021, 東北矯正歯科学会
先端巨大症患者の顎顔面頭蓋の形態的特徴に関するセファロ分析による研究

田中篤史, 飯久保正弘, 小嶋郁穂, 熊坂晃, 阪本真弥, 佐々木紀代, 福永智広, 溝口到

日本歯科放射線学会第1回秋季学術大会, Oct 31, 2020
Diabetes medicine DPP-4 inhibitor inhibits orthodontic tooth movement and associated root resorption in mouse tooth movement model

Noguchi T, Kitaura H, Qi J, Ogawa S, Ohori F, Marahleh A, Nara Y, Pramusita A, Kinjo R, Mizoguchi I

Oct 4, 2020
Facial asymmetry and unilateral condylar hyperplasia treated with ipsilateral condylectomy and orthodontic treatment

Kishikawa A, Fukunaga T, Nogami S, Seiryu M, Shigemi S, Kumamoto H, Takahashi T, Mizoguchi I

Oct 4, 2020
3D cast analysis of 10 years retention case treated with miniscrews for distalization of maxillary molar

Irie D, Oyanagi T, Ito-Okubo M, Mayama A, Seiryu M, Mizoguchi I

The 9th International Orthodontic Congress, Yokohama, Japan, Oct 4, 2020
Three-dimensional evaluation of temporomandibular joint cavity in three cases with severe skeletal asymmetry and occlusal cant

OyanagiT, Maeda T, Yoshizawa M, Kimura S, Mayama A, Seiryu M, Mizoguchi I

The 9th International Orthodontic Congress, Yokohama, Japan, Oct 4, 2020
Five-year clinical investigation of orthodontic anchor screws used for surgical orthodontic treatment

Sasaki S, Mayama A, Oyanagi T, Ito A, Ogura H, Seiryu M, Mizoguchi I

The 9th International Orthodontic Congress, Yokohama, Japan, Oct 4, 2020
3D evaluation of changes in the alveolar bone due to upper anterior teeth retraction with orthodontic anchor screws: A retrospective radiometric study

Ito A, Mayama A, Oyanagi T, Sasaki S, Ogura H, Seiryu M, Mizoguchi I

The 9th International Orthodontic Congress, Yokohama, Japan, Oct 4, 2020
TNF-α induces orthodontic tooth movement and enhances osteocyte RANKL expression by activating MAPKs and NFκB pathway

Marahleh A, Kitaura H, Ohori F, Ogawa S, Noguchi T, Nara Y, Pramusita A, Kinjo R, Mizoguchi I

The 9th International Orthodontic Congress, Yokohama, Japan, Oct 4, 2020
Solt-sensitive hypertension exacerbates osteoclastogenesis and bone resorption in vivo

Pramusita A, Kitaura H, Ogawa S, Ohori F, Noguchi T, Marahleh A, Nara Y, Kinjo R, Mizoguchi I

The 9th International Orthodontic Congress, Yokohama, Japan, Oct 4, 2020
Micro-osteoperforations induce TNF-α expression and accelerate orthodontic tooth movement in mice

Kinjo R, Kitaura H, Ogawa S, Ohori F, Noguchi T, Marahleh A, Nara Y, Pramusita A, Mizoguchi I

The 9th International Orthodontic Congress, Yokohama, Japan, Oct 4, 2020
Craniofacial characteristics, malocclusions and successful orthodontic treatment results in 3 Diamond Blackfan Syndrome patients

Sasaki S, Kitaura H, Yoshida M, Mayama A, Mizoguchi I

The 9th International Orthodontic Congress, Yokohama, Japan, Oct 4, 2020
Statistical and clinical survey of congenital disease patients in the past 10-year period in Tohoku University Hospital Department of orthodontics

Sasaki S, Kitaura H, Maeda T, Ogawa S, Ogura H, Kameda M, Kinjo R, Shigemi S, Numazaki K, Mizoguchi I

The 9th International Orthodontic Congress, Yokohama, Japan, Oct 4, 2020
Role of TNF-α-responsible stromal clls to osteoclast and odontoclast formation during orthodontic tooth movement

Ogawa S, Kitaura H, Ohori F, Noguchi T, Marahleh A, Nara Y, Pramusita A, Mizoguchi I

The 9th International Orthodontic Congress, Yokohama, Japan, Oct 4, 2020
TNF-α stimulates the expression of RANK during orthodontic tooth movement

Noguchi T, Kitaura H, Ogawa S, Ohori F, Marahleh A, Nara Y, Pramusita A, Kinjo R, Mizoguchi I

The 9th International Orthodontic Congress, Yokohama, Japan, Oct 4, 2020
Diabetes Medicine Glucagon-Like Peptode-1 Receptor Agonist Inhibits Orthodontic Tooth Movement and Root Resorption

Ohori F, Kitaura H, Shen WR, Ogawa S, Noguchi T, Marahleh A, Nara Y, Pramusita A, Kinjo R, Mizoguchi I

The 9th International Orthodontic Congress, Yokohama, Japan, Oct 4, 2020
Inhibitory Effect of IL-33 on TNF-α-Induced Osteoclastogenesis and Orthodontic Tooth Movement

Ohori F, Kitaura H, Ogawa S, Noguchi T, Marahleh A, Nara Y, Pramusita A, Kinjo R, Mizoguchi I

The 9th International Orthodontic Congress, Yokohama, Japan, Oct 4, 2020
矯正学的歯の移動時におけるGli1陽性歯根膜細胞の分化能

関有里, 建部廣明, 北浦英樹, 飯嶋雅弘, 溝口到, 細矢明宏

第79回日本矯正歯科学会学術大会、横浜, Oct 4, 2020
Investigation of the Molecular Mechanism of TNF-α-Induced RANK on Osteoclast Precursors in Orthodontic Tooth Movement

Noguchi T, Kitaura H, Ogawa S, Ohori F, Marahleh A, Nara Y, Pramusita A, Kinjo R, Mizoguchi I

American Society for Bone and Mineral Research 2020 Annual Meeting. Seattle, U.S.A., Sep 11, 2020

Teaching Experience

Jun, 2018 - Present

Orthodontics (Tohoku University Graduate Schoool of Dentistry)
Sep, 1998 - May, 2018

歯科矯正学 (北海道医療大学歯学部)

Professional Memberships

Major Research Projects

Roles of extracellular matrices in TMJ disordres -response properties of TMJ disc to mechanical stress

Grants-in-Aid for Scientific Research Grant-in-Aid for Scientific Research (B), Grant-in-Aid for Scientific Research (B), Japan Society for the Promotion of Science, Apr, 2013 - Mar, 2017

Mizoguchi itaru
Evaluation of relationships between root resorption accompanied with orthodontic tooth movement and cell death of cementum-related cells

Grants-in-Aid for Scientific Research Grant-in-Aid for Scientific Research (B), Grant-in-Aid for Scientific Research (B), Japan Society for the Promotion of Science, 2008 - 2011

MIZOGUCHI Itaru, TAKUMA Taishin, TORIYA Naoko
Clarification of the Mechanisms that Causes Internal Derangement of the Temporomandibular Joint

Grants-in-Aid for Scientific Research Grant-in-Aid for Scientific Research (B), Grant-in-Aid for Scientific Research (B), Japan Society for the Promotion of Science, 2004 - 2007

MIZOGUCHI Itaru, TAKUMA Taishin, SASANO Yasuyuki, OKAYAMA Miki
Effects of food consistency on expression of extracellular matrices in the temporo-mandibular joints

Grants-in-Aid for Scientific Research Grant-in-Aid for Scientific Research (B), Grant-in-Aid for Scientific Research (B), Japan Society for the Promotion of Science, 2001 - 2003

MIZOGUCHI Itaru, SASANO Yasuyuki, TAKUMA Taishin, YAJIMA Shihiko, KASUNOKI Shinichiro
Reaction of intercellular network of osteocytes in alveolar bone during experimental tooth movement

Grants-in-Aid for Scientific Research (基盤研究(B), 基盤研究(B), Ministry of Education, Culture, Sports, Science and Technology, 1998 - 2000

Itaru MIZOGUCHI, 笹野泰之, 武内真利, 坂倉康則, 加賀山学, 矢嶋俊彦

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