清水透 (Toru Shimizu) - マイポータル

基本情報

所属: Charles University in Prague Visiting Professor
: Shantou University Medical College Visiting Professor
: 国立研究開発法人産業技術総合研究所東北センター外来研究員

学位: 理学博士(東北大学)

J-GLOBAL ID: 200901027788600325
researchmap会員ID: 1000005725

外部リンク: http://db.tohoku.ac.jp/whois/detail/ea1ef4b248c8b94cd805054c0eae90c4.html

東北大学を定年退職の後、チェコの大学、中国の大学、及び、産総研で研究。

研究キーワード

研究分野

経歴

2012年4月 - 現在

東北大学, 東北大学名誉教授
1994年4月 - 2012年3月

東北大学多元物質科学研究所有機・生命科学研究部門生体高分子化学研究分野, 教授
1988年 - 1994年

東北大学反応化学研究所助教授
1994年

- 東北大学多元物質科学研究所教授
1981年 - 1988年

東北大学非水溶液化学研究所助手
1978年 - 1981年

慶応義塾大学医学部生化学教室助手
1976年 - 1978年

A. Einstein 医科大学分子薬理教室博士研究員
1976年 - 1978年

Department of Molecular Pharmacology, Albert Einstein College of Medicine

学歴

受賞

1992年

日本化学会学術賞

論文

Signal transduction mechanisms in heme-based global-coupled oxygen sensors with a focus on a histidine kinase (AfGcHK) and a diguanylate cyclase (YddV or EcDosC)

Jakub Vabra, Autor Segunin, Petr Jerabek, Toru Shimizu, Marketa Martinkova

Biological Chemistry 2022年9月査読有り
Disruption of the dimerization interface of the sensing domain in the dimeric heme-based oxygen sensor AfGcHK abolishes bacterial signal transduction

Toru Shimizu

Journal of Biological Chemistry 2020年2月7日査読有り
Heme: emergent roles of heme in signal transduction, functional regulation and as catalytic centres

Toru Shimizu, Alzbeta Lengalova, Václav Martínek, Markéta Martínková

Chemical Society Reviews 2019年
Coordination and redox state-dependent structural changes of the heme-based oxygen sensor AfGcHK associated with intraprotein signal transduction

Martin Stranava, Petr Man, Tereza Skalova, Petr Kolenko, Jan Blaha, Veronika Fojtikova, Vaclav Martinek, Jan Dohnalek, Alzbeta Lengalova, Michal Rosulek …

JOURNAL OF BIOLOGICAL CHEMISTRY 292(51) 20921-20935 2017年12月査読有り
Structural characterization of the heme-based oxygen sensor, AfGcHK, its interactions with the cognate response regulator, and their combined mechanism of action in a bacterial two-component signaling system

Martin Stranava, Vaclav Martinek, Petr Man, Veronika Fojtikova, Daniel Kavan, Ondrej Vanek, Toru Shimizu, Marketa Martinkova

PROTEINS-STRUCTURE FUNCTION AND BIOINFORMATICS 84(10) 1375-1389 2016年10月査読有り
Effects of hydrogen sulfide on the heme coordination structure and catalytic activity of the globin-coupled oxygen sensor AfGcHK

Veronika Fojtikova, Martina Bartosova, Petr Man, Martin Stranava, Toru Shimizu, Marketa Martinkova

BIOMETALS 29(4) 715-729 2016年8月査読有り
Ultrafast Spectroscopy Evidence for Picosecond Ligand Exchange at the Binding Site of a Herne Protein: Heme-Based Sensor YddV

Jean-Christophe Lambry, Martin Stranava, Laura Lobato, Marketa Martinkova, Toru Shimizu, Ursula Liebl, Marten H. Vos

JOURNAL OF PHYSICAL CHEMISTRY LETTERS 7(1) 69-74 2016年1月査読有り
Catalytic enhancement of the heme-based oxygen-sensing phosphodiesterase EcDOS by hydrogen sulfide is caused by changes in heme coordination structure

Fang Yan, Veronika Fojtikova, Petr Man, Martin Stranava, Marketa Martinkova, Yongming Du, Dongyang Huang, Toru Shimizu

BIOMETALS 28(4) 637-652 2015年8月査読有り
Kinetic Analysis of a Globin-Coupled Histidine Kinase, AfGcHK: Effects of the Heme Iron Complex, Response Regulator, and Metal Cations on Autophosphorylation Activity.

Fojtikova V, Stranava M, Vos MH, Liebl U, Hranicek J, Kitanishi K, Shimizu T, Martinkova M

Biochemistry 54(32) 5017-5029 2015年8月査読有り
Gaseous O2, NO, and CO in Signal Transduction: Structure and Function Relationships of Heme-based Gas Sensors and Heme Redox Sensors

Toru Shimizu

Chemical Reviews 115 6491-6533 2015年査読有り筆頭著者責任著者
Probing the ligand recognition and discrimination environment of the globin-coupled oxygen sensor protein YddV by FTIR and time-resolved step-scan FTIR spectroscopy

Andrea Pavlou, Marketa Martinkova, Toru Shimizu, Kenichi Kitanishi, Martin Stranava, Andreas Loullis, Eftychia Pinakoulaki

PHYSICAL CHEMISTRY CHEMICAL PHYSICS 17(26) 17007-17015 2015年査読有り
Pressure effects reveal that changes in the redox states of the heme iron complexes in the sensor domains of two heme-based oxygen sensor proteins, EcDOS and YddV, have profound effects on their flexibility

Pavel Anzenbacher, Stephane Marchal, Jan Palacky, Eva Anzenbacherova, Thomas Domaschke, Reinhard Lange, Toru Shimizu, Kenichi Kitanishi, Martin Stranava, Marie Stiborova …

FEBS JOURNAL 281(23) 5208-5219 2014年12月査読有り
Introduction of water into the heme distal side by Leu65 mutations of an oxygen sensor, YddV, generates verdoheme and carbon monoxide, exerting the heme oxygenase reaction

Martin Stranava, Marketa Martinkova, Marie Stiborova, Petr Man, Kenichi Kitanishi, Lucie Muchova, Libor Vitek, Vaclav Martinek, Toru Shimizu

JOURNAL OF INORGANIC BIOCHEMISTRY 140 29-38 2014年11月査読有り
Conversion of a heme-based oxygen sensor to a heme oxygenase by hydrogen sulfide: effects of mutations in the heme distal side of a heme-based oxygen sensor phosphodiesterase (Ec DOS)

Yongming Du, Gefei Liu, Yinxia Yan, Dongyang Huang, Wenhong Luo, Marketa Martinkova, Petr Man, Toru Shimizu

BIOMETALS 26(5) 839-852 2013年10月査読有り
Heme-based Globin-coupled Oxygen Sensors: Linking Oxygen Binding to Functional Regulation of Diguanylate Cyclase, Histidine Kinase, and Methyl-accepting Chemotaxis

Marketa Martinkova, Kenichi Kitanishi, Toru Shimizu

JOURNAL OF BIOLOGICAL CHEMISTRY 288(39) 27702-27711 2013年9月査読有り
Revisit of the interactions between hydrogen sulfide and heme proteins

Toru Shimizu

Current Chemical Biology 7(2) 207-212 2013年査読有り
The heme-based oxygen-sensor phosphodiesterase Ec DOS (DosP): Structure-function relationships

Toru Shimizu

Biosensors 3(2) 211-237 2013年査読有り
Hydrogen sulfide stimulates the catalytic activity of a heme-regulated phosphodiesterase from Escherichia coli (Ec DOS)

Hiroto Takahashi, Madoka Sekimoto, Masahiro Tanaka, Atsunari Tanaka, Jotaro Igarashi, Toru Shimizu

JOURNAL OF INORGANIC BIOCHEMISTRY 109 66-71 2012年4月査読有り
Heme binding characteristics of mouse per1, a transcriptional regulatory factor associated with circadian rhythms

Ryoko Nagata, Mami Harada, Kenichi Kitanishi, Jotaro Igarashi, Takeshi Uchida, Koichiro Ishimori, Toru Shimizu

Circadian Rhythms: Biology, Cognition and Disorders 133-160 2012年3月
Leu65 in the heme distal side is critical for the stability of the Fe(II)-O₂ complex of YddV, a globin-coupled oxygen sensor diguanylate cyclase

Nakajima, K, Kitanishi, K, Kobayashi, K, Kobayashi, N, Igarashi, J, Shimizu, T

J. Inorg. Biochem. 108 163-170 2012年3月査読有り

もっとみる

MISC

235

The role of heme as an important mediator of biochemical processes

V. Fojtikova, M. Stranava, A. Lengalova, T. Shimizu, M. Martinkova

FEBS JOURNAL 284 379-379 2017年9月
Gaseous O2, NO, and CO in Signal Transduction: Structure and Function Relationships of Heme-Based Gas Sensors and Heme-Redox Sensors

Toru Shimizu, Dongyang Huang, Fang Yan, Martin Stranava, Martina Bartosova, Veronika Fojtikova, Marketa Martinkova

CHEMICAL REVIEWS 115(13) 6491-6533 2015年7月査読有り筆頭著者責任著者
Phosphorylation of a Heme-regulated Eukaryotic Initiation Factor 2α Kinase Enhances the Interaction with Heat shock Protein 90 and Substantially Upregulates Kinase Activity

Kentaro Mukai, Toru Shimizu, Jotaro Igarashi

Proteins & Peptide Letters 18(12) 1251-1257 2011年12月
Identification and Functional and Spectral Characterization of a Globin-coupled Histidine Kinase from Anaeromyxobacter sp Fw109-5

Kenichi Kitanishi, Kazuo Kobayashi, Takeshi Uchida, Koichiro Ishimori, Jotaro Igarashi, Toru Shimizu

JOURNAL OF BIOLOGICAL CHEMISTRY 286(41) 35522-35534 2011年10月
Structural Dynamics of EcDOS Heme Domain Revealed by Time-Resolved Ultraviolet Resonance Raman Spectroscopy

Samir F. El-Mashtoly, Minoru Kubo, Satoru Nakashima, Toru Shimizu, Teizo Kitagawa

JOURNAL OF PHYSICAL CHEMISTRY LETTERS 2(17) 2212-2217 2011年9月
Autophophorylation of heme-regulated eukaryotic initiation factor 2α kinase and the role of the modification in catalysis

Jotaro Igarashi, Takehiko Sasaki, Noriko Kobayashi, Shinji Yoshioka, Miyuki Matsushita, Toru Shimizu

FEBS Journal 278(6) 918-928 2011年4月
Heme-binding characteristics of the isolated PAS-B domain of mouse Per2, a transcriptional regulatory factor associated with circadian rhythms

Koya Hayasaka, Kenichi Kitanishi, Jotaro Igarashi, Toru Shimizu

BIOCHIMICA ET BIOPHYSICA ACTA-PROTEINS AND PROTEOMICS 1814(2) 326-333 2011年2月
Emerging Roles of Heme as a Signal and a Gas-Sensing Site: Heme-Sensing and Gas-Sensing Proteins

Igarashi, Jotaro, Kitanishi, Kenichi, Shimizu, Toru, Kadish, KM, Smith, KM, Guilard, R

Handbook of Porphyrin Science With Applications To Chemistry, Physics, Materials Science, Engineering, Biology and Medicine, Vol 15: Biochemistry of Tetrapyrroles 15 2011年
Emerging Roles of Heme as a Signal and a Gas-Sensing Site: Heme-Sensing and Gas-Sensing Proteins

IGARASHI Jotaro, SHIMIZU Toru

Handbook of Porphyrin Science 15(73) 399-460 2011年査読有り
Heme-binding characteristics of the isolated PAS-B domain of mouse Per2, a transcriptional regulatory factor associated with circadian rhythms

Koya Hayasaka, Kenichi Kitanishi, Jotaro Igarashi, Toru Shimizu

Biochimica et Biophysica Acta 1814(2) 326-333 2011年
Autophophorylation of heme-regulated eukaryotic initiation factor 2α kinase and the role of the modification in catalysis

Jotaro Igarashi, Takehiko Sasaki, Noriko Kobayashi, Shinji Yoshioka, Miyuki Matsushita, Toru Shimizu

FEBS Journal 278(6) 918-928 2011年
Structural Dynamics of EcDOS Heme Domain Revealed by Time-Resolved Ultraviolet Resonance Raman Spectroscopy

Samir F. El-Mashtoly, Minoru Kubo, Satoru Nakashima, Toru Shimizu, Teizo Kitagawa

The Journal of Physical Chemistry Letters 2 2212-2217 2011年
Identification and Functional and Spectral Characterization of a Globin-coupled Histidine Kinase from Anaeromyxobactoer sp. Fw109-5

Kenichi Kitanishi, Kazuo Kobayashi, Takeshi Uchida, Koichiro Ishimori, Jotaro Igarashi, Toru Shimizu

Journal of Biological Chemistry 286(41) 35522-35534 2011年
Phosphorylation of a Heme-regulated Eukaryotic Initiation Factor 2α Kinase Enhances the Interaction with Heat shock Protein 90 and Substantially Upregulates Kinase Activity

Kentaro Mukai, Toru Shimizu, Jotaro Igarashi

Proteins & Peptide Letters 18(12) 1251-1257 2011年
Important Roles of Tyr43 at the Putative Heme Distal Side in the Oxygen Recognition and Stability of the Fe(II)-O-2 Complex of YddV, a Globin-Coupled Heme-Based Oxygen Sensor Diguanylate Cyclase

Kenichi Kitanishi, Kazuo Kobayashi, Yuriko Kawamura, Izumi Ishigami, Takashi Ogura, Kyosuke Nakajima, Jotaro Igarashi, Atsunari Tanaka, Toru Shimizu

BIOCHEMISTRY 49(49) 10381-10393 2010年12月
Catalysis and oxygen binding of Ec DOS: a haem-based oxygen-sensor enzyme from Escherichia coli

Kazuo Kobayashi, Atsunari Tanaka, Hiroto Takahashi, Jotaro Igarashi, Yukako Ishitsuka, Nao Yokota, Toru Shimizu

JOURNAL OF BIOCHEMISTRY 148(6) 693-703 2010年12月
NO-induced catalytic activation and heme-induced catalytic suppression of humen heme-regulated eukaryotic initiation factor 2α kinase, HRI, associated with lung cancer

Yasuna Nakamura, Ayano Yamamura, Jotaro Igarashi, Toru Shimizu

Nitric Oxide, Biology and Chemistry 22(Supplement) S46-S47 2010年6月
NO-induced catalytic activation of mouse heme-regualted eukaryotic initiation factor 2α kinase (HRI) is attributable to a five-coordinated NO-heme complex and SNO formation

Jotaro Igarashi, Takehiko Sasaki, Jun Iwashita, Toru Shimizu

Nitric Oxide, Biology and Chemistry 22(Supplement) S43-S43 2010年6月
NO-induced catalytic activation and heme-induced catalytic suppression of human heme-regulated eukaryotic initiation factor 2 alpha kinase, HRI, associated with lung cancer

Yasuna Nakamura, Ayano Yamamura, Jotaro Igarashi, Toru Shimizu

NITRIC OXIDE-BIOLOGY AND CHEMISTRY 22(Supplement) S46-S47 2010年6月
NO-induced catalytic activation of mouse heme-regulated eukaryotic initiation factor 2 alpha kinase (HRI) is attributable to a five-coordinated NO-heme complex and SNO formation

Jotaro Igarashi, Takehiko Sasaki, Jun Iwashita a, Toru Shimizu

NITRIC OXIDE-BIOLOGY AND CHEMISTRY 22(Supplement) S43-S43 2010年6月

もっとみる

書籍等出版物

酵素利用技術体系ー基礎・解析から改変・高機能化・産業利用までー

エヌ・ティー・エス 2010年
Handbook of Porphyrin Science

World Science 2010年
酵素利用技術体系ー基礎・解析から改変・高機能化・産業利用までー

エヌ・ティー・エス 2010年
Handbook of Porphyrin Science

World Science 2010年
P450の分子生物学第2版

講談社 2009年
P450の分子生物学第2版

講談社 2009年
P450の分子生物学

講談社サイエンティフィク 2003年
P450の分子生物学

講談社サイエンティフィク 2003年

講演・口頭発表等

NO activation of a heme-regulated kinase: A paradigm for PAS protein intereactions with NO?

Gordon Research Conference, Nitric Oxide 2005年
NO activation of a heme-regulated kinase: A paradigm for PAS protein intereactions with NO?

Gordon Research Conference, Nitric Oxide 2005年
Structure and Function Relationships of a Heme-regulated Phosphodiesterase from Escherichia coli (Ec DOS)

The 1st Pacific-Rim International Conference on Protein Science, Japan 2004年
Molecular mechanisms for the regulation of NO formation in neuronal nitric-oxide synthase

The 3rd International Conference on the Biology, Chemistry and Therapeutic Applications of Nitric Oxide 2004年
Structure and Function Relationships of Heme-regulated Enzymes

3rd Symposium on Advances in Bioinorganic Chemistry and 2nd Asian Biological Inorganic Chemistry Conference 2004年
Structure and Function Relationships of a Heme-regulated Phosphodiesterase from Escherichia coli (Ec DOS)

The 1st Pacific-Rim International Conference on Protein Science, Japan 2004年
Molecular mechanisms for the regulation of NO formation in neuronal nitric-oxide synthase

The 3rd International Conference on the Biology, Chemistry and Therapeutic Applications of Nitric Oxide 2004年
Structure and Function Relationships of Heme-regulated Enzymes

3rd Symposium on Advances in Bioinorganic Chemistry and 2nd Asian Biological Inorganic Chemistry Conference 2004年

所属学協会

Works(作品等)

イギリス生化学会誌 Biochemical Journal 編集委員

2005年
Editorial Advisory Panel for Biochemical Journal

2005年
NO合成酵素の活性発現におけるプテリンの役割

2001年 - 2004年
NO合成酵素の活性発現におけるプテリンの役割

2001年 - 2004年
アメリカ生化学・分子生物学会誌編集委員

2001年
Editorial Board for Journal of Biological Chemistry

2001年

共同研究・競争的資金等の研究課題

人工変異により高度に活性化されたP450導入酵母による毒物特異的分子変換システム

日本学術振興会科学研究費助成事業基盤研究(B) 基盤研究(B) 1997年 - 2000年

清水透, ダフサイモン, 佐藤秀明, 佐上郁子, 松井敏高
金属酵素の構造ー機能相関関係

科学研究費補助金 1976年 - 1976年
Structure and function relationships of metallo enzymes

Grant-in-Aid for Scientific Research 1976年 - 1976年