2004年9月
Protective effect of (+)-catechin against 5-fluorouracil-induced myelosuppression in mice
TOXICOLOGY
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- 巻
- 201
- 号
- 1-3
- 開始ページ
- 133
- 終了ページ
- 142
- 記述言語
- 英語
- 掲載種別
- DOI
- 10.1016/j.tox.2004.04.009
- 出版者・発行元
- ELSEVIER IRELAND LTD
The object of this study was to investigate the efficacy of (+)-catechin, which was isolated from Actinidia arguta Planch (Actinidiaceae), as a bone marrow cell proliferation-promoting compound against the hematotoxicity of 5-fluorouracil (5-FU) in mice. Intraperitoneally injected (+)-catechin (1 and 10 mg/kg per day) accelerated the recovery of the number of white blood cells (WBC) and platelets (PLT) but did not affect the number of circulating red blood cells (RBC). (+)-Catechin also augmented the number of myelocytes and splenocytes. Dual color flow cytometric analysis revealed that (+)-catechin reversed the reduction of the population of leukocytes (CD11b(+) monocytes, Gr-1(+) granulocytes and CD3(+) T and CD45RA(+) B lymphocytes) in whole blood, spleen and bone marrow caused by 5-FU. (+)-Catechin (I and 10 mg/kg per day) showed remarkable recovery of Gr-1(+) cells in all three types of tissues and of CD11b(+) cells in the bone marrow cells. These findings suggest that (+)-catechin selectively enhances the recovery of the population of granulocytes reduced by 5-FU in mice. (C) 2004 Elsevier Ireland Ltd. All rights reserved.
- リンク情報
- ID情報
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- DOI : 10.1016/j.tox.2004.04.009
- ISSN : 0300-483X
- Web of Science ID : WOS:000224015700015