古川賢一 (Ken'ichi Furukawa) - マイポータル

基本情報

所属: 弘前大学医学研究科客員研究員

学位: 理学博士(大阪大学)

J-GLOBAL ID: 200901066166017393
researchmap会員ID: 1000005944

外部リンク

研究キーワード

研究分野

ライフサイエンス / 薬理学 /

学歴

委員歴

1993年

日本薬理学会, 学術評議員

受賞

1994年

日本薬学会東北支部奨励賞

論文

A genome-wide association study identifies susceptibility loci for ossification of the posterior longitudinal ligament of the spine

Masahiro Nakajima, Atsushi Takahashi, Takashi Tsuji, Tatsuki Karasugi, Hisatoshi Baba, Kenzo Uchida, Shigenori Kawabata, Atsushi Okawa, Shigeo Shindo, Kazuhiro Takeuchi …

NATURE GENETICS 46(9) 1012-+ 2014年9月査読有り
Identification of a novel COL2A1 mutation (c.1744G>A) in a Japanese family: A case report

Masaki Kishiya, Yoshihide Nakamura, Hirotaka Ohishi, Ken-Ichi Furukawa, Yasuyuki Ishibashi

Journal of Medical Case Reports 8(1) 276 2014年8月14日査読有り
8-Methyltryptanthrin-Induced Differentiation of P19CL6 Embryonal Carcinoma Cells into Spontaneously Beating Cardiomyocyte-like Cells

Kazuhiko Seya, Asako Yarnaya, Sayuri Kamachi, Mana Murakami, Haruo Kitahara, Jun Kawakami, Ken Okumura, Manabu Murakami, Shigeru Motomura, Ken-ichi Furukawa

JOURNAL OF NATURAL PRODUCTS 77(6) 1413-1419 2014年6月査読有り
Comparison of initial versus delayed introduction of a treat-to-target strategy in patients with recent-onset rheumatoid arthritis: results of the T-4 3-year study

Yukitomo Urata, Yoshihide Nakamura, Ken-ichi Furukawa

ANNALS OF THE RHEUMATIC DISEASES 73(2) 470-+ 2014年2月査読有り
Recent Advances in Research on Human Aortic Valve Calcification

Ken-Ichi Furukawa

JOURNAL OF PHARMACOLOGICAL SCIENCES 124(2) 129-137 2014年2月査読有り
Osteogenic lineage commitment of mesenchymal stem cells from patients with ossification of the posterior longitudinal ligament

Yoshifumi Harada, Ken-Ichi Furukawa, Toru Asari, Shunfu Chin, Atsushi Ono, Toshihiro Tanaka, Hiroki Mizukami, Manabu Murakami, Soroku Yagihashi, Shigeru Motomura …

BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS 443(3) 1014-1020 2014年1月査読有り
CD34-negative mesenchymal stern-like cells may act as the cellular origin of human aortic valve calcification

Anan Nomura, Kazuhiko Seya, Zaiqiang Yu, Kazuyuki Daitoku, Shigeru Motomura, Manabu Murakami, Ikuo Fukuda, Ken-Ichi Furukawa

BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS 440(4) 780-785 2013年11月査読有り
Immunohistochemical localization of mesenchymal stem cells in ossified human spinal ligaments

Shunfu Chin, Ken-Ichi Furukawa, Atsushi Ono, Toru Asari, Yoshifumi Harada, Kanichiro Wada, Toshihiro Tanaka, Wataru Inaba, Hiroki Mizukami, Shigeru Motomura …

BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS 436(4) 698-704 2013年7月査読有り
Cytosolic Ca2+-Induced Apoptosis in Rat Cardiomyocytes via Mitochondrial NO-cGMP-Protein Kinase G Pathway

Kazuhiko Seya, Kyoichi Ono, Susumu Fujisawa, Ken Okumura, Shigeru Motomura, Ken-Ichi Furukawa

JOURNAL OF PHARMACOLOGY AND EXPERIMENTAL THERAPEUTICS 344(1) 77-84 2013年1月査読有り
Post injury changes in the properties of mesenchymal stem cells derived from human anterior cruciate ligaments

Shuya Nohmi, Yuji Yamamoto, Hiroki Mizukami, Yasuyuki Ishibashi, Eiichi Tsuda, Keiichiro Maniwa, Soroku Yagihashi, Shigeru Motomura, Satoshi Toh, Ken-Ichi Furukawa

INTERNATIONAL ORTHOPAEDICS 36(7) 1515-1522 2012年7月査読有り
Mesenchymal stem cell isolation and characterization from human spinal ligaments

Toru Asari, Ken-ichi Furukawa, Sunao Tanaka, Hitoshi Kudo, Hiroki Mizukami, Atsushi Ono, Takuya Numasawa, Gentaro Kumagai, Shigeru Motomura, Soroku Yagihashi …

BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS 417(4) 1193-1199 2012年1月査読有り
[Bone and calcium update; diagnosis and therapy of bone metabolism disease update. Molecular mechanism in cardiac valve calcification].

Furukawa K, Motomura S

Clinical calcium 21 61-66 2011年12月査読有り
Genetic Differences in the Osteogenic Differentiation Potency According to the Classification of Ossification of the Posterior Longitudinal Ligament of the Cervical Spine

Hitoshi Kudo, Ken-Ichi Furukawa, Toru Yokoyama, Atsushi Ono, Takuya Numasawa, Kanichiro Wada, Sunao Tanaka, Toru Asari, Kazumasa Ueyama, Shigeru Motomura …

SPINE 36(12) 951-957 2011年5月査読有り
Tumor necrosis factor-α accelerates the calcification of human aortic valve interstitial cells obtained from patients with calcific aortic valve stenosis via the BMP2-Dlx5 pathway.

Yu Z, Seya K, Daitoku K, Motomura S, Fukuda I, Furukawa K

The Journal of pharmacology and experimental therapeutics 337(1) 16-23 2011年4月査読有り
P2Y1 Transient Overexpression Induced Mineralization in Spinal Ligament Cells Derived from Patients with Ossification of the Posterior Longitudinal Ligament of the Cervical Spine

Sunao Tanaka, Hitoshi Kudo, Toru Asari, Atsushi Ono, Shigeru Motomura, Satoshi Toh, Ken-Ichi Furukawa

CALCIFIED TISSUE INTERNATIONAL 88(4) 263-271 2011年4月査読有り
Contribution of Bone Morphogenetic Protein-2 to Aortic Valve Calcification in Aged Rat

Kazuhiko Seya, Zaiqiang Yu, Kouta Kanemaru, Kazuyuki Daitoku, Yui Akemoto, Hiroyuki Shibuya, Ikuo Fukuda, Ken Okumura, Shigeru Motomura, Ken-Ichi Furukawa

JOURNAL OF PHARMACOLOGICAL SCIENCES 115(1) 8-14 2011年1月査読有り
Comparison of cardiovascular parameters between patients with ossification of posterior longitudinal ligament and patients with cervical spondylotic myelopathy

Masaki Kishiya, Ken-Ichi Furukawa, Toru Yokoyama, Hitoshi Kudo, Atsushi Ono, Takuya Numasawa, Kanichiro Wada, Satoshi Toh

Journal of Spinal Disorders and Techniques 22(5) 361-366 2009年7月査読有り
Opposite Effects of Two Resveratrol (trans-3,5,4 ' Trihydroxystilbene) Tetramers, Vitisin A and Hopeaphenol, on Apoptosis of Myocytes Isolated from Adult Rat Heart

Kazuhiko Seya, Kouta Kanemaru, Chiharu Sugimoto, Megumi Suzuki, Teruko Takeo, Shigeru Motomura, Haruo Kitahara, Masatake Niwa, Yoshiteru Oshima, Ken-Ichi Furukawa

JOURNAL OF PHARMACOLOGY AND EXPERIMENTAL THERAPEUTICS 328(1) 90-98 2009年1月査読有り
Pharmacological aspect of ectopic ossification in spinal ligament tissues

Ken-Ichi Furukawa

PHARMACOLOGY & THERAPEUTICS 118(3) 352-358 2008年6月査読有り
A functional RNAi screen for runx2-regulated genes associated with ectopic bone formation in human spinal ligaments

Masaki Kishiya, Toshitada Sawada, Kohta Kanemaru, Hitoshi Kudo, Takuya Numasawa, Toru Yokoyama, Sunao Tanaka, Shigeru Motomura, Kazumasa Ueyama, Seiko Harata …

JOURNAL OF PHARMACOLOGICAL SCIENCES 106(3) 404-414 2008年3月査読有り

もっとみる

MISC

pH Change-induced increase in perfusion pressure of the rat coronary artery enhanced by elevation of blood pressure.

Journal of Pharmacological Science 97, 400-407 2005年
Nifedipine enhances cGMP production through the activation of guanylyl cyclase in rat cardiac muscle.

Journal of Pharmacy and Pharmacology 57, 511-514 2005年
PLZF promotes osteoblastic differentiation of human mesenchymal stem cells as an upstream regulator of CBFA1.

Journal of Biological Chemistry 280, 8523-8530 2005年
Gene expression and functional activity of sodium/calcium exchanger were enhanced in vascular smooth muscle cells of spontaneously hypertensive rats.

Journal of Cardiovascular Pharmacology 43, 629-637 2004年
Uni-axial cyclic stretch induces Cbfa1 expression in spinal ligament cells derived from patients with ossification of posterior longitudinal ligaments.

Calcified Tissue International 74, 448-457 2004年
Role of prostaglandin I-2 in the gene expression induced by mechanical stress in spinal ligament cells derived from patients with ossification of the posterior longitudinal ligament

H Ohishi, KI Furukawa, K Iwasaki, K Ueyama, A Okada, S Motomura, S Harata, S Toh

JOURNAL OF PHARMACOLOGY AND EXPERIMENTAL THERAPEUTICS 305(3) 818-824 2003年6月
Genomewide linkage and linkage disequilibrium analyses pinpoint the ossification of the posterior longitudinal ligament of the spine to COL6A1 locus on chromosome 21.

American Journal of Cardiovascular Pharmacology. 73, 812-822 2003年
Vasodilative effects of urocortin II via protein kinase A and a mitogen-activated protein kinase in rat thoracic aorta.

Journal of Cardiovascular Pharmacology 42, 561-565 2003年
Uni-axial cyclic stretch induces osteogenic differentiation and syntheses of bone morphogenetic proteins of spinal ligament cells derived from patients with ossification of the posteior longitudinal ligaments.

Bone 33, 475-484 2003年
Endothelium-dependent vasodilatory effect of vitisin C, a novel plant oligostilbene from Vitis Coignetiae (Vitaceae) in rabbit aorta.

Clinical Science 105, 73-79 2003年
Stimulated tyrosine phosphorylation of phosphatidylinositol 3-kinase causes acidic pH-induced contraction in spontaneously hypertensive rat aorta

DK Rohra, T Yamakuni, K Furukawa, N Ishii, T Shinkawa, T Isobe, Y Ohizumi

JOURNAL OF PHARMACOLOGY AND EXPERIMENTAL THERAPEUTICS 303(3) 1255-1264 2002年12月
Antisense-Inhibition of Plasma Membrane Ca2+ Pump Induces Apoptosis in Vascular Smooth Muscle Cells.

Japanese Journal of Pharmacology 90, 164-17 2002年
Roles of CTGF/Hcs24 in the occurrence and development of ossification of the posterior longitudinal ligament of the spine

Spine 27, 1852-1857 2002年
The vaso-contractile action of zooxanthellatoxin-B from a marine dinoflagellate is mediated via massive Ca2+ influx in the rabbit aorta

Canadian Journal of Physiology and Pharmacology 79, 1030-1035 2001年
Halenaquinone, a novel phosphatidyl inositol 3-kinase inhibitor from a marine sponge, induces apoptosis in PC12 cell.

European Journal of Pharmacology 413, 37-45 2001年
Coronary vasodilation and positive inotropism by urocortin in the isolated rat heart.

Journal of Endoclinology 169, 177-183 2001年
Virol A, a Toxic Polyacetylenic Alcohol of Cicuta virosa, inhibits the GABA-induced Cl- Current in the Rat Hippocampal CA1 Neurons.

Brain Research 169, 177-183 2001年
Novel acyl alpha-pyronoids, dictyopyrone A, B, and C, from Dictyostelium cellular slime molds

Y Takaya, H Kikuchi, Y Terui, J Komiya, KI Furukawa, K Seya, S Motomura, A Ito, Y Oshima

JOURNAL OF ORGANIC CHEMISTRY 65(4) 985-989 2000年2月
Inhibition by antisense oligonucleotides of plasma membrane Ca2+ ATPase in vascular endothelial cells

M Nakao, KI Furukawa, E Satoh, K Ono, T Iijima

EUROPEAN JOURNAL OF PHARMACOLOGY 387(3) 273-277 2000年1月
A fluorometric assay for cyclic guanosine 3 ',5 '-monophosphate incorporating a Sep-Pak cartridge and enzymatic cycling

K Seya, KI Furukawa, S Motomura

ANALYTICAL BIOCHEMISTRY 272(2) 243-249 1999年8月

もっとみる

所属学協会

共同研究・競争的資金等の研究課題

脊柱靱帯骨化症の病因として間葉系幹細胞が果たす役割の解明

文部科学省科学研究費補助金(基盤研究(C)) 基盤研究(C) 2012年 - 2014年

古川賢一, 大島吉輝, 小野睦
脊柱靭帯骨化症の薬物治療戦略を構築するための分子標的の探索

文部科学省科学研究費補助金(基盤研究(C)) 基盤研究(C) 2008年 - 2010年

古川賢一, 瀬谷和彦, 沼沢拓也
間葉系幹細胞の単離と治療への応用

2009年
Isolation of mesenchymal stem cells and its application to regenerative medicine

2009年
循環器の異所性石灰化・骨化の機構解明

2008年
機械的ストレスが誘発する異所性骨化の関連遺伝子解析とそれを標的とする薬物の探索

文部科学省科学研究費補助金(基盤研究(B)) 基盤研究(B) 2004年 - 2005年

古川賢一, 井ノ上逸朗, 岡田晶博, 瀬谷和彦
筋小胞体カルシウム遊離チャネルの新規活性調節因子の探索とその作用機構の解明

文部科学省科学研究費補助金(基盤研究(B)) 基盤研究(B) 2000年 - 2002年

古川賢一, 大島吉輝, 瀬谷和彦, 元村成
メカニカルストレス応答機構の解析

厚生労働科学研究費補助金 1998年
Ectopic bone formation

Health and Labour Sciences Research Grants 1998年
リアノジンレセプターカルシウム遊離チャンネルの分子調節機構の解析

文部科学省科学研究費補助金(基盤研究(C)) 基盤研究(C) 1996年 - 1997年

古川賢一, 松永公浩
カルシウム情報伝達系の解析

1983年
筋収縮の分子機構

1980年
Analysis of Ca²⁺ signaling
Molecular mechanism of muscle contraction