伊藤英晃 (Hideaki Itoh) - マイポータル

基本情報

所属: 秋田大学大学院理工学研究科生命科学専攻教授

学位: 医学博士(秋田大学)
理学博士(茨城大学)

J-GLOBAL ID: 200901034176677325
researchmap会員ID: 1000006375

外部リンク: http://www.gipc.akita-u.ac.jp/~itohh/

研究キーワード

研究分野

ライフサイエンス / 分子生物学 /

経歴

- 現在

秋田大学大学院, 理工学研究科生命科学専攻生化学・分子生物学, 教授

委員歴

2016年1月 - 現在

日本生化学会, Journal of Biochemistry Associated Editor
2014年1月

臨床ストレス応答学会, アドバイザー
2010年1月 - 2013年1月

臨床ストレス応答学会, 会長

受賞

1992年

第3回秋田医学会学術奨励賞

論文

The regulation mechanisms of AhR by molecular chaperone complex

Ikuru Kudo, Miki Hosaka, Asami Haga, Noriko Tsuji, Yuhtaroh Nagata, Hirotaka Okada, Kana Fukuda, Yuka Kakizaki, Tomoya Okamoto, Ewa Grave …

Journal of Biochemistry 163(3) 223-232 2018年3月1日査読有り
Physicochemical properties of the mammalian molecular chaperone HSP60

Ryuichi Ishida, Tomoya Okamoto, Fumihiro Motojima, Hiroshi Kubota, Hiroki Takahashi, Masako Tanabe, Toshihiko Oka, Akira Kitamura, Masataka Kinjo, Masasuke Yoshida …

International Journal of Molecular Sciences 19(2) 2018年2月6日査読有り
Cisplatin Inhibits AhR Activation

Sasaki-Kudoh E, Kudo I, Kakizaki Y, Hosaka M, Ikeda S, Uemura S, Grave E, Togashi S, Sugawara T, Shimizu H

American Journal of Molecular Biology 8 69-82 2018年査読有り
HSP60 possesses a GTPase activity and mediates protein folding with HSP10

Tomoya Okamoto, Hiroshi Yamamoto, Ikuru Kudo, Kazuya Matsumoto, Masafumi Odaka, Ewa Grave, Hideaki Itoh

SCIENTIFIC REPORTS 7(1) 16931 2017年12月査読有り
High dose of antibiotic colistin induces oligomerization of molecular chaperone HSP90

Shuntaro Togashi, Kyosuke Takahashi, Arisa Tamura, Ikumi Toyota, Shiori Hatakeyama, Atsushi Komatsuda, Ikuru Kudo, Erina Sasaki Kudoh, Tomoya Okamoto, Asami Haga …

JOURNAL OF BIOCHEMISTRY 162(1) 27-36 2017年7月査読有り
Novel antimicrobial activities of a peptide derived from a Japanese soybean fermented food, Natto, against Streptococcus pneumoniae and Bacillus subtilis group strains

Manabu Kitagawa, Tsukasa Shiraishi, Soh Yamamoto, Ryosuke Kutomi, Yasuo Ohkoshi, Toyotaka Sato, Hideki Wakui, Hideaki Itoh, Atsushi Miyamoto, Shin-ichi Yokota

AMB EXPRESS 7(1) 127 2017年6月査読有り
NIP-SNAP-1 and-2 mitochondrial proteins are maintained by heat shock protein 60

Soh Yamamoto, Tomoya Okamoto, Noriko Ogasawara, Shin Hashimoto, Tsukasa Shiraishi, Toyotaka Sato, Keisuke Yamamoto, Hiroyuki Tsutsumi, Kenichi Takano, Testuo Himi …

BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS 483(3) 917-922 2017年2月査読有り
Characterization of Aes nuclear foci in colorectal cancer cells

Yoshiro Itatani, Masahiro Sonoshita, Fumihiko Kakizaki, Katsuya Okawa, Stefano Stifani, Hideaki Itoh, Yoshiharu Sakai, M. Mark Taketo

JOURNAL OF BIOCHEMISTRY 159(1) 133-140 2016年1月査読有り
Functional structure and physiological functions of mammalian wild-type HSP60

Tomoya Okamoto, Ryuichi Ishida, Hiroshi Yamamoto, Masako Tanabe-Ishida, Asami Haga, Hiroki Takahashi, Kyosuke Takahashi, Daisuke Goto, Ewa Grave, Hideaki Itoh

ARCHIVES OF BIOCHEMISTRY AND BIOPHYSICS 586 10-19 2015年11月査読有り
Geranylgeranylacetone selectively binds to the HSP70 of Helicobacter pylori and alters its coccoid morphology

Ewa Grave, Shin-ichi Yokota, Soh Yamamoto, Arisa Tamura, Takako Ohtaki-Mizoguchi, Kenji Yokota, Keiji Oguma, Kazuhiko Fujiwara, Nobuaki Ogawa, Tomoya Okamoto …

SCIENTIFIC REPORTS 5 13738 2015年9月査読有り
Structural characterization of the substrate transfer mechanism in Hsp70/Hsp90 folding machinery mediated by Hop

Sara Alvira, Jorge Cuellar, Alina Roehl, Soh Yamamoto, Hideaki Itoh, Carlos Alfonso, German Rivas, Johannes Buchner, Jose M. Valpuesta

NATURE COMMUNICATIONS 5 5484 2014年11月査読有り
ATPase Activity and ATP-dependent Conformational Change in the Co-chaperone HSP70/HSP90-organizing Protein ( HOP)*

Soh Yamamoto, Ganesh Prasad Subedi, Shinya Hanashima, Tadashi Satoh, Michiro Otaka, Hideki Wakui, Ken-ichi Sawada, Shin-ichi Yokota, Yoshiki Yamaguchi, Hiroshi Kubota …

JOURNAL OF BIOLOGICAL CHEMISTRY 289(14) 9880-9886 2014年4月査読有り
The activation mechanism of the aryl hydrocarbon receptor (AhR) by molecular chaperone HSP90

Noriko Tsuji, Kana Fukuda, Yuhtaroh Nagata, Hirotaka Okada, Asami Haga, Shiori Hatakeyama, Shiho Yoshida, Tomoya Okamoto, Miki Hosaka, Kazuhiro Sekine …

FEBS OPEN BIO 4 796-803 2014年査読有り
Aminoglycosides Suppress the Protein Folding Activity of the Molecular Chaperone HSC70: Implication of a Structure-Activity Relationship

Soh Yamamoto, Hideki Wakui, Hiroshi Kubota, Atsushi Kornatsuda, Hideaki Itoh, Shin-Ichi Yokota

CHEMOTHERAPY 60(1) 37-46 2014年査読有り
Zinc-l-carnosine binds to molecular chaperone HSP70 and inhibits the chaperone activity of the protein

Asami Haga, Tomoya Okamoto, Shintaroh Yamada, Toshihiko Kubota, Ann Sanpei, Shota Takahashi, Masahiro Nakayama, Miki Nagai, Michiro Otaka, Toshio Miyazaki …

Journal of Biochemistry 154(3) 249-256 2013年9月査読有り
Cisplatin Binding and Inactivation of Mitochondrial Glutamate Oxaloacetate Transaminase in Cisplatin-Induced Rat Nephrotoxicity

Taku Ozaki, Sei-ichi Ishiguro, Hideaki Itoh, Kazuhisa Furuhama, Mitsuru Nakazawa, Tetsuro Yamashita

BIOSCIENCE BIOTECHNOLOGY AND BIOCHEMISTRY 77(8) 1645-1649 2013年8月査読有り
Traditional Herbal Medicine, Rikkunshito, Induces HSP60 and Enhances Cytoprotection of Small Intestinal Mucosal Cells as a Nontoxic Chaperone Inducer.

Tamaki K, Otaka M, Shibuya T, Sakamoto N, Yamamoto S, Odashima M, Itoh H, Watanabe S

Evidence-based complementary and alternative medicine : eCAM 2012 278958 2012年査読有り
Evidence for Enhanced Cytoprotective Function of HSP90-Overexpressing Small Intestinal Epithelial Cells

Kumiko Tamaki, Michiro Otaka, Makiko Takada, Soh Yamamoto, Masaru Odashima, Hideaki Itoh, Sumio Watanabe

DIGESTIVE DISEASES AND SCIENCES 56(7) 1954-1961 2011年7月査読有り
Increased expression of co-chaperone HOP with HSP90 and HSC70 and complex formation in human colonic carcinoma

Hiroshi Kubota, Soh Yamamoto, Eri Itoh, Yuki Abe, Asami Nakamura, Yukina Izumi, Hirotaka Okada, Masatake Iida, Hiroshi Nanjo, Hideaki Itoh …

CELL STRESS & CHAPERONES 15(6) 1003-1011 2010年11月査読有り
Correlation of Heat Shock Protein Expression to Gender Difference in Development of Stress-Induced Gastric Mucosal Injury in Rats

Taiji Takahashi, Michiro Otaka, Masaru Odashima, Kumiko Tamaki, Makiko Takada, Yuko Izumi, Tomoyoshi Shibuya, Naoto Sakamoto, Hideaki Itoh, Sumio Watanabe

JOURNAL OF CLINICAL BIOCHEMISTRY AND NUTRITION 47(1) 64-73 2010年7月査読有り

もっとみる

MISC

哺乳類分子シャペロンの作用機構

伊藤英晃

生化学 77(9) 1137-1151 2005年
Mammalian HSP60 is quickly sorted into the mitochondria under conditions of dehydration

H Itoh, A Komatsuda, H Ohtani, H Wakui, H Imai, K Sawada, M Otaka, M Ogura, A Suzuki, F Hamada

EUROPEAN JOURNAL OF BIOCHEMISTRY 269(23) 5931-5938 2002年12月
Characterization of the 105-KDa Moleculan Chaperone

European Journal of Biochemistry 269,5632-5641 2002年
Overexpression of the Heat Shock Protein 70 Confers Protection Against Oxidative Iujury in HEPG2 Cells

Transplautation Proceedings 34,2647-2649 2002年
Germ cell-specific heat shook protein 105 binds to p53 in a temperature-sensitive manner in rat testis(共著)

European Journal of Biochemistry 267(10) 3073-3078 2000年
A novel chaperone-activity reducing mechanisms of the 90-KDa molecular chaperone HSP90(共著)

Biochemical Journal 343(3) 697-703 1999年
Mammalian HSP60 is a major target for an immunosuppressant mizoribine(共著)

Journal of Biological Chemistry 274(49) 35147-35151 1999年
The circadian rhythm of HSP60 in pancreas of rat

S Shibata, Y Asanuma, H Itoh, K Koyama

PANCREAS 17(3) 316-318 1998年10月
Transcription factor ZBP-89 regulates the activity of the ornithine de carboxylase promotor(共著).

Journal of Biological Chemistry 273(32) 19955-19964 1998年
Novel 30 kDa protein possessing ATP-binding and chaperone activities

H Itoh, Y Tashima

BIOCHEMICAL JOURNAL 326 567-572 1997年9月
Detection of circulating anti-p53 antibodies in patients with colorectal carcinoma and the antibody's relation to clinical factors

Y Shibata, H Kotanagi, H Andoh, K Koyama, H Itoh, SE Kudo

DISEASES OF THE COLON & RECTUM 39(11) 1269-1274 1996年11月
Expression of 90-kDa heat shock protein within cellular crescents in human diseased kidneys

A Komatsuda, H Wakui, H Imai, AB Miura, H Itoh, Y Tashima

NEPHROLOGY 2(2) 87-91 1996年4月
INDUCTION AND INTRACELLULAR-LOCALIZATION OF 90-KILODALTON HEAT-SHOCK PROTEIN IN RAT KIDNEYS WITH ACUTE GENTAMICIN NEPHROPATHY

H OHTANI, H WAKUI, A KOMATSUDA, K SATOH, AB MIURA, H ITOH, Y TASHIMA

LABORATORY INVESTIGATION 72(2) 161-165 1995年2月
INDUCTION OF HEAT-SHOCK PROTEINS HSP73 AND HSP90 IN RAT KIDNEYS AFTER ISCHEMIA

K MORITA, H WAKUI, A KOMATSUDA, H OHTANI, AB MIURA, H ITOH, Y TASHIMA

RENAL FAILURE 17(4) 405-419 1995年
Mammalian 60-kDa stress protein (chaperonin homolog)

The Journal of Biological Chemistry 270(22) 13429-13435 1995年
Domain Structure of the 90-kDa Stress Protein : Heparin-and Antibody-Binding Domain

Int. J. Biochem. 25(2) 157-161 1993年
Physicochemical Property of Bovine Brain 73-kDa Stress Protein

Int. J. Biochem. 25(1) 69-77 1993年
Localization of HSP90 in Rat Brain.

Int. J. Biochem. 25(1) 93-99 1993年
Purification of a mature form of 60-kDa heat shock protein (chaperonin homolog) from porcine kidene and its partial amino acid sequence.

International Journal of Biochemistry 24(9) 1507-1510 1992年
Renal localization of the constitutive 73-kDa heat-shock (HSP73) in normal rat and its alteration in rat with nephrosis.

Kidney International 41 1204-1212 1992年

もっとみる

書籍等出版物

抗菌ペプチドの機能解明と技術利用

伊藤英晃

シーエムシー出版社 2017年5月
Cisplatin: Pharmacology, Clinical Uses and Adverse Effects

伊藤英晃 (担当:共著, 範囲:Chapter 8 - Molecular Chaperone HSP90 as a Cisplatin Specific Binding Protein.)

NOVA Scientific Publishers 2012年

講演・口頭発表等

215

Structure and functions of mammalian HSP60 and HSP10

伊藤英晃

18th International Conferance on Stractural Biology 2019年10月14日招待有り
Identification and purification of the anticancer, antimicrobial, and antivirus peptide from Japanese fermented foods

伊藤英晃

Food Teck 2018 2018年10月23日招待有り
納豆抽出抗菌ペプチドの抗がん剤への応用

伊藤英晃

2018年度日本農芸化学会大会シンポジウム 2018年3月15日招待有り
Identification and purificationof the anticancer, antimicrobial, and antivirus peptide from

伊藤英晃

International Conference on Fermentation. 2014年10月24日招待有り
70-kDa Molecular Chaperone HSP70 Is a Direct Target of Antibiotic Gentamicin

伊藤英晃

5th International Conference on Drug Discovery and Therapy (ICDDT) 2013 2013年2月13日招待有り
Cisplatin, a HSP90 inhibitor

伊藤英晃

4th International Conference on Drug Discovery and Therapy (ICDDT) 2012年2月12日招待有り

所属学協会

共同研究・競争的資金等の研究課題

産業財産権

特願2014-260849 抗ウイルス剤，および抗菌剤

伊藤英晃
特願2018-034878 抗ウイルス剤

伊藤英晃