2017年10月
Prospective observational study of carbon-ion radiotherapy for non-squamous cell carcinoma of the head and neck
CANCER SCIENCE
- 巻
- 108
- 号
- 10
- 開始ページ
- 2039
- 終了ページ
- 2044
- 記述言語
- 英語
- 掲載種別
- DOI
- 10.1111/cas.13325
- 出版者・発行元
- WILEY
To evaluate the efficacy and safety of carbon-ion radiotherapy for non-squamous cell carcinoma of the head and neck, 35 patients were enrolled in this prospective study. The primary end-point was the 3-year local control rate, and the secondary end-points included the 3-year overall survival rate and adverse events. Acute and late adverse events were evaluated according to the Common Terminology Criteria for Adverse Events, version 4.0. The median follow-up time for all patients was 39months. Thirty-two and three patients received 64.0Gy (relative biological effectiveness) and 57.6Gy (relative biological effectiveness) in 16 fractions, respectively. Adenoid cystic carcinoma was dominant (60%). Four patients had local recurrence and five patients died. The 3-year local control and overall survival rates were 93% and 88%, respectively. Acute grade 2-3 radiation mucositis (65%) and dermatitis (31%) was common, which improved immediately with conservative therapy. Late mucositis of grade 2, grade 3, and grade 4 were observed in 11, one, and no patients, respectively. There were no adverse events of grade 5. Carbon-ion radiotherapy achieved excellent local control and overall survival rates for non-squamous cell carcinoma. However, the late mucosal adverse events were not rare, and meticulous treatment planning is required. Trial registration no. UMIN000007886.
- リンク情報
- ID情報
-
- DOI : 10.1111/cas.13325
- ISSN : 1349-7006
- eISSN : 1349-7006
- Web of Science ID : WOS:000412104100018