2018年3月16日
Clinical management and outcomes of completely resected stage I follicular lymphoma.
Journal of clinical and experimental hematopathology : JCEH
- 巻
- 58
- 号
- 1
- 開始ページ
- 10
- 終了ページ
- 16
- 記述言語
- 英語
- 掲載種別
- Scientific Journal
- DOI
- 10.3960/jslrt.17031
Recent studies have revealed the clinical and biological features of stage I follicular lymphoma (FL), but information about patients with stage I FL who underwent total resection after tissue biopsy is limited. Among 305 FL patients diagnosed between 2001 and 2013, clinical stage I disease was observed in 36 patients. Of these, 18 patients underwent total resection after diagnostic tissue biopsy. We used 18F-fluorodeoxyglucose positron emission CT for staging assessment in 13 of 18 patients (72.2%). The median age was 56.5 years. Six patients (33.3%) were male. The soluble interleukin-2 receptor alpha concentration was significantly lower than in patients with residual disease. Among these 18 patients, 7 patients (38.9%) were treated with a "watch-and-wait" (WW) policy, 7 (38.9%) were treated with involved-field irradiation, and 4 (22.2%) received systemic chemotherapy. Patients with resected disease were treated with significantly different strategies from those with residual disease (p = 0.0026). Five patients experienced relapse during follow-up (median follow-up: 48.2 months). All relapses were distant from the primary site, irrespective of treatment strategy. Among all stage I patients, disease resection was not a significant factor for survival (p = 0.9294). Collectively, the choice of treatment strategy was significantly influenced by patient status. Resection status was not significantly associated with survival after several treatment strategies.
- リンク情報
- ID情報
-
- DOI : 10.3960/jslrt.17031
- PubMed ID : 29415976
- PubMed Central 記事ID : PMC6144197