This work deals with the domination numbers of generalized de Bruijn digraphs and generalized Kautz digraphs. Dominating sets for digraphs are not familiar compared with dominating sets for undirected graphs. Whereas dominating sets for digraphs have more applications than those for undirected graphs. We construct dominating sets of generalized de Bruijn digraphs where obtained dominating sets have some qualifications. For generalized Kautz digraphs, there is a minimum dominating set in those constructed dominating sets. (C) 2003 Elsevier Science B.V. All rights reserved.