Tsutomu Ishikawa

Profile Information

Affiliation: Chiba University (Professor Emeritus), TOKIWA PHYTOCHEMICAL CO.,LTD.

Degree: Doctor of Philosophy(Kyoto University)

J-GLOBAL ID: 200901045199591241
researchmap Member ID: 1000010727

External link: http://www.tokiwaph.co.jp/

Research Interests

化学薬学 Pharmaceutical Chemistry 創薬化学 Medicinal Chemsitry 天然物有機化学 Natural Product Chemistry 機能性分子化学 Intelligent Molecular Chemistry
Pharmaceutical Chemistry Medicinal Chemsitry Natural Product Chemistry Intelligent Molecular Chemistry

Research Areas

Life sciences / Pharmaceuticals - chemistry and drug development /

Awards

1980

宮田専治学術賞

Papers

HPLC analysis of ammonium glycyrrhizate listed in the European, United States, and Japanese Pharmacopoeias under reported and modified conditions: revision of the peak assignment for 18α-glycyrrhizin in the European and United States Pharmacopoeias.

Kazuaki Kamata, Jin Tatsuzaki, Tsutomu Ishikawa, Ryoko Arai, Takashi Hakamatsuka, Nahoko Uchiyama

Journal of natural medicines, Sep 6, 2022
Is 18α-Glycyrrhizin a real natural product? Improved preparation of 18α-Glycyrrhizin from 18β-Glycyrrhizin as a positive standard for HPLC analysis of licorice extracts.

Kritamorn Jitrangsri, Kazuaki Kamata, Mana Akiba, Yoshie Yajiri, Masami Ishibashi, Jin Tatsuzaki, Tsutomu Ishikawa

Journal of natural medicines, 76(2) 367-378, Mar, 2022
Quercetin 3,5,7,3',4'-pentamethyl ether from Kaempferia parviflora directly and effectively activates human SIRT1.

Mimin Zhang, Peng Lu, Tohru Terada, Miaomiao Sui, Haruka Furuta, Kilico Iida, Yukie Katayama, Yi Lu, Ken Okamoto, Michio Suzuki …

Communications biology, 4(1) 209-209, Feb 19, 2021
Quantification of terpene trilactones in Ginkgo biloba with a 1H NMR method.

Tingfu Liang, Takuya Miyakawa, Jinwei Yang, Tsutomu Ishikawa, Masaru Tanokura

Journal of natural medicines, 72(3) 793-797, Jun, 2018
A simple and effective preparation of quercetin pentamethyl ether from quercetin.

Jin Tatsuzaki, Tomohiko Ohwada, Yuko Otani, Reiko Inagi, Tsutomu Ishikawa

Beilstein journal of organic chemistry, 14 3112-3121, 2018
Changes in intracellular copper concentration and copper-regulating gene expression after PC12 differentiation into neurons

Yasumitsu Ogra, Aya Tejima, Naohiro Hatakeyama, Moeko Shiraiwa, Siyuan Wu, Tsutomu Ishikawa, Ayako Yawata, Yasumi Anan, Noriyuki Suzuki

SCIENTIFIC REPORTS, 6, Sep, 2016 Peer-reviewed
Construction of a bicyclo[3.2.1]octane system carrying the (R)-carvone core under oxidative radical conditions: Synthetic access to (+)-miroestrols

Mizuna Hamano, Mayuko Akimoto, Keiko Funada, Natsuko Kagawa, Noriyuki Suzuki, Tsutomu Ishikawa

Synlett, 26 547-551, Mar, 2015 Peer-reviewed
Synthesis of ortho-Phenylenebis(guanidine) Derivatives with Potential Chirality

Masahiro Fukuzumi, Waka Nakanishi, Tsutomu Ishikawa, Takuya Kumamoto

HELVETICA CHIMICA ACTA, 97(11) 1453-1468, Nov, 2014 Peer-reviewed
New Synthetic Procedure for 2-Aryl-1,4-naphthoquinone-1-oxime Methyl Ethers with Potent Antitumor Activity

Scebi Mkhize, Noriyuki Suzuki, Ayako Kurosawa, Makiko Fujinami, Chanya Chaicharoenpong, Tsutomu Ishikawa

SYNLETT, 25(14) 2059-2063, Sep, 2014 Peer-reviewed
Immobilized 1,2-Bis(guanidinoalkyl)benzenes: Potentially Useful for the Purification of Arsenic-Polluted Water

Suzuki, Noriyuki, Kishimoto, Kaito, Yamazaki, Kohei, Kumamoto, Takuya, Ishikawa, Tsutomu, Margetic, Davor

SYNLETT, 24(19) 2510-2514, 2013
Synthesis of the Aziridinomitosene Skeleton by Application of Guanidinium Ylide-Mediated Aziridination

Kojima, Hiroyuki, Takahata, Chisato, Lemin, David, Takahashi, Masato, Kumamoto, Takuya, Nakanishi, Waka, Suzuki, Noriyuki, Ishikawa, Tsutomu

HELVETICA CHIMICA ACTA, 96(3) 379-388, 2013
Enantioselective Construction of a Polyhydroxylated Pyrrolidine Skeleton from 3-Vinylaziridine-2-carboxylates: Synthesis of (+)-DMDP and a Potential Common Intermediate for (+)-Hyacinthacine A(1) and (+)-1-epi-Australine

Kondo Yukari, Suzuki Noriyuki, Takahashi Masato, Kumamoto Takuya, Masu Hyuma, Ishikawa Tsutomu

JOURNAL OF ORGANIC CHEMISTRY, 77(18) 7988-7999, Sep 21, 2012 Peer-reviewed
Aryl-beta-C-glucosidation using glucal boronate: application to the synthesis of tri-O-methylnorbergenin

Shigeki Sakamaki, Eiji Kawanishi, Sumihiro Nomura, Tsutomu Ishikawa

TETRAHEDRON, 68(29) 5744-5753, Jul, 2012 Peer-reviewed
New 2-Aryl-1,4-naphthoquinone-1-oxime Methyl Ether Compound Induces Microtubule Depolymerization and Subsequent Apoptosis

Sato, Hiromi, Yamada, Ryota, Yanagihara, Midori, Okuzawa, Hiroko, Iwata, Hiroki, Kurosawa, Ayako, Ichinomiya, Saki, Suzuki, Rina, Okabe, Hiroyuki, Yano, Tomohiro …

JOURNAL OF PHARMACOLOGICAL SCIENCES, 118(4) 467-478, 2012
CHIBA-G-CATALYZED INTRAMOLECULAR OXO-MICHAEL ADDITION: SYNTHETIC APPROACHES TO VITAMINE E SKELETON

Tokunou, Sayaka, Nakanishi, Waka, Kagawa, Natsuko, Kumamoto, Takuya, Ishikawa, Tsutomu

HETEROCYCLES, 84(2) 1045-1056, 2012
Synthesis of jadomycin A and related jadomycin aglycons: structural re-examination of jadomycins S and T may be needed

Tajima, Takayoshi, Akagi, Yuhsuke, Kumamoto, Takuya, Suzuki, Noriyuki, Ishikawa, Tsutomu

TETRAHEDRON LETTERS, 53(4) 383-387, 2012
Synthesis of (-)-benzolactam-V8 by application of asymmetric aziridination

Khantikaew, Itsara, Takahashi, Masato, Kumamoto, Takuya, Suzuki, Noriyuki, Ishikawa, Tsutomu

TETRAHEDRON, 68(3) 878-882, 2012
Enantioselective synthesis of chelidonine, a B/C-cis-11-hydroxyhexahydrobenzo[c]phenanthridine alkaloid

Miki Ito, Fujiko Konno, Takuya Kumamoto, Noriyuki Suzuki, Masatoshi Kawahata, Kentaro Yamaguchi, Tsutomu Ishikawa

TETRAHEDRON, 67(41) 8041-8049, Oct, 2011 Peer-reviewed
P-14 Enantioselective Synthesis of Pyrrolidine Alkaloids from Aziridine System(Poster Presentation)

Kondo Yukari, Kumamoto Takuya, Suzuki Noriyuki, Ishikawa Tsutomu

Symposium on the Chemistry of Natural Products, symposium papers, (53) 523-528, Sep 2, 2011
2-Aryl-1,4-naphthoquinone-1-oxime Methyl Ethers: Their Cytotoxic Activity

Tsutomu Ishikawa, Tatsuru Saito, Ayako Kurosawa, Toshiko Watanabe, Sakiko Maruyama, Yuh-ichiro Ichikawa, Ryota Yamada, Hiroko Okuzawa, Hiromi Sato, Koichi Ueno

CHEMICAL & PHARMACEUTICAL BULLETIN, 59(4) 472-475, Apr, 2011 Peer-reviewed

Misc.

Guanidine-Assisted Asymmetric Syntheses (共著)

Chemistry Eurropian Journal, 8(3) 552-557, 2020
Guanidinium ylide mediated aziridination: Identification of a spiro imidazolidine-oxazolidine intermediate

Wannaporn Disadee, Tsutomu Ishikawa, Masatoshi Kawahata, Kentaro Yamaguchi

JOURNAL OF ORGANIC CHEMISTRY, 71(17) 6600-6603, Aug, 2006
Guanidines in organic synthesis

T Ishikawa, T Kumamoto

SYNTHESIS-STUTTGART, (5) 737-752, Mar, 2006
Preparation of Nα-Acetyl-Nε-3-(methylpyridinium)lysine (MP-lysine) as a Hapten of Antibody

Heterocycles, 67(1) 361-367, Jan 1, 2006
Chirality transfer from guanidinium ylides to 3-alkenyl (or 3-alkynyl) aziridine-2-carboxylates and application to the syntheses of (2R,3S)-3-hydroxyleucinate and D-erythro-sphingosine

W Disadee, T Ishikawa

JOURNAL OF ORGANIC CHEMISTRY, 70(23) 9399-9406, Nov, 2005
Mechanistic approaches to asymmetric synthesis of aziridines from guanidinium ylides and aryl aldehydes

T Haga, T Ishikawa

TETRAHEDRON, 61(11) 2857-2869, Mar, 2005
o-bisguanidinobenzene, a powerful hydrogen acceptor: Crystal structures of organic complexes with benzoic acid, phenol, and benzyl alcohol

M Kawahata, K Yamaguchi, T Ishikawa

CRYSTAL GROWTH & DESIGN, 5(1) 373-377, Jan, 2005
Guanidines as a nitrogen source for direct conversion of epoxides to aziridines

Y Tsuchiya, T Kumamoto, T Ishikawa

JOURNAL OF ORGANIC CHEMISTRY, 69(24) 8504-8505, Nov, 2004
Kwakhurin, a unique isoflavone with rejuvenating activity from "kwao keur": Further characterization by 2D-NMR spectrometry and synthesis of triisopropylkwakhurin

M Iwasaki, T Watanabe, T Ishikawa, S Chansakaow, Y Higuchi, S Tahara

HETEROCYCLES, 63(6) 1375-1392, Jun, 2004
Isolation of salicin derivatives from Homalium cochinchinensis and their antiviral activities

T Ishikawa, K Nishigaya, K Takami, H Uchikoshi, IS Chen, IL Tsai

JOURNAL OF NATURAL PRODUCTS, 67(4) 659-663, Apr, 2004
Concise synthesis of anti-HIV-1 active (+)-inophyllum B and (+)-calanolide a by application of (-)-quinine-catalyzzed intramolecular oxo-michael addition

E Sekino, T Kumamoto, T Tanaka, T Ikeda, T Ishikawa

JOURNAL OF ORGANIC CHEMISTRY, 69(8) 2760-2767, Apr, 2004
Science of Synthesis (Pteridines and Related Structures; Other Diazinodiazines in Vol 16）

Thieme, 2004
Chemistry of Structurally Confused Kinamycins

KUMAMOTO Takuya, ISHIKAWA Tsutomu, OMURA Satoshi

J. Synth. Org. Chem. Jpn., 62(1) 49-58, 2004
Science of Synthesis (Pteridines and Related Structures; Other Diazinodiazines in Vol 16）

Thieme, 2004
Chiral guanidines

Tsutomu Ishikawa, Toshio Isobe

Yuki Gosei Kagaku Kyokaishi/Journal of Synthetic Organic Chemistry, 61(1) 58-66, 2003
Stereoselective total synthesis of (±)-homochelidonine

Makoto Yoshida, Toshiko Watanabe, Tsutomu Ishikawa

Tetrahedron Letters, 43(38) 6751-6753, Sep 16, 2002
Polymer-Supported DMI as a Potential Heterogeneous Dchydrating Agent : Application ti Esterification and Amidation (共著)

Synlett, (1) 115-117, 2002
Guanidinium ylides as a new and recyclable source for aziridines and their roles as chiral auxiliaries

K Hada, T Watanabe, T Isobe, T Ishikawa

JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, 123(31) 7705-7706, Aug, 2001
Anti HIV-1 Active Calophyllum Coumarins:Distribution,Chemistry,and Activity

ISHIKAWA T.

Heterocycles, 53(2) 453-474, Feb, 2000
Mild air-oxidation of 1,3-dicarbonyl compounds with cesium salts: Novel alpha-hydroxylation accompanied by partial hydrolysis of malonate derivatives

T Watanabe, T Ishikawa

TETRAHEDRON LETTERS, 40(44) 7795-7798, Oct, 1999

Works

創薬指向有機化学

Research Projects

Challenge to Environmental and Resource Chemistry : Preparation, Modification, and Assessment of Bisguanidine Polymers

Grants-in-Aid for Scientific Research, Grant-in-Aid for Challenging Exploratory Research, Japan Society for the Promotion of Science, 2009 - 2011

ISHIKAWA Tsutomu
ビスグアニジン型分子結晶からの新知見:オルト置換ベンゼンは軸不斉化合物となり得るか?

科学研究費助成事業, 萌芽研究, 日本学術振興会, 2003 - 2004

石川勉, 山口健太郎
New Guanidine Chemistry

Grants-in-Aid for Scientific Research, Grant-in-Aid for Scientific Research (B), Japan Society for the Promotion of Science, 2002 - 2004

ISHIKAWA Tsutomu, WATANABE Toshiko, SEKI Hiroko
Field Research on Southeast Asian Endangered Medicinal Plants

Grants-in-Aid for Scientific Research, Grant-in-Aid for Scientific Research (B), Japan Society for the Promotion of Science, 2001 - 2003

SEKINE Toshikazu, WATANABE Toshiko, IKEGAMI Fumio, ISHIKAWA Tsutomu
Utilization and Evaluation of Tropical Medicinal Resources

Grants-in-Aid for Scientific Research, Grant-in-Aid for Scientific Research (B)., Japan Society for the Promotion of Science, 1997 - 1999

AIMI Norio, SUZUKI Kazuo,t., NAKAGAWA Masako, WATANABE Kazuo, ISHIKAWA Tsutomu, YAMAMOTO Keiji
N-ヒドロキシグアニジン誘導体を基調とした一酸化窒素の有機化学的研究

科学研究費助成事業, 萌芽的研究, 日本学術振興会, 1997 - 1997

石川勉
Molecular design and synthesis of coumarin by indexing

Grants-in-Aid for Scientific Research, Grant-in-Aid for General Scientific Research (C), Japan Society for the Promotion of Science, 1989 - 1991

HARAYAMA Takashi, ISHIKAWA Tsutomu
Synthetic Studies on the Antitumor Benzo[c]phenanthridine Alkaloids Directing toward Medicinals Development

Grants-in-Aid for Scientific Research, Grant-in-Aid for Developmental Scientific Research, Japan Society for the Promotion of Science, 1987 - 1989

ISHII Hisashi, ISHIKAWA Tsutomu, HARAYAMA Takashi
Synthesis of an antitumor active chelerythrine type alkaloid using Claisen rearrangement of a propargyl ether

Grants-in-Aid for Scientific Research, Grant-in-Aid for General Scientific Research (C), Japan Society for the Promotion of Science, 1986 - 1988

ISHII Hisashi, ISHIKAWA Tsutomu
生理活性有機化合物の合成/構造活性相関/シード化合物の単離・同定/新規機能性分子の開拓

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