HOSOKAWA Masakiyo

J-GLOBAL         Last updated: Jun 26, 2019 at 15:37
 
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Name
HOSOKAWA Masakiyo
Affiliation
Chiba Institute of Science
Job title
Associate Professor
Degree
Ph.D.(Doctor of Pharmacy)(Chiba University), Master of Agriculture(Chiba University)

Research Areas

 
 

Academic & Professional Experience

 
 
   
 
Research Assistant
 
 
   
 
Science/NIH
 
1985
 - 
1990
Tokyo University of Pharmacy and Life Science,
 
1990
 - 
1992
National Institutes of Environmental Health
 
1992
 - 
1997
Chiba University, Research Assistant
 
1997
 - 
2000
Chiba University, Lecture
 
2000
   
 
- Chiba University, Associate Professor
 
Apr 2000
 - 
Mar 2001
Associate Professor, Faculty of Pharmaceutical Sciences, Chiba University
 
Apr 2001
 - 
Mar 2004
Associate Professor, Graduate School of Pharmaceutical Sciences, Graduate School of Chiba University
 
Apr 2005
 - 
Today
Professor, Faculty of Pharmacy, Chiba Institute of Science
 
Apr 2006
 - 
Today
Professor, Graduate School of Pharmaceutical Sciences, Chiba Institute of Science
 
Apr 2012
 - 
Mar 2019
Dean/Professor, Faculty of Pharmaceutical Science, Chiba Institute of Science
 
Apr 2012
 - 
Mar 2019
Graduate School of Pharmacy, Chiba Institute of Science
 

Education

 
 
 - 
1985
Graduate School, Division of Pharmaceutical Sciences, Chiba University
 
 
 - 
1982
Graduate School, Division of Horticulture, Chiba University
 
 
 - 
1980
Faculty of Agriculture, Meiji University
 

Awards & Honors

 
Feb 2012
Molecules Best Paper Award 2012, Molecules
 
Nov 2009
DMPK Editors’ Award for Most Excellent Article in 2008
 

Published Papers

 
Kenta Mizoi, Masato Takahashi, Sachiko Sakai, Takuo Ogihara, Masami Haba and Masakiyo Hosokawa
Xenobiotica      Jun 2019   [Refereed]
HOSOKAWA Masakiyo
Eur J Pharm Sci.   132 125-131   2019   [Refereed]
Yasuhiro Uno, Yoshiyuki Igawa, Maori Tanaka, Kayoko Ohura, Masakiyo Hosokawa, Teruko Imai
Xenobiotica   49(2) 247-255   2019   [Refereed]
Yuma Ishizaki , Tomomi Furihata, Yusuke Oyama, Kayoko Ohura, Teruko Imai, Masakiyo Hosokawa, Hidetaka Akita, Kan Chiba.
Biol Pharm Bull   41(5) 697-706   2018   [Refereed]
Yasuhiro Uno, Shotaro Uehara, Hassan MD Mahadhi, Kayoko Ohura, Masakiyo Hosokawa , Teruko Imai.
J Med Primatol.   47(3) 185-191   2018   [Refereed]
Masato Takahashi, Tomohiro Ogawa, Hiroshi Kashiwagi, Fumiya Fukushima, Misaki Yoshitsugu, Masami Haba, Masakiyo Hosokawa.
Bioorg Med Chem Lett.   28(6) 997-1000   2018   [Refereed]
Kabeya T, Matsumura W, Iwao T, Hosokawa M, Matsunaga T.
Biochem Biophys Res Commun   486(1) 143-148   2017   [Refereed]
Mizoi Kenta, Takahashi Masato, Haba Masami and Hosokawa Masakiyo
Bioorganic & Medicinal Chemistry Letters   26(3) 921-923   2016   [Refereed]
Uno Yasuhiro, Hosokawa Masakiyo, Imai Teruko
J Vet Med Sci.   77(6) 721-724   2015   [Refereed]
Morimoto Kaori, Nagaoka Kei, Nagai Akira, Kashii Hirohumi, Hosokawa Masakiyo, Takahashi Yukitoshi, Ogihara Takuo, Kubota Masaya
BMC Neurol.   15 130   2015   [Refereed]
Mizoi Kenta, Mashima Yu, Kawashima Yyuya, Takahashi Masato, Mimori Seisuke, Hosokawa Masakiyo, Murakami Yasuoki, Hamana Hiroshi
Chem. Pharm. Bull   63 538-545   2015   [Refereed]
Uno Y, Uehara S, Hosokawa M, Imai T
Drug Metab Dispos   42(12) 2002-2006   2014   [Refereed]
Suzaki Y, Uemura N, Hosokawa M, Ohashi K.
Eur J Clin Pharmacol.   69(3) 735-736   2013   [Refereed]
Suzaki Y, Uemura N, Takada M, Ohyama T, Itohda A, Morimoto T, Imai H, HamasakiH, Inano A, Hosokawa M, Tateishi M, Ohashi K
ur J Clin Pharmacol   69(1) 21-30   2013   [Refereed]
T Hori, L Jin, A Fujii, T Furihata, Y Nagahara, K Chiba, M Hosokawa
Xenobiotica   42(7) 614-623   2012   [Refereed]
Carboxylesterases: Overview, structure, function and polymorphism
Hosokawa M and Satoh T
Anticholinesterase Pesticides: Metabolism, Neurotoxicity, and Epidemiology   (4) 43-56   2011   [Refereed][Invited]
Hori T, Hosokawa M
Xenobiotica.   40(2) 119-128   2010   [Refereed]
Igarashi M, Osuga J, Uozaki H, Sekiya M, Nagashima S, Takahashi M, Takase S, Takanashi M, Li Y, Ohta K, Kumagai M, Nishi M, Hosokawa M, Fledelius C, Jacobsen P, Yagyu H, Fukayama M, Nagai R, Kadowaki T, Ohashi K, Ishibashi S.
Circ Res   107(11) 1387-1395   2010   [Refereed]
Holmes RS, Wright MW, Laulederkind SJ, Cox LA, Hosokawa M, Imai T, Ishibashi S, Lehner R, Miyazaki M, Perkins EJ, Potter PM, Redinbo MR, Robert J, Satoh T, Yamashita T, Yan B, Yokoi T, Zechner R, Maltais LJ.
Mamm Genome.   21 427-441   2010   [Refereed]
Sai K, Saito Y, Tatewaki N, Hosokawa M, Kaniwa N, Nishimaki-Mogami T, Naito M, Sawada J, Shirao K, Hamaguchi T, Yamamoto N, Kunitoh H, Tamura T, Yamada Y, Ohe Y, Yoshida T, Minami H, Ohtsu A, Matsumura Y, Saijo N, Okuda H.
Br J Clin Pharmacol.   70(2) 222-233   2010   [Refereed]
92. Carboxylesterases: Structure, Function and Polymorphism in Mammals.
Satoh T, Hosokawa M
J. Pestic.Sci,   35(3) 205-211   2010   [Refereed]
Prodrug approach using carboxylesterases activity:Catalytic properties and gene regulation of carboxylesterase in mammalian tissue
Imai T, Hosokawa M
J. Pestic.Sci,   35(3) 229-239   2010   [Refereed]
Are non-human primates useful experimental animals for pre-clinical study?
HOSOKAWA Masakiyo
Drug Metab Pharmacokinet.   25(3) 221-222   2010   [Refereed]
Carboxylesterases; Structure, function and polymorphism
SatohT and Hosokawa M
Biomolecules and Therapeutics   17(4) 335-347   2009   [Refereed]
HOSOKAWA Masakiyo
Molecules   13 412-431   2008   [Refereed]
Yoshimura M, Kimura T, Ishii M, Ishii K, Matsuura T, Geshi E, Hosokawa M, Muramatsu M
Biochem Biophys Res Commun.   369(3) 939-942   2008   [Refereed]
Katakawa K, Nozoe A, Kogure N, Kitajima M, Hosokawa M, Takayama H
J Nat. Prod.   70 1024-1028   2007   [Refereed]
Hosokawa M, Furihata T, Yaginuma Y, Yamamoto N, Koyano N, Fujii A, Nagahara Y, Satoh T, and Chiba K
Drug.Metab.Rev   39 1-15   2007   [Refereed]
Structure, function and regulatory mechanism of the human carboxyl esterase gene
Hosokawa M, Yamamoto N, Yaginuma Y, Yoshimura M, Nagahara Y, Fujii A, Koyno N, Furihata T、Muramatsu M, Chiba K
Drug Metab. Rev   39 360-361   2007   [Refereed]
Kawashima S, Kobayashi K, Takama K, Higuchi T, Furihata T, Hosokawa M and Chiba K
Drug Metab Dispos   34 1012-1018   2006   [Refereed]
Functional characterization of OATP-C (SLCO1B1) variants, OATP-C*5, OATP-C*15 and OATP-C*15+C1007G by using transiently expression systems of HeLa and HEK293 cells
Kameyama Y, Yamashita K, Kobayashi K, Hosokawa M, Chiba K
Pharmacogenetics and Genomics   15(7) 513-522   2006   [Refereed]
Miyazaki M, Yamashita T, Hosokawa M, Taira H and Suzuki A
Comp Biochem Physiol B Biochem Mol Biol   145 270-277   2006   [Refereed]
Imai T, Taketani M, Shii M, Hosokawa M and Chiba K
Drug Metab Dispos   34 1734-1741   2006   [Refereed]
Satoh T and Hosokawa
Chem Biol Interact   162 195-211   2006   [Refereed]
Furihata T, Hosokawa M, Masuda M, Satoh T and Chiba K
Arch Biochem Biophys   447 107-117   2006   [Refereed]
Kobayashi K, Yamanaka Y, Iwazaki N, Nakajio I, Hosokawa M, Negishi M, Chiba K
Drug Metabolism and Disposition   33(7) 924-929   2005   [Refereed]
Furihata T, Hosokawa M, Fujii A, Derbel M, Satoh T ,Chiba K
Biochem. Pharmacol   69 1287-1297   2005   [Refereed]
Expression of CYP3A4 by an immortalized human hepatocyte line in a three-dimensional culture using a radial-flow bioreactor
International Journal of Molecular Medicine   14(4) 663-668   Oct 2004   [Refereed]
abata T Katoh M, Tokudome S, Hosakawa M, Chiba K, Nakajima M, Yokoi T.
Drug Metab Dispos   32(7):762-7.(7) 762-767   2004   [Refereed]
Hum Mol Genet   Sep 30 [Epub ahead of print]    2004   [Refereed]
Drug. Metab. Dispos   30, 488-493    2002
Kinetics of testosteron 6β-hydroxylation in the reconstituted system with similar ratios of puridied Cyp3A4, NADPI cytochrone p450 oxidoreductase and cytochron b5
Res. commun. Mol. Pathol. Pharmacol.   109, 53-63    2001
Kinetics of testosterone 6b-hydroxylation in the reconstituted system with similar ratios of purified CYP3A4, NADPH-cytochrome P450 oxidoreductase and cytochrome B5 to human liver microsomes.
Res. Commun. Mol. Pathol. Pharmacol   109, 53-63,    2001
Kinetics of testosterone 6beta-hydroxylation were determined using a reconstituted system that consisted of CYP3A4, cytochrome b5 and NADPH-cytochrome P450 oxidoreductase (OR) with similar ratios as those seen in human liver microsomes and compare...
CYP2C9 Ile359 and len359 variants : enzyme kinetic study with seren substrates
Pharmacogenetics   10 95-104   2000
Phenacetin deacetylase activity in human liver microsmes : distribution, kinetics and Chemical inhibition and stimulation
J. Pharmacol. Exp. Ther.   294 80-88   2000
Establishment of a system for large-Scale isolation of human hepatocyte microsomes for use in en vironment pollutant testing
Evrironmental Sciences   7 83-100   2000
Phenacetin Deacetylase Activity in Human Liver Microsomes: Distribution, Kinetics and Chemical Inhibition and Stimulation
J. Pharmacol Exp Ther   294, 80-88    2000
Establishment of a system for large-scale isolation of human hepatocyte microsomes for use in environmental pollutant testing
Environmental Sciences   7, 083-100,    2000
Organophosphates and their impact on the global environment
Neuro toxicology   21 223-227   2000   [Refereed]
CYP2C9 Ile359 and Leu359 variants: enzyme kinetic study with seven substrates
Pharmacogenetics   10: 95-104    2000
Analgesic component of Glehnia Root (Glehnia littoralis)
Natural Medicine   52 491-501   1998
Analgenic component of Glehnia root (Glehnia littoralis)
Natural Medicine   52, 491-501    1998
Ann. Rev. Pharmacol Toxicol   38 257-288   1998
Purification and characterization of monkey liver amido hydrolases, and its relationship to a metabolic polymorphism of E6/23, a platelet actirating factor receptor antagonist
Drug Metabolism and Disposition   24 1186   1996
Tetsuo SATOH, Masakiyo HOSOKAWA
Xenobiotic Metabolism and Disposition   11(2) 219-230   1996
Inter species variation of Liver microsomal drug metabolizing enzymes in mammals and humans
Laboratory animal technology and science   8(5) 248   1996
Purification and charcterization of monkey liver amido hydrolases, and its relationship to a metabolic polymorphism of E6123, a platelet activating factor receptor antagonist
Drug. Metab. Dispos   24, 1186-1191    1996
Molecular aspect of carboxylesterase isoforms in comparison with other esterases
Toxicological Letters   82(.439)    1995
Toxicology Letters   82, 439-445    1995   [Refereed]
Interindividual variation in carboxylesterase levels in human liver microsomes
Drug Metabolism and Disposition   23(.1022)    1995   [Refereed]
Masakiyo HOSOKAWA
Xenobiotic Metabolism and Disposition   13(4) 405-417   1995   [Refereed][Invited]
N-nitrosodiethylamine and 4-lmethy(nitrosamino)-1-(3-pyridyl)-1-bntanore induced morphological transformation of C3H/10T1/2CL8 cells expressing human cytochrome P4502A6
Mutation Research   324 93-102   1994
Immunohistochemistry with an antibody to hwman liver curboxylesterase in human brain tissues.
Brain Research.   658 163-167   1994
Species differences in the induction of hepatic microsomul carboxylesterase caused by dietary exposure to di(2-ethylhexyl) phthalate, a peroxisome proliferator
Drug Metabolism and Disposition   22(6) 889-894   1994
Species differences in the induction of hepatic microsomal carboxylesterase caused by dietary exposure to di(2-ethylhexyl)phthalate, a peroxisome proliferator
Drug Metab. Dispos.   22, 889-894    1994   [Refereed]
Immunohistochemistry with an antibody to human liver carboxylesterase in human brain tissues
Brain Res.   658, 163-167    1994   [Refereed]
N-nitrosodiethylamine and 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone indiced morphological transformation of C3H/10T1/2CL8 cells expressing human cytochrome P450 2A6
Mutation Res.   324, 93-102    1994   [Refereed]
Tetsuo SATOH, Masakiyo HOSOKAWA, Ryo ATSUMI, Wataru SUZUKI, Hideo HAKUSUI, Eiichi NAGAI
Biol. Pharm. Bull.   17(5) 662-664   1994   [Refereed]
Changes in carboxylesterase isozymes of rat liver microsomes during hepatocarcinogenesis
Japanese Journal of Cancer Research   82    1991   [Refereed]
Differences in the functional roles of hepatic microsomal carboxylesterase isozymes in various manmals and humans
5(6)    1990
Characterization of Molecular species of Liver microsomal carboxylesterases of several animal species and humans
Archires of Biochemistry and Biophysics   277(2) 219-227   1990   [Refereed]
Differences in the regulation of carboxylesterase isozymes in rat liver microsomes.
Biol. Chem. Hoppe-Seyler   370,980-981    1989
Differnces in the regulation of carboxylesterase isozymes in rat liver microsomes
Biol. Chem. Hoppe-Seyler.   370, 988-989    1989
Multiplicity and physiological roles of carboxylesterase/lipase.
Boil. Chem. Hoppe-Seyler   370,988    1989

Books etc

 
Carboxylesterases: Overview, structure, function and polymorphism.
Masakiyo Hosokawa & Tetsuo Satoh (Part:Joint Work, nticholinesterase Pesticides: Metabolism, Neurotoxicity, and Epidemiology)
Jan 2011   
Toxicology of Organophosphate & Carbamate Compounds
HOSOKAWA Masakiyo (Part:Joint Work)
ELSEVIER   2006   
Measnrement of carboxylesterase(CES) activities
Current Protocols in Toxicology   2002   
Multiplicity and toxicological implications of liver microsomal carboxylesterase
Pesticides and Future : Toxicological studies of Risks and Benefits. North Carolina Unv. Press.   1991   
Carboxylesterase
1989   

Works

 
Role in metabolic activation of carboxyl esterase isozymes
2001

Research Grants & Projects

 
Genetic variation of the regulatory element of human carboxyl esterase isozymes
Structural organization of the regulatory element of carboxylesterase in mammals and humans.
Differences in the functional roles of hepatic microsomal Carboxylesterase isozymes in varions mammals and humans.