澁谷正史 (Masabumi Shibuya) - マイポータル

基本情報

所属: 東京医科歯科大学大学院医歯学総合研究科分子腫瘍医学客員教授,その他
: 東京大学名誉教授
: 上武大学上武大学副学長

学位: 医学博士(東京大学)
医学博士(東京大学)

J-GLOBAL ID: 200901028370848343
researchmap会員ID: 1000010910

研究キーワード

研究分野

学歴

- 1970年

東京大学, 医学部, 医学科
- 1970年

東京大学

委員歴

受賞

2007年

高松宮妃癌研究基金・学術賞
2005年

日本癌学会学術賞吉田富三賞
2005年

Japanese Cancer Association Tomizo-Yoshida Prize

MISC

146

RACK1 Regulates VEGF/Flt1-mediated Cell Migration via Activation of a PI3K/Akt Pathway

Feng Wang, Mai Yamauchi, Masashi Muramatsu, Tsuyoshi Osawa, Rika Tsuchida, Masabumi Shibuya

JOURNAL OF BIOLOGICAL CHEMISTRY 286(11) 9097-9106 2011年3月
VEGFR-1 signaling promotes mobilization of macrophage-lineage cells from bone marrow and stimulates solid tumor growth.

Cancer Res 70 8211-8221 2010年
Unique signal transduction of the VEGF family members VEGF-A and VEGF-E

Masabumi Shibuya

BIOCHEMICAL SOCIETY TRANSACTIONS 37(6) 1161-1166 2009年12月
Hypoxia and low-nutrition double stress induces aggressiveness in a murine model of melanoma

Tsuyoshi Osawa, Masashi Muramatsu, Makoto Watanabe, Masabumi Shibuya

CANCER SCIENCE 100(5) 844-851 2009年5月
VEGFR1 tyrosine kinase signaling promotes lymphangiogenesis as well as angiogenesis indirectly via macrophage recruitment

Masato Murakami, Yujuan Zheng, Masanori Hirashima, Toshio Suda, Yohei Morita, Jun Ooehara, Hideo Ema, Guo-Hua Fong, Masabumi Shibuya

ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY 28(4) 658-664 2008年4月
Vascular endothelial growth factor-dependent and –independent regulation of angiogenesis.

BMB Rep 41(4) 278-286 2008年4月
Signaling of vascular endothelial growth factor receptor-1 tyrosine kinase promotes rheumatoid arthritis through activation of monocytes/macrophages

Masato Murakami, Shinobu Iwai, Sachie Hiratsuka, Mai Yamauchi, Kazuhide Nakamura, Yoichiro Iwakura, Masabumi Shibuya

BLOOD 108(6) 1849-1856 2006年9月
Membrane fixation of vascular endothelial growth factor receptor 1 ligand-binding domain is important for vasculogenesis and angiogenesis in mice

S Hiratsuka, K Nakao, K Nakamura, M Katsuki, Y Maru, M Shibuya

MOLECULAR AND CELLULAR BIOLOGY 25(1) 346-354 2005年1月
VEGF-A is involved in guidance of VEGF-receptor-positive cells to the anterior portion of early embryos

Mol. Cell. Biol. 25 355-363 2005年
Essential role of Flk-1 (VEGF receptor 2) tyrosine residue 1173 in vasculogenesis in mice

Y Sakurai, K Ohgimoto, Y Kataoka, N Yoshida, M Shibuya

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA 102(4) 1076-1081 2005年1月
Vascular endothelial growth factor receptor-1 signaling is essential for osteoclast development and bone-marrow formation in CSF-1-deficient mice.

Proc. Natl. Acad. Sci. USA 102 14016-14021 2005年
Selective cytotoxic mechanism of GTP-14564, a novel tyrosine kinase inhibitor in leukemia cells expressing a constitutively active Fms-like tyrosine kinase 3 (FLT3)

K Murata, H Kumagai, T Kawashima, K Tamitsu, M Irie, H Nakajima, S Suzu, M Shibuya, S Kamihira, T Nosaka …

JOURNAL OF BIOLOGICAL CHEMISTRY 278(35) 32892-32898 2003年8月
Endothelial cell injury and coagulation system activation during synergistic hepatotoxicity from monocrotaline and bacterial lipopolysaccharide coexposure

SB Yee, UM Hanumegowda, BL Copple, M Shibuya, PE Ganey, RA Roth

TOXICOLOGICAL SCIENCES 74(1) 203-214 2003年7月
Role of PIGF in the intra- and intermolecular cross talk between the VEGF receptors Flt1 and Flk1

M Autiero, J Waltenberger, D Communi, A Kranz, L Moons, D Lambrechts, J Kroll, S Plaisance, M De Mol, F Bono …

NATURE MEDICINE 9(7) 936-943 2003年7月
Mammalian Sprouty4 suppresses Ras-independent ERK activation by binding to Raf1

A Sasaki, T Taketomi, R Kato, K Saeki, A Nonami, M Sasaki, M Kuriyama, N Saito, M Shibuya, A Yoshimura

NATURE CELL BIOLOGY 5(5) 427-432 2003年5月
Different differentiation kinetics of vascular progenitor cells in primate and mouse embryonic stem cells

M Sone, H Itoh, J Yamashita, T Yurugi-Kobayashi, Y Suzuki, Y Kondo, A Nonoguchi, N Sawada, K Yamahara, K Miyashita …

CIRCULATION 107(16) 2085-2088 2003年4月
A set of loop-1 and-3 structures in the novel vascular endothelial growth factor (VEGF) family member, VEGF-ENZ-7, is essential for the activation of VEGFR-2 signaling

A Kiba, N Yabana, M Shibuya

JOURNAL OF BIOLOGICAL CHEMISTRY 278(15) 13453-13461 2003年4月
A chemically defined culture of VEGFR2(+) cells derived from embryonic stem cells reveals the role of VEGFR1 in tuning the threshold for VEGF in developing endothelial cells

M Hirashima, M Ogawa, S Nishikawa, K Matsumura, K Kawasaki, M Shibuya, SI Nishikawa

BLOOD 101(6) 2261-2267 2003年3月
VEGFR-2-specific ligand VEGF-E induces non-edematous hyper-vascularization in mice

A Kiba, H Sagara, T Hara, M Shibuya

BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS 301(2) 371-377 2003年2月
Mammalian Sprouty4 Suppresses Ras-Independent ERK Activation by Binding to Raf1

Atsuo Sasaki, Takaharu Taketomi, Reiko Kato, Kazuko Saeki, Atsushi Nonami, Mika Sasaki, Masamitsu Kuriyama, Naoaki Saito, Masafumi Shibuya, Akihiko Yoshimura

CELL CYCLE 2(4) 281-282 2003年

もっとみる

書籍等出版物

Development of liver vascular system

Morphogenesis of Endothelium(Harwood Acad. Publ) 2000年
Structure and function of Flt-1(Vascular Endothelial Growth Factor Receptor-1).

Current Topics in Microbiology and Immunology 1997年
A review on the role of VEGF-Flt receptor system in normal and tumor angiogenesis.

Adv. Cancer Res. 1995年
Possible involvement of receptor-type tyrosine Kinases EGF-R and FLT in the development of brain tumors.

Gann Monograph on Cancer Research 1994年
Possible involvement of VEGF-FLT tyrosine kinase receptor system in normal and tumor angiogenesis.

Proceedings of the 24th International Symposium of The Princess Takamatsu Cancer Research Fund. 1994年

澁谷正史

基本情報

研究キーワード

研究分野

学歴

委員歴

受賞

MISC

書籍等出版物

所属学協会

共同研究・競争的資金等の研究課題

メニュー