2009年9月
G2A as a receptor for oxidized free fatty acids
PROSTAGLANDINS & OTHER LIPID MEDIATORS
- ,
- 巻
- 89
- 号
- 3-4
- 開始ページ
- 66
- 終了ページ
- 72
- 記述言語
- 英語
- 掲載種別
- DOI
- 10.1016/j.prostaglandins.2008.11.002
- 出版者・発行元
- ELSEVIER SCIENCE INC
G2A was identified as a G protein-coupled receptor that can be induced by different classes of DNA-damaging agents and block cell cycle progression in lymphocytes. We recently reported that G2A functions as a receptor for oxidized free fatty acids derived from linoleic and arachidonic acids. When ectopically expressed in CHO cells, G2A mediates intracellular signaling events such as intracellular calcium mobilization and JNK activation in response to oxidized free fatty acids. In human epidermal keratinocytes, G2A mediates the secretion of cytokines including interleukin-6 and -8, and blocks cell cycle progression at the G1 phase in response to ligands. G2A might function as a sensor that monitors the oxidative states and mediates appropriate cellular responses such as secretion of paracrine signals and attenuation of proliferation. (C) 2008 Elsevier Inc. All rights reserved.
- リンク情報
- ID情報
-
- DOI : 10.1016/j.prostaglandins.2008.11.002
- ISSN : 1098-8823
- PubMed ID : 19063986
- Web of Science ID : WOS:000270777100003