2009年5月
GAB2 is not associated with late-onset Alzheimer's disease in Japanese
EUROPEAN JOURNAL OF HUMAN GENETICS
- 巻
- 17
- 号
- 5
- 開始ページ
- 682
- 終了ページ
- 686
- 記述言語
- 英語
- 掲載種別
- DOI
- 10.1038/ejhg.2008.181
- 出版者・発行元
- NATURE PUBLISHING GROUP
The epsilon 4 allele of the apolipoprotein E gene (APOE) is unequivocally recognized as a genetic risk factor for late-onset Alzheimer's disease (LOAD). Recently, single-nucleotide polymorphisms (SNPs) of the GRB2-associated binding protein 2 gene (GAB2) were shown to be associated with LOAD in Caucasians carrying the APOE-epsilon 4 allele through a genome-wide association study. Here, we attempted to replicate the finding by genotyping these SNPs in a large clinical cohort of Japanese. We observed no association of any of the SNPs with LOAD. GAB2 may not be a disease susceptibility gene for LOAD in Japanese.
- リンク情報
- ID情報
-
- DOI : 10.1038/ejhg.2008.181
- ISSN : 1018-4813
- Web of Science ID : WOS:000265507900019