MISC

1998年2月

Production of eosinophil chemotactic factor by CD8(+) T-cells in Toxocara canis-infected mice

PARASITOLOGY RESEARCH
  • M Owhashi
  • ,
  • H Arita
  • ,
  • A Niwa

84
2
開始ページ
136
終了ページ
138
記述言語
英語
掲載種別
DOI
10.1007/s004360050370
出版者・発行元
SPRINGER VERLAG

Production of eosinophil chemotactic factor by T-lymphocytes (ECF-L) was examined in Toxocara canis-infected mice. When spleen cells from T. canis-infected mice were cultured in serum-free RPMI1640, ECF-L production was detectable in an antigen-specific manner. The ECF-L production peaked at day 9 postinfection and then decreased. Depletion of Thy 1.2(+) cells or CD8(+) cells completely abrogated ECF-L production, whereas depletion of CD4(+) cells did not, indicating that CD8(+) T-cells are involved in the production of ECF-L. When bone marrow eosinophils obtained from T. canis-infected mice were preincubated with ECF-L, their chemotactic reactivity to parasite-derived ECFs was enhanced, whereas that of peritoneal cavity-derived eosinophils was not. Thus. ECF-L seems to be important not only as a chemoattractant but also as an activator of the chemotactic reactivity of naive eosinophils to the parasite-derived ECF in T. canis infection.

Web of Science ® 被引用回数 : 25

リンク情報
DOI
https://doi.org/10.1007/s004360050370
Web of Science
https://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcAuth=JSTA_CEL&SrcApp=J_Gate_JST&DestLinkType=FullRecord&KeyUT=WOS:000071278600008&DestApp=WOS_CPL
ID情報
  • DOI : 10.1007/s004360050370
  • ISSN : 0044-3255
  • Web of Science ID : WOS:000071278600008

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