MISC

2002年6月

Effect of dietary fiber on morphine-induced constipation in rats

BIOSCIENCE BIOTECHNOLOGY AND BIOCHEMISTRY
  • T Niwa
  • ,
  • M Nakao
  • ,
  • S Hoshi
  • ,
  • K Yamada
  • ,
  • K Inagaki
  • ,
  • M Nishida
  • ,
  • T Nabeshima

66
6
開始ページ
1233
終了ページ
1240
記述言語
英語
掲載種別
DOI
10.1271/bbb.66.1233
出版者・発行元
TAYLOR & FRANCIS LTD

Morphine is used to alleviate chronic cancer pain. However, constipation is a major adverse effect that often detracts from the patient's quality of life. In this study, we investigated the effectiveness of dietary fiber on morphine-induced constipation. Rats were fed on a normal diet or one containing either 10% or 20% apple fiber for two weeks before morphine was administered. In the control diet group, the fecal number and dry weight were decreased by treating with morphine in a dose-dependent manner. Moreover, the motility of the small and large intestines was reduced. The fecal number and weight were increased and the colon motility was promoted by dietary fiber, regardless of whether morphine was being administered. The dietary fiber increased the concentration of short-chain fatty acids (SC-FAs) in the cecum. These results suggest that dietary fiber has a preventative effect on morphine-induced constipation by increasing SCFAs in the cecum, and thereby promoting colon motility in rats.


リンク情報
DOI
https://doi.org/10.1271/bbb.66.1233
CiNii Articles
http://ci.nii.ac.jp/naid/110002693811
PubMed
https://www.ncbi.nlm.nih.gov/pubmed/12162543
Web of Science
https://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcAuth=JSTA_CEL&SrcApp=J_Gate_JST&DestLinkType=FullRecord&KeyUT=WOS:000176603800007&DestApp=WOS_CPL
ID情報
  • DOI : 10.1271/bbb.66.1233
  • ISSN : 0916-8451
  • eISSN : 1347-6947
  • CiNii Articles ID : 110002693811
  • PubMed ID : 12162543
  • Web of Science ID : WOS:000176603800007

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