2002年6月
Effect of dietary fiber on morphine-induced constipation in rats
BIOSCIENCE BIOTECHNOLOGY AND BIOCHEMISTRY
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- 巻
- 66
- 号
- 6
- 開始ページ
- 1233
- 終了ページ
- 1240
- 記述言語
- 英語
- 掲載種別
- DOI
- 10.1271/bbb.66.1233
- 出版者・発行元
- TAYLOR & FRANCIS LTD
Morphine is used to alleviate chronic cancer pain. However, constipation is a major adverse effect that often detracts from the patient's quality of life. In this study, we investigated the effectiveness of dietary fiber on morphine-induced constipation. Rats were fed on a normal diet or one containing either 10% or 20% apple fiber for two weeks before morphine was administered. In the control diet group, the fecal number and dry weight were decreased by treating with morphine in a dose-dependent manner. Moreover, the motility of the small and large intestines was reduced. The fecal number and weight were increased and the colon motility was promoted by dietary fiber, regardless of whether morphine was being administered. The dietary fiber increased the concentration of short-chain fatty acids (SC-FAs) in the cecum. These results suggest that dietary fiber has a preventative effect on morphine-induced constipation by increasing SCFAs in the cecum, and thereby promoting colon motility in rats.
- リンク情報
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- DOI
- https://doi.org/10.1271/bbb.66.1233
- CiNii Articles
- http://ci.nii.ac.jp/naid/110002693811
- PubMed
- https://www.ncbi.nlm.nih.gov/pubmed/12162543
- Web of Science
- https://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcAuth=JSTA_CEL&SrcApp=J_Gate_JST&DestLinkType=FullRecord&KeyUT=WOS:000176603800007&DestApp=WOS_CPL
- ID情報
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- DOI : 10.1271/bbb.66.1233
- ISSN : 0916-8451
- eISSN : 1347-6947
- CiNii Articles ID : 110002693811
- PubMed ID : 12162543
- Web of Science ID : WOS:000176603800007