2006年5月
A small Ras-like protein Ray/Rab1c modulates the p53-regulating activity of PRPK
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
- 巻
- 344
- 号
- 1
- 開始ページ
- 377
- 終了ページ
- 385
- 記述言語
- 英語
- 掲載種別
- DOI
- 10.1016/j.bbrc.2006.03.071
- 出版者・発行元
- ACADEMIC PRESS INC ELSEVIER SCIENCE
PRPK phosphorylates serine-15 residue of p53 and enhances transcriptional activity. PRPK possesses a bipartite nuclear localization signal and localizes in nucleus when over-expressed in cells. However, intrinsic PRPK localizes mainly in the cytosol in situ. While studying the mechanisms in the distribution of intrinsic PRPK, we identified a PRPK binding protein, an ubiquitously expressed Small Ras-like GTPase, Rabic, also named Ray or Rab35. The over-expressed Ray was distributed in the nucleus, cytosol.. and cell membrane. Both Ray wild type and GTP-restrictively binding mutant Ray-Q67L, but not guanine nucleotide unstable binding Mutant Ray-N120I, partially distributed the over-expressed PRPK to the cytosol and also Suppressed the PRPK-induced p53-transcriptional activity profoundly. A Small Ras-like GTPase protein Ray was thus indicated to modulate p53 transcriptional activity of PRPK. (c) 2006 Elsevier Inc. All rights reserved.
- リンク情報
-
- DOI
- https://doi.org/10.1016/j.bbrc.2006.03.071
- CiNii Articles
- http://ci.nii.ac.jp/naid/80019198329
- PubMed
- https://www.ncbi.nlm.nih.gov/pubmed/16600182
- Web of Science
- https://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcAuth=JSTA_CEL&SrcApp=J_Gate_JST&DestLinkType=FullRecord&KeyUT=WOS:000237408000054&DestApp=WOS_CPL
- ID情報
-
- DOI : 10.1016/j.bbrc.2006.03.071
- ISSN : 0006-291X
- CiNii Articles ID : 80019198329
- PubMed ID : 16600182
- Web of Science ID : WOS:000237408000054