MIYAZAKI Tatsuhiko

J-GLOBAL         Last updated: Jul 2, 2019 at 02:42
 
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Name
MIYAZAKI Tatsuhiko
Affiliation
Gifu University
Section
Graduate School of Medicine
Job title
Associate Professor,Associate professor, Ehime University Proteo-Medicine Research Center

Profile

Studies on development of autoimmune diseases/clinicopathological analyses of vasculitic syndrome and autoimmune glomerulonephritis/clinicopathological studies on bone and soft tissue tumors

Research Areas

 
 

Academic & Professional Experience

 
Oct 2013
 - 
Today
Hospital Professor, Pathology Division, Gifu University Hospital, Gifu University Graduate School of Medicine
 
Sep 2013
 - 
Sep 2013
Associate Professor, Pathology Division, Gifu University Hospital, Gifu University
 
Apr 2006
 - 
Aug 2013
Associate Professor, Ehime University Graduate School of Medicine
 
2006
   
 
- Department of Pathogenomics, Ehime University Graduate School of Medicine
 
2006
   
 
- Ehimr University School of Medicine
 
1990
 - 
2005
Ehime University School of Medicine
 

Education

 
 
 - 
1990
Faculty of Medicine, Ehime University
 

Committee Memberships

 
2000
   
 
Japanese Society of Pathology  Academic Councilor
 
2004
   
 
Japanese Society of Pathology  a public relation officer, division of Chugoku-Shikoku area, Japanese Society of Pathology
 

Published Papers

 
Kawaguchi M, Kato H, Miyazaki T, Kato K, Hatakeyama D, Mizuta K, Aoki M, Matsuo M
Dento maxillo facial radiology   20180085   Apr 2018   [Refereed]
Tezuka Y, Fukuda M, Watanabe S, Nakano T, Okamoto K, Kuzume K, Yano Y, Eguchi M, Ishimae M, Ishii E, Miyazaki T
Blood cells, molecules & diseases   68 194-199   Feb 2018   [Refereed]
Shibata Y, Hara T, Matsumoto T, Nakamura N, Nakamura H, Ninomiya S, Kitagawa J, Goto N, Nannya Y, Ito H, Kito Y, Miyazaki T, Takeuchi T, Saito K, Seishima M, Takami T, Moriwaki H, Shimizu M, Tsurumi H
Hematological oncology   35(4) 637-644   Dec 2017   [Refereed]
Kawashima M, Usui T, Okada H, Mori I, Yamauchi M, Ikeda T, Kajita K, Kito Y, Miyazaki T, Fujioka K, Ishizuka T, Morita H
Modern rheumatology   27(6) 1093-1097   Nov 2017   [Refereed]
Hideki Matsumoto, Hideki Matsumoto, Michio Ozeki, Tomohiro Hori, Kaori Kanda, Norio Kawamoto, Akihito Nagano, Eiichi Azuma, Tatsuhiko Miyazaki, Toshiyuki Fukao
Journal of Pediatric Hematology/Oncology   38(8) e322-e325   Nov 2016   [Refereed]
Copyright © 2016 Wolters Kluwer Health, Inc. All rights reserved.Kasabach-Merritt phenomenon (KMP) is a life-threatening consumptive coagulopathy associated with underlying kaposiform hemangioendothelioma (KHE) in infancy. We describe the case of ...
Niwa A, Kuwano S, Tomita H, Kimura K, Orihara Y, Kanayama T, Noguchi K, Hisamatsu K, Nakashima T, Hatano Y, Hirata A, Miyazaki T, Kaneko K, Tanaka T, Hara A
Oncotarget   9(13) 11427   Feb 2018   [Refereed]
Tajima JY, Futamura M, Gaowa S, Mori R, Tanahashi T, Tanaka Y, Matsuhashi N, Takahashi T, Yamaguchi K, Miyazaki T, Yoshida K
Journal of Cancer   9(2) 358-366   2018   [Refereed]
Yoshihiro Tanaka, Kazuhiro Yoshida, Atsuko Yamada, Toshiyuki Tanahashi, Naoki Okumura, Nobuhisa Matsuhashi, Kazuya Yamaguchi, Tatsuhiko Miyazaki
Cancer Chemotherapy and Pharmacology   77(6) 1153-1155   Jun 2016   [Refereed]
Mizutani K, Horie K, Nagai S, Tsuchiya T, Saigo C, Kobayashi K, Miyazaki T, Deguchi T
Molecular and clinical oncology   7(6) 988-990   Dec 2017   [Refereed]
Matsuyama K, Mizutani Y, Takahashi T, Shu E, Kanoh H, Miyazaki T, Seishima M
Archives of dermatological research   309(9) 749-756   Nov 2017   [Refereed]
Yamamoto Y, Goto N, Takemura M, Yamasuge W, Yabe K, Takami T, Miyazaki T, Takeuchi T, Shiraki M, Shimizu M, Adachi S, Saito K, Shibata Y, Nakamura N, Hara T, Serrero G, Saito K, Tsurumi H
Clinica chimica acta; international journal of clinical chemistry   473 139-146   Oct 2017   [Refereed]
Nakashima T, Tomita H, Hirata A, Ishida K, Hisamatsu K, Hatano Y, Kanayama T, Niwa A, Noguchi K, Kato K, Miyazaki T, Tanaka T, Shibata T, Hara A
Cancer medicine   6(10) 2424-2439   Oct 2017   [Refereed]
Ozeki M, Nozawa A, Kanda K, Hori T, Nagano A, Shimada A, Miyazaki T, Fukao T
Journal of pediatric hematology/oncology   39(6) e328-e331   Aug 2017   [Refereed]
Takuro Matsumoto, Takeshi Hara, Yuhei Shibata, Nobuhiko Nakamura, Hiroshi Nakamura, Soranobu Ninomiya, Junichi Kitagawa, Nobuhiro Kanemura, Naoe Goto, Yusuke Kito, Senji Kasahara, Toshiki Yamada, Michio Sawada, Tatsuhiko Miyazaki, Tsuyoshi Takami, Tamotsu Takeuchi, Hisataka Moriwaki, Hisashi Tsurumi
Hematological Oncology   35(3) 288-295   Jan 2016   [Refereed]
© 2016 John Wiley & Sons, Ltd.We have reported the efficacy of the salvage chemotherapy P-IMVP16/CBDCA for patients with diffuse large B cell lymphoma (DLBCL) who had previously received CHOP before the availability of rituximab (R). Here, we conf...
Hisamatsu K, Noguchi K, Tomita H, Muto A, Yamada N, Kobayashi K, Hirata A, Kanayama T, Niwa A, Ishida K, Nakashima T, Hatano Y, Suzui N, Miyazaki T, Hara A
Oncology reports   38(2) 775-784   Aug 2017   [Refereed]
Yuhei Shibata, Takeshi Hara, Senji Kasahara, Toshiki Yamada, Michio Sawada, Ryoko Mabuchi, Ryoko Mabuchi, Takuro Matsumoto, Nobuhiko Nakamura, Hiroshi Nakamura, Soranobu Ninomiya, Junichi Kitagawa, Nobuhiro Kanemura, Yusuke Kito, Naoe Goto, Tatsuhiko Miyazaki, Tsuyoshi Takami, Tamotsu Takeuchi, Masahito Shimizu, Hisashi Tsurumi
Hematological Oncology   35 163-171   Jun 2017
Copyright © 2015 John Wiley & Sons, Ltd.The CHOP regimen consisting of cyclophosphamide, doxorubicin (DOX), vincristine and prednisolone has been the most used regimen for peripheral T-cell lymphoma, not otherwise specified (PTCL-NOS). Pirarubicin...
Klemis V, Ghura H, Federico G, Würfel C, Bentmann A, Gretz N, Miyazaki T, Gröne HJ, Nakchbandi IA
Kidney international   91(6) 1374-1385   Jun 2017   [Refereed]
Niwa A, Kuwano S, Tomita H, Kimura K, Orihara Y, Kanayama T, Noguchi K, Hisamatsu K, Nakashima T, Hatano Y, Hirata A, Miyazaki T, Kaneko K, Tanaka T, Hara A
Oncotarget   8(25) 41078-41090   Jun 2017   [Refereed]
Kobayashi K, Tomita H, Shimizu M, Tanaka T, Suzui N, Miyazaki T, Hara A
International journal of molecular sciences   18(6)    Jun 2017   [Refereed]
Mori R, Futamura M, Morimitsu K, Saigo C, Miyazaki T, Yoshida K
World journal of surgical oncology   15(1) 117   Jun 2017   [Refereed]
Hoa Thanh Nguyen, Maria Claret Lauan Tsuchiya, Maria Claret Lauan Tsuchiya, Jean Yoo, Midori Iida, Tetsuro Agusa, Tetsuro Agusa, Masashi Hirano, Eun Young Kim, Tatsuhiko Miyazaki, Masato Nose, Hisato Iwata
Archives of Toxicology   91 1763-1782   Apr 2017
© 2016, Springer-Verlag Berlin Heidelberg.Dioxins cause various toxic effects through the aryl hydrocarbon receptor (AHR) in vertebrates, with dramatic species and strain differences in susceptibility. Although inbred mouse strains C3H/HeJ-lpr/lpr...
Kameyama K, Horie K, Mizutani K, Kato T, Fujita Y, Kawakami K, Kojima T, Miyazaki T, Deguchi T, Ito M
International journal of oncology   50(1) 75-84   Jan 2017   [Refereed]
Yoshihiro Tanaka, Kazuhiro Yoshida, Atsuko Yamada, Toshiyuki Tanahashi, Naoki Okumura, Nobuhisa Matsuhashi, Kazuya Yamaguchi, Tatsuhiko Miyazaki
Cancer Chemotherapy and Pharmacology   77 1143-1152   Jun 2016
© 2016, The Author(s).The prognosis of esophageal cancer patients is still unsatisfactory. Although a docetaxel, cisplatin, and 5-Fu (DCF) regimen has been reported, it is often difficult to accomplish because of severe toxicity. Therefore, we dev...
Fumitaka Ito, Masanori Kawasaki, Yasushi Ohno, Sayaka Toyoshi, Megumi Morishita, Daizo Kaito, Komei Yanase, Norihiko Funaguchi, Masahiro Asano, Junki Endo, Hidenori Mori, Kazuhiro Kobayashi, Kazuhiko Nishigaki, Tatsuhiko Miyazaki, Genzou Takemura, Shinya Minatoguchi
Chest   149 1276-1284   May 2016
Copyright © 2016 American College of Chest Physicians. Published by Elsevier Inc. All rights reserved.BACKGROUND: Endobronchial ultrasonography (EBUS) facilitates a lung cancer diagnosis. However, qualitative tissue characterization of lung tumors...
Kenji Hisamatsu, Masayuki Niwa, Kazuhiro Kobayashi, Kazuhiro Kobayashi, Tatsuhiko Miyazaki, Akihiro Hirata, Yuichiro Hatano, Hiroyuki Tomita, Akira Hara
NeuroReport   27 311-317   Mar 2016
Copyright © 2016 Wolters Kluwer Health, Inc. All rights reserved.Recent evidence has suggested that the hippocampal CA2 region plays an important role in the recognition process. We have reported that ischemic damage in the hippocampal CA2 region ...
Michio Ozeki, Tomohiro Hori, Kaori Kanda, Norio Kawamoto, Takashi Ibuka, Tatsuhiko Miyazaki, Toshiyuki Fukao
Pediatrics   137    Mar 2016
Copyright © 2016 by the American Academy of Pediatrics.Primary intestinal lymphangiectasia (PIL), also known as Waldmann's disease, is an exudative enteropathy resulting from morphologic abnormalities in the intestinal lymphatics. In this article,...
Hiroki Kato, Masayuki Kanematsu, Masayuki Kanematsu, Haruo Watanabe, Akihito Nagano, En Shu, Mariko Seishima, Tatsuhiko Miyazaki
Acta Radiologica   57 726-732   Jan 2016
© The Foundation Acta Radiologica 2015.Background: Magnetic resonance imaging (MRI) findings of pilomatricomas have yet to be determined. Purpose: To assess the correlation between MRI and pathological findings of pilomatricomas. Material and Meth...
Nagano A, Ohno T, Oshima K, Ishimaru D, Nishimoto Y, Ohno Y, Hirakawa A, Miyazaki T, Akiyama H
Case reports in orthopedics   2016 1472932   2016   [Refereed]
Nobuhiko Nakamura, Takeshi Hara, Yuhei Shibata, Takuro Matsumoto, Hiroshi Nakamura, Soranobu Ninomiya, Yusuke Kito, Junichi Kitagawa, Nobuhiro Kanemura, Naoe Goto, Makoto Shiraki, Tatsuhiko Miyazaki, Tamotsu Takeuchi, Masahito Shimizu, Hisashi Tsurumi
Annals of Hematology   94 2043-2053   Dec 2015
© 2015, Springer-Verlag Berlin Heidelberg.Sarcopenia reportedly predicts poor outcomes in elderly patients with diffuse large B-cell lymphoma (DLBCL). However, because previous studies only involved elderly patients, it is difficult to generalize ...
See Wun Cho, See Wun Cho, Ken ichi Suzuki, Yoshiaki Miura, Tatsuhiko Miyazaki, Masato Nose, Masato Nose, Hisato Iwata, Eun Young Kim, Eun Young Kim
Archives of Toxicology   89 2027-2038   Nov 2015
© 2014, Springer-Verlag Berlin Heidelberg.The aryl hydrocarbon receptor (AHR) is responsible for susceptibility to its ligand-dependent responses. However, the effect of non-AHR factors is less clear. To explore the non-AHR factors, we used two mo...
Sho Mokuda, Sho Mokuda, Sho Mokuda, Sho Mokuda, Tatsuhiko Miyazaki, Yoshifumi Ubara, Masamoto Kanno, Eiji Sugiyama, Kiyoshi Takasugi, Junya Masumoto
Arthritis Research and Therapy   17    Sep 2015
© 2015 Mokuda et al.Introduction: Proto-oncogene survivin is a member of the inhibitor of apoptosis (IAP) family of proteins. The presence of serous antibodies against survivin in patients with systemic sclerosis has been previously reported; howe...
Sachiko Onishi, Endy Adnan, Jun Ishizaki, Tatsuhiko Miyazaki, Yuki Tanaka, Takuya Matsumoto, Koichiro Suemori, Masachika Shudou, Takafumi Okura, Hiroyuki Takeda, Tatsuya Sawasaki, Masaki Yasukawa, Hitoshi Hasegawa
PLoS ONE   10    Jun 2015
© 2015 Onishi et al.Systemic lupus erythematosus (SLE) is characterized by production of a variety of autoantibodies. Although anti-double-stranded DNA (anti-dsDNA) antibodies contribute to the pathogenesis of lupus nephritis (LN), they are not su...
Sho Mokuda, Sho Mokuda, Sho Mokuda, Sho Mokuda, Tatsuhiko Miyazaki, Yuki Ito, Satoshi Yamasaki, Hiroko Inoue, Yun Guo, Weng Sheng Kong, Masamoto Kanno, Kiyoshi Takasugi, Eiji Sugiyama, Junya Masumoto
Scientific Reports   5    May 2015
Survivin is an independent prognostic factor for joint destruction in rheumatoid arthritis (RA). However, the expression and function of survivin in RA synoviocytes remain unclear. We certified the expression of survivin in RA synovial tissues and...
Kazuhiro Kobayashi, Kazuhiro Kobayashi, Masayuki Niwa, Masato Hoshi, Kuniaki Saito, Kenji Hisamatsu, Yuichiro Hatano, Hiroyuki Tomita, Tatsuhiko Miyazaki, Akira Hara
Neuroscience Letters   592 107-112   Apr 2015
© 2015 Elsevier Ireland Ltd.Galectin-3 is a β-galactosidase-binding lectin which is important in cell proliferation and apoptotic regulation. Encephalomyocarditis virus (EMCV), which includes the Enterovirus genus, can cause not only acute myocard...
Hideshi Okada, Genzou Takemura, Hiromitsu Kanamori, Akiko Tsujimoto, Kazuko Goto, Itta Kawamura, Takatomo Watanabe, Kentaro Morishita, Nagisa Miyazaki, Toshiki Tanaka, Hiroaki Ushikoshi, Masanori Kawasaki, Masanori Kawasaki, Tatsuhiko Miyazaki, Natsuko Suzui, Kazuhiko Nishigaki, Atsushi Mikami, Shinji Ogura, Shinya Minatoguchi
Circulation: Heart Failure   8 149-155   Jan 2015
© 2015 American Heart Association, Inc.Background-Extravascular smooth muscle cells are often observed in the endocardium of human failing hearts. Here, we characterized the phenotype of those cells and investigated their physiological significanc...
Akira I. Hida, Kenji Bando, Atsuro Sugita, Toshiharu Maeda, Norifumi Ueda, Shoichi Matsukage, Mamoru Nakanishi, Katsumi Kito, Tatsuhiko Miyazaki, Yuji Ohtsuki, Yumi Oshiro, Hiromichi Inoue, Hidetoshi Kawaguchi, Natsumi Yamashita, Kenjiro Aogi, Takuya Moriya
Journal of Clinical Pathology   68 356-361   Jan 2015
Aims: Personalised breast cancer therapy requires pathological characterisation of tumours. The proliferative index, based on Ki67, is pivotal, but a standard method has not been established. Here we look for an easy and practical way to evaluate ...
Sho Mokuda, Sho Mokuda, Sho Mokuda, Tatsuhiko Miyazaki, Yukari Saeki, Junya Masumoto, Masamoto Kanno, Kiyoshi Takasugi
Modern Rheumatology   25 166-168   Jan 2015
Hiroshi Nakata, Tatsuhiko Miyazaki, Tomoyuki Iwasaki, Atsushi Nakamura, Teruki Kidani, Kenshi Sakayama, Junya Masumoto, Hiromasa Miura
Oncology Reports   33 1593-1598   Jan 2015
In recent years, chemotherapy with caffeine has manifested potently high efficacy against osteosarcoma, although adverse effects have been observed. Recently, we developed a novel drug delivery system (DDS) with nonionic vesicles prepared from Spa...
Kaori Tanaka, Kaori Tanaka, Hiroyuki Tomita, Kenji Hisamatsu, Takayuki Nakashima, Yuichiro Hatano, Yoshiyuki Sasaki, Shinji Osada, Takuji Tanaka, Tatsuhiko Miyazaki, Kazuhiro Yoshida, Akira Hara
Oncotarget   6 24722-24732   Jan 2015
Aldehyde dehydrogenase 1A1 (ALDH1A1) is considered to be a cancer stem cell marker in several human malignancies. However, the role of ALDH1A1 in hepatocellular carcinoma (HCC) has not been well elucidated. In this study, we investigated the relat...
Yuko Adachi, Yoko Mizutani, En Shu, Hiroyuki Kanoh, Tatsuhiko Miyazaki, Mariko Seishima
Case Reports in Dermatology   7 79-83   Jan 2015
© 2015 S. Karger AG, Basel.Eosinophilic fasciitis is clinically characterized by symmetrical scleroderma-like indurations of the skin with pain. The histological features are fascial inflammation with lymphocytes and eosinophils as well as thicken...
Masayuki Niwa, Takashi MaruYama, Kenji Hisamatsu, Kazuhiro Kobayashi, Kazuhiro Kobayashi, Tatsuhiko Miyazaki, Akihiro Hirata, Akihiro Hirata, Yuichiro Hatano, Hiroyuki Tomita, Akira Hara
Microglia: Physiology, Regulation and Health Implications   205-216   Jan 2015
© 2015 by Nova Science Publishers, Inc. All rights reserved.The β-galactoside-binding lectin, galectin-3, is expressed in a variety of mammalian cells and tissues. Galectin-3 contains a highly conserved motif known as the carbohydrate recognition ...
Kimiaki Takagi, Manabu Takai, Kei Kawata, Kengo Horie, Mina Kikuchi, Taku Kato, Kosuke Mizutani, Kensaku Seike, Tomohiro Tsuchiya, Mitsuru Yasuda, Shigeaki Yokoi, Masahiro Nakano, Hiroaki Ushikoshi, Tatsuhiko Miyazaki, Takashi Deguchi
Acta Urologica Japonica   61 347-351   Jan 2015
Sorafenib is a tyrosine kinase inhibitor (TKI) of the vascular endothelial growth factor receptor (VEGFR) used for advanced renal cell carcinoma. Treatment with sorafenib prolongs progression-free survival in patients with advanced clear-cell rena...
Shigenori Iwagaki, Shigenori Iwagaki, Tatsuhiko Miyazaki, Tomoko Mizuno, Hiroshi Kondo, Ken Ichirou Morishige
Journal of Obstetrics and Gynaecology Research   41 1469-1472   Jan 2015
© Japan Society of Obstetrics and Gynecology.To the best of our knowledge, this is the first report of post-partum hemorrhage (PPH) caused by an occult abnormal artery detected shortly after delivery on pelvic angiography (PAG). Initially, a diagn...
Nagisa Miyazaki, Ichijiro Murata, Genzou Takemura, Genzou Takemura, Hideshi Okada, Hiromitsu Kanamori, Jun Matsumoto-Miyazaki, Gakuro Yoshida, Kumiko Izumi, Kumiko Izumi, Hitomi Kashi, Kaori Niimi, Ayuko Nishiwaki, Tatsuhiko Miyazaki, Michiya Ohno, Hiroshige Ohashi, Fumiaki Suzuki, Shinya Minatoguchi
International Journal of Clinical and Experimental Pathology   7 7485-7496   Jan 2014
Prorenin receptor (PRR) has been implicated in the onset and progression of various renal diseases, though its possible association with immunoglobulin A (IgA) nephropathy remains unclear. In the present study, we tried to clarify expression and p...
Tatsuhiko Miyazaki
Japanese Journal of Nephrology   56 124-130   Jan 2014
Oishi Hisashi, Tsubaki Takahito, Miyazaki Tatsuhiko, Ono Masao, Nose Masato, Takahashi Satoru
Journal of immunology (Baltimore, Md. : 1950)   190(5) 2129-2137   Mar 2013   [Refereed]
Systemic lupus erythematosus is considered to be under the control of polygenic inheritance, developing according to the cumulative effects of susceptibility genes with polymorphic alleles; however, the mechanisms underlying the roles of polygenes...
Mizutani Yasuyoshi, Matsuoka Kazuhiro, Takeda Hiroyuki, Shiogama Kazuya, Inada Ken-ichi, Hayakawa Kazue, Yamada Harumoto, Miyazaki Tatsuhiko, Sawasaki Tatsuya, Endo Yaeta, Tsutsumi Yutaka
Journal of immunological methods   387(1-2) 57   Jan 2013   [Refereed]
Synovial tissue in rheumatoid arthritis (RA) shows dense infiltration of plasmacytes. The purpose of the present study is to identify and localize autoantibodies produced in these immunocytes in RA synovitis. Wedeveloped a novel screening system f...
Nose Masato, Komori Hiroaki, Miyazaki Tatsuhiko, Mori Shiro
Annals of vascular diseases   6(1) 16   2013   [Refereed]
A genome analysis of mouse models may shed some light on the complex clinicopathological manifestations of systemic vasculitis. In the study of susceptibility loci to vasculitis in MRL mouse models, we found that systemic vasculitis developed thro...
Chika Namba, Saori Miyawaki, Shinji Murakami, Koji Hashimoto, Koji Sayama, Masanori Joutoku, Jitsuo Higaki, Tatsuhiko Miyazaki, Yoshinobu Hoshii, Keisuke Sugiura
Nishinihon Journal of Dermatology   74 387-390   Dec 2012
A 92-year-old man presented with pruritic erythema, blisters and erosions on forearms and dorsum that had persisted for 1-month. Histology of the abdominal erythema showed a subepidermal blister and moderate infiltration of lymphocytes and eosinop...
Miyoshi Seigo, Hamada Hironobu, Hamaguchi Naohiko, Kato Aki, Katayama Hitoshi, Irifune Kazunori, Ito Ryoji, Miyazaki Tatsuhiko, Okura Takafumi, Higaki Jitsuo
International journal of oncology   41(2) 449-456   Aug 2012   [Refereed]
Malignant pleural mesothelioma (MPM) is an aggressive malignancy for whichthere is no approved targeted therapy. Weexamined the therapeutic efficacy of the mitogen-activated protein kinase kinase(MEK) and phosphatidylinositol 3-kinase (PI3K) inhib...
Kurata Mie, Okura Takafumi, Kumon Yoshiaki, Tagawa Masahiko, Watanabe Hideaki, Nakahara Toshinori, Miyazaki Tatsuhiko, Higaki Jitsuo, Nose Masato
Hypertension research : official journal of the Japanese Society of Hypertension   35(2) 207-212   Feb 2012   [Refereed]
Atherothrombosis is the primary pathophysiology that underlies ischemic cerebral infarction. Osteopontin (OPN) is produced in atherosclerotic lesions and is cleaved by activated thrombin. We hypothesized that the rupture or damage of an unstable a...
Hayashi Keita, Walde Peter, Miyazaki Tatsuhiko, Sakayama Kenshi, Nakamura Atsushi, Kameda Kenji, Masuda Seizo, Umakoshi Hiroshi, Kato Keiichi
Journal of drug delivery   2012 842785   2012   [Refereed]
Previously, we demonstrated that the novel lectin Eucheuma serra agglutinin from a marine red alga (ESA) induces apoptotic cell death in carcinoma. We now find that ESA induces apoptosis also in the case of sarcoma cells. First, propidium iodide a...
Hayashi Keita, Shimanouchi Toshinori, Kato Keiichi, Miyazaki Tatsuhiko, Nakamura Atsushi, Umakoshi Hiroshi
Colloids and surfaces. B, Biointerfaces   87(1) 28   Oct 2011   [Refereed]
The surface properties of Span 80 vesicles at various cholesterol contents, together with those of various liposomes, were characterized by using fluorescence probes. The membrane fluidity of the Span 80 vesicles was measured by 1,6-diphenyl-1.3.5...
Nishikawa Yukiko, Miyazaki Tatsuhiko, Nakashiro Koh-Ichi, Yamagata Hidehisa, Isokane Mayumi, Goda Hiroyuki, Tanaka Hiroshi, Oka Ryota, Hamakawa Hiroyuki
Oncology reports   26(3) 587-592   Sep 2011   [Refereed]
FAT1 [Homo sapiens FAT tumor suppressor homolog 1 (Drosophila)]is an intrinsic membrane protein classified as a member of the cadherin superfamily. The FAT1 gene is atumor suppressor in humans as well as being the pivotal gene for cell morphogenes...
Hamaguchi Naohiko, Hamada Hironobu, Miyoshi Seigo, Irifune Kazunori, Ito Ryoji, Miyazaki Tatsuhiko, Higaki Jitsuo
Cancer science   101(9) 1955-1964   Sep 2010   [Refereed]
Malignant pleural mesothelioma (MPM), an aggressive and refractory tumor type, is increasing in frequency throughout the world. Peroxisome proliferator activated receptor-γ (PPAR-γ) agonists have anticancer activity against several cancer cell lin...
Akira Ozawa, Nozomu Tanji, Yuuichiro Sawada, Shinpei Oda, Yutaka Yanagihara, Toyokazu Sasaki, Takayasu Nishida, Tadahiko Kikugawa, Kenji Shimamoto, Katsunori Aoki, Masayoshi Yokoyama, Tatsuhiko Miyazaki
Nishinihon Journal of Urology   72 319-323   Jun 2010
Systemic chemotherapy with radical surgery is one of the modalities that provide the potential for long-term survival in cases of locally advanced urothelial carcinoma (UC). We examined the clinical and pathological responses of gemcitabine plus c...
Mizuki Shinichi, Oishi Hisashi, Zhang Ming-Cai, Kamogawa Junji, Miyazaki Tatsuhiko, Ono Masao, Takahashi Satoru, Yamamoto Haruyasu, NoseMasato
Pathology international   60(6) 430-437   Jun 2010   [Refereed]
A cumulative effect of the susceptibility genes with polymorphic alleles may be responsible for rheumatoid arthritis (RA). The objective of this study was to clarify whether susceptibility to RA is under the control of common allelic loci betweent...
Seigo Miyoshi, Hironobu Hamada, Hitoshi Katayama, Naohiko Hamaguchi, Toru Kadowaki, Ryoji Ito, Kazunori Irifune, Tatsuhiko Miyazaki, Jitsuo Higaki
Journal of Cardiology Cases   1(2) e120-e123   Apr 2010
We describe a case of pulmonary tumor thrombotic microangiopathy (PTTM) associated with lung cancer. A 63-year-old woman, who had been treated for lung cancer, was admitted to our hospital because of progressive dyspnea. Chest CT films showed reti...
OmokawaYousuke, Miyazaki Tatsuhiko, Walde Peter, Akiyama Koichi, Sugahara Takuya, Masuda Seizo, Inada Akihiro, Ohnishi Yasuyuki,Saeki Toshiaki, Kato Keiichi
International journal of pharmaceutics   389(1-2) 157-167   Apr 2010   [Refereed]
The lectin Eucheuma serra agglutinin (ESA) is known from previous studies to specifically bind to high-mannose type N-glycans and to induce apoptotic cancer cell death in vitro. In this study, Span 80 vesicles, with an average diameter between abo...
Yuki Tanaka, Yuki Tanaka, Hiroaki Komori, Shiro Mori, Yoshiko Soga, Takahito Tsubaki, Miho Terada, Tatsuhiko Miyazaki, Takahiro Fujino, Satoshi Nakamura, Hiroyuki Kanno, Tatsuya Sawasaki, Yaeta Endo, Masato Nose, Masato Nose
Tohoku Journal of Experimental Medicine   220(3) 199-206   Mar 2010
Enzyme-linked immunosorbent assays (ELISA) have been widely used to determine quantitatively autoantibodies. However, the processes for the purification and immobilization of antigens in conventional ELISA methods include multiple steps, which hav...
Tomoyuki Kamao, Tomoyuki Kamao, Tatsuhiko Miyazaki, Yoshiko Soga, Hiroaki Komori, Miho Terada, Yuichi Ohashi, Masato Nose
Investigative Ophthalmology and Visual Science   50(7) 3257-3265   Dec 2009
PURPOSE. Sjögren's syndrome (SS) is a systemic autoimmune disease in which the main lesions are dacryoadenitis and sialadenitis. It is unclear whether these lesions develop in a common genetic background. A quantitative trait locus (QTL) analysis ...
Kamei Setsuya, Sakayama Kenshi, Tamashiro Shinta, Aizawa Junichi, Miyawaki Joji, Miyazaki Tatsuhiko, Yamamoto Haruyasu, Norimatsu Yoshiaki, Masuno Hiroshi
Journal of orthopaedic research : official publication of the Orthopaedic Research Society   27(7) 909-915   Jul 2009   [Refereed]
The aim of thisstudy was to investigate whetherketoprofen (KP)in topical formulation affected the tumor growth and pulmonary metastasis of LM8 cells, which were inoculated subcutaneously into the back space of male nude mice. At 7 days after inocu...
Kamada Kazuo, Arita Norimasa, Tsubaki Takahito, Takubo Nobuo, Fujino Takahiro, Soga Yoshiko, Miyazaki Tatsuhiko, Yamamoto Haruyasu, Nose Masato
Pathology international   59(6) 382-389   Jun 2009   [Refereed]
Gene expression profiles in synovial tissues from rheumatoid arthritis (RA) patients have yielded useful information on the pathogenetic process of the synovitis. In one group of them, sphingosine kinase 2 (SPHK2), anuclear protein regulating cell...
Yoshiko Soga, Masato Nose, Masato Nose, Norimasa Arita, Hiroaki Komori, Tatsuhiko Miyazaki, Toshiharu Maeda, Keizo Furuya
Pathology International   59(3) 197-200   Mar 2009
This is the first report of segmental arterial mediolysis (SAM) accompanied with polyarteritis nodosa (PN), and manifesting aneurysms of the renal arteries. A 73-year-old woman was admitted to hospital because of a high fever. Laboratory tests sho...
Soga Yoshiko, Komori Hiroaki, Miyazaki Tatsuhiko, Arita Norimasa, TeradaMiho, Kamada Kazuo, Tanaka Yuki, Fujino Takahiro, Hiasa Yoichi, Matsuura Bunzo, Onji Morikazu, Nose Masato
The Tohoku journal of experimental medicine   217(3) 175-184   Mar 2009   [Refereed]
Innate immunity plays important roles in host defense against pathogens, but may also contribute to the development of autoimmune diseases under certain conditions. Toll-like receptors (TLRs) recognize various pathogens and induce innate immunity....
Kenshi Sakayama, Hisamichi Tauchi, Yoshifumi Sugawara, Teruki Kidani, Kiriko Tokuda, Tatsuhiko Miyazaki, Yuji Watanabe, Haruyasu Yamamoto
Anticancer Research   28(4C) 2361-2367   Jul 2008
A case of sclerosing rhabdomyosarcoma (RMS) in a young adult with multiple lung and skip bone metastases is reported. Complete remission was achieved with this patient by treatment with multi-agent chemotherapy and peripheral blood stem cell trans...
Yuuki Miyauchi, Nozomu Tanji, Tatsuhiko Miyazaki, Kenji Shimamoto, Kenshi Sakayama, Masayoshi Yokoyama
Pathology   40(4) 431-434   Jun 2008
Kenshi Sakayama, Naohiko Mashima, Teruki Kidani, Tatsuhiko Miyazaki, Haruyasu Yamamoto, Hiroshi Masuno
Cancer Chemotherapy and Pharmacology   61(3) 3471-3479   Mar 2008
Purpose: The aim of this study is to investigate whether cortisol inhibited cell proliferation and the expressions of lipoprotein lipase (LPL), a key enzyme involved in the energy metabolism in tumor cells, and vascular endothelial growth factor (...
Sakayama Kenshi, Mashima Naohiko, Kidani Teruki, Miyazaki Tatsuhiko, Yamamoto Haruyasu, Masuno Hiroshi
Cancer chemotherapy and pharmacology   61(3) 471-479   Mar 2008   [Refereed]
The aim of this study is to investigate whether cortisol inhibited cell proliferation and the expressions of lipoprotein lipase (LPL), a key enzyme involved in the energy metabolism in tumor cells, and vascular endothelial growth factor (VEGF), a ...
Hasegawa H, Inoue A, Kohno M, Lei J, Miyazaki T, Yoshie O, Nose M, Yasukawa M
Gene therapy   15(3) 171-182   Feb 2008   [Refereed]
Adoptive transfer of CD4+CD25+ regulatory T cells has been shown to have therapeutic effects in experimental graft-vs-host disease (GVHD) models. Chemokines play an important role in the recruitmentof alloreactive donor T cells into target organs ...
Masato Nose, Hiroaki Komori, Tatsuhiko Miyazaki, Tatsu Ya Sawasaki, Yaeta Endo
Seikagaku   79 287-295   Dec 2007
Nakatani K, Qu W-M, Zhang M-C, Fujii H, Furukawa H, Miyazaki T, Iwano M, Saito Y, Nose M, Ono M
Scandinavian journal of immunology   66(6) 654-661   Dec 2007   [Refereed]
Aging readily affects immune system under the influence of environmental and/or intrinsic factors while accelerating the development of various immune disorders including autoimmune diseases. Little is known about molecular and cellular mechanisms...
Tadanori Ogata, Tadanori Ogata, Tatsuhiko Miyazaki, Tadao Morino, Masato Nose, Haruyasu Yamamoto
Journal of Neurosurgery: Spine   7(4) 454-458   Oct 2007
Periosteal chondromas located in the spine are rare. The authors document a case of periosteal chondroma in the lumbar spinal canal of a 77-year-old man. The patient had severe pain in his right leg and used a wheelchair because of weakness in bot...
Naoko Misu, Naoko Misu, Mingcai Zhang, Shiro Mori, Tatsuhiko Miyazaki, Hiroshi Furukawa, Takeshi Sasaki, Masato Nose, Masao Ono
European Journal of Immunology   37(10) 2787-2796   Oct 2007
Sex-related differences (SrD) are a general characteristic of human autoimmune dieases. There is an increasing body of evidence that suggests a link between sex-related hormones and autoimmune onsets. Here, through a genetic approach using a lupus...

Misc

 
Takafumi Morishima, Yoko Mizutani, Tomoko Takahashi, Tatsuhiko Miyazaki, Mariko Seishima
Journal of Dermatology   45    May 2018
Kawashima Mikako, Usui Taro, Okada Hideyuki, Mori Ichiro, Yamauchi Masahiro, Ikeda Takahide, Kajita Kazuo, Kito Yusuke, Miyazaki Tatsuhiko, Fujioka Kei, Ishizuka Tatsuo, Morita Hiroyuki
Modern Rheumatology   27(6) 1093-1097   Nov 2017
NIWA Hirofumi, TAKAHASHI Tomoko, MATSUYAMA Kanako, SHU En, HIRAKAWA Akihiro, KAWASHIMA Keisuke, MIYAZAKI Tatsuhiko, SEISHIMA Mariko
Skin Cancer   31(3) 261-267   2017
<p>A small, red nodule developed on the metatarsophalangeal joint of the left index finger in 2007 and was surgically resected in November 2013. It was histopathologically diagnosed as Bowen's disease. The patient was admitted to a regional hospit...
Nakashima Takashi, Iwasa Masamitsu, Kanamori Hiromitsu, Ushikoshi Hiroaki, Kawasaki Masanori, Nishigaki Kazuhiko, Ogura Hiroki, Ishida Narihiro, Shimabukuro Katsuya, Miyazaki Tatsuhiko, Takemura Hirofumi, Minatoguchi Shinya
Shinzo   48(7) 774-780   2016
<p> Carney複合 (Carney complex ; CNC) は, 皮膚色素沈着, 副腎皮質腫瘍や下垂体腫瘍などの内分泌機能亢進で特徴づけられる症候群で常染色体優性遺伝疾患である. 心臓腫瘍を高率に合併し, 孤発性心臓腫瘍と比較し多発性で再発率が高い. 遺伝子検査でtype 1α regulatory subunit of cAMP-dependent protein kinaseのc. 597del C (p. Phe200LeufsX6) 変異が確認され, CNCと診断された...
Iwagaki Shigenori, Miyazaki Tatsuhiko, Mizuno Tomoko, Kondo Hiroshi, Morishige Ken-ichirou
The Journal of Obstetrics and Gynaecology Research   41(9) 1469-1472   Sep 2015
帝王切開歴があり、妊娠38週で再び帝王切開にて分娩した35歳健常女性症例について検討した。胎盤娩出直後に大量出血が生じ、循環血液量減少性ショックに陥った。骨盤検査または超音波検査から原因は特定されず、子宮弛緩症が疑われたが、子宮収縮薬を投与しても出血は継続し、血圧と意識レベルの低下が生じた。子宮動脈塞栓術を施行し、骨盤血管造影から右子宮動脈上行枝遠位端からの重篤な活動性出血が確認された。ゼラチンスポンジおよびメタルコイルを出血部位に留置したが、再出血が生じたため、子宮摘出術を施行した。子宮...

Books etc

 
The Questions of Caffeine (Latosinska JN, Latosinska M Ed.)
MIYAZAKI Tatsuhiko (Part:Joint Work, Development of Tumor-Specific Caffeine-Potentiated Chemotherapy Using Span 80 Nano-Vesicles DDS)
Intech d.o.o.   Jun 2017   ISBN:978-953-51-3274-5
DOI: 10.5772/intechopen.69155
Genetic Hypertension
TabeiR., Kondo M., Miyazaki T., Fujiwara T., Terada M., Watanabe Y (Part:Joint Work, pp241-243)
INSERM/John Libbey Eurotext Ltd. Paris   1992   

Research Grants & Projects

 
Study on development of autoimmune duseases
Functional analyses of polymorphic protein with cell free protein synthesis system using wheat germ
Project Year: 2003   
Establishent of a new drug delivery system by using detergent Span80 vesicle.
Project Year: 2006   
Analyses for Immunomodulation by glycosphyngolipid
Project Year: 2007   
Clinicopathologica analysis of vasculitis syndrome and autoimmune glomerulonephritis

Others

 
Dec 2016   Aurhorized cytologic diagnostic doctor