MISC

1999年11月

Bile ductular proliferation as a prognostic factor in biliary atresia: An immunohistochemical assessment

JOURNAL OF PEDIATRIC SURGERY
  • Y Kinugasa
  • ,
  • Y Nakashima
  • ,
  • S Matsuo
  • ,
  • K Shono
  • ,
  • S Suita
  • ,
  • K Sueishi

34
11
開始ページ
1715
終了ページ
1720
記述言語
英語
掲載種別
出版者・発行元
W B SAUNDERS CO

Purpose: The correlation between the histological findings of the intrahepatic biliary epithelium and postoperative bile drainage in biliary atresia (BA) was investigated.
Methods: The patients with BA were classified into 2 groups, consisting of a good bile drainage group (GBD, n = 14, mean age at initial operation, 57.6 +/- 18.0 days) and a poor bile drainage group (PBD, n = 11, mean age at initial operation, 86.9 +/- 42.7 days). Liver specimens from an initial Kasai's operation were examined by immunostaining using anticytokeratin 7 (CK7) antibody and anti-MIB-1 antibody. The number of CK7-positive cells in the bile ductules was microscopically calculated within the 40-mu m-thick interstitium along the limiting plate (LP), and the CK7-positive cell number per unit length of the LP was estimated. In addition, the MIB-1 index in bile ductules also was determined.
Results: The number of CK7-positive cells in PBD was significantly higher than that in GBD (167.6 +/- 45.6 v 117.8 +/- 32.4/mm, P < .05). However, the MIB-1 index in biliary cells did not differ between the 2 groups.
Conclusion: An increased number of intrahepatic bile duct epithelial cells in liver specimens at the initial operation may be a poor prognostic factor in BA and appears to depend on the duration of bile stasis rather than the degree of bile stasis. Copyright (C) 1999 by W.B. Saunders Company.

Web of Science ® 被引用回数 : 20

リンク情報
Web of Science
https://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcAuth=JSTA_CEL&SrcApp=J_Gate_JST&DestLinkType=FullRecord&KeyUT=WOS:000083798900031&DestApp=WOS_CPL