MISC

2002年1月

Relationship between biologic behavior and phenotypic expression in intramucosal gastric carcinomas

HUMAN PATHOLOGY
  • A Kabashima
  • ,
  • T Yao
  • ,
  • K Sugimachi
  • ,
  • M Tsuneyoshi

33
1
開始ページ
80
終了ページ
86
記述言語
英語
掲載種別
DOI
10.1053/hupa.2002.30182
出版者・発行元
W B SAUNDERS CO

We investigated the biologic behavior of gastric phenotype carcinoma of the stomach, especially in association with degradation of the extracellular matrix. One hundred fourteen lesions of intramucosal gastric carcinoma (IMGC) of differentiated type were studied. IMGCs were classified into 4 phenotypic categories-complete intestinal type (C type), incomplete intestinal type (I type), gastric type (G type), and unclassified type-through a combination of the expression of CD10, MUC2, HGM, and Con A. The expression of MMP-2, MMP-9, TIMP-2, and type IV collagen was investigated by immunohistochemical staining. The incidence of C-type IMGC, I-type IMGC, and G-type IMGC was 7.9%, 55.3%, and 36.8%, respectively. The incidence of positive MMP-9 expression in G-type IMGCs (57%) was significantly higher than that in C-type IMGCs (11%) or I-type IMGCs (35%) (P < 0.1). There was no significant correlation between phenotypes and expression of MMP-2, TIMP-2, or type IV collagen. There was a reverse correlation between the expression of type IV collagen and the expression of type IV collagenase (P < .001). In conclusion, gastric phenotype carcinomas have been shown to be highly invasive and metastatic, However, although they can potentially degrade the extracellular matrix via overexpression of MMPs compared with intestinal phenotype carcinoma, our data show no statistically significant separation of subtypes of intramucosal gastric cancer based on gross classification, histologic type, lymphatic or venous invasion, or lymph node metastases. Copyright (C) 2002 by W.B. Saunders Company.

Web of Science ® 被引用回数 : 45

リンク情報
DOI
https://doi.org/10.1053/hupa.2002.30182
Web of Science
https://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcAuth=JSTA_CEL&SrcApp=J_Gate_JST&DestLinkType=FullRecord&KeyUT=WOS:000173546300011&DestApp=WOS_CPL