早川浩 (Hiroshi Hayakawa) - マイポータル

基本情報

所属: 福岡歯科大学機能生物化学講座生化学分野教授

学位: 博士(理学)(九州大学)

J-GLOBAL ID: 200901039344287947
researchmap会員ID: 1000041333

研究キーワード

研究分野

ライフサイエンス / 分子生物学 /

経歴

1984年 - 1987年

スタンフォード大学医学センターポストドク
1984年 - 1987年

Stanford Univ., Postdoctoral fellow
1987年

- 九大・医・生化学(現・医化学) 助手
1987年

- Kyushu Univ., Research Assistant
1981年 - 1984年

九大・医・生化学教室助手
1981年 - 1984年

Kyushu Univ., Research Assistant

学歴

論文

Age-dependent increases in the oxidative damage of DNA, RNA, and their metabolites in normal and senescence-accelerated mice analyzed by LC-MS/MS: Urinary 8-oxoguanosine as a novel biomarker of aging

Wei Gan, Ben Nie, Fei Shi, Xin-Min Xu, Jian-Chang Qian, Yasumitsu Takagi, Hiroshi Hayakawa, Mutsuo Sekiguchi, Jian-Ping Cai

FREE RADICAL BIOLOGY AND MEDICINE 52(9) 1700-1707 2012年5月査読有り
Lowered Nudix type 5 (NUDT5) expression leads to cell cycle retardation in HeLa cells

Li-Qun Zhang, Da-Peng Dai, Wei Gan, Yasumitsu Takagi, Hiroshi Hayakawa, Mutsuo Sekiguchi, Jian-Ping Cai

MOLECULAR AND CELLULAR BIOCHEMISTRY 363(1-2) 377-384 2012年4月査読有り
Oxidative Damage to RNA and Expression Patterns of MTH1 in the Hippocampi of Senescence-Accelerated SAMP8 Mice and Alzheimer's Disease Patients

Xiao-Ning Song, Li-Qun Zhang, Dong-Ge Liu, Jing Lin, Jun-De Zheng, Da-Peng Dai, Ai-Lian Hei, Hiroshi Hayakawa, Mutsuo Sekiguchi, Jian-Ping Cai

NEUROCHEMICAL RESEARCH 36(8) 1558-1565 2011年8月査読有り
Cleavage of oxidized guanine nucleotide and ADP sugar by human NUDT5 protein

Riyoko Ito, Mutsuo Sekiguchi, Daiki Setoyama, Yoshimichi Nakatsu, Yuriko Yamagata, Hiroshi Hayakawa

JOURNAL OF BIOCHEMISTRY 149(6) 731-738 2011年6月査読有り
Human proteins that specifically bind to 8-oxoguanine-containing RNA and their responses to oxidative stress

Hiroshi Hayakawa, Aya Fujikane, Riyoko Ito, Masaki Matsumoto, Keiichi I. Nakayama, Mutsuo Sekiguchi

BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS 403(2) 220-224 2010年12月査読有り
RNA quality control in mammalian cells

HAYAKAWA Hiroshi

J. Fukuoka Dent. Coll. 33 109-117 2007年査読有り
Exogenous 8-oxo-dG is not utilized for nucleotide synthesis but enhances the accumulation of 8-oxo-Gua in DNA through error-prone DNA synthesis

JE Kim, JW Hyun, H Hayakawa, S Choi, J Choi, MH Chung

MUTATION RESEARCH-FUNDAMENTAL AND MOLECULAR MECHANISMS OF MUTAGENESIS 596(1-2) 128-136 2006年4月査読有り
Human Polynuleotide Phosphorylase Protein in Responcse to Oxidative Stress

HAYAKAWA Hiroshi

Biochemistry 44 6670-6674 2006年査読有り
Multiple enzyme activities of Escherichia coli MutT protein for sanitization of DNA and RNA precursor pools

R Ito, H Hayakawa, M Sekiguchi, T Ishibashi

BIOCHEMISTRY 44(17) 6670-6674 2005年5月査読有り
Mammalian enzymes for preventing transcriptional errors caused by oxidative damage

T Ishibashi, H Hayakawa, R Ito, M Miyazawa, Y Yamagata, M Sekiguchi

NUCLEIC ACIDS RESEARCH 33(12) 3779-3784 2005年査読有り

MISC

RNA quality control in mammalian cells.

Hayakawa, H

J. Fukuoka Dent. Coll. 33 109-117 2007年
Human polynucleotide phosphorylase protein in response to oxidative stress

Hiroshi Hayakawa, Mutsuo Sekiguchi

BIOCHEMISTRY 45(21) 6749-6755 2006年5月
Exogenous 8-oxo-dG is not utilized for nucleotide synthesis but enhances the accumulation of 8-oxo-Gua in DNA through error-prone DNA synthesis

JE Kim, JW Hyun, H Hayakawa, S Choi, J Choi, MH Chung

MUTATION RESEARCH-FUNDAMENTAL AND MOLECULAR MECHANISMS OF MUTAGENESIS 596(1-2) 128-136 2006年4月
Multiple enzyme activities of Escherichia coli MutT protein for sanitization of DNA and RNA precursor pools

R Ito, H Hayakawa, M Sekiguchi, T Ishibashi

BIOCHEMISTRY 44(17) 6670-6674 2005年5月
Mammalian enzymes for preventing transcriptional errors caused by oxidative damage.

Nucl. Acids Res. 33(12) 3779-3784 2005年
Mouse MTH2 protein which prevents mutations caused by 8-oxoguanine nucleotides

JP Cai, T Ishibashi, Y Takagi, H Hayakawa, M Sekiguchi

BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS 305(4) 1073-1077 2003年6月
A novel mechanism for preventing mutations caused by oxidation of guanine nucleotides

T Ishibashi, H Hayakawa, M Sekiguchi

EMBO REPORTS 4(5) 479-483 2003年5月
The basic and clinical implications of ABC transporters, Y-box- binding protein-1 (YB-1) and angiogenesis-related factors in human malignanciess

Cancer Scienceˇ 94, 9-14 2003年
Binding capacity of human YB-1 protein for RNA containing 8-oxoguanine

H Hayakawa, T Uchiumi, T Fukuda, M Ashizuka, K Kohno, M Kuwano, M Sekiguchi

BIOCHEMISTRY 41(42) 12739-12744 2002年10月
Role of tryptophane residues in the recognition of mutagenic oxidized nucleotides by human antimutator MTH1 protein

J.M.B. 319, 129-139 2002年
Specific Binding of 8-Oxoguanine-containing RNA to Polynucleotide Phosphorylase Protein

Biochemistry (Inpress) 2001年
Nucleotide excision repair DNA synthesis by excess DNA polymerase beta: a potential source of genetic instability in cancer cells

Y Canitrot, JS Hoffmann, P Calsou, H Hayakawa, B Salles, C Cazaux

FASEB JOURNAL 14(12) 1765-1774 2000年9月
Metabolic fate of oxidized guanine ribonucleotides in mammalian cells

H Hayakawa, A Hofer, L Thelander, S Kitajima, Y Cai, S Oshiro, H Yakushiji, Y Nakabeppu, M Kuwano, M Sekiguchi

BIOCHEMISTRY 38(12) 3610-3614 1999年3月
Potential of Escherichia coli GTP CyclohydrolaseII for Hydrolyzing 8-oxo-dGTP, a Mutagenic Substrate for DNS Synthesis

J. Biol. Chem. 273 1998年
Transcriptional Errors Caused by Oxidative Damage are Counteracted by MutT Protein

SCIENCE 1997年
GENERATION AND ELIMINATION OF 8-OXO-7,8-DIHYDRO-2'-DEOXYGUANOSINE 5'-TRIPHOSPHATE, A MUTAGENIC SUBSTRATE FOR DNA-SYNTHESIS, IN HUMAN-CELLS

H HAYAKAWA, A TAKETOMI, K SAKUMI, M KUWANO, M SEKIGUCHI

BIOCHEMISTRY 34(1) 89-95 1995年1月
INTRACELLULAR-LOCALIZATION AND FUNCTION OF DNA-REPAIR METHYLTRANSFERASE IN HUMAN-CELLS

T ISHIBASHI, Y NAKABEPPU, H KAWATE, K SAKUMI, H HAYAKAWA, M SEKIGUCHI

MUTATION RESEARCH-DNA REPAIR 315(3) 199-212 1994年11月
REQUIREMENT OF THE PRO-CYS-HIS-ARG SEQUENCE FOR O-6 METHYLGUANINE-DNA METHYLTRANSFERASE ACTIVITY REVEALED BY SATURATION MUTAGENESIS WITH NEGATIVE AND POSITIVE SCREENING

K IHARA, H KAWATE, LL CHUEH, H HAYAKAWA, M SEKIGUCHI

MOLECULAR & GENERAL GENETICS 243(4) 379-389 1994年5月
Organization and Expression of the Human Gene for O⁶-methylguanive-DNA Methyl transferase

Mutation Research 293 1993年
Induced synthesis of O⁶ -methylguanive DNA methyltransferase in rat hepatoma cells exposed to DNA-damaging agents

Jpn. J Cancer Res 83 1992年

もっとみる

書籍等出版物

Mammalian Enzymes for Preventing Mutations Caused by Oxidation of Guanine Nucleotides

DNA damage and Repair : Molecular and Cell Biology, Humana Press Inc. , Totowa, NJ 1998年

早川浩

基本情報

研究キーワード

研究分野

経歴

学歴

論文

MISC

書籍等出版物

所属学協会

共同研究・競争的資金等の研究課題

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