2004年
Increased risk of cholelithiasis after esophagectomy
JOURNAL OF HEPATO-BILIARY-PANCREATIC SURGERY
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- 巻
- 11
- 号
- 5
- 開始ページ
- 319
- 終了ページ
- 323
- 記述言語
- 英語
- 掲載種別
- 研究論文(学術雑誌)
- DOI
- 10.1007/s00534-004-0914-7
- 出版者・発行元
- SPRINGER TOKYO
Background/Purpose. Truncal vagotomy enhances gallstone formation. As esophagectomy involves truncal vagotomy, it was hypothesized that esophagectomy would increase the risk of cholelithiasis. This study was intended to test this hypothesis and to elucidate factors influencing the incidence of cholelithiasis after esophagectomy.
Methods. The study was a retrospective analysis of 136 patients with esophageal carcinoma who had survived for 5 years or longer after esophagectomy. Eight patients (5.9%) had cholelithiasis before esophagectomy. Of the remaining 128 patients, 113 underwent abdominal ultrasonographic examination for cholelithiasis twice a year after esophagectomy; the median follow-up time was 89.5 months (range, 60-1.17 months).
Results. Gallstones developed in 26 (23%) of the 113 patients undergoing regular ultrasonographic examination. The cumulative incidence of cholelithiasis reached a plateau of 34% at 10 years after esophagectomy. Reduction of body mass index after esophagectomy was the strongest independent predictor of gallstone formation after esophagectomy (P = 0.0001, log-rank test; P = 0.0003, Cox's proportional hazards model). The prevalence of cholelithiasis at 5 years after esophagectomy (18/113; 16%) was significantly higher than that before esophagectomy (8/136: 5.9%: P = 0.012, Fisher's exact test).
Conclusions. Esophagectomy yields an increased risk of the development of cholelithiasis. Truncal vagotomy and postsuraical malnutrition may contribute to this increased gallstone formation after esophagectomy.
Methods. The study was a retrospective analysis of 136 patients with esophageal carcinoma who had survived for 5 years or longer after esophagectomy. Eight patients (5.9%) had cholelithiasis before esophagectomy. Of the remaining 128 patients, 113 underwent abdominal ultrasonographic examination for cholelithiasis twice a year after esophagectomy; the median follow-up time was 89.5 months (range, 60-1.17 months).
Results. Gallstones developed in 26 (23%) of the 113 patients undergoing regular ultrasonographic examination. The cumulative incidence of cholelithiasis reached a plateau of 34% at 10 years after esophagectomy. Reduction of body mass index after esophagectomy was the strongest independent predictor of gallstone formation after esophagectomy (P = 0.0001, log-rank test; P = 0.0003, Cox's proportional hazards model). The prevalence of cholelithiasis at 5 years after esophagectomy (18/113; 16%) was significantly higher than that before esophagectomy (8/136: 5.9%: P = 0.012, Fisher's exact test).
Conclusions. Esophagectomy yields an increased risk of the development of cholelithiasis. Truncal vagotomy and postsuraical malnutrition may contribute to this increased gallstone formation after esophagectomy.
- リンク情報
- ID情報
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- DOI : 10.1007/s00534-004-0914-7
- ISSN : 0944-1166
- PubMed ID : 15549430
- Web of Science ID : WOS:000224817900003