論文

査読有り
1997年

K-ras and p53 mutations are an independent unfavourable prognostic indicator in patients with non-small-cell lung cancer

British Journal of Cancer
  • Y. Fukuyama
  • ,
  • T. Mitsudomi
  • ,
  • K. Sugio
  • ,
  • T. Ishida
  • ,
  • K. Akazawa
  • ,
  • K. Sugimachi

75
8
開始ページ
1125
終了ページ
1130
記述言語
英語
掲載種別
研究論文(学術雑誌)
DOI
10.1038/bjc.1997.194
出版者・発行元
Nature Publishing Group

We examined 159 consecutive cases of non-small-cell lung cancer (NSCLC) for a mutation at codon 12 of the K-ras gene and for a mutation of the p53 gene occurring in exons 5-8. Eleven (6.9%) had mutations of the K-ras (ras+) and 57 (35.8%) had mutations of the p53 (p53+). There were 95 cases (59.7%) with ras-p53-, seven cases (4.4%) with ras+/p53-, 53 cases (33.3%) with ras -/p53+ and four cases (2.5%) with ras+/p53+. The ras+ group had a worse prognosis than the ras- group in all cases and in 107 early-stage cases (stage I-II, P &lt
0.05). The p53+ group had a worse prognosis in 107 early-stage cases (P &lt
0.01), but there was no statistically significant difference when 52 advanced-stage cases (stage III-IV) or all patients were considered. Both ras and p53 mutations were unfavourable prognostic factors in 94 cases with adenocarcinoma, but there was no statistical significance in 57 cases with squamous cell carcinoma. According to Cox's model, the pathological stage, ras mutation and p53 mutation were found to be independent prognostic factors. Our results suggest that ras and p53 mutations were independent unfavourable prognostic markers especially in the early stage of NSCLC or in adenocarcinoma.

リンク情報
DOI
https://doi.org/10.1038/bjc.1997.194
PubMed
https://www.ncbi.nlm.nih.gov/pubmed/9099959
ID情報
  • DOI : 10.1038/bjc.1997.194
  • ISSN : 0007-0920
  • PubMed ID : 9099959
  • SCOPUS ID : 0030894182

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