2008年4月
Diversity of the a sequence of herpes simplex virus type 1 developed during evolution
JOURNAL OF GENERAL VIROLOGY
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- ,
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- 巻
- 89
- 号
- 4
- 開始ページ
- 841
- 終了ページ
- 852
- 記述言語
- 英語
- 掲載種別
- DOI
- 10.1099/vir.0.83467-0
- 出版者・発行元
- SOC GENERAL MICROBIOLOGY
Herpes simplex virus type 1 (HSV-1) is a ubiquitous human pathogen. The a sequence of HSV-1 is the cis-acting site required for the cleavage and encapsidation of unit-length HSV-1 DNA from concatemeric forms. The consensus a sequence consists of (i) DR1 (direct repeat 1), (ii) Ub, (iii) a DR2 array [a repeat of various copy numbers of DR2 elements (111 or 12 bp)], (iv) a DR4 stretch and (v) Uc. In the present study, the nucleoticle sequences of the a sequences of 26 HSV-1 isolates were determined and the DR4 stretches were classified into three groups. The state of a set of 20 DNA polymorphisms in the genomes of these HSV-1 isolates was determined previously. A correct classification rate of 100 % was achieved when discriminant analysis was performed between the DR4 stretch (criterion variable) and the set of 20 DNA polymorphisms (predictor variables), suggesting a close association of the DR4 stretch with HSV-1 diversification. DR2 elements of 9, 13 and 14 bp were detected in addition to those of 11 and 12 bp, and a correct classification rate of 93 O/o was achieved when discriminant analysis was performed between the DR2 array and the set of 20 DNA polymorphisms. Some DR2 elements of one HSV-1 isolate had the same nucleoticle sequences as part of the adjacent DR4 stretch, and these variations were adequately explained by postulating recombination involving DR2 elements; hence, the DR2 array was deduced to be prone to recombination.
- リンク情報
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- DOI
- https://doi.org/10.1099/vir.0.83467-0
- CiNii Articles
- http://ci.nii.ac.jp/naid/80019423670
- PubMed
- https://www.ncbi.nlm.nih.gov/pubmed/18343824
- Web of Science
- https://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcAuth=JSTA_CEL&SrcApp=J_Gate_JST&DestLinkType=FullRecord&KeyUT=WOS:000254890900001&DestApp=WOS_CPL
- ID情報
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- DOI : 10.1099/vir.0.83467-0
- ISSN : 0022-1317
- CiNii Articles ID : 80019423670
- PubMed ID : 18343824
- Web of Science ID : WOS:000254890900001