Taku Matsushita - My portal

Profile Information

Affiliation: professor, Faculty of Biotechnology and Life Science, Department of Applied Life Science, Sojo University Faculty of Biotechnology and Life Science Department of Applied Life Science, Sojo University

Degree: (BLANK)(The University of Tokyo)

J-GLOBAL ID: 200901005017999044
researchmap Member ID: 1000042217

External link: http://www.life.sojo-u.ac.jp/biomed/index.html

Research Interests

Research Areas

Research History

2000 - 2005

Sojo University
2005

- 崇城大学教授
1995 - 2000

Kyushu University
1995 - 2000

Kyushu University, Associate Professor
2000

- Sojo University, Associate Professor
1997 - 1998

ミネソタ大学客員助教授
1997 - 1998

University of Minnesota, Visiting Associate
1988 - 1995

Kyushu University
1988 - 1995

Kyushu University, Research Assistant
Professor

Education

Committee Memberships

Awards

1995

日本人工臓器学会論文賞
1992

化学工学会賞奨励賞

Misc.

Effective Drug Delivery System for Duchenne Muscular Dystrophy Using Hybrid Liposomes Including Gentamicin along with Reduced Toxicity

Mamiko Yukihara, Kaori Ito, Osamu Tanoue, Koichi Goto, Taku Matsushita, Yoko Matsumoto, Masako Masuda, Shigemi Kimura, Ryuichi Ueoka

BIOLOGICAL & PHARMACEUTICAL BULLETIN, 34(5) 712-716, May, 2011
Enhancement of drug efflux activity via MDR1 protein by spheroid culture of human hepatic cancer cells

Ayumi Oshikata, Taku Matsushita, Ryuichi Ueoka

JOURNAL OF BIOSCIENCE AND BIOENGINEERING, 111(5) 590-593, May, 2011
ハイブリッドリポソームを用いた形質転換肝幹細胞の選択的排除に関する基礎研究

押方歩, 宮崎龍介, 松下琢, 上岡龍一

薬学雑誌, 131(5) 757-763, 2011
Spheroid Formation and Enhancement of Cytochrome P450 Activity for Human Fetal Hepatocytes on Poly-L-glutamic Acid Coated Dish

MATSUSHITA Taku, KIYOTA Akifumi, NISHIKURA Yasufumi, ANNO Masaru, UEOKA Ryuichi

Journal of oral tissue engineering, 4(1) 25-31, 2006
Spheroid formation and functional restoration of human fetal hepatocytes on poly-amino acid-coated dishes after serial proliferation

Cytotechnology, Vol.42, No.2, pp.57-66, 2003
Hepatic Tissne Self-Assembly -A model System for Tissne Organization-

RIKEN Review, No. 41 pp. 67. 68, 2001
Probing Enhanced Cytoohnme P450 2131/2 Activity in Rat Hepatocyte Sphcroids through Confocal Laser Scanning Microsoopy

Cell Transplantation, Vol. 10, No. 3 pp. 329-342, 2001
Conditions required for a hybrid artificial liver support system using a PUF/hepatocyte-spheroid packed-bed module and it's use in dogs with liver failure

H Ijima, K Nakazawa, S Koyama, M Kaneko, T Matsushita, T Gion, K Shirabe, M Shimada, K Takenaka, K Sugimachi …

INTERNATIONAL JOURNAL OF ARTIFICIAL ORGANS, 23(7) 446-453, Jul, 2000
Development of a hybrid artificial liver using a polyurethane foam/hepatocyte-spheroid packed-bed module

H Ijima, K Nakazawa, S Koyama, M Kaneko, T Matsushita, T Gion, K Shirabe, M Shimada, K Takenaka, K Sugmiachi …

INTERNATIONAL JOURNAL OF ARTIFICIAL ORGANS, 23(6) 389-397, Jun, 2000
Vitronectin enhances adhesion force and t-PA production of weakly adherent 293 cells exposed to a shear stress

T Matsushita, Y Kawakubo, M Sawano, K Funatsu

CYTOTECHNOLOGY, 32(3) 181-190, Mar, 2000
Evaluation of a hybrid artificial liver using a polyurethane foam packed-bed culture system in dogs

T Gion, M Shimada, K Shirabe, K Nakazawa, H Ijima, T Matsushita, K Funatsu, K Sugimachi

JOURNAL OF SURGICAL RESEARCH, 82(2) 131-136, Apr, 1999
初代ブタ肝細胞のポリウレタンフォーム(PUF)/スフェロイド培養法を用いたハイブリッド型人工肝臓開発のための培養条件の検討(共著)

中澤浩二, 井嶋博之, 金子充, 伊東俊純, 松下琢, 祇園智信, 調憲, 島田光生, 竹中賢治, 杉町圭蔵 …

人工臓器, 27(1) 222-226, 1998
The formation of a spheroid of primary hepatocytes and the expression of liver-specific functions depend on the characteristics of polyurethane foam

Hiroyuki Ijima, Kohji Nakazawa, Mitsuru Kaneko, Hiroshi Mizumoto, Taku Matsushita, Tomonobu Gion, Mitsuo Shimada, Ken Shirabe, Kenji Takenaka, Keizo Sugimachi …

Journal of Artificial Organs, 1(2) 83-88, 1998
Formation of a spherical multicellular oggregate(spheroid)of animal cells in the pores of polyurethane foam as a cell culture substratum and its application to a hybrid artificial liver(共著)

Journal Biomaterial Science Polymer Edition, 9(7) 765-778, 1998
Investigation of optimum culture condition for hybrid artificial liver module using PUF/borcine hepatocyte spheroid culture

K. NAKAZAWA, H. IJIMA, M. KANEKO, T. ITO, T. MATSUSHITA, T. GION, K. SHIRABE, M. SHIMADA, K. TAKENAKA, K. SUGIMACHI …

The Japanese Journal of Artificial Organs, 27(1) 222-226, 1998
Hepatocyte spheroids in polyurethane foams: Functional analysis and application for a hybrid artificial liver

Hiroyuki Ijima, Taku Matsushita, Kohji Nakazawa, Yasuo Fujii, Kazumori Funatsu

Tissue Engineering, 4(2) 213-226, 1998
PUF/肝細胞スフェロイド充填層型人工肝臓のイヌ温虚血肝不全モデルへの適用(共著)

肝臓, 38(4) 278-280, 1997
APPLICATION OF HYBRID ARTIFICIAL LIVER USING PUF/HEPATOCYTES-SPHEROID PACKEDBED MODULE TO WARM ISCHEMIC LIVER FAILURE DOG

MATSUSHITA T., KOYAMA S., IJIMA H., NAKAZAWA K., GION T., SHIRABE K., SHIMADA M., TAKENAKA K., SUGIMACHI K., FUNATSU K.

Journal of the Japanese Society for Artificial Organs and Tissues, 26(2) 455-459, 1997
人工肝臓-この一年の進歩(共著)

人工臓器, 25(6) 923-925, 1997
解説ハイブリッド型人工肝臓

船津和守, 井嶋博之, 中澤浩二

バイオサイエンスとインダストリー, 55(1) 21-24, 1997

Books and Other Publications

動物細胞工学ハンドブック(共著)(編集)

朝倉書店, 2000
Development of a hybrid artificial liver support system with porcine hepatocyte spheroids for preclinical use(共著)

Animal Cell Technology : Basic&Applied Aspects, 1999
Formation of cylindrical multicellular aggregate(cylindroid)of rat hepatocytes on pressed sheet of polyurethane foam(共著)

Animal Cell Technology : Basic&Applied Aspects., 1999
Development of Drug Metabolism Simulator Using Three-Dimensional Culture of Hepatocytes of Rats and Dogs(共著)

Animal Cell Technology -From Vaccines to Genetic Medcine-, 1997
Sheroid Formation of Primary Dog Hepatocytes Using Polyurethane Foam and Its Application to Hybrid Artificial Liver(共著)

Animal Cell Technology -From Vaccines to Genetic Medicine-, 1997
培養細胞による人工臓器作成(共著)

動物生産生命工学, 1996
新タンパク質応用工学「(共著)」

(株)フジ. テクノシステム, 1996
Development of An Artificial Organ Using Culture Cell

1996
Finite element analysis of 3-D. flow in an agitated bioreactor

Animal Cell Teachnology-Developments towards the 21st Century, 1995
Development of a hybrid artifical liver support system using PHF/spheroid packed-bed

Animal Cell Teachnology-Developments towards the 21st Century, 1995
バイオプロセスシステム工学(共著)

アイピーシー(株), 1994
Bioprocess System Engineering

1994
Establishment of a rat extracorporeal circulation system to estimate the performance of a hybrid artificial liver (共著)

Animal Cell Technology : Basic & Applied Aspects, 1994
High density culture of plant cells using an air-lift column for production of valuable metabolites (共著)

Studies in Plant Science : Advances in Plant Biotechnology, 1994

Professional Memberships

Works

Research Projects

ヒト肝細胞の三次元培養モジュールの開発とその応用に関する研究

2008
幹細胞のがん化（形質転換）を阻止する新規培養プロセスの構築

科学研究費補助金
肝細胞の三次元培養を利用した新薬の超微量スクリーニングシステムの開発
ハイブリッド型人工肝臓の開発に関する研究

共同研究
Development of micro screening system using three dimensional culture of hepatocyte for discovering new drugs
Study on Development of High density and Mass Culture Vessel of Animal Cells and Its Application

Grant-in-Aid for Scientific Research
Study on Development of Hybrid Artificial Liver

Cooperative Research

Industrial Property Rights

”スフェロイド形成促進剤”