Supramolecular hydrogels with unique dynamic properties (e.g. stimuli-responsiveness and reversibility) have been expected as novel smart biomaterials. Herein, we describe the recent progress of functional supramolecular hydrogels in artificial and natural multi-component systems. Rational hybridization of functional materials with supramolecular hydrogels, and double network supramolecular hydrogels afforded us novel materials with intriguing properties derived from each component Additionaly. formation of supramolecular polymers in cell or in vivo have been achieved for biological applications. The recent examples clearly indicate tremendous potentials of supramolecular polymers in multi-component systems.