2009年5月
Ligand-directed tosyl chemistry for protein labeling in vivo
NATURE CHEMICAL BIOLOGY
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- 巻
- 5
- 号
- 5
- 開始ページ
- 341
- 終了ページ
- 343
- 記述言語
- 英語
- 掲載種別
- 研究論文(学術雑誌)
- DOI
- 10.1038/nchembio.157
- 出版者・発行元
- NATURE PUBLISHING GROUP
Here we describe a method for the site-selective attachment of synthetic molecules into specific 'endogenous' proteins in vivo using ligand-directed tosyl (LDT) chemistry. This approach was applied not only for chemically labeling proteins in living cells, tissues and mice but also for constructing a biosensor directly inside cells without genetic engineering. These data establish LDT chemistry as a new tool for the study and manipulation of biological systems.
- リンク情報
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- DOI
- https://doi.org/10.1038/nchembio.157
- J-GLOBAL
- https://jglobal.jst.go.jp/detail?JGLOBAL_ID=200902230064883876
- PubMed
- https://www.ncbi.nlm.nih.gov/pubmed/19330012
- Web of Science
- https://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcAuth=JSTA_CEL&SrcApp=J_Gate_JST&DestLinkType=FullRecord&KeyUT=WOS:000265427000015&DestApp=WOS_CPL
- ID情報
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- DOI : 10.1038/nchembio.157
- ISSN : 1552-4450
- eISSN : 1552-4469
- J-Global ID : 200902230064883876
- PubMed ID : 19330012
- Web of Science ID : WOS:000265427000015