2010年5月
Development of Highly Sensitive Fluorescent Probes for Detection of Intracellular Copper(I) in Living Systems
JOURNAL OF THE AMERICAN CHEMICAL SOCIETY
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- 巻
- 132
- 号
- 17
- 開始ページ
- 5938
- 終了ページ
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- 記述言語
- 英語
- 掲載種別
- 研究論文(学術雑誌)
- DOI
- 10.1021/ja100714p
- 出版者・発行元
- AMER CHEMICAL SOC
We describe here the new copper-selective fluorescent probes FluTPA1 and FluTPA2, in which the tetradentate ligand tris[(2-pyridyl)methyl]amine (TPA) is connected to a reduced form of a fluorescein platform through a benzyl ether linkage. These probes selectively react with copper ions in the presence of submillimolar glutathione and emit intense green fluorescence from the reaction product, O-methylfluorescein. Confocal images of live cells further show that FluTPA2 is membrane-permeable and allows visualization of Cu(I) present in living cells.
- リンク情報
- ID情報
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- DOI : 10.1021/ja100714p
- ISSN : 0002-7863
- PubMed ID : 20377254
- Web of Science ID : WOS:000277158500008